ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.8m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $551.18. Options: 19 managers hold calls ($275.6m notional), 15 hold puts ($126.6m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
| Q1 2023 | 273 |
| Q2 2023 | 291 |
| Q3 2023 | 342 |
| Q4 2023 | 347 |
| Q1 2024 | 328 |
| Q2 2024 | 336 |
| Q3 2024 | 358 |
| Q4 2024 | 397 |
| Q1 2025 | 449 |
| Q2 2025 | 439 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 208 | 117 |
| Q4 2023 | 193 | 156 |
| Q1 2024 | 166 | 176 |
| Q2 2024 | 177 | 147 |
| Q3 2024 | 187 | 149 |
| Q4 2024 | 204 | 157 |
| Q1 2025 | 236 | 177 |
| Q2 2025 | 225 | 204 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $291.6m | $274.9m | 0.94 |
| Q4 2024 | $375.1m | $181.5m | 0.48 |
| Q1 2025 | $318.8m | $173.6m | 0.54 |
| Q2 2025 | $275.6m | $126.6m | 0.46 |
Biggest buyers
| JANUS HENDERSON GROUP PLC | Added | +422.3k |
| CITADEL ADVISORS LLC | Added | +314.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +161.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +158.5k |
| FRANKLIN RESOURCES INC | Added | +142.6k |
| Clearbridge Investments, LLC | Added | +108.5k |
| Balyasny Asset Management L.P. | Added | +79.7k |
| Hudson Bay Capital Management LP | New | +67.9k |
| Artia Global Partners LP | Added | +67.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added | +62.0k |
Biggest sellers
| BlackRock, Inc. | Reduced | -471.2k |
| MORGAN STANLEY | Reduced | -447.9k |
| Artisan Partners Limited Partnership | Reduced | -436.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -404.6k |
| FMR LLC | Reduced | -239.7k |
| LORD, ABBETT & CO. LLC | Reduced | -173.6k |
| Invesco Ltd. | Reduced | -139.0k |
| D. E. Shaw & Co., Inc. | Reduced | -122.4k |
| DEUTSCHE BANK AG\ | Reduced | -77.0k |
| T. Rowe Price Investment Management, Inc. | Reduced | -71.1k |
Biggest calls
| Caption Management, LLC | Reduced | $57.1m103.6k shares |
| NATIONAL BANK OF CANADA /FI/ | Reduced | $49.6m900 shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $34.2m62.1k shares |
| D. E. Shaw & Co., Inc. | Added | $34.1m61.8k shares |
| LMR Partners LLP | Added | $33.0m59.9k shares |
| GROUP ONE TRADING LLC | Reduced | $13.3m24.1k shares |
| PEAK6 LLC | Added | $10.7m19.4k shares |
| CITADEL ADVISORS LLC | Reduced | $9.8m17.7k shares |
| Squarepoint Ops LLC | New | $9.8m17.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $7.7m13.9k shares |
Biggest puts
| Jefferies Financial Group Inc. | Reduced | $49.8m90.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $19.3m35.0k shares |
| PEAK6 LLC | New | $13.8m25.0k shares |
| CITADEL ADVISORS LLC | Added | $9.9m17.9k shares |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | Reduced | $9.4m17.1k shares |
| NOMURA HOLDINGS INC | New | $6.9m12.5k shares |
| D. E. Shaw & Co., Inc. | Added | $5.8m10.5k shares |
| JANE STREET GROUP, LLC | Reduced | $3.6m6.6k shares |
| SIMPLEX TRADING, LLC | Added | $2.6m4.8k shares |
| Caption Management, LLC | Reduced | $1.9m3.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.17% of their portfolio | 5.4m $3.0bn | Reduced -239.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.31% of their portfolio | 5.0m $2.7bn | Reduced -404.6k |
| JANUS HENDERSON GROUP PLC 0.69% of their portfolio | 2.6m $1.4bn | Added +422.3k |
| Artisan Partners Limited Partnership 1.93% of their portfolio | 2.3m $1.3bn | Reduced -436.1k |
| Capital World Investors 0.16% of their portfolio | 2.0m $1.1bn | Added +13.1k |
| Avoro Capital Advisors LLC 11.34% of their portfolio | 1.2m $647.7m | Reduced -60.2k |
| CITADEL ADVISORS LLC 0.41% of their portfolio | 866.0k $477.3m | Added +314.0k |
| Clearbridge Investments, LLC 0.35% of their portfolio | 772.9k $426.0m | Added +108.5k |
| RTW INVESTMENTS, LP 5.29% of their portfolio | 673.5k $371.2m | Unchanged |
| Bellevue Group AG 6.94% of their portfolio | 571.0k $314.8m | Reduced -7.8k |
| BlackRock, Inc. 0.01% of their portfolio | 550.1k $303.3m | Reduced -471.2k |
| MILLENNIUM MANAGEMENT LLC 0.21% of their portfolio | 429.8k $236.9m | Added +161.2k |
| MORGAN STANLEY 0.02% of their portfolio | 429.3k $236.6m | Reduced -447.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 405.3k $223.4m | Reduced -871 |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 336.1k $185.3m | Reduced -4.0k |
| SEI INVESTMENTS CO 0.20% of their portfolio | 316.4k $174.4m | Reduced -44.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.28% of their portfolio | 297.1k $163.8m | Added +158.5k |
| FRANKLIN RESOURCES INC 0.04% of their portfolio | 279.8k $154.2m | Added +142.6k |
| JENNISON ASSOCIATES LLC 0.09% of their portfolio | 264.6k $145.9m | Added +15.2k |
| Invesco Ltd. 0.02% of their portfolio | 243.7k $134.4m | Reduced -139.0k |
| ORBIMED ADVISORS LLC 2.88% of their portfolio | 208.0k $114.7m | Added +1.3k |
| AMERICAN CENTURY COMPANIES INC 0.06% of their portfolio | 205.9k $113.5m | Added +57.1k |
| Pictet Asset Management Holding SA 0.11% of their portfolio | 197.3k $108.8m | Reduced -32.2k |
| BRAIDWELL LP 3.67% of their portfolio | 194.5k $107.2m | Added +33.6k |
| Allspring Global Investments Holdings, LLC 0.17% of their portfolio | 185.0k $100.3m | Added +8.5k |
| BAMCO INC /NY/ 0.27% of their portfolio | 180.7k $99.6m | Reduced -32.7k |
| MARSHALL WACE, LLP 0.12% of their portfolio | 177.7k $98.0m | Added +51.0k |
| Rock Springs Capital Management LP 6.04% of their portfolio | 175.8k $96.9m | Unchanged |
| 1832 Asset Management L.P. 0.17% of their portfolio | 172.4k $95.0m | Reduced -10.9k |
| Fiera Capital Corp 0.30% of their portfolio | 158.5k $87.4m | Added +4.1k |
| Jefferies Financial Group Inc. 1.41% of their portfolio | 155.4k $85.7m | Reduced -60.6k |
| Checkpoint Capital L.P. 38.52% of their portfolio | 150.0k $82.7m | Added +35.0k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 142.2k $78.4m | Reduced -26.6k |
| D. E. Shaw & Co., Inc. 0.08% of their portfolio | 138.0k $76.0m | Reduced -122.4k |
| TimesSquare Capital Management, LLC 1.06% of their portfolio | 133.6k $73.6m | Added +8.3k |
| LAZARD ASSET MANAGEMENT LLC 0.10% of their portfolio | 127.5k $70.3m | Added +57.2k |
| Legal & General Group Plc 0.02% of their portfolio | 125.8k $69.3m | Added +11.7k |
| EVENTIDE ASSET MANAGEMENT, LLC 1.21% of their portfolio | 125.4k $69.1m | Added +11.6k |
| FEDERATED HERMES, INC. 0.13% of their portfolio | 123.7k $68.2m | Added +14.7k |
| TD Asset Management Inc 0.06% of their portfolio | 120.0k $66.2m | Reduced -20.5k |
| Assenagon Asset Management S.A. 0.10% of their portfolio | 112.1k $61.8m | Added +1.7k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 111.2k $61.3m | Added +42.3k |
| LORD, ABBETT & CO. LLC 0.18% of their portfolio | 101.1k $55.7m | Reduced -173.6k |
| Perpetual Ltd 0.63% of their portfolio | 97.0k $53.4m | Reduced -17.6k |
| Ensign Peak Advisors, Inc 0.09% of their portfolio | 93.3k $51.4m | Added +47.4k |
| Caisse de depot et placement du Quebec 0.11% of their portfolio | 90.9k $50.1m | Added +28.8k |
| Balyasny Asset Management L.P. 0.11% of their portfolio | 89.3k $49.2m | Added +79.7k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.12% of their portfolio | 87.4k $48.2m | Added +62.0k |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 86.9k $47.9m | Added +7.4k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 82.6k $45.5m | Added +44.3k |
| Public Sector Pension Investment Board 0.19% of their portfolio | 82.1k $45.2m | Unchanged |
| ARMISTICE CAPITAL, LLC 1.67% of their portfolio | 80.0k $44.1m | Reduced -18.0k |
| Artia Global Partners LP 11.10% of their portfolio | 78.3k $43.2m | Added +67.0k |
| Eagle Health Investments LP 10.53% of their portfolio | 77.4k $42.7m | Added +2.4k |
| PINEBRIDGE INVESTMENTS, L.P. 0.34% of their portfolio | 76.7k $42.3m | Added +3.6k |
| PGGM Investments 0.73% of their portfolio | 76.7k $42.3m | Added +27.9k |
| ALKEON CAPITAL MANAGEMENT LLC 0.20% of their portfolio | 75.0k $41.3m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 72.6k $40.0m | Added +5.7k |
| Aberdeen Group plc 0.07% of their portfolio | 70.3k $38.7m | Added +15.7k |
| UBS Group AG 0.01% of their portfolio | 68.3k $37.6m | Reduced -33.9k |
| Hudson Bay Capital Management LP 0.25% of their portfolio | 67.9k $37.4m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 66.8k $36.8m | Reduced -66.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.05% of their portfolio | 64.1k $35.3m | Reduced -148 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio | 63.2k $34.9m | Added +3.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 62.9k $34.7m | Added +10.5k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 58.8k $32.4m | Reduced -2.6k |
| Qube Research & Technologies Ltd 0.04% of their portfolio | 58.3k $32.1m | Reduced -19.7k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 55.4k $30.5m | Reduced -11.9k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 53.8k $29.7m | Added +52.4k |
| Tri Locum Partners LP 7.99% of their portfolio | 47.8k $26.3m | Added +29.9k |
| MOORE CAPITAL MANAGEMENT, LP 0.52% of their portfolio | 47.0k $25.9m | Added +22.0k |
| Candriam S.C.A. 0.14% of their portfolio | 45.6k $25.1m | Added +4.3k |
| First Turn Management, LLC 4.52% of their portfolio | 44.0k $24.2m | Added +2.0k |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 43.9k $24.2m | Reduced -30.1k |
| Soleus Capital Management, L.P. 1.63% of their portfolio | 42.9k $23.6m | Added +13.9k |
| VAN ECK ASSOCIATES CORP 0.03% of their portfolio | 41.6k $22.9m | Reduced -2.8k |
| Woodline Partners LP 0.12% of their portfolio | 40.3k $22.2m | Reduced -49.5k |
| Handelsbanken Fonder AB 0.08% of their portfolio | 39.8k $21.9m | Added +1.7k |
| Railway Pension Investments Ltd 0.31% of their portfolio | 39.5k $21.8m | Unchanged |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.08% of their portfolio | 39.3k $21.7m | Reduced -36.3k |
| BAKER BROS. ADVISORS LP 0.20% of their portfolio | 37.8k $20.8m | Reduced -40.0k |
| Verition Fund Management LLC 0.12% of their portfolio | 37.7k $20.8m | Reduced -2.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 36.0k $19.8m | Added +3.8k |
| Squarepoint Ops LLC 0.04% of their portfolio | 31.3k $17.3m | Added +875 |
| AXA S.A. 0.05% of their portfolio | 31.1k $17.2m | Added +1.6k |
| Patient Square Capital LP 5.76% of their portfolio | 29.0k $16.0m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 26.3k $14.5m | Reduced -326 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 24.4k $13.5m | Added +23.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 23.8k $13.1m | Added +21.9k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 23.6k $13.0m | New |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 22.6k $12.4m | Added +45 |
| COOKSON PEIRCE & CO INC 0.54% of their portfolio | 22.2k $12.3m | Reduced -1.5k |
| LPL Financial LLC 0.00% of their portfolio | 22.1k $12.2m | Added +1.2k |
| Prosight Management, LP 2.96% of their portfolio | 22.0k $12.1m | Added +8.3k |
| ODDO BHF ASSET MANAGEMENT SAS 0.45% of their portfolio | 21.6k $11.9m | Unchanged |
| Engineers Gate Manager LP 0.14% of their portfolio | 21.1k $11.6m | Added +3.8k |
| LMR Partners LLP 0.18% of their portfolio | 20.8k $11.5m | Added +7.7k |
| Driehaus Capital Management LLC 0.09% of their portfolio | 20.7k $11.4m | Reduced -28.3k |
| Quadrature Capital Ltd 0.19% of their portfolio | 20.5k $11.3m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 19.9k $11.0m | Reduced -77.0k |