ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.5m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $591.56. Options: 17 managers hold calls ($318.8m notional), 14 hold puts ($173.6m).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
| Q1 2023 | 273 |
| Q2 2023 | 291 |
| Q3 2023 | 342 |
| Q4 2023 | 347 |
| Q1 2024 | 328 |
| Q2 2024 | 336 |
| Q3 2024 | 358 |
| Q4 2024 | 397 |
| Q1 2025 | 449 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 151 | 117 |
| Q3 2023 | 208 | 117 |
| Q4 2023 | 193 | 156 |
| Q1 2024 | 166 | 176 |
| Q2 2024 | 177 | 147 |
| Q3 2024 | 187 | 149 |
| Q4 2024 | 204 | 157 |
| Q1 2025 | 236 | 177 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $133.8m | $205.6m | 1.54 |
| Q3 2024 | $291.6m | $274.9m | 0.94 |
| Q4 2024 | $375.1m | $181.5m | 0.48 |
| Q1 2025 | $318.8m | $173.6m | 0.54 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +204.2k |
| Capital World Investors | Added | +151.1k |
| UBS Group AG | Added | +82.2k |
| BANK OF AMERICA CORP /DE/ | Added | +81.6k |
| BRAIDWELL LP | Added | +80.1k |
| Assenagon Asset Management S.A. | Added | +75.4k |
| TWO SIGMA INVESTMENTS, LP | New | +73.9k |
| Qube Research & Technologies Ltd | Added | +71.3k |
| LORD, ABBETT & CO. LLC | Added | +68.5k |
| AMERIPRISE FINANCIAL INC | Added | +61.9k |
Biggest sellers
| Paradigm Biocapital Advisors LP | Reduced | -421.6k |
| T. Rowe Price Investment Management, Inc. | Reduced | -407.2k |
| Artisan Partners Limited Partnership | Reduced | -284.1k |
| JANUS HENDERSON GROUP PLC | Reduced | -169.3k |
| Point72 Asset Management, L.P. | Sold out | -148.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -132.3k |
| Siren, L.L.C. | Sold out | -115.0k |
| MARSHALL WACE, LLP | Reduced | -64.8k |
| MORGAN STANLEY | Reduced | -61.4k |
| FEDERATED HERMES, INC. | Reduced | -61.3k |
Biggest calls
| NATIONAL BANK OF CANADA /FI/ | Unchanged | $88.8m1.5k shares |
| Caption Management, LLC | Added | $66.9m113.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $43.1m72.8k shares |
| D. E. Shaw & Co., Inc. | Added | $33.4m56.4k shares |
| GROUP ONE TRADING LLC | Added | $29.3m49.5k shares |
| LMR Partners LLP | Added | $15.4m26.1k shares |
| CITADEL ADVISORS LLC | Reduced | $12.7m21.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $10.0m16.9k shares |
| PEAK6 LLC | Added | $7.1m12.0k shares |
| JANE STREET GROUP, LLC | Reduced | $6.5m10.9k shares |
Biggest puts
| Jefferies Financial Group Inc. | Unchanged | $88.8m150.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $28.8m48.7k shares |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | New | $18.9m32.0k shares |
| CITADEL ADVISORS LLC | Unchanged | $9.3m15.7k shares |
| JANE STREET GROUP, LLC | Reduced | $6.3m10.6k shares |
| Caption Management, LLC | New | $5.6m9.5k shares |
| GROUP ONE TRADING LLC | Added | $5.1m8.6k shares |
| D. E. Shaw & Co., Inc. | New | $3.7m6.3k shares |
| AMERIPRISE FINANCIAL INC | New | $2.4m4.1k shares |
| Walleye Trading LLC | New | $1.7m2.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q1 2025.
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.21% of their portfolio | 5.7m $3.4bn | Added +45.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.39% of their portfolio | 5.4m $3.2bn | Reduced -132.3k |
| Artisan Partners Limited Partnership 2.67% of their portfolio | 2.8m $1.6bn | Reduced -284.1k |
| JANUS HENDERSON GROUP PLC 0.69% of their portfolio | 2.1m $1.3bn | Reduced -169.3k |
| Capital World Investors 0.19% of their portfolio | 1.9m $1.1bn | Added +151.1k |
| Avoro Capital Advisors LLC 11.41% of their portfolio | 1.2m $731.1m | Reduced -3.3k |
| BlackRock, Inc. 0.01% of their portfolio | 1.0m $604.5m | Reduced -47.6k |
| MORGAN STANLEY 0.04% of their portfolio | 877.1k $519.2m | Reduced -61.4k |
| RTW INVESTMENTS, LP 6.10% of their portfolio | 673.5k $398.6m | Unchanged |
| Clearbridge Investments, LLC 0.34% of their portfolio | 664.4k $393.2m | Added +34.5k |
| Bellevue Group AG 7.68% of their portfolio | 578.9k $342.6m | Reduced -14.3k |
| CITADEL ADVISORS LLC 0.32% of their portfolio | 551.9k $326.7m | Added +37.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 406.2k $240.4m | Reduced -18.8k |
| Invesco Ltd. 0.04% of their portfolio | 382.7k $226.5m | Reduced -21.3k |
| SEI INVESTMENTS CO 0.27% of their portfolio | 361.0k $213.7m | Reduced -5.6k |
| BANK OF AMERICA CORP /DE/ 0.02% of their portfolio | 340.1k $201.3m | Added +81.6k |
| LORD, ABBETT & CO. LLC 0.58% of their portfolio | 274.7k $162.6m | Added +68.5k |
| MILLENNIUM MANAGEMENT LLC 0.15% of their portfolio | 268.6k $159.0m | Added +204.2k |
| D. E. Shaw & Co., Inc. 0.18% of their portfolio | 260.3k $154.1m | Reduced -28.0k |
| JENNISON ASSOCIATES LLC 0.10% of their portfolio | 249.5k $147.6m | Reduced -52.7k |
| Pictet Asset Management Holding SA 0.15% of their portfolio | 229.4k $135.8m | Reduced -55.3k |
| Jefferies Financial Group Inc. 2.20% of their portfolio | 216.0k $127.8m | Added +248 |
| BAMCO INC /NY/ 0.37% of their portfolio | 213.4k $126.3m | Reduced -28.8k |
| ORBIMED ADVISORS LLC 2.94% of their portfolio | 206.7k $122.3m | Added +17.0k |
| 1832 Asset Management L.P. 0.21% of their portfolio | 183.3k $108.5m | Reduced -24.0k |
| Allspring Global Investments Holdings, LLC 0.17% of their portfolio | 176.4k $100.1m | Added +32.2k |
| Rock Springs Capital Management LP 5.95% of their portfolio | 175.8k $104.0m | Reduced -53.9k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 168.8k $99.9m | Added +21.8k |
| BRAIDWELL LP 3.35% of their portfolio | 160.8k $95.2m | Added +80.1k |
| Fiera Capital Corp 0.33% of their portfolio | 154.4k $91.4m | Reduced -844 |
| AMERICAN CENTURY COMPANIES INC 0.05% of their portfolio | 148.9k $88.1m | Reduced -6.5k |
| TD Asset Management Inc 0.08% of their portfolio | 140.6k $83.2m | Reduced -32.1k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio | 138.6k $82.1m | Added +48.9k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 137.2k $81.2m | Added +2.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.06% of their portfolio | 133.4k $78.9m | First filing |
| MARSHALL WACE, LLP 0.10% of their portfolio | 126.8k $75.0m | Reduced -64.8k |
| TimesSquare Capital Management, LLC 1.19% of their portfolio | 125.3k $74.2m | Added +1.1k |
| Checkpoint Capital L.P. 37.34% of their portfolio | 115.0k $68.1m | Added +22.5k |
| Perpetual Ltd 0.82% of their portfolio | 114.5k $67.8m | Reduced -6.4k |
| Legal & General Group Plc 0.02% of their portfolio | 114.1k $67.5m | Added +1.1k |
| EVENTIDE ASSET MANAGEMENT, LLC 1.34% of their portfolio | 113.7k $67.3m | Added +9.6k |
| Assenagon Asset Management S.A. 0.12% of their portfolio | 110.4k $65.3m | Added +75.4k |
| FEDERATED HERMES, INC. 0.14% of their portfolio | 108.9k $64.5m | Reduced -61.3k |
| UBS Group AG 0.01% of their portfolio | 102.1k $60.5m | Added +82.2k |
| ARMISTICE CAPITAL, LLC 1.55% of their portfolio | 98.0k $58.0m | Reduced -26.0k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 96.9k $57.4m | Reduced -5.1k |
| Woodline Partners LP 0.35% of their portfolio | 89.8k $53.1m | Added +15.6k |
| Public Sector Pension Investment Board 0.21% of their portfolio | 82.1k $48.6m | Reduced -23.9k |
| T. Rowe Price Investment Management, Inc. 0.03% of their portfolio | 80.6k $47.7m | Reduced -407.2k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 2.27% of their portfolio | 80.0k $47.3m | Added +50.4k |
| ENVESTNET ASSET MANAGEMENT INC 0.02% of their portfolio | 79.5k $47.0m | Added +4.4k |
| Qube Research & Technologies Ltd 0.07% of their portfolio | 78.0k $46.2m | Added +71.3k |
| BAKER BROS. ADVISORS LP 0.51% of their portfolio | 77.8k $46.0m | Reduced -34.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.17% of their portfolio | 75.6k $44.8m | Added +29.3k |
| ALKEON CAPITAL MANAGEMENT LLC 0.26% of their portfolio | 75.0k $44.4m | Unchanged |
| Eagle Health Investments LP 11.53% of their portfolio | 75.0k $44.4m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.10% of their portfolio | 73.9k $43.8m | New |
| PINEBRIDGE INVESTMENTS, L.P. 0.34% of their portfolio | 73.2k $43.3m | Added +16.2k |
| LAZARD ASSET MANAGEMENT LLC 0.06% of their portfolio | 70.2k $41.6m | Reduced -387 |
| PFM Health Sciences, LP 3.13% of their portfolio | 69.0k $40.8m | Added +5.3k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 68.9k $40.5m | Added +61.9k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 67.3k $39.8m | Added +14.6k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 66.9k $39.6m | Reduced -3.9k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.06% of their portfolio | 64.2k $38.0m | Added +716 |
| Caisse de depot et placement du Quebec 0.08% of their portfolio | 62.1k $36.7m | Added +34.2k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 61.4k $36.3m | Reduced -14.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio | 59.7k $35.3m | Reduced -2.4k |
| Paradigm Biocapital Advisors LP 1.63% of their portfolio | 59.7k $35.3m | Reduced -421.6k |
| PERCEPTIVE ADVISORS LLC 1.25% of their portfolio | 59.5k $35.2m | Reduced -8.0k |
| Aberdeen Group plc 0.06% of their portfolio | 54.6k $32.3m | Reduced -6.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 52.4k $31.0m | Reduced -1.7k |
| Driehaus Capital Management LLC 0.28% of their portfolio | 49.1k $29.0m | Added +1.7k |
| PGGM Investments 0.39% of their portfolio | 48.8k $28.9m | Reduced -8.0k |
| Ensign Peak Advisors, Inc 0.05% of their portfolio | 46.0k $27.2m | Added +5.8k |
| VAN ECK ASSOCIATES CORP 0.03% of their portfolio | 44.4k $26.3m | Reduced -2.4k |
| First Turn Management, LLC 5.00% of their portfolio | 41.9k $24.8m | Reduced -1.2k |
| Candriam S.C.A. 0.15% of their portfolio | 41.3k $24.4m | Reduced -6.9k |
| Verition Fund Management LLC 0.14% of their portfolio | 39.9k $23.6m | Added +36.7k |
| Railway Pension Investments Ltd 0.33% of their portfolio | 39.5k $23.4m | Unchanged |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 38.3k $22.7m | Added +353 |
| Handelsbanken Fonder AB 0.09% of their portfolio | 38.0k $22.5m | Added +4.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 32.2k $19.1m | Added +7.3k |
| Squarepoint Ops LLC 0.04% of their portfolio | 30.4k $18.0m | Added +7.8k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 30.2k $17.9m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 29.8k $17.6m | Added +15.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 29.5k $17.5m | New |
| AXA S.A. 0.06% of their portfolio | 29.5k $17.4m | Reduced -4.0k |
| Soleus Capital Management, L.P. 1.34% of their portfolio | 28.9k $17.1m | New |
| JANE STREET GROUP, LLC 0.03% of their portfolio | 28.3k $16.7m | Added +383 |
| Iron Triangle Partners LP 2.60% of their portfolio | 27.9k $16.5m | Reduced -7.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 26.6k $15.7m | Reduced -624 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio | 25.4k $15.0m | Added +25.0k |
| MOORE CAPITAL MANAGEMENT, LP 0.49% of their portfolio | 25.0k $14.8m | Reduced -9.0k |
| COOKSON PEIRCE & CO INC 0.71% of their portfolio | 23.8k $14.1m | Added +294 |
| AWM Investment Company, Inc. 1.87% of their portfolio | 23.0k $13.6m | Reduced -2.0k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 22.5k $13.3m | Added +7.2k |
| ODDO BHF ASSET MANAGEMENT SAS 0.52% of their portfolio | 21.6k $12.8m | Added +2.2k |
| NATIXIS ADVISORS, LLC 0.02% of their portfolio | 21.2k $12.6m | Added +5.3k |
| LPL Financial LLC 0.00% of their portfolio | 20.9k $12.4m | Added +4.6k |
| CenterBook Partners LP 0.77% of their portfolio | 20.3k $12.0m | Added +18.2k |