Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

52 institutional holders -18 vs Q3 2025
67,228,37767.2m shares reported held*
$6.8mreported value*
9 new 12 added 20 reduced 25 sold out net sold ≈ $2.7m (-27.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.10. Options: 5 managers hold calls ($33.1k notional), 4 hold puts ($39.5k).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 39Q1 23: 37Q2 23: 41Q3 23: 56Q4 23: 84Q1 24: 90Q2 24: 95Q3 24: 127Q4 24: 120Q1 25: 91Q2 25: 76Q3 25: 70Q4 25: 5252Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337
Q2 202341
Q3 202356
Q4 202384
Q1 202490
Q2 202495
Q3 2024127
Q4 2024120
Q1 202591
Q2 202576
Q3 202570
Q4 202552

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 24: 64 bought or addedQ1 24: 41 cut or sold outQ2 24: 59 bought or addedQ2 24: 47 cut or sold outQ2 24Q3 24: 76 bought or addedQ3 24: 46 cut or sold outQ4 24: 77 bought or addedQ4 24: 72 cut or sold outQ4 24Q1 25: 38 bought or addedQ1 25: 70 cut or sold outQ2 25: 29 bought or addedQ2 25: 59 cut or sold outQ2 25Q3 25: 26 bought or addedQ3 25: 41 cut or sold outQ4 25: 21 bought or addedQ4 25: 45 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20246441
Q2 20245947
Q3 20247646
Q4 20247772
Q1 20253870
Q2 20252959
Q3 20252641
Q4 20252145

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600k$800kQ1 25 calls: $226.2kQ1 25 puts: $96.9kQ1 25P/C 0.43Q2 25 calls: $131.1kQ2 25 puts: $76.4kQ2 25P/C 0.58Q3 25 calls: $682.1kQ3 25 puts: $210.7kQ3 25P/C 0.31Q4 25 calls: $33.1kQ4 25 puts: $39.5kQ4 25P/C 1.19
Numbers
QuarterCallsPutsP/C
Q1 2025$226.2k$96.9k0.43
Q2 2025$131.1k$76.4k0.58
Q3 2025$682.1k$210.7k0.31
Q4 2025$33.1k$39.5k1.19

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +8,689,027+8.7m
DELTEC ASSET MANAGEMENT LLC New +3,847,449+3.8m
RENAISSANCE TECHNOLOGIES LLC New +2,706,156+2.7m
JANE STREET GROUP, LLC New +2,087,404+2.1m
VANGUARD GROUP INC Added +1,250,329+1.3m
Graham Capital Management, L.P. New +572,759+572.8k
Virtu Financial LLC Added +445,271+445.3k
Lynx1 Capital Management LP New +410,500+410.5k
EQUITEC PROPRIETARY MARKETS, LLC New +300,600+300.6k
GEODE CAPITAL MANAGEMENT, LLC Added +214,747+214.7k

Biggest sellers

Vestal Point Capital, LP Sold out -14,250,000-14.2m
Propel Bio Management, LLC Sold out -11,285,420-11.3m
Simplify Asset Management Inc. Sold out -4,487,505-4.5m
PNC Financial Services Group, Inc. Sold out -2,901,184-2.9m
MARSHALL WACE, LLP Reduced -2,205,299-2.2m
Rock Springs Capital Management LP Sold out -2,075,991-2.1m
FRANKLIN RESOURCES INC Sold out -2,003,338-2.0m
Knoll Capital Management, LLC Reduced -1,749,687-1.7m
UBS Group AG Reduced -1,186,701-1.2m
Qube Research & Technologies Ltd Sold out -1,167,269-1.2m

Biggest calls

SIMPLEX TRADING, LLC Reduced $13.3k132.6k shares
GROUP ONE TRADING LLC Added $12.1k120.9k shares
CITADEL ADVISORS LLC Reduced $5.8k57.7k shares
DIADEMA PARTNERS LP Added $2.0k20.2k shares
Persistent Asset Partners Ltd Added $155 shares

Biggest puts

EQUITEC PROPRIETARY MARKETS, LLC New $25.2k252.4k shares
CITADEL ADVISORS LLC Reduced $13.5k135.0k shares
GROUP ONE TRADING LLC Reduced $4304.3k shares
SIMPLEX TRADING, LLC Added $3303.3k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 30,092,32730.1m $3.0m $3.0m 0.00% Added +8.7m +8,689,027
2 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 6,353,0186.4m $635.3k $635.3k 0.00% Added +1.3m +1,250,329
3 Knoll Capital Management, LLC 0.28% of their portfolio MIAMI, FL 6,050,0006.0m $605.0k $605.0k 0.28% Reduced -1.7m -1,749,687
4 DELTEC ASSET MANAGEMENT LLC 0.06% of their portfolio New York, NY 3,847,4493.8m $384.7k $384.7k 0.06% New
5 BlackRock, Inc. 0.00% of their portfolio New York, NY 3,251,4623.3m $325.1k $325.1k 0.00% Reduced -592.3k -592,271
6 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 2,706,1562.7m $270.6k $270.6k 0.00% New
7 Pathstone Holdings, LLC 0.00% of their portfolio ENGLEWOOD, NJ 2,643,5402.6m $305.1k $305.1k 0.00% Unchanged
8 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 2,087,4042.1m $208.7k $208.7k 0.00% New
9 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,492,9031.5m $149.3k $149.3k 0.00% Added +214.7k +214,747
10 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 1,211,6291.2m $121.2k $121.2k 0.00% Reduced -1.0m -1,000,000
11 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,051,8461.1m $105.2k $105.2k 0.00% Reduced -855.4k -855,368
12 UBS Group AG 0.00% of their portfolio ZURICH, V8 718,924718.9k $71.9k $71.9k 0.00% Reduced -1.2m -1,186,701
13 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 622,226622.2k $62.2k $62.2k 0.00% Unchanged
14 Graham Capital Management, L.P. 0.00% of their portfolio ROWAYTON, CT 572,759572.8k $57.3k $57.3k 0.00% New
15 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 558,178558.2k $55.8k $55.8k 0.00% Added +39.7k +39,660
16 Virtu Financial LLC 0.00% of their portfolio New York, NY 496,288496.3k $50.0k $50.0k 0.00% Added +445.3k +445,271
17 Lynx1 Capital Management LP 0.01% of their portfolio DORADO, PR 410,500410.5k $41.0k $41.0k 0.01% New
18 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 337,389337.4k $33.7k $33.7k 0.00% Reduced -2.2m -2,205,299
19 Hennion & Walsh Asset Management, Inc. 0.00% of their portfolio Parsippany, NJ 327,137327.1k $32.7k $32.7k 0.00% Added +44.3k +44,289
20 EQUITEC PROPRIETARY MARKETS, LLC 0.14% of their portfolio CHICAGO, IL 300,600300.6k $30.1k $30.1k 0.14% New
21 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 253,575253.6k $25.4k $25.4k 0.00% Added +174.2k +174,157
22 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 245,144245.1k $24.5k $24.5k 0.00% Added +71.4k +71,429
23 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 241,897241.9k $24.2k $24.2k 0.00% Reduced -150.0k -150,000
24 GTS SECURITIES LLC 0.00% of their portfolio NEW YORK, NY 200,009200.0k $20.0k $20.0k 0.00% New
25 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 178,474178.5k $17.8k $17.8k 0.00% Reduced -534.8k -534,841
26 CreativeOne Wealth, LLC 0.00% of their portfolio OVERLAND PARK, KS 169,974170.0k $17.0k $17.0k 0.00% Added +70.0k +69,962
27 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 163,449163.4k $16.3k $16.3k 0.00% Added +156.6k +156,608
28 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 146,219146.2k $14.6k $14.6k 0.00% Reduced -8.9k -8,922
29 Roble, Belko & Company, Inc 0.00% of their portfolio SEWICKLEY, PA 65,57165.6k $7.0k $7.0k 0.00% Added +34.7k +34,730
30 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 57,45457.5k $5.7k $5.7k 0.00% Unchanged
31 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 52,69252.7k $5.3k $5.3k 0.00% Reduced -424.5k -424,465
32 SPHERA FUNDS MANAGEMENT LTD. 0.00% of their portfolio TEL AVIV, L3 50,00050.0k $5.0k $5.0k 0.00% Unchanged
33 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 48,67548.7k $4.9k $4.9k 0.00% Reduced -26.6k -26,586
34 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 41,74841.7k $4.0k $4.0k 0.00% Added +25.3k +25,344
35 Adams Wealth Management 0.00% of their portfolio LOGAN, UT 38,63738.6k $3.9k $3.9k 0.00% Unchanged
36 CacheTech Inc. 0.00% of their portfolio LOGAN, UT 38,63738.6k $3.9k $3.9k 0.00% Unchanged
37 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 19,67519.7k $2.0k $2.0k 0.00% Reduced -14.7k -14,680
38 Cresset Asset Management, LLC 0.00% of their portfolio Chicago, IL 17,09117.1k $1.7k $1.7k 0.00% Unchanged
39 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 17,02017.0k $1.7k $1.7k 0.00% New
40 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 13,41313.4k $1.3k $1.3k 0.00% Reduced -96.3k -96,274
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 12,06412.1k $1.2k $1.2k 0.00% Reduced -3.2k -3,198
42 Perennial Investment Advisors, LLC 0.00% of their portfolio Los Angeles, CA 11,60011.6k $1.2k $1.2k 0.00% Unchanged
43 AlphaQuest LLC 0.00% of their portfolio New York, NY 4,6614.7k $466 $466 0.00% Unchanged
44 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 3,1093.1k $311 $311 0.00% Reduced -8.6k -8,561
45 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 2,9743.0k $297 $297 0.00% Reduced -501 -501
46 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 852852 $0 $0 0.00% Reduced -202.0k -201,960
47 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 788788 $79 $79 0.00% Reduced -35 -35
48 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 544544 $54 $54 0.00% Unchanged
49 Optiver Holding B.V. 0.00% of their portfolio AMSTERDAM, P7 427427 $43 $43 0.00% New
50 FMR LLC 0.00% of their portfolio BOSTON, MA 184184 $18 $18 0.00% Reduced -17.3k -17,298
51 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 8484 $8 $8 0.00% Unchanged
52 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 11 $0 $0 0.00% Reduced -5.3k -5,264