ARDELYX INC ARDX
COM · Common Stock · CUSIP 039697107 · ISIN US0396971071
Company in Fremont, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersFremont, CA
- Founded2007
- Websiteardelyx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($75.2k this quarter). Holder counts are more reliable. Shares outstanding: 245.2m as of 2026-02-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.83. Options: 10 managers hold calls ($9.9m notional), 7 hold puts ($7.8m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 84 |
| Q4 2022 | 106 |
| Q1 2023 | 131 |
| Q2 2023 | 147 |
| Q3 2023 | 151 |
| Q4 2023 | 163 |
| Q1 2024 | 190 |
| Q2 2024 | 198 |
| Q3 2024 | 204 |
| Q4 2024 | 214 |
| Q1 2025 | 222 |
| Q2 2025 | 207 |
| Q3 2025 | 223 |
| Q4 2025 | 229 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 113 | 81 |
| Q2 2024 | 104 | 95 |
| Q3 2024 | 103 | 87 |
| Q4 2024 | 111 | 95 |
| Q1 2025 | 128 | 86 |
| Q2 2025 | 104 | 107 |
| Q3 2025 | 116 | 93 |
| Q4 2025 | 111 | 110 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $11.5m | $13.3m | 1.16 |
| Q2 2025 | $8.5m | $7.0m | 0.82 |
| Q3 2025 | $10.8m | $9.7m | 0.90 |
| Q4 2025 | $9.9m | $7.8m | 0.79 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +4.3m |
| STATE STREET CORP | Added | +2.2m |
| J. Goldman & Co LP | Added | +1.5m |
| Qube Research & Technologies Ltd | New | +1.1m |
| Point72 Asset Management, L.P. | New | +958.7k |
| AIGH Capital Management LLC | Added | +951.5k |
| FIRST TRUST ADVISORS LP | Added | +853.9k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Added | +845.9k |
| JANUS HENDERSON GROUP PLC | Added | +690.6k |
| FMR LLC | Added | +656.0k |
Biggest sellers
| MACQUARIE GROUP LTD | Sold out | -10.5m |
| MARSHALL WACE, LLP | Reduced | -3.8m |
| D. E. Shaw & Co., Inc. | Reduced | -1.9m |
| JPMORGAN CHASE & CO | Reduced | -1.3m |
| Walleye Capital LLC | Reduced | -989.8k |
| ROYAL BANK OF CANADA | Reduced | -906.5k |
| Aberdeen Group plc | Sold out | -865.6k |
| HRT FINANCIAL LP | Sold out | -667.1k |
| FRANKLIN RESOURCES INC | Reduced | -601.4k |
| MORGAN STANLEY | Reduced | -526.5k |
Biggest calls
| ORACLE INVESTMENT MANAGEMENT INC | Reduced | $3.5m600.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.0m338.1k shares |
| CITADEL ADVISORS LLC | Added | $1.3m220.1k shares |
| GROUP ONE TRADING LLC | Reduced | $1.2m208.7k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $541.6k92.9k shares |
| IMC-Chicago, LLC | Added | $475.1k81.5k shares |
| JANE STREET GROUP, LLC | Reduced | $367.9k63.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $299.7k51.4k shares |
| Caption Management, LLC | New | $240.2k41.2k shares |
| Clay Northam Wealth Management, LLC | New | $13.7k19.5k shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $4.4m752.5k shares |
| CITADEL ADVISORS LLC | Reduced | $1.4m231.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.1m188.4k shares |
| GROUP ONE TRADING LLC | Reduced | $587.7k100.8k shares |
| SIG BROKERAGE, LP | Unchanged | $226.2k38.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $118.3k20.3k shares |
| JPMORGAN CHASE & CO | Reduced | $11.7k2.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Rubric Capital Management LP 13G · institution new · filed 2026-08-14 | 6.6% |
| INTEGRATED CORE STRATEGIES (US) LLC 13G · passive investor -1.7 pts · filed 2026-08-11 | 5.7% |
| STATE STREET CORP 13G · institution +0.6 pts · filed 2026-05-12 | 5.5% |
Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (3.4%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 8 | $1.5m | $1.0m |
| Q2 2024 | 0 | — | 8 | $7.6m | $1.5m |
| Q3 2024 | 0 | — | 7 | $1.5m | $870.7k |
| Q4 2024 | 1 | $2.0m | 6 | $1.1m | $472.3k |
| Q1 2025 | 1 | $1.4m | 4 | $877.9k | $667.9k |
| Q2 2025 | 1 | $3.4m | 6 | $708.9k | $368.3k |
| Q3 2025 | 0 | — | 6 | $996.9k | $489.6k |
| Q4 2025 | 0 | — | 6 | $453.0k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-11-21 | RAAB MICHAEL President & CEO, director | Sold | $259.8k46.9k shares |
| 2025-11-21 | Reilly Joseph James Officer | Sold | $61.4k11.1k shares |
| 2025-11-21 | Williams Laura A Chief Patient Officer | Sold | $35.6k6.4k shares |
| 2025-11-21 | GRAMMER ELIZABETH A Officer | Sold | $33.2k6.0k shares |
| 2025-11-21 | Foster Eric Duane Chief Commercial Officer | Sold | $32.2k5.8k shares |
| 2025-11-21 | Kelliher Mike Officer | Sold | $30.8k5.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 21.1m $123.2m | Added +315.5k |
| VANGUARD GROUP INC 0.00% of their portfolio | 19.0m $110.7m | Added +610.2k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 14.5m $84.6m | Added +690.6k |
| STATE STREET CORP 0.00% of their portfolio | 11.9m $69.4m | Added +2.2m |
| MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio | 11.9m $69.4m | Added +4.3m |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.08% of their portfolio | 9.3m $54.4m | First filing |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 5.8m $34.0m | Added +70.8k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 5.2m $30.2m | Reduced -3.8m |
| Nuveen, LLC 0.01% of their portfolio | 5.2m $30.1m | Reduced -10.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 3.1m $17.9m | Added +479.9k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 2.9m $16.8m | Added +383.1k |
| MORGAN STANLEY 0.00% of their portfolio | 2.4m $13.8m | Reduced -526.5k |
| Rock Springs Capital Management LP 0.69% of their portfolio | 2.3m $13.4m | Added +13.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 2.2m $12.9m | Reduced -445.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.1m $12.3m | Reduced -77.5k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 2.1m $12.0m | Reduced -133.1k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.0m $11.8m | Reduced -119.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.0m $11.8m | Reduced -98.7k |
| ORACLE INVESTMENT MANAGEMENT INC 7.15% of their portfolio | 1.9m $10.9m | Added +368.8k |
| JONES FINANCIAL COMPANIES LLLP 0.01% of their portfolio | 1.9m $10.8m | Reduced -19.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 1.8m $10.5m | Added +104.7k |
| Eversept Partners, LP 0.56% of their portfolio | 1.7m $10.0m | Added +285.8k |
| J. Goldman & Co LP 0.37% of their portfolio | 1.6m $9.5m | Added +1.5m |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 1.4m $8.3m | Added +845.9k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 1.4m $8.2m | Reduced -1.9m |
| TWO SIGMA ADVISERS, LP 0.02% of their portfolio | 1.3m $7.9m | Reduced -265.9k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.3m $7.7m | Reduced -201.1k |
| AIGH Capital Management LLC 1.98% of their portfolio | 1.1m $6.7m | Added +951.5k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 1.1m $6.4m | New |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 1.0m $6.0m | Added +853.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 1.0m $5.8m | Added +135.7k |
| Hennion & Walsh Asset Management, Inc. 0.19% of their portfolio | 959.5k $5.6m | Added +179.2k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 958.7k $5.6m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 776.2k $4.5m | Added +156.2k |
| BARCLAYS PLC 0.00% of their portfolio | 763.4k $4.5m | Added +34.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 736.2k $4.3m | Reduced -1.3m |
| Bank of New York Mellon Corp 0.00% of their portfolio | 723.2k $4.2m | Reduced -16.2k |
| Freestone Grove Partners LP 0.03% of their portfolio | 699.1k $4.1m | Added +297.4k |
| FMR LLC 0.00% of their portfolio | 677.4k $3.9m | Added +656.0k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 659.2k $3.8m | Reduced -527 |
| UBS Group AG 0.00% of their portfolio | 578.3k $3.4m | Added +117.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 500.2k $2.9m | Added +306.2k |
| Y-Intercept (Hong Kong) Ltd 0.07% of their portfolio | 499.7k $2.9m | Added +193.1k |
| Swiss National Bank 0.00% of their portfolio | 475.2k $2.8m | Added +11.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 431.2k $2.5m | Added +61.1k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 390.2k $2.3m | Added +75.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 388.8k $2.3m | Reduced -60.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 368.4k $2.1m | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 347.6k $2.0m | Added +2.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 346.1k $2.0m | Reduced -50.7k |
| Trexquant Investment LP 0.02% of their portfolio | 327.2k $1.9m | Reduced -177.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 318.4k $1.9m | Added +117.2k |
| Invesco Ltd. 0.00% of their portfolio | 317.4k $1.9m | Added +59.6k |
| Clay Northam Wealth Management, LLC 1.02% of their portfolio | 315.0k $1.8m | Reduced -8.4k |
| Pekin Hardy Strauss, Inc. 0.16% of their portfolio | 305.2k $1.8m | Reduced -97.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 297.9k $1.7m | Reduced -43.0k |
| CAPITAL FUND MANAGEMENT S.A. 0.02% of their portfolio | 283.9k $1.7m | Reduced -211.5k |
| Raiffeisen Bank International AG 0.02% of their portfolio | 270.0k $1.6m | New |
| Legal & General Group Plc 0.00% of their portfolio | 268.3k $1.6m | Reduced -878 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 267.3k $1.6m | Unchanged |
| DIADEMA PARTNERS LP 0.88% of their portfolio | 252.2k $1.5m | Reduced -147.8k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 246.4k $1.4m | Reduced -8.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 234.5k $1.4m | Added +7.1k |
| Walleye Capital LLC 0.01% of their portfolio | 221.3k $1.3m | Reduced -989.8k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 217.7k $1.3m | Added +19 |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 199.6k $1.2m | Added +22.7k |
| Jump Financial, LLC 0.01% of their portfolio | 199.5k $1.2m | Added +161.9k |
| Headlands Technologies LLC 0.10% of their portfolio | 199.3k $1.2m | Added +108.1k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 197.6k $1.2m | Added +110.1k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 195.9k $1.1m | Reduced -49.2k |
| MONIMUS CAPITAL MANAGEMENT, LP 0.75% of their portfolio | 194.7k $1.1m | Reduced -7.6k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 193.8k $1.1m | Added +103.8k |
| SG Americas Securities, LLC 0.00% of their portfolio | 171.6k $1.0m | Added +39.7k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 162.8k $949.0k | Added +6.4k |
| LPL Financial LLC 0.00% of their portfolio | 159.9k $932.4k | Reduced -2.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 154.7k $901.9k | Reduced -601.4k |
| HARBOR CAPITAL ADVISORS, INC. 0.07% of their portfolio | 153.8k $897.0k | Added +53.7k |
| GROUP ONE TRADING LLC 0.03% of their portfolio | 153.8k $896.7k | Added +60.5k |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 151.9k $885.8k | Reduced -57.3k |
| PROFUND ADVISORS LLC 0.03% of their portfolio | 145.3k $847.3k | Added +76.1k |
| PFG Investments, LLC 0.04% of their portfolio | 137.9k $803.7k | Reduced -435 |
| Engineers Gate Manager LP 0.01% of their portfolio | 137.6k $802.1k | Reduced -102.8k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 134.2k $782.4k | Added +48.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 134.0k $780.7k | Added +8.3k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 131.9k $769.0k | New |
| Lion Point Capital, LP 3.88% of their portfolio | 128.7k $750.0k | Reduced -34.1k |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 124.4k $725.1k | Added +11.1k |
| Man Group plc 0.00% of their portfolio | 124.2k $724.1k | Reduced -70.7k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 123.4k $719.5k | Reduced -1.5k |
| XTX Topco Ltd 0.02% of their portfolio | 119.6k $697.5k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 119.1k $694.4k | Reduced -18.2k |
| Caption Management, LLC 0.03% of their portfolio | 115.0k $670.5k | New |
| Pavaki Capital Management LLC 0.47% of their portfolio | 115.0k $670.5k | First filing |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 113.3k $656.0k | Added +87.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 110.2k $642.6k | Reduced -6.5k |
| Virtus Investment Advisers, LLC 0.17% of their portfolio | 110.0k $641.6k | Reduced -9.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 100.1k $583.5k | Reduced -2.5k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 100.0k $806.0k | Unchanged |
| SEI INVESTMENTS CO 0.00% of their portfolio | 98.4k $573.8k | Reduced -3.0k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 95.9k $559.3k | Added +12.0k |