| 1 |
FMR LLC
0.01% of their portfolio |
BOSTON, MA |
4,690,9984.7m
$148.3m |
$148.3m |
0.01% |
Reduced
-675.2k |
-675,182 |
| 2 |
PERCEPTIVE ADVISORS LLC
3.69% of their portfolio |
NEW YORK, NY |
4,016,3974.0m
$127.0m |
$127.0m |
3.69% |
Added
+174.7k |
+174,658 |
| 3 |
SR One Capital Management, LP
53.81% of their portfolio |
Redwood City, CA |
3,946,6303.9m
$124.8m |
$124.8m |
53.81% |
Reduced
-1.6m |
-1,553,377 |
| 4 |
NEA Management Company, LLC
9.04% of their portfolio |
TIMONIUM, MD |
3,745,2623.7m
$118.4m |
$118.4m |
9.04% |
Reduced
-1.0m |
-1,000,000 |
| 5 |
MONTANOVA CAPITAL, LLC
4.82% of their portfolio |
New York, NY |
2,848,1672.8m
$90.1m |
$90.1m |
4.82% |
Added
+449.8k |
+449,846 |
| 6 |
BlackRock Inc.
0.00% of their portfolio |
New York, NY |
2,602,4852.6m
$82.3m |
$82.3m |
0.00% |
Added
+380.1k |
+380,128 |
| 7 |
LORD, ABBETT & CO. LLC
0.14% of their portfolio |
JERSEY CITY, NJ |
2,530,7442.5m
$80.0m |
$80.0m |
0.14% |
Added
+386.3k |
+386,330 |
| 8 |
Paradigm Biocapital Advisors LP
6.01% of their portfolio |
NEW YORK, NY |
2,347,0002.3m
$74.2m |
$74.2m |
6.01% |
Added
+589.2k |
+589,221 |
| 9 |
Cormorant Asset Management, LP
3.60% of their portfolio |
BOSTON, MA |
2,000,0002.0m
$63.2m |
$63.2m |
3.60% |
Added
+400.0k |
+400,000 |
| 10 |
VANGUARD GROUP INC
0.00% of their portfolio |
Valley Forge, PA |
1,994,5872.0m
$63.1m |
$63.1m |
0.00% |
Added
+567.6k |
+567,631 |
| 11 |
STATE STREET CORP
0.00% of their portfolio |
BOSTON, MA |
1,931,7651.9m
$61.1m |
$61.1m |
0.00% |
Added
+57.3k |
+57,309 |
| 12 |
JANUS HENDERSON GROUP PLC
0.03% of their portfolio |
LONDON, X0 |
1,754,2471.8m
$55.5m |
$55.5m |
0.03% |
Added
+167.0k |
+166,995 |
| 13 |
PRICE T ROWE ASSOCIATES INC /MD/
0.00% of their portfolio |
BALTIMORE, MD |
1,057,7811.1m
$33.4m |
$33.4m |
0.00% |
Added
+1.0m |
+1,035,556 |
| 14 |
GOLDMAN SACHS GROUP INC
0.01% of their portfolio |
NEW YORK, NY |
1,018,9141.0m
$32.2m |
$32.2m |
0.01% |
Reduced
-251.8k |
-251,812 |
| 15 |
Soleus Capital Management, L.P.
3.52% of their portfolio |
GREENWICH, CT |
1,001,9991.0m
$31.7m |
$31.7m |
3.52% |
Reduced
-246.1k |
-246,148 |
| 16 |
NOVO HOLDINGS A/S
2.44% of their portfolio |
HELLERUP, G7 |
1,000,0001.0m
$31.6m |
$31.6m |
2.44% |
Reduced
-225.0k |
-225,000 |
| 17 |
GEODE CAPITAL MANAGEMENT, LLC
0.00% of their portfolio |
BOSTON, MA |
685,228685.2k
$21.7m |
$21.7m |
0.00% |
Added
+123.6k |
+123,624 |
| 18 |
SAMSARA BIOCAPITAL, LLC
3.41% of their portfolio |
PALO ALTO, CA |
613,921613.9k
$19.4m |
$19.4m |
3.41% |
Reduced
-295.7k |
-295,658 |
| 19 |
PICTET ASSET MANAGEMENT SA
0.02% of their portfolio |
GENEVA 73, V8 |
556,408556.4k
$17.6m |
$17.6m |
0.02% |
Reduced
-471.8k |
-471,802 |
| 20 |
Logos Global Management LP
2.18% of their portfolio |
San Francisco, CA |
500,000500.0k
$15.8m |
$15.8m |
2.18% |
New |
|
| 21 |
Vivo Capital, LLC
0.95% of their portfolio |
Palo Alto, CA |
433,785433.8k
$13.7m |
$13.7m |
0.95% |
Added
+143.1k |
+143,072 |
| 22 |
Candriam S.C.A.
0.09% of their portfolio |
STRASSEN, N4 |
398,020398.0k
$12.6m |
$12.6m |
0.09% |
Reduced
-49.1k |
-49,134 |
| 23 |
ADAGE CAPITAL PARTNERS GP, L.L.C.
0.03% of their portfolio |
Boston, MA |
372,904372.9k
$11.8m |
$11.8m |
0.03% |
Reduced
-4.0k |
-4,000 |
| 24 |
CITADEL ADVISORS LLC
0.01% of their portfolio |
MIAMI, FL |
361,075361.1k
$11.4m |
$11.4m |
0.01% |
Reduced
-1.2m |
-1,153,821 |
| 25 |
NORTHERN TRUST CORP
0.00% of their portfolio |
CHICAGO, IL |
359,550359.6k
$11.4m |
$11.4m |
0.00% |
Added
+93.4k |
+93,386 |
| 26 |
RENAISSANCE TECHNOLOGIES LLC
0.02% of their portfolio |
NEW YORK, NY |
344,667344.7k
$10.9m |
$10.9m |
0.02% |
Added
+328.2k |
+328,167 |
| 27 |
JPMORGAN CHASE & CO
0.00% of their portfolio |
NEW YORK, NY |
327,438327.4k
$10.4m |
$10.4m |
0.00% |
Reduced
-221.8k |
-221,759 |
| 28 |
TWO SIGMA INVESTMENTS, LP
0.03% of their portfolio |
NEW YORK, NY |
326,093326.1k
$10.3m |
$10.3m |
0.03% |
Added
+186.5k |
+186,467 |
| 29 |
MORGAN STANLEY
0.00% of their portfolio |
NEW YORK, NY |
279,111279.1k
$8.8m |
$8.8m |
0.00% |
Added
+170.7k |
+170,713 |
| 30 |
VOLORIDGE INVESTMENT MANAGEMENT, LLC
0.04% of their portfolio |
JUPITER, FL |
274,571274.6k
$8.7m |
$8.7m |
0.04% |
Added
+119.4k |
+119,418 |
| 31 |
PFM Health Sciences, LP
0.33% of their portfolio |
SAN FRANCISCO, CA |
255,832255.8k
$8.1m |
$8.1m |
0.33% |
Reduced
-270.0k |
-269,984 |
| 32 |
MILLENNIUM MANAGEMENT LLC
0.01% of their portfolio |
NEW YORK, NY |
242,135242.1k
$7.7m |
$7.7m |
0.01% |
Added
+121.3k |
+121,337 |
| 33 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
0.00% of their portfolio |
SAN FRANCISCO, CA |
240,938240.9k
$7.6m |
$7.6m |
0.00% |
Added
+33.7k |
+33,687 |
| 34 |
Nuveen Asset Management, LLC
0.00% of their portfolio |
CHICAGO, IL |
237,066237.1k
$7.5m |
$7.5m |
0.00% |
Added
+138.6k |
+138,577 |
| 35 |
Affinity Asset Advisors, LLC
2.82% of their portfolio |
NEW YORK, NY |
226,275226.3k
$7.2m |
$7.2m |
2.82% |
Added
+23.4k |
+23,441 |
| 36 |
Walleye Capital LLC
0.12% of their portfolio |
NEW YORK, NY |
217,634217.6k
$6.9m |
$6.9m |
0.12% |
Added
+57.2k |
+57,191 |
| 37 |
Parkman Healthcare Partners LLC
1.07% of their portfolio |
STAMFORD, CT |
195,260195.3k
$6.2m |
$6.2m |
1.07% |
Added
+47.6k |
+47,614 |
| 38 |
FEDERATED HERMES, INC.
0.01% of their portfolio |
PITTSBURGH, PA |
164,671164.7k
$5.2m |
$5.2m |
0.01% |
Added
+153.9k |
+153,922 |
| 39 |
DEUTSCHE BANK AG\
0.00% of their portfolio |
FRANKFURT AM MAIN, 2M |
146,011146.0k
$4.6m |
$4.6m |
0.00% |
Added
+127.7k |
+127,694 |
| 40 |
Rafferty Asset Management, LLC
0.03% of their portfolio |
New York, NY |
144,096144.1k
$4.6m |
$4.6m |
0.03% |
Added
+2.7k |
+2,679 |
| 41 |
Bank of New York Mellon Corp
0.00% of their portfolio |
NEW YORK, NY |
130,524130.5k
$4.1m |
$4.1m |
0.00% |
Added
+5.5k |
+5,503 |
| 42 |
TWO SIGMA ADVISERS, LP
0.01% of their portfolio |
NEW YORK, NY |
129,800129.8k
$4.1m |
$4.1m |
0.01% |
Added
+76.2k |
+76,200 |
| 43 |
UBS Group AG
0.00% of their portfolio |
ZURICH, V8 |
121,507121.5k
$3.8m |
$3.8m |
0.00% |
Added
+120.5k |
+120,515 |
| 44 |
Russell Investments Group, Ltd.
0.01% of their portfolio |
Seattle, WA |
116,342116.3k
$3.7m |
$3.7m |
0.01% |
Added
+66.2k |
+66,210 |
| 45 |
Qube Research & Technologies Ltd
0.01% of their portfolio |
LONDON, X0 |
110,744110.7k
$3.5m |
$3.5m |
0.01% |
New |
|
| 46 |
Cubist Systematic Strategies, LLC
0.04% of their portfolio |
STAMFORD, CT |
108,589108.6k
$3.4m |
$3.4m |
0.04% |
Added
+80.8k |
+80,800 |
| 47 |
CLOUGH CAPITAL PARTNERS L P
0.34% of their portfolio |
Boston, MA |
105,862105.9k
$3.3m |
$3.3m |
0.34% |
Reduced
-91.6k |
-91,616 |
| 48 |
BANK OF AMERICA CORP /DE/
0.00% of their portfolio |
CHARLOTTE, NC |
90,70590.7k
$2.9m |
$2.9m |
0.00% |
Reduced
-97.5k |
-97,550 |
| 49 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
0.00% of their portfolio |
WEST SACRAMENTO, CA |
86,01386.0k
$2.7m |
$2.7m |
0.00% |
Added
+61.5k |
+61,534 |
| 50 |
SPHERA FUNDS MANAGEMENT LTD.
0.53% of their portfolio |
TEL AVIV, L3 |
77,48877.5k
$2.5m |
$2.5m |
0.53% |
Reduced
-90.0k |
-90,000 |
| 51 |
BARCLAYS PLC
0.00% of their portfolio |
LONDON, X0 |
75,59675.6k
$2.4m |
$2.4m |
0.00% |
Added
+16.5k |
+16,482 |
| 52 |
JANE STREET GROUP, LLC
0.00% of their portfolio |
NEW YORK, NY |
73,93073.9k
$2.3m |
$2.3m |
0.00% |
Added
+57.7k |
+57,739 |
| 53 |
CITIGROUP INC
0.00% of their portfolio |
NEW YORK, NY |
63,39863.4k
$2.0m |
$2.0m |
0.00% |
Reduced
-50.2k |
-50,205 |
| 54 |
HighVista Strategies LLC
0.91% of their portfolio |
BOSTON, MA |
62,86962.9k
$2.0m |
$2.0m |
0.91% |
Added
+8.6k |
+8,589 |
| 55 |
VOYA INVESTMENT MANAGEMENT LLC
0.00% of their portfolio |
ATLANTA, GA |
56,98357.0k
$1.8m |
$1.8m |
0.00% |
Reduced
-29.2k |
-29,153 |
| 56 |
WELLINGTON MANAGEMENT GROUP LLP
0.00% of their portfolio |
Boston, MA |
56,20256.2k
$1.8m |
$1.8m |
0.00% |
Reduced
-56.3k |
-56,261 |
| 57 |
SCHRODER INVESTMENT MANAGEMENT GROUP
0.00% of their portfolio |
London, X0 |
55,97756.0k
$1.8m |
$1.8m |
0.00% |
New |
|
| 58 |
Informed Momentum Co LLC
0.33% of their portfolio |
SOLANA BEACH, CA |
55,71455.7k
$1.8m |
$1.8m |
0.33% |
Reduced
-48.6k |
-48,587 |
| 59 |
Swiss National Bank
0.00% of their portfolio |
ZURICH, V8 |
52,10052.1k
$1.6m |
$1.6m |
0.00% |
Added
+19.0k |
+19,000 |
| 60 |
RHUMBLINE ADVISERS
0.00% of their portfolio |
BOSTON, MA |
50,42950.4k
$1.6m |
$1.6m |
0.00% |
Added
+3.9k |
+3,915 |
| 61 |
Schonfeld Strategic Advisors LLC
0.01% of their portfolio |
NEW YORK, NY |
49,25849.3k
$1.6m |
$1.6m |
0.01% |
Added
+13.7k |
+13,662 |
| 62 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE
0.00% of their portfolio |
Toronto, A6 |
42,86842.9k
$1.4m |
$1.4m |
0.00% |
Added
+30.7k |
+30,712 |
| 63 |
AQR CAPITAL MANAGEMENT LLC
0.00% of their portfolio |
Greenwich, CT |
42,26042.3k
$1.3m |
$1.3m |
0.00% |
New |
|
| 64 |
VICTORY CAPITAL MANAGEMENT INC
0.00% of their portfolio |
San Antonio, TX |
41,70541.7k
$1.3m |
$1.3m |
0.00% |
New |
|
| 65 |
PUTNAM INVESTMENTS LLC
0.00% of their portfolio |
BOSTON, MA |
41,61241.6k
$1.3m |
$1.3m |
0.00% |
Reduced
-12.1k |
-12,057 |
| 66 |
WELLS FARGO & COMPANY/MN
0.00% of their portfolio |
SAN FRANCISCO, CA |
40,52640.5k
$1.3m |
$1.3m |
0.00% |
Added
+7.7k |
+7,730 |
| 67 |
FIRST TRUST ADVISORS LP
0.00% of their portfolio |
Wheaton, IL |
40,30140.3k
$1.3m |
$1.3m |
0.00% |
Added
+22.2k |
+22,225 |
| 68 |
BAMCO INC /NY/
0.00% of their portfolio |
NEW YORK, NY |
40,00040.0k
$1.3m |
$1.3m |
0.00% |
New |
|
| 69 |
Knott David M Jr
0.51% of their portfolio |
SYOSSET, NY |
40,00040.0k
$1.3m |
$1.3m |
0.51% |
Added
+12.0k |
+12,000 |
| 70 |
Squarepoint Ops LLC
0.01% of their portfolio |
NEW YORK, NY |
39,29539.3k
$1.2m |
$1.2m |
0.01% |
Added
+22.6k |
+22,554 |
| 71 |
GREAT POINT PARTNERS LLC
0.24% of their portfolio |
Greenwich, CT |
37,50037.5k
$1.2m |
$1.2m |
0.24% |
Reduced
-219.5k |
-219,506 |
| 72 |
ALLIANCEBERNSTEIN L.P.
0.00% of their portfolio |
NASHVILLE, TN |
36,21036.2k
$1.1m |
$1.1m |
0.00% |
Added
+9.5k |
+9,510 |
| 73 |
ALPS ADVISORS INC
0.01% of their portfolio |
Denver, CO |
35,27835.3k
$1.1m |
$1.1m |
0.01% |
Added
+6.4k |
+6,387 |
| 74 |
CREDIT SUISSE AG/
0.00% of their portfolio |
ZURICH, V8 |
34,95335.0k
$1.1m |
$1.1m |
0.00% |
Added
+22.1k |
+22,059 |
| 75 |
TWINBEECH CAPITAL LP
0.02% of their portfolio |
PURCHASE, NY |
32,66832.7k
$1.0m |
$1.0m |
0.02% |
New |
|
| 76 |
TD Asset Management Inc
0.00% of their portfolio |
Toronto, A6 |
28,80028.8k
$910.7k |
$910.7k |
0.00% |
New |
|
| 77 |
Jump Financial, LLC
0.03% of their portfolio |
Chicago, IL |
26,79626.8k
$847.3k |
$847.3k |
0.03% |
Reduced
-3.4k |
-3,355 |
| 78 |
PROFUND ADVISORS LLC
0.04% of their portfolio |
BETHESDA, MD |
26,34526.3k
$833.0k |
$833.0k |
0.04% |
Added
+56 |
+56 |
| 79 |
Jefferies Financial Group Inc.
0.02% of their portfolio |
NEW YORK, NY |
25,47625.5k
$805.6k |
$805.6k |
0.02% |
New |
|
| 80 |
CONGRESS ASSET MANAGEMENT CO
0.01% of their portfolio |
BOSTON, MA |
25,04525.0k
$791.9k |
$791.9k |
0.01% |
New |
|
| 81 |
STATE OF WISCONSIN INVESTMENT BOARD
0.00% of their portfolio |
MADISON, WI |
24,71824.7k
$781.6k |
$781.6k |
0.00% |
Added
+11.0k |
+10,955 |
| 82 |
Legal & General Group Plc
0.00% of their portfolio |
London, X0 |
24,63724.6k
$779.0k |
$779.0k |
0.00% |
Added
+17.5k |
+17,484 |
| 83 |
Mirae Asset Global Investments Co., Ltd.
0.00% of their portfolio |
SEOUL, M5 |
23,35323.4k
$736.2k |
$736.2k |
0.00% |
Added
+3.7k |
+3,679 |
| 84 |
ADAMS STREET PARTNERS LLC
0.19% of their portfolio |
CHICAGO, IL |
22,92422.9k
$724.9k |
$724.9k |
0.19% |
New |
|
| 85 |
Aigen Investment Management, LP
0.10% of their portfolio |
NEW YORK, NY |
20,56420.6k
$650.2k |
$650.2k |
0.10% |
New |
|
| 86 |
MARTINGALE ASSET MANAGEMENT L P
0.01% of their portfolio |
BOSTON, MA |
20,22820.2k
$639.6k |
$639.6k |
0.01% |
New |
|
| 87 |
D. E. Shaw & Co., Inc.
0.00% of their portfolio |
New York, NY |
20,21020.2k
$639.0k |
$639.0k |
0.00% |
New |
|
| 88 |
MetLife Investment Management, LLC
0.00% of their portfolio |
Whippany, NJ |
20,18420.2k
$638.2k |
$638.2k |
0.00% |
Added
+3.3k |
+3,338 |
| 89 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY
0.01% of their portfolio |
FRANKFORT, KY |
18,44318.4k
$583.0k |
$583.0k |
0.01% |
Reduced
-1.5k |
-1,528 |
| 90 |
AMERICAN INTERNATIONAL GROUP, INC.
0.00% of their portfolio |
New York, NY |
18,26818.3k
$577.6k |
$577.6k |
0.00% |
Added
+4.0k |
+3,996 |
| 91 |
Invesco Ltd.
0.00% of their portfolio |
ATLANTA, GA |
17,76817.8k
$561.8k |
$561.8k |
0.00% |
Added
+3.9k |
+3,927 |
| 92 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
0.00% of their portfolio |
NEW YORK, NY |
16,60016.6k
$511.4k |
$511.4k |
0.00% |
Unchanged |
|
| 93 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP
0.00% of their portfolio |
BALA CYNWYD, PA |
16,10216.1k
$509.1k |
$509.1k |
0.00% |
Reduced
-41.4k |
-41,355 |
| 94 |
DekaBank Deutsche Girozentrale
0.00% of their portfolio |
FRANKFURT, 2M |
16,00016.0k
$499.0k |
$499.0k |
0.00% |
Unchanged |
|
| 95 |
NEW YORK STATE COMMON RETIREMENT FUND
0.00% of their portfolio |
ALBANY, NY |
15,32615.3k
$484.6k |
$484.6k |
0.00% |
Added
+271 |
+271 |
| 96 |
Walleye Trading LLC
0.02% of their portfolio |
NEW YORK, NY |
14,42514.4k
$456.1k |
$456.1k |
0.02% |
Added
+5.4k |
+5,433 |
| 97 |
Utah Retirement Systems
0.01% of their portfolio |
SALT LAKE CITY, UT |
12,89512.9k
$407.7k |
$407.7k |
0.01% |
New |
|
| 98 |
Graham Capital Management, L.P.
0.01% of their portfolio |
ROWAYTON, CT |
12,51412.5k
$395.7k |
$395.7k |
0.01% |
New |
|
| 99 |
HighTower Advisors, LLC
0.00% of their portfolio |
CHICAGO, IL |
12,29012.3k
$388.0k |
$388.0k |
0.00% |
Added
+64 |
+64 |
| 100 |
GLOBEFLEX CAPITAL L P
0.04% of their portfolio |
SAN DIEGO, CA |
12,20012.2k
$385.8k |
$385.8k |
0.04% |
New |
|