ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($8.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $840.48. Options: 18 managers hold calls ($364.4m notional), 13 hold puts ($165.4m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
| Q1 2023 | 273 |
| Q2 2023 | 291 |
| Q3 2023 | 342 |
| Q4 2023 | 347 |
| Q1 2024 | 328 |
| Q2 2024 | 336 |
| Q3 2024 | 358 |
| Q4 2024 | 397 |
| Q1 2025 | 449 |
| Q2 2025 | 439 |
| Q3 2025 | 469 |
| Q4 2025 | 509 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 166 | 176 |
| Q2 2024 | 177 | 147 |
| Q3 2024 | 187 | 149 |
| Q4 2024 | 204 | 157 |
| Q1 2025 | 236 | 177 |
| Q2 2025 | 225 | 204 |
| Q3 2025 | 266 | 192 |
| Q4 2025 | 247 | 219 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $318.8m | $173.6m | 0.54 |
| Q2 2025 | $275.6m | $126.6m | 0.46 |
| Q3 2025 | $549.2m | $262.8m | 0.48 |
| Q4 2025 | $364.4m | $165.4m | 0.45 |
Biggest buyers
| SANDS CAPITAL MANAGEMENT, LLC | Added | +340.2k |
| Invesco Ltd. | Added | +331.5k |
| ALLIANCEBERNSTEIN L.P. | Added | +329.4k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | New | +223.7k |
| BlackRock, Inc. | Added | +211.8k |
| VOYA INVESTMENT MANAGEMENT LLC | Added | +147.5k |
| AGF MANAGEMENT LTD | New | +124.7k |
| MORGAN STANLEY | Added | +83.7k |
| BESSEMER GROUP INC | Added | +62.5k |
| BANK OF AMERICA CORP /DE/ | Added | +58.4k |
Biggest sellers
| Artisan Partners Limited Partnership | Reduced | -429.6k |
| CITADEL ADVISORS LLC | Reduced | -362.7k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -287.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -278.1k |
| Clearbridge Investments, LLC | Reduced | -243.1k |
| ALKEON CAPITAL MANAGEMENT LLC | Sold out | -175.0k |
| Jefferies Financial Group Inc. | Reduced | -125.0k |
| Woodline Partners LP | Reduced | -124.0k |
| D. E. Shaw & Co., Inc. | Reduced | -123.5k |
| JANUS HENDERSON GROUP PLC | Reduced | -117.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $100.2m119.1k shares |
| D. E. Shaw & Co., Inc. | Added | $63.5m75.5k shares |
| LMR Partners LLP | Reduced | $62.2m74.0k shares |
| JPMORGAN CHASE & CO | New | $24.0m28.5k shares |
| CITADEL ADVISORS LLC | Reduced | $20.3m24.1k shares |
| IMC-Chicago, LLC | Reduced | $19.7m23.4k shares |
| Caption Management, LLC | Reduced | $18.5m22.0k shares |
| Squarepoint Ops LLC | Added | $15.8m18.8k shares |
| JANE STREET GROUP, LLC | Reduced | $9.5m11.3k shares |
| NOMURA HOLDINGS INC | Added | $6.7m8.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $97.0m115.3k shares |
| CITADEL ADVISORS LLC | Reduced | $22.4m26.6k shares |
| IMC-Chicago, LLC | Reduced | $10.2m12.1k shares |
| NOMURA HOLDINGS INC | Added | $6.7m8.0k shares |
| Walleye Trading LLC | Added | $5.0m5.9k shares |
| Walleye Capital LLC | Added | $4.9m5.8k shares |
| JANE STREET GROUP, LLC | Reduced | $4.2m5.0k shares |
| Point72 Asset Management, L.P. | New | $3.8m4.5k shares |
| GROUP ONE TRADING LLC | Added | $3.1m3.7k shares |
| D. E. Shaw & Co., Inc. | Reduced | $3.0m3.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.24% of their portfolio | 5.6m $4.7bn | Reduced -100.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.30% of their portfolio | 3.4m $2.8bn | Reduced -278.1k |
| JANUS HENDERSON GROUP PLC 0.92% of their portfolio | 2.5m $2.1bn | Reduced -117.1k |
| Capital World Investors 0.22% of their portfolio | 1.9m $1.6bn | Reduced -43.3k |
| Artisan Partners Limited Partnership 2.26% of their portfolio | 1.8m $1.5bn | Reduced -429.6k |
| Avoro Capital Advisors LLC 8.18% of their portfolio | 990.0k $832.5m | Unchanged |
| BlackRock, Inc. 0.01% of their portfolio | 735.6k $618.6m | Added +211.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.10% of their portfolio | 679.2k $571.2m | Reduced -50.8k |
| RTW INVESTMENTS, LP 5.67% of their portfolio | 673.5k $566.4m | Unchanged |
| MORGAN STANLEY 0.03% of their portfolio | 518.9k $436.3m | Added +83.7k |
| Clearbridge Investments, LLC 0.35% of their portfolio | 513.8k $432.1m | Reduced -243.1k |
| Bellevue Group AG 7.36% of their portfolio | 461.9k $388.4m | Reduced -84.5k |
| Invesco Ltd. 0.03% of their portfolio | 416.4k $350.2m | Added +331.5k |
| ALLIANCEBERNSTEIN L.P. 0.11% of their portfolio | 414.2k $348.3m | Added +329.4k |
| BANK OF AMERICA CORP /DE/ 0.02% of their portfolio | 400.8k $337.0m | Added +58.4k |
| SANDS CAPITAL MANAGEMENT, LLC 0.91% of their portfolio | 356.9k $300.1m | Added +340.2k |
| CITADEL ADVISORS LLC 0.20% of their portfolio | 350.9k $295.0m | Reduced -362.7k |
| SEI INVESTMENTS CO 0.27% of their portfolio | 330.5k $277.9m | Added +18.2k |
| TWO SIGMA INVESTMENTS, LP 0.32% of their portfolio | 258.6k $217.4m | Reduced -35.6k |
| FRANKLIN RESOURCES INC 0.05% of their portfolio | 237.7k $199.9m | Reduced -20.6k |
| JENNISON ASSOCIATES LLC 0.12% of their portfolio | 229.8k $193.2m | Reduced -10.5k |
| Fiera Capital Corp 0.60% of their portfolio | 226.0k $190.0m | Added +48.3k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.52% of their portfolio | 223.7k $188.1m | New |
| AMERICAN CENTURY COMPANIES INC 0.09% of their portfolio | 221.0k $185.9m | Reduced -8.7k |
| LORD, ABBETT & CO. LLC 0.53% of their portfolio | 203.9k $171.4m | Added +7.0k |
| AMERIPRISE FINANCIAL INC 0.04% of their portfolio | 187.1k $157.4m | Added +21.5k |
| Allspring Global Investments Holdings, LLC 0.24% of their portfolio | 172.7k $145.1m | Reduced -38.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.14% of their portfolio | 169.1k $142.2m | Added +147.5k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 167.2k $140.6m | Reduced -25.9k |
| BAMCO INC /NY/ 0.35% of their portfolio | 153.7k $129.3m | Reduced -14.0k |
| Pictet Asset Management Holding SA 0.13% of their portfolio | 153.2k $128.8m | Reduced -16.1k |
| ORBIMED ADVISORS LLC 2.51% of their portfolio | 146.0k $122.8m | Reduced -26.3k |
| Legal & General Group Plc 0.03% of their portfolio | 144.4k $121.4m | Reduced -4.3k |
| Checkpoint Capital L.P. 37.83% of their portfolio | 142.0k $119.4m | Reduced -8.0k |
| TWO SIGMA ADVISERS, LP 0.22% of their portfolio | 135.5k $113.9m | Reduced -4.2k |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 134.7k $113.3m | Added +46.0k |
| LAZARD ASSET MANAGEMENT LLC 0.19% of their portfolio | 133.0k $111.9m | Reduced -4.2k |
| AGF MANAGEMENT LTD 0.45% of their portfolio | 124.7k $104.9m | New |
| EVENTIDE ASSET MANAGEMENT, LLC 1.59% of their portfolio | 121.2k $101.9m | Reduced -4.2k |
| ACADIAN ASSET MANAGEMENT LLC 0.16% of their portfolio | 117.9k $99.1m | Added +55.1k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.11% of their portfolio | 115.4k $97.0m | Added +34.7k |
| 1832 Asset Management L.P. 0.12% of their portfolio | 110.7k $93.1m | Unchanged |
| TimesSquare Capital Management, LLC 1.37% of their portfolio | 108.5k $91.3m | Reduced -19.0k |
| FEDERATED HERMES, INC. 0.15% of their portfolio | 106.8k $89.8m | Reduced -17.5k |
| Rock Springs Capital Management LP 4.45% of their portfolio | 103.2k $86.8m | Reduced -39.5k |
| TD Asset Management Inc 0.07% of their portfolio | 101.5k $85.4m | Reduced -19.4k |
| Ensign Peak Advisors, Inc 0.13% of their portfolio | 90.5k $76.1m | Reduced -5.9k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.95% of their portfolio | 82.6k $69.5m | Reduced -9.8k |
| ENVESTNET ASSET MANAGEMENT INC 0.02% of their portfolio | 80.0k $67.3m | Reduced -15.7k |
| PINEBRIDGE INVESTMENTS LLC 0.45% of their portfolio | 72.0k $60.6m | First filing |
| BNP PARIBAS FINANCIAL MARKETS 0.04% of their portfolio | 70.7k $59.5m | Reduced -36.0k |
| Nuveen, LLC 0.01% of their portfolio | 66.2k $55.7m | Reduced -15.2k |
| Artia Global Partners LP 8.74% of their portfolio | 64.7k $54.4m | Reduced -13.6k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 64.2k $54.0m | Reduced -5.5k |
| Eagle Health Investments LP 11.59% of their portfolio | 62.7k $52.8m | Reduced -14.7k |
| BESSEMER GROUP INC 0.08% of their portfolio | 62.5k $52.6m | Added +62.5k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 60.5k $50.8m | Reduced -287.1k |
| UBS Group AG 0.01% of their portfolio | 60.4k $50.8m | Added +6.6k |
| Jain Global LLC 0.48% of their portfolio | 58.2k $49.0m | Added +56.0k |
| ARMISTICE CAPITAL, LLC 1.19% of their portfolio | 58.0k $48.8m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio | 57.5k $48.3m | Reduced -11.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.04% of their portfolio | 57.4k $48.1m | Reduced -7.9k |
| PGGM Investments 0.73% of their portfolio | 54.8k $46.1m | Reduced -21.9k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 54.4k $45.7m | Reduced -1.3k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 53.9k $45.3m | Reduced -11.1k |
| Handelsbanken Fonder AB 0.13% of their portfolio | 52.7k $44.3m | Added +11.6k |
| Aberdeen Group plc 0.07% of their portfolio | 52.3k $44.0m | Reduced -14.3k |
| NOMURA ASSET MANAGEMENT CO LTD 0.11% of their portfolio | 49.4k $41.5m | Added +35.8k |
| Candriam S.C.A. 0.20% of their portfolio | 48.7k $41.0m | Added +541 |
| Life Cycle Investment Partners Ltd 0.27% of their portfolio | 45.8k $38.5m | First filing |
| D. E. Shaw & Co., Inc. 0.03% of their portfolio | 45.5k $38.3m | Reduced -123.5k |
| Woodline Partners LP 0.15% of their portfolio | 45.4k $38.2m | Reduced -124.0k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.06% of their portfolio | 45.3k $38.1m | First filing |
| NEW YORK STATE COMMON RETIREMENT FUND 0.05% of their portfolio | 44.0k $37.0m | Reduced -21.1k |
| Amundi 0.01% of their portfolio | 42.5k $35.7m | Added +34.3k |
| Balyasny Asset Management L.P. 0.07% of their portfolio | 41.9k $35.3m | New |
| Tri Locum Partners LP 4.11% of their portfolio | 37.7k $31.7m | Reduced -5.8k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 36.8k $31.0m | Reduced -3.4k |
| Public Sector Pension Investment Board 0.10% of their portfolio | 36.6k $30.8m | New |
| Davern Capital Partners, LP 9.70% of their portfolio | 35.7k $30.0m | First filing |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 35.7k $30.0m | Reduced -11.4k |
| VAN ECK ASSOCIATES CORP 0.02% of their portfolio | 34.5k $29.0m | Reduced -1.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 33.8k $28.5m | New |
| Soleus Capital Management, L.P. 1.13% of their portfolio | 31.7k $26.7m | Reduced -37.7k |
| BRAIDWELL LP 0.83% of their portfolio | 31.0k $26.1m | Reduced -45.1k |
| Perpetual Ltd 0.38% of their portfolio | 30.9k $26.0m | Reduced -18.4k |
| Jefferies Financial Group Inc. 0.21% of their portfolio | 30.0k $25.2m | Reduced -125.0k |
| JANE STREET GROUP, LLC 0.03% of their portfolio | 28.5k $24.0m | Reduced -21.4k |
| Squarepoint Ops LLC 0.05% of their portfolio | 28.2k $23.7m | Added +9.2k |
| BLAIR WILLIAM & CO/IL 0.06% of their portfolio | 26.3k $22.2m | Added +24.0k |
| Patient Square Capital LP 4.68% of their portfolio | 26.0k $21.9m | Added +10.5k |
| LPL Financial LLC 0.01% of their portfolio | 25.7k $21.6m | Reduced -114 |
| Quadrature Capital Ltd 0.22% of their portfolio | 25.4k $21.4m | Reduced -25.2k |
| BAKER BROS. ADVISORS LP 0.12% of their portfolio | 25.2k $21.2m | Reduced -12.6k |
| MOORE CAPITAL MANAGEMENT, LP 0.43% of their portfolio | 25.0k $21.0m | Added +10.0k |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 24.3k $20.5m | New |
| ARDSLEY ADVISORY PARTNERS LP 2.57% of their portfolio | 24.0k $20.2m | Added +9.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio | 24.0k $20.1m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 23.7k $19.9m | Reduced -2.4k |
| ODDO BHF ASSET MANAGEMENT SAS 0.74% of their portfolio | 23.5k $19.7m | Reduced -5.4k |