APREA THERAPEUTICS INC APRE
COM NEW · Common Stock · CUSIP 03836J201
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDoylestown, PA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 12.6m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.80.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 16 |
| Q2 2023 | 19 |
| Q3 2023 | 21 |
| Q4 2023 | 20 |
| Q1 2024 | 23 |
| Q2 2024 | 28 |
| Q3 2024 | 22 |
| Q4 2024 | 27 |
| Q1 2025 | 27 |
| Q2 2025 | 24 |
| Q3 2025 | 23 |
| Q4 2025 | 22 |
| Q1 2026 | 22 |
| Q2 2026 | 28 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 6 | 11 |
| Q4 2024 | 9 | 5 |
| Q1 2025 | 4 | 8 |
| Q2 2025 | 8 | 8 |
| Q3 2025 | 7 | 8 |
| Q4 2025 | 10 | 12 |
| Q1 2026 | 9 | 11 |
| Q2 2026 | 14 | 7 |
Biggest buyers
| Nantahala Capital Management, LLC | Added | +205.8k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +80.7k |
| CITADEL ADVISORS LLC | New | +58.6k |
| DIADEMA PARTNERS LP | New | +44.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +21.9k |
| NORTHERN TRUST CORP | New | +13.7k |
| Persistent Asset Partners Ltd | New | +11.5k |
| XTX Topco Ltd | New | +10.6k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +5.4k |
| MORGAN STANLEY | Added | +3.5k |
Biggest sellers
| Scientech Research LLC | Sold out | -60.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -44.3k |
| TWO SIGMA SECURITIES, LLC | Sold out | -13.5k |
| LPL Financial LLC | Reduced | -5.0k |
| UBS Group AG | Reduced | -2.1k |
| Tower Research Capital LLC (TRC) | Reduced | -1.5k |
| BlackRock, Inc. | Reduced | -1.3k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Vestal Point Capital, LP 13G · institution new · filed 2026-05-15 | 9.9% |
Fell to 5% or below in the last year: LYTTON LAURENCE W (3.2%, 2026-08-13), Nantahala Capital Management, LLC (4.5%, 2026-02-13), Sio Capital Management, LLC (1.9%, 2025-11-12)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 4 | $165.9k | 1 | $29.6k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 1 | $10.1k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 2 | $31.0k | 0 | — | — |
| Q1 2026 | 2 | $30.1k | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| AIGH Capital Management LLC 0.07% of their portfolio | 1.0m $814.8k | Unchanged |
| Nantahala Capital Management, LLC 0.01% of their portfolio | 411.5k $330.2k | Added +205.8k |
| Vestal Point Capital, LP 0.01% of their portfolio | 350.0k $280.8k | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. 0.03% of their portfolio | 270.0k $216.6k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 105.8k $84.9k | Added +80.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 74.9k $60.1k | Reduced -44.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 58.6k $47.0k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 45.2k $36.3k | Added +5.4k |
| DIADEMA PARTNERS LP 0.01% of their portfolio | 44.9k $36.0k | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 38.5k $30.8k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 34.9k $28.0k | Added +21.9k |
| MORGAN STANLEY 0.00% of their portfolio | 25.8k $20.7k | Added +3.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 22.9k $18.4k | Added +3.3k |
| LPL Financial LLC 0.00% of their portfolio | 16.1k $12.9k | Reduced -5.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 13.9k $11.1k | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 13.7k $11.0k | New |
| Persistent Asset Partners Ltd 0.00% of their portfolio | 11.5k $9.2k | New |
| XTX Topco Ltd 0.00% of their portfolio | 10.6k $8.5k | New |
| BlackRock, Inc. 0.00% of their portfolio | 7.2k $5.8k | Reduced -1.3k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.6k $2.9k | Reduced -1.5k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 577 $463 | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 473 $379 | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 295 $236 | Unchanged |
| WealthCollab, LLC 0.00% of their portfolio | 158 $127 | Unchanged |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 46 $36 | New |
| FMR LLC 0.00% of their portfolio | 45 $36 | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 16 $13 | Unchanged |
| UBS Group AG 0.00% of their portfolio | 3 $2 | Reduced -2.1k |