Vault-13

ARGENX SE ARGX

SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019

397 institutional holders +39 vs Q3 2024
34,122,84934.1m shares reported held*
$21.0bnreported value*
60 new 144 added 122 reduced 35 sold out net sold ≈ $567.5m (-944.3k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $615.04. Options: 15 managers hold calls ($375.1m notional), 12 hold puts ($181.5m).

Trends to Q4 2024

Institutional holders

Managers reporting a position, each quarter

0200400Q3 22: 255Q4 22: 271Q1 23: 273Q2 23: 291Q3 23: 342Q4 23: 347Q1 24: 328Q2 24: 336Q3 24: 358Q4 24: 397397Q3 22Q1 23Q3 23Q1 24Q3 24Q4 24
Numbers
QuarterHolders
Q3 2022255
Q4 2022271
Q1 2023273
Q2 2023291
Q3 2023342
Q4 2023347
Q1 2024328
Q2 2024336
Q3 2024358
Q4 2024397

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q1 23: 123 bought or addedQ1 23: 139 cut or sold outQ2 23: 151 bought or addedQ2 23: 117 cut or sold outQ2 23Q3 23: 208 bought or addedQ3 23: 117 cut or sold outQ4 23: 193 bought or addedQ4 23: 156 cut or sold outQ4 23Q1 24: 166 bought or addedQ1 24: 176 cut or sold outQ2 24: 177 bought or addedQ2 24: 147 cut or sold outQ2 24Q3 24: 187 bought or addedQ3 24: 149 cut or sold outQ4 24: 204 bought or addedQ4 24: 157 cut or sold outQ4 24
Numbers
QuarterBought or addedCut or sold out
Q1 2023123139
Q2 2023151117
Q3 2023208117
Q4 2023193156
Q1 2024166176
Q2 2024177147
Q3 2024187149
Q4 2024204157

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300m$400mQ1 24 calls: $90.7mQ1 24 puts: $105.0mQ1 24P/C 1.16Q2 24 calls: $133.8mQ2 24 puts: $205.6mQ2 24P/C 1.54Q3 24 calls: $291.6mQ3 24 puts: $274.9mQ3 24P/C 0.94Q4 24 calls: $375.1mQ4 24 puts: $181.5mQ4 24P/C 0.48
Numbers
QuarterCallsPutsP/C
Q1 2024$90.7m$105.0m1.16
Q2 2024$133.8m$205.6m1.54
Q3 2024$291.6m$274.9m0.94
Q4 2024$375.1m$181.5m0.48

Biggest buyers

FMR LLC Added +824,750+824.8k
D. E. Shaw & Co., Inc. Added +186,697+186.7k
Point72 Asset Management, L.P. New +147,989+148.0k
Allspring Global Investments Holdings, LLC Added +143,834+143.8k
MARSHALL WACE, LLP Added +124,271+124.3k
Public Sector Pension Investment Board New +105,972+106.0k
Capital World Investors Added +86,687+86.7k
LAZARD ASSET MANAGEMENT LLC Added +64,684+64.7k
JENNISON ASSOCIATES LLC Added +64,183+64.2k
1832 Asset Management L.P. Added +58,000+58.0k

Biggest sellers

Artisan Partners Limited Partnership Reduced -443,247-443.2k
Deep Track Capital, LP Sold out -365,000-365.0k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -303,653-303.7k
T. Rowe Price Investment Management, Inc. Reduced -283,719-283.7k
ALKEON CAPITAL MANAGEMENT LLC Reduced -270,000-270.0k
Holocene Advisors, LP Reduced -184,534-184.5k
JANUS HENDERSON GROUP PLC Reduced -166,849-166.8k
CITADEL ADVISORS LLC Reduced -100,821-100.8k
Boxer Capital, LLC Sold out -100,000-100.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -79,000-79.0k

Biggest calls

NATIONAL BANK OF CANADA /FI/ Unchanged $92.2m1.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $84.6m137.5k shares
Caption Management, LLC Added $63.7m103.6k shares
GROUP ONE TRADING LLC Added $23.4m38.1k shares
D. E. Shaw & Co., Inc. Added $22.8m37.0k shares
CITADEL ADVISORS LLC Added $19.6m31.9k shares
SIMPLEX TRADING, LLC Added $15.3m24.9k shares
JANE STREET GROUP, LLC Added $13.8m22.5k shares
LMR Partners LLP Reduced $13.4m21.8k shares
JPMORGAN CHASE & CO New $9.2m15.0k shares

Biggest puts

Jefferies Financial Group Inc. Reduced $92.2m150.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $43.4m70.6k shares
JANE STREET GROUP, LLC Reduced $17.5m28.4k shares
CITADEL ADVISORS LLC Reduced $9.7m15.7k shares
JPMORGAN CHASE & CO Added $9.2m15.0k shares
SIMPLEX TRADING, LLC Reduced $4.7m7.7k shares
GROUP ONE TRADING LLC Added $1.7m2.7k shares
Arrowpoint Investment Partners (Singapore) Pte. Ltd. First filing $1.1m1.8k shares
PEAK6 LLC First filing $1.0m1.7k shares
Balyasny Asset Management L.P. Reduced $492.0k800 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

No one currently above 5% in the filings since 19 Dec 2024.

Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)

Insider purchases and sales in Q4 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

None reported in Q4 2024.

Holders, Q4 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.21% of their portfolio BOSTON, MA 5,618,2225.6m $3.5bn $3.5bn 0.21% Added +824.8k +824,750
2 PRICE T ROWE ASSOCIATES INC /MD/ 0.39% of their portfolio BALTIMORE, MD 5,516,8945.5m $3.4bn $3.4bn 0.39% Reduced -303.7k -303,653
3 Artisan Partners Limited Partnership 2.91% of their portfolio Milwaukee, WI 3,069,9953.1m $1.9bn $1.9bn 2.91% Reduced -443.2k -443,247
4 JANUS HENDERSON GROUP PLC 0.72% of their portfolio LONDON, X0 2,312,3582.3m $1.4bn $1.4bn 0.72% Reduced -166.8k -166,849
5 Capital World Investors 0.17% of their portfolio LOS ANGELES, CA 1,786,9361.8m $1.1bn $1.1bn 0.17% Added +86.7k +86,687
6 Avoro Capital Advisors LLC 10.77% of their portfolio NEW YORK, NY 1,238,4671.2m $761.7m $761.7m 10.77% Unchanged
7 BlackRock, Inc. 0.01% of their portfolio New York, NY 1,068,9501.1m $657.4m $657.4m 0.01% Reduced -55.9k -55,866
8 MORGAN STANLEY 0.04% of their portfolio NEW YORK, NY 938,538938.5k $577.2m $577.2m 0.04% Added +7.8k +7,789
9 RTW INVESTMENTS, LP 6.26% of their portfolio NEW YORK, NY 673,497673.5k $414.2m $414.2m 6.26% Added +19.1k +19,067
10 Clearbridge Investments, LLC 0.31% of their portfolio NEW YORK, NY 629,828629.8k $387.3m $387.3m 0.31% Added +40.3k +40,330
11 Bellevue Group AG 7.02% of their portfolio ZURICH, V8 593,184593.2k $364.8m $364.8m 7.02% Reduced -39.6k -39,645
12 CITADEL ADVISORS LLC 0.29% of their portfolio MIAMI, FL 514,105514.1k $316.2m $316.2m 0.29% Reduced -100.8k -100,821
13 T. Rowe Price Investment Management, Inc. 0.19% of their portfolio BALTIMORE, MD 487,853487.9k $300.0m $300.0m 0.19% Reduced -283.7k -283,719
14 Paradigm Biocapital Advisors LP 10.30% of their portfolio NEW YORK, NY 481,305481.3k $296.0m $296.0m 10.30% Added +931 +931
15 WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio Boston, MA 424,974425.0k $261.4m $261.4m 0.05% Reduced -57.4k -57,372
16 Invesco Ltd. 0.05% of their portfolio ATLANTA, GA 404,016404.0k $248.5m $248.5m 0.05% Reduced -29.5k -29,500
17 SEI INVESTMENTS CO 0.29% of their portfolio OAKS, PA 366,620366.6k $225.5m $225.5m 0.29% Reduced -14.1k -14,075
18 JENNISON ASSOCIATES LLC 0.11% of their portfolio NEW YORK, NY 302,149302.1k $185.8m $185.8m 0.11% Added +64.2k +64,183
19 D. E. Shaw & Co., Inc. 0.20% of their portfolio New York, NY 288,299288.3k $177.3m $177.3m 0.20% Added +186.7k +186,697
20 Pictet Asset Management Holding SA 0.19% of their portfolio CAROUGE, V8 284,694284.7k $175.1m $175.1m 0.19% Reduced -66.9k -66,909
21 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 258,549258.5k $159.0m $159.0m 0.01% Reduced -77.2k -77,158
22 BAMCO INC /NY/ 0.39% of their portfolio NEW YORK, NY 242,178242.2k $148.9m $148.9m 0.39% Reduced -8.1k -8,126
23 Rock Springs Capital Management LP 5.38% of their portfolio Baltimore, MD 229,600229.6k $141.2m $141.2m 5.38% Reduced -3.9k -3,900
24 Jefferies Financial Group Inc. 1.48% of their portfolio NEW YORK, NY 215,752215.8k $132.7m $132.7m 1.48% Added +55.8k +55,752
25 1832 Asset Management L.P. 0.23% of their portfolio TORONTO, A6 207,300207.3k $127.5m $127.5m 0.23% Added +58.0k +58,000
26 LORD, ABBETT & CO. LLC 0.40% of their portfolio JERSEY CITY, NJ 206,202206.2k $126.8m $126.8m 0.40% Added +43.2k +43,239
27 MARSHALL WACE, LLP 0.15% of their portfolio LONDON, X0 191,553191.6k $117.8m $117.8m 0.15% Added +124.3k +124,271
28 ORBIMED ADVISORS LLC 2.42% of their portfolio New York, NY 189,700189.7k $116.7m $116.7m 2.42% Reduced -14.8k -14,800
29 TD Asset Management Inc 0.09% of their portfolio Toronto, A6 172,681172.7k $106.2m $106.2m 0.09% Reduced -8.0k -7,989
30 FEDERATED HERMES, INC. 0.23% of their portfolio PITTSBURGH, PA 170,247170.2k $104.7m $104.7m 0.23% Reduced -40.9k -40,897
31 AMERICAN CENTURY COMPANIES INC 0.05% of their portfolio KANSAS CITY, MO 155,376155.4k $95.6m $95.6m 0.05% Reduced -76.5k -76,533
32 Fiera Capital Corp 0.30% of their portfolio MONTREAL, A8 155,260155.3k $95.5m $95.5m 0.30% Reduced -3.1k -3,093
33 Point72 Asset Management, L.P. 0.25% of their portfolio STAMFORD, CT 147,989148.0k $91.0m $91.0m 0.25% New
34 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 146,960147.0k $90.4m $90.4m 0.02% Added +14.8k +14,778
35 Allspring Global Investments Holdings, LLC 0.14% of their portfolio CHARLOTTE, NC 144,211144.2k $89.4m $89.4m 0.14% Added +143.8k +143,834
36 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 134,591134.6k $82.8m $82.8m 0.02% Added +573 +573
37 TimesSquare Capital Management, LLC 1.11% of their portfolio NEW YORK, NY 124,245124.2k $76.4m $76.4m 1.11% Added +14.8k +14,755
38 ARMISTICE CAPITAL, LLC 1.77% of their portfolio NEW YORK, NY 124,000124.0k $76.3m $76.3m 1.77% Reduced -28.0k -28,000
39 Perpetual Ltd 0.87% of their portfolio SYDNEY, NEW SOUTH WALES, C3 120,914120.9k $74.4m $74.4m 0.87% Reduced -19.9k -19,866
40 Siren, L.L.C. 3.13% of their portfolio New York, NY 115,045115.0k $70.8m $70.8m 3.13% Reduced -28.6k -28,602
41 Legal & General Group Plc 0.02% of their portfolio London, X0 112,970113.0k $69.5m $69.5m 0.02% Added +3.4k +3,417
42 BAKER BROS. ADVISORS LP 0.74% of their portfolio NEW YORK, NY 111,904111.9k $68.8m $68.8m 0.74% Unchanged
43 Public Sector Pension Investment Board 0.28% of their portfolio MONTREAL, A8 105,972106.0k $65.2m $65.2m 0.28% New
44 EVENTIDE ASSET MANAGEMENT, LLC 1.17% of their portfolio Boston, MA 104,144104.1k $64.1m $64.1m 1.17% Reduced -4.0k -4,045
45 DEUTSCHE BANK AG\ 0.02% of their portfolio FRANKFURT AM MAIN, 2M 102,025102.0k $62.7m $62.7m 0.02% Reduced -4.7k -4,665
46 Checkpoint Capital L.P. 28.95% of their portfolio SAN FRANCISCO, CA 92,50092.5k $56.9m $56.9m 28.95% Unchanged
47 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.10% of their portfolio Boston, MA 89,78789.8k $55.2m $55.2m 0.10% Reduced -79.0k -79,000
48 BRAIDWELL LP 1.47% of their portfolio STAMFORD, CT 80,76680.8k $49.7m $49.7m 1.47% Reduced -16.0k -15,958
49 FIRST TRUST ADVISORS LP 0.04% of their portfolio Wheaton, IL 75,40975.4k $46.4m $46.4m 0.04% Reduced -6.7k -6,677
50 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 75,03775.0k $46.1m $46.1m 0.01% Added +7.1k +7,146
51 ALKEON CAPITAL MANAGEMENT LLC 0.27% of their portfolio New York, NY 75,00075.0k $46.1m $46.1m 0.27% Reduced -270.0k -270,000
52 Eagle Health Investments LP 11.31% of their portfolio Greenwich, CT 74,99075.0k $46.1m $46.1m 11.31% Unchanged
53 Woodline Partners LP 0.31% of their portfolio San Francisco, CA 74,23774.2k $45.7m $45.7m 0.31% Added +55.7k +55,656
54 RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio ST. PETERSBURG, FL 70,80270.8k $43.5m $43.5m 0.02% First filing
55 LAZARD ASSET MANAGEMENT LLC 0.06% of their portfolio NEW YORK, NY 70,63770.6k $43.4m $43.4m 0.06% Added +64.7k +64,684
56 PERCEPTIVE ADVISORS LLC 1.16% of their portfolio NEW YORK, NY 67,47167.5k $41.5m $41.5m 1.16% Reduced -51.4k -51,368
57 MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio NEW YORK, NY 64,42464.4k $39.6m $39.6m 0.03% Reduced -45.3k -45,336
58 PFM Health Sciences, LP 2.98% of their portfolio SAN FRANCISCO, CA 63,69963.7k $39.2m $39.2m 2.98% Reduced -23.1k -23,133
59 NEW YORK STATE COMMON RETIREMENT FUND 0.05% of their portfolio ALBANY, NY 63,53463.5k $39.1m $39.1m 0.05% Reduced -41.0k -41,000
60 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio Toronto, A6 62,11362.1k $38.2m $38.2m 0.03% Added +527 +527
61 Aberdeen Group plc 0.07% of their portfolio EDINBURGH, X0 61,26261.3k $37.7m $37.7m 0.07% Reduced -6.0k -6,000
62 Tri Locum Partners LP 7.42% of their portfolio NEW YORK, NY 58,25858.3k $35.8m $35.8m 7.42% Reduced -4.2k -4,216
63 PINEBRIDGE INVESTMENTS, L.P. 0.26% of their portfolio NEW YORK, NY 56,92556.9k $35.0m $35.0m 0.26% Added +7.9k +7,909
64 PGGM Investments 0.46% of their portfolio ZEIST, P7 56,77156.8k $34.9m $34.9m 0.46% Reduced -7.6k -7,638
65 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 54,12854.1k $33.3m $33.3m 0.00% Added +16.2k +16,188
66 Finepoint Capital LP 3.75% of their portfolio BOSTON, MA 52,92852.9k $32.6m $32.6m 3.75% Reduced -1.5k -1,500
67 WELLS FARGO & COMPANY/MN 0.01% of their portfolio SAN FRANCISCO, CA 52,71152.7k $32.4m $32.4m 0.01% Added +7.1k +7,149
68 Candriam S.C.A. 0.17% of their portfolio STRASSEN, N4 48,21048.2k $29.6m $29.6m 0.17% Reduced -3.2k -3,208
69 Driehaus Capital Management LLC 0.24% of their portfolio Chicago, IL 47,35447.4k $29.1m $29.1m 0.24% Added +1.7k +1,699
70 VAN ECK ASSOCIATES CORP 0.04% of their portfolio NEW YORK, NY 46,80946.8k $28.8m $28.8m 0.04% Added +8.6k +8,568
71 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.10% of their portfolio JUPITER, FL 46,35746.4k $28.5m $28.5m 0.10% New
72 First Turn Management, LLC 4.75% of their portfolio DEL MAR, CA 43,07843.1k $26.5m $26.5m 4.75% Reduced -11.4k -11,362
73 Russell Investments Group, Ltd. 0.03% of their portfolio Seattle, WA 40,52040.5k $24.9m $24.9m 0.03% Reduced -3.4k -3,432
74 Ensign Peak Advisors, Inc 0.04% of their portfolio SALT LAKE CITY, UT 40,16440.2k $24.7m $24.7m 0.04% Reduced -1.5k -1,540
75 Railway Pension Investments Ltd 0.32% of their portfolio LONDON, X0 39,50039.5k $24.3m $24.3m 0.32% Added +16.7k +16,700
76 ROYAL BANK OF CANADA 0.01% of their portfolio TORONTO, A6 37,95338.0k $23.3m $23.3m 0.01% Added +2.3k +2,341
77 Iron Triangle Partners LP 2.51% of their portfolio Cos Cob, CT 35,00035.0k $21.5m $21.5m 2.51% New
78 Assenagon Asset Management S.A. 0.04% of their portfolio SENNINGERBERG, N4 34,95535.0k $21.5m $21.5m 0.04% Added +6.2k +6,161
79 MOORE CAPITAL MANAGEMENT, LP 0.39% of their portfolio NEW YORK, NY 34,00034.0k $20.9m $20.9m 0.39% Added +12.0k +12,000
80 Handelsbanken Fonder AB 0.08% of their portfolio STOCKHOLM, V7 33,64733.6k $20.7m $20.7m 0.08% Added +6.0k +6,005
81 AXA S.A. 0.06% of their portfolio PARIS, I0 33,52233.5k $20.6m $20.6m 0.06% Reduced -52 -52
82 Thrivent Financial for Lutherans 0.04% of their portfolio Minneapolis, MN 33,06533.1k $20.3m $20.3m 0.04% Reduced -4.3k -4,287
83 ROYAL LONDON ASSET MANAGEMENT LTD 0.05% of their portfolio UNITED KINGDOM, X0 31,73731.7k $19.5m $19.5m 0.05% Reduced -1.2k -1,201
84 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 0.61% of their portfolio Boston, MA 29,61129.6k $18.2m $18.2m 0.61% New
85 Caisse de depot et placement du Quebec 0.04% of their portfolio Montreal, A8 27,90027.9k $17.2m $17.2m 0.04% New
86 JANE STREET GROUP, LLC 0.03% of their portfolio NEW YORK, NY 27,87527.9k $17.1m $17.1m 0.03% Added +19.1k +19,065
87 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 27,20727.2k $16.7m $16.7m 0.00% Added +458 +458
88 AWM Investment Company, Inc. 1.87% of their portfolio NEW YORK, NY 25,00025.0k $15.4m $15.4m 1.87% Unchanged
89 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 24,92924.9k $15.3m $15.3m 0.00% Added +4.4k +4,445
90 COOKSON PEIRCE & CO INC 0.65% of their portfolio PITTSBURGH, PA 23,48323.5k $14.4m $14.4m 0.65% Reduced -83 -83
91 Squarepoint Ops LLC 0.04% of their portfolio NEW YORK, NY 22,66422.7k $13.9m $13.9m 0.04% Added +4.3k +4,264
92 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 20,42520.4k $12.6m $12.6m 0.00% Reduced -20.4k -20,417
93 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 20,29020.3k $12.5m $12.5m 0.00% Reduced -1.3k -1,324
94 DCF Advisers, LLC 6.21% of their portfolio MOUNT PLEASANT, SC 20,00020.0k $12.3m $12.3m 6.21% Unchanged
95 UBS Group AG 0.00% of their portfolio ZURICH, V8 19,90019.9k $12.2m $12.2m 0.00% Added +18.0k +17,983
96 Saturn V Capital Management LP 4.76% of their portfolio AUSTIN, TX 19,75419.8k $12.1m $12.1m 4.76% Reduced -2.4k -2,357
97 ODDO BHF ASSET MANAGEMENT SAS 0.60% of their portfolio PARIS, I0 19,40119.4k $11.9m $11.9m 0.60% New
98 LMR Partners LLP 0.20% of their portfolio LONDON, X0 18,81018.8k $11.6m $11.6m 0.20% Added +1.0k +1,016
99 Erste Asset Management GmbH 0.13% of their portfolio VIENNA, C4 16,80016.8k $10.5m $10.5m 0.13% Unchanged
100 QVT Financial LP 0.91% of their portfolio New York, NY 16,49816.5k $10.1m $10.1m 0.91% Reduced -16.0k -16,000