ARCUS BIOSCIENCES INC RCUS
COM · Common Stock · CUSIP 03969F109
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersHayward, CA
- Founded2015
- Websitearcusbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.4m this quarter). Holder counts are more reliable. Shares outstanding: 108.0m as of 2025-10-23, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $23.83. Options: 12 managers hold calls ($92.8m notional), 10 hold puts ($5.3m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 185 |
| Q4 2022 | 201 |
| Q1 2023 | 182 |
| Q2 2023 | 183 |
| Q3 2023 | 188 |
| Q4 2023 | 186 |
| Q1 2024 | 173 |
| Q2 2024 | 194 |
| Q3 2024 | 188 |
| Q4 2024 | 187 |
| Q1 2025 | 188 |
| Q2 2025 | 187 |
| Q3 2025 | 190 |
| Q4 2025 | 209 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 79 | 90 |
| Q2 2024 | 100 | 84 |
| Q3 2024 | 88 | 95 |
| Q4 2024 | 75 | 91 |
| Q1 2025 | 125 | 57 |
| Q2 2025 | 109 | 77 |
| Q3 2025 | 93 | 84 |
| Q4 2025 | 135 | 66 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $1.1m | $1.0m | 0.95 |
| Q2 2025 | $26.4m | $1.5m | 0.06 |
| Q3 2025 | $46.2m | $2.2m | 0.05 |
| Q4 2025 | $92.8m | $5.3m | 0.06 |
Biggest buyers
| WELLINGTON MANAGEMENT GROUP LLP | Added | +3.9m |
| MARSHALL WACE, LLP | New | +3.4m |
| BlackRock, Inc. | Added | +3.2m |
| SAMLYN CAPITAL, LLC | New | +1.6m |
| MONTANOVA CAPITAL, LLC | Added | +1.5m |
| TORONTO DOMINION BANK | New | +1.5m |
| VANGUARD GROUP INC | Added | +1.3m |
| Fisher Asset Management, LLC | Added | +1.2m |
| STATE STREET CORP | Added | +1.2m |
| BARCLAYS PLC | Added | +935.2k |
Biggest sellers
| FMR LLC | Reduced | -1.2m |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -1.1m |
| Point72 Asset Management, L.P. | Reduced | -1.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -466.1k |
| MACQUARIE GROUP LTD | Sold out | -379.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -360.0k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -331.9k |
| NORDEA INVESTMENT MANAGEMENT AB | Sold out | -328.5k |
| MORGAN STANLEY | Reduced | -325.3k |
| SECTORAL ASSET MANAGEMENT INC | Reduced | -311.1k |
Biggest calls
| Balyasny Asset Management L.P. | Reduced | $29.4m1.2m shares |
| Caption Management, LLC | New | $25.7m1.1m shares |
| Logos Global Management LP | New | $25.0m1.1m shares |
| GROUP ONE TRADING LLC | Added | $4.1m172.7k shares |
| CITADEL ADVISORS LLC | Reduced | $2.3m94.6k shares |
| JANE STREET GROUP, LLC | Reduced | $1.8m74.9k shares |
| NOMURA HOLDINGS INC | Added | $1.2m51.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.1m48.0k shares |
| CITIGROUP INC | Added | $714.9k30.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $650.6k27.3k shares |
Biggest puts
| Caption Management, LLC | New | $1.9m81.4k shares |
| CITADEL ADVISORS LLC | Added | $888.9k37.3k shares |
| CITIGROUP INC | Added | $714.9k30.0k shares |
| NOMURA HOLDINGS INC | New | $714.9k30.0k shares |
| JANE STREET GROUP, LLC | Added | $512.3k21.5k shares |
| Walleye Capital LLC | New | $140.6k5.9k shares |
| GROUP ONE TRADING LLC | Reduced | $123.9k5.2k shares |
| BARCLAYS PLC | New | $119.2k5.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $64.3k2.7k shares |
| Walleye Trading LLC | New | $38.1k1.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
GILEAD SCIENCES, INC.
13D · may seek influence
-0.9 pts · filed 2026-08-07
Stated purposeOn May 27, 2020, Gilead and the Issuer entered into an Option, License and Collaboration Agreement (the "Collaboration Agreement") pursuant to with Gilead obtained an exclusive option to acquire an exclusive license to all of the Issuer's current and future clinical programs during the 10-year collaboration term and, for those programs that enter clinical development prior to the end of the collaboration term, for up to an additional three years thereafter. In addition to the Collaboration Agreement, Gilead and the Issuer entered into a Common Stock Purchase Agreement (the "Purchase Agreement"), which was amended and restated on January 31, 2021 to account for the Second Purchase (the "Amended and Restated Purchase Agreement"), on June 27, 2023 to account for the Third Purchase (the "Seco… Full filing |
24.7% |
| BlackRock, Inc. 13G · institution +1.0 pts · filed 2026-01-08 | 10.4% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26), Point72 Asset Management, L.P. (4.1%, 2025-11-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 3 | $2.3m | $2.3m |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 1 | $20.3k | $20.3k |
| Q4 2024 | 0 | — | 2 | $57.0k | $57.0k |
| Q1 2025 | 2 | $402.8k | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $55.6k | $55.6k |
| Q4 2025 | 0 | — | 7 | $10.0m | $10.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-31 | Goeltz II Robert C. Chief Financial Officer | Sold plan | $153.2k6.6k shares |
| 2025-12-18 | Azoy Alexander Chief Accounting Officer | Sold plan | $96.6k4.3k shares |
| 2025-12-17 | ROSEN TERRY J Chief Executive Officer, director | Sold plan | $570.5k25.7k shares |
| 2025-12-17 | Jaen Juan C. President | Sold plan | $221.2k10.0k shares |
| 2025-12-17 | Jarrett Jennifer Chief Operating Officer | Sold plan | $221.2k10.0k shares |
| 2025-12-17 | Tang Carolyn C. General Counsel | Sold plan | $150.9k6.8k shares |
| 2025-12-17 | Goeltz II Robert C. Chief Financial Officer | Sold plan | $132.1k6.0k shares |
| 2025-12-17 | Markus Richard Chief Medical Officer | Sold plan | $99.6k4.5k shares |
| 2025-12-17 | Azoy Alexander Chief Accounting Officer | Sold plan | $46.8k2.1k shares |
| 2025-12-16 | ROSEN TERRY J Chief Executive Officer, director | Sold plan | $633.4k28.9k shares |
| 2025-12-16 | Jaen Juan C. President | Sold plan | $245.6k11.2k shares |
| 2025-12-16 | Jarrett Jennifer Chief Operating Officer | Sold plan | $245.6k11.2k shares |
| 2025-12-16 | Tang Carolyn C. General Counsel | Sold plan | $167.6k7.7k shares |
| 2025-12-16 | Goeltz II Robert C. Chief Financial Officer | Sold plan | $146.6k6.7k shares |
| 2025-12-16 | Markus Richard Chief Medical Officer | Sold plan | $110.5k5.1k shares |
| 2025-12-16 | Azoy Alexander Chief Accounting Officer | Sold plan | $52.0k2.4k shares |
| 2025-12-04 | Jaen Juan C. President · By Trust | Sold plan | $2.1m83.0k shares |
| 2025-11-26 | Goeltz II Robert C. Chief Financial Officer | Sold plan | $125.0k5.0k shares |
| 2025-11-26 | Azoy Alexander Chief Accounting Officer | Sold plan | $49.4k1.9k shares |
| 2025-11-18 | Jaen Juan C. President · By Trust | Sold plan | $99.7k5.0k shares |
| 2025-11-17 | Jaen Juan C. President · By Trust | Sold plan | $913.1k45.0k shares |
| 2025-11-07 | Jarrett Jennifer Chief Operating Officer | Sold plan | $954.0k50.3k shares |
| 2025-10-30 | Jaen Juan C. President · By Trust | Sold plan | $87.7k4.3k shares |
| 2025-10-29 | Jaen Juan C. President · By Trust | Sold plan | $1.6m77.8k shares |
| 2025-10-28 | Jaen Juan C. President · By Trust | Sold plan | $384.0k19.0k shares |
| 2025-10-28 | Goeltz II Robert C. Chief Financial Officer | Sold plan | $100.0k5.0k shares |
| 2025-10-08 | Jarrett Jennifer Chief Operating Officer | Sold plan | $568.8k37.8k shares |
| 2025-10-06 | Jarrett Jennifer Chief Operating Officer | Sold plan | $181.8k12.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| GILEAD SCIENCES, INC. 38.69% of their portfolio | 31.4m $748.9m | Unchanged |
| BlackRock, Inc. 0.01% of their portfolio | 15.0m $357.4m | Added +3.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 8.0m $189.8m | Added +1.3m |
| MONTANOVA CAPITAL, LLC 3.08% of their portfolio | 5.2m $123.7m | Added +1.5m |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 5.2m $123.5m | Added +3.9m |
| STATE STREET CORP 0.00% of their portfolio | 4.6m $109.1m | Added +1.2m |
| Woodline Partners LP 0.35% of their portfolio | 3.8m $89.8m | Added +104 |
| MARSHALL WACE, LLP 0.08% of their portfolio | 3.4m $80.7m | New |
| Point72 Asset Management, L.P. 0.12% of their portfolio | 3.3m $78.2m | Reduced -1.1m |
| Siren, L.L.C. 2.14% of their portfolio | 3.0m $71.7m | Added +95.0k |
| Fisher Asset Management, LLC 0.02% of their portfolio | 1.9m $46.5m | Added +1.2m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $45.5m | Added +308.9k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.05% of their portfolio | 1.7m $40.2m | Added +267.4k |
| SAMLYN CAPITAL, LLC 0.61% of their portfolio | 1.6m $38.2m | New |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 1.5m $36.3m | Added +21.7k |
| TORONTO DOMINION BANK 0.06% of their portfolio | 1.5m $35.4m | New |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $28.9m | Reduced -325.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.2m $27.8m | Added +217.8k |
| FMR LLC 0.00% of their portfolio | 1.1m $27.1m | Reduced -1.2m |
| BARCLAYS PLC 0.01% of their portfolio | 1.1m $26.5m | Added +935.2k |
| Sofinnova Investments, Inc. 1.13% of their portfolio | 1.1m $26.1m | Reduced -125.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.0m $23.8m | Reduced -360.0k |
| Parkman Healthcare Partners LLC 2.20% of their portfolio | 968.6k $23.1m | Added +315.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 968.2k $23.1m | Added +97.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.09% of their portfolio | 930.0k $22.2m | Reduced -190.1k |
| Trails Edge Capital Partners, LP 5.40% of their portfolio | 916.3k $21.8m | First filing |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 853.5k $20.3m | New |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 815.6k $19.4m | Added +715.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 794.8k $18.9m | Added +87.0k |
| Candriam S.C.A. 0.09% of their portfolio | 790.6k $18.8m | Added +412.2k |
| Caption Management, LLC 0.81% of their portfolio | 767.7k $18.3m | New |
| Soleus Capital Management, L.P. 0.72% of their portfolio | 712.0k $17.0m | New |
| First Turn Management, LLC 1.54% of their portfolio | 565.1k $13.5m | New |
| Decheng Capital LLC 1.74% of their portfolio | 541.6k $12.9m | Reduced -6.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 504.5k $12.0m | Added +34.3k |
| DAFNA Capital Management LLC 2.39% of their portfolio | 431.3k $10.3m | Reduced -196.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 424.1k $10.1m | Added +340.0k |
| Invesco Ltd. 0.00% of their portfolio | 414.4k $9.9m | Added +122.0k |
| UBS Group AG 0.00% of their portfolio | 411.3k $9.8m | Added +243.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 407.5k $9.7m | Added +73.0k |
| PDT Partners, LLC 0.60% of their portfolio | 388.3k $9.3m | Unchanged |
| Aberdeen Group plc 0.01% of their portfolio | 384.6k $9.2m | Added +52.9k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 379.1k $9.0m | First filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 341.9k $8.1m | Reduced -47.3k |
| Affinity Asset Advisors, LLC 0.51% of their portfolio | 300.0k $7.1m | New |
| Public Sector Pension Investment Board 0.02% of their portfolio | 295.4k $7.0m | Added +25.6k |
| BAKER BROS. ADVISORS LP 0.04% of their portfolio | 270.0k $6.4m | New |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 240.0k $5.7m | Reduced -100.0k |
| Susquehanna Portfolio Strategies, LLC 0.09% of their portfolio | 240.0k $5.7m | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 227.1k $5.4m | Added +17.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 225.9k $5.4m | Added +16.1k |
| TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio | 208.6k $5.0m | New |
| Legal & General Group Plc 0.00% of their portfolio | 205.2k $4.9m | Added +26.8k |
| Nicholas Investment Partners, LP 0.35% of their portfolio | 204.3k $4.9m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 203.3k $4.8m | Added +117.2k |
| Rock Springs Capital Management LP 0.22% of their portfolio | 180.0k $4.3m | New |
| Patient Square Capital LP 0.87% of their portfolio | 170.0k $4.1m | New |
| Granahan Investment Management, LLC 0.17% of their portfolio | 169.9k $4.0m | Reduced -285.7k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 168.9k $4.0m | Reduced -466.1k |
| Swiss National Bank 0.00% of their portfolio | 168.0k $4.0m | Added +34.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 144.1k $3.4m | Added +56.3k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 142.5k $3.4m | New |
| Nuveen, LLC 0.00% of their portfolio | 141.6k $3.4m | Added +14.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 139.6k $3.3m | Reduced -331.9k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 136.1k $3.2m | Added +53.9k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.74% of their portfolio | 134.2k $3.2m | Reduced -19.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 133.1k $3.2m | Reduced -4.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 128.9k $3.1m | Added +3.4k |
| Knott David M Jr 1.34% of their portfolio | 121.2k $2.9m | Added +26.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 104.7k $2.5m | Reduced -190.4k |
| LMR Partners LLP 0.02% of their portfolio | 100.0k $2.4m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 99.3k $2.4m | Added +31.0k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 97.3k $2.3m | Added +48.4k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 92.9k $2.2m | Added +23.3k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 92.4k $2.2m | Added +1.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 90.7k $2.2m | Added +26.7k |
| Parallel Advisors, LLC 0.04% of their portfolio | 86.6k $2.1m | Reduced -1.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 86.2k $2.1m | Added +2.4k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 85.6k $2.0m | Added +65.7k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 80.4k $1.9m | Added +30.5k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 79.5k $1.9m | Added +9.2k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 73.9k $1.8m | Added +14.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 72.8k $1.7m | Reduced -55.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 62.7k $1.5m | Added +14.3k |
| WINTON GROUP Ltd 0.05% of their portfolio | 62.3k $1.5m | Reduced -30.0k |
| DARK FOREST CAPITAL MANAGEMENT LP 0.07% of their portfolio | 60.6k $1.4m | Reduced -79.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 58.8k $1.4m | Added +28.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 58.6k $1.4m | Added +9.3k |
| SECTORAL ASSET MANAGEMENT INC 1.09% of their portfolio | 56.9k $1.4m | Reduced -311.1k |
| Fort Baker Capital Management LP 0.14% of their portfolio | 52.5k $1.3m | New |
| Burkehill Global Management, LP 0.08% of their portfolio | 50.0k $1.2m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 46.5k $1.1m | Reduced -179.1k |
| SG Americas Securities, LLC 0.00% of their portfolio | 45.5k $1.1m | Added +12.7k |
| Corient Private Wealth LP 0.00% of their portfolio | 45.1k $1.1m | Added +23.0k |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 44.8k $1.1m | New |
| State of Alaska, Department of Revenue 0.01% of their portfolio | 43.5k $1.0m | Added +8.6k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 43.4k $1.0m | Added +2.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 43.0k $1.0m | Added +21.1k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 42.3k $1.0m | Added +11.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 42.0k $1.0m | Added +7.0k |