Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

120 institutional holders -7 vs Q3 2024
112,225,443112.2m shares reported held*
$96.1mreported value*
35 new 42 added 27 reduced 45 sold out net bought ≈ $1.5m (+1.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.4m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $0.86. Options: 9 managers hold calls ($1.4m notional), 10 hold puts ($969.3k).

Trends to Q4 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 39Q1 23: 37Q2 23: 41Q3 23: 56Q4 23: 84Q1 24: 90Q2 24: 95Q3 24: 127Q4 24: 120120Q3 22Q1 23Q3 23Q1 24Q3 24Q4 24
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337
Q2 202341
Q3 202356
Q4 202384
Q1 202490
Q2 202495
Q3 2024127
Q4 2024120

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 23: 19 bought or addedQ1 23: 18 cut or sold outQ2 23: 21 bought or addedQ2 23: 12 cut or sold outQ2 23Q3 23: 36 bought or addedQ3 23: 14 cut or sold outQ4 23: 54 bought or addedQ4 23: 15 cut or sold outQ4 23Q1 24: 64 bought or addedQ1 24: 41 cut or sold outQ2 24: 59 bought or addedQ2 24: 47 cut or sold outQ2 24Q3 24: 76 bought or addedQ3 24: 46 cut or sold outQ4 24: 77 bought or addedQ4 24: 72 cut or sold outQ4 24
Numbers
QuarterBought or addedCut or sold out
Q1 20231918
Q2 20232112
Q3 20233614
Q4 20235415
Q1 20246441
Q2 20245947
Q3 20247646
Q4 20247772

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ1 24 calls: $45.8mQ1 24 puts: $1.7mQ1 24P/C 0.04Q2 24 calls: $5.0mQ2 24 puts: $436.3kQ2 24P/C 0.09Q3 24 calls: $17.1mQ3 24 puts: $17.5mQ3 24P/C 1.02Q4 24 calls: $1.4mQ4 24 puts: $969.3kQ4 24P/C 0.68
Numbers
QuarterCallsPutsP/C
Q1 2024$45.8m$1.7m0.04
Q2 2024$5.0m$436.3k0.09
Q3 2024$17.1m$17.5m1.02
Q4 2024$1.4m$969.3k0.68

Biggest buyers

Vestal Point Capital, LP Added +10,355,000+10.4m
Schonfeld Strategic Advisors LLC Added +8,419,781+8.4m
T. Rowe Price Investment Management, Inc. Added +5,213,370+5.2m
Propel Bio Management, LLC Added +3,047,562+3.0m
BlackRock, Inc. Added +2,353,376+2.4m
Qube Research & Technologies Ltd Added +1,938,161+1.9m
Alyeska Investment Group, L.P. Added +1,725,824+1.7m
MILLENNIUM MANAGEMENT LLC Added +1,051,779+1.1m
MARSHALL WACE, LLP Added +773,377+773.4k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added +522,150+522.1k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -10,505,737-10.5m
PERCEPTIVE ADVISORS LLC Reduced -7,145,000-7.1m
FRANKLIN RESOURCES INC Reduced -4,797,510-4.8m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -2,150,732-2.2m
STATE STREET CORP Reduced -1,628,271-1.6m
STEMPOINT CAPITAL LP Sold out -1,554,586-1.6m
Opaleye Management Inc. Sold out -1,320,000-1.3m
MORGAN STANLEY Reduced -1,088,750-1.1m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -986,108-986.1k
Parkman Healthcare Partners LLC Sold out -907,294-907.3k

Biggest calls

ADAR1 Capital Management, LLC Added $454.0k530.3k shares
GROUP ONE TRADING LLC Reduced $366.5k428.1k shares
CITADEL ADVISORS LLC Added $172.4k201.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $145.1k168.7k shares
SIMPLEX TRADING, LLC Added $113.0k132.4k shares
JANE STREET GROUP, LLC Added $111.6k130.3k shares
WOLVERINE TRADING, LLC Added $30.9k37.9k shares
TORONTO DOMINION BANK New $27.4k32.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

GROUP ONE TRADING LLC Added $257.6k300.9k shares
CITADEL ADVISORS LLC Added $201.5k235.3k shares
Caption Management, LLC Added $175.0k204.4k shares
GOLDMAN SACHS GROUP INC Added $102.7k120.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $85.4k99.3k shares
LMR Partners LLP Unchanged $61.9k72.3k shares
Altium Capital Management LLC Unchanged $48.0k56.1k shares
SIMPLEX TRADING, LLC Reduced $27.0k32.5k shares
WOLVERINE TRADING, LLC New $10.1k12.4k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q4 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Vestal Point Capital, LP 0.58% of their portfolio NEW YORK, NY 11,500,00011.5m $9.8m $9.8m 0.58% Added +10.4m +10,355,000
2 Venrock Adviser, LLC 0.59% of their portfolio NEW YORK, NY 9,990,59110.0m $8.6m $8.6m 0.59% Added +165.6k +165,591
3 Propel Bio Management, LLC 8.18% of their portfolio Los Angeles, CA 9,615,4209.6m $8.2m $8.2m 8.18% Added +3.0m +3,047,562
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 9,296,0759.3m $8.0m $8.0m 0.00% Added +2.4m +2,353,376
5 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 8,815,7808.8m $7.5m $7.5m 0.00% Reduced -1.1m -1,088,750
6 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 8,762,2918.8m $7.5m $7.5m 0.05% Added +8.4m +8,419,781
7 Knoll Capital Management, LLC 3.20% of their portfolio MIAMI, FL 5,799,6875.8m $5.0m $5.0m 3.20% Added +225.0k +225,000
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 5,548,2315.5m $4.7m $4.7m 0.00% Added +305.3k +305,282
9 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 5,420,9205.4m $4.6m $4.6m 0.00% Added +5.2m +5,213,370
10 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 4,468,1224.5m $3.8m $3.8m 0.00% Added +30.5k +30,520
11 Simplify Asset Management Inc. 0.17% of their portfolio Las Vegas, NV 2,817,5052.8m $2.4m $2.4m 0.17% Unchanged
12 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 2,707,4972.7m $2.3m $2.3m 0.01% Added +1.7m +1,725,824
13 TANG CAPITAL MANAGEMENT LLC 0.14% of their portfolio SAN DIEGO, CA 2,428,1692.4m $2.1m $2.1m 0.14% Reduced -301.8k -301,831
14 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,084,1422.1m $1.8m $1.8m 0.00% Reduced -7.5k -7,527
15 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,066,3362.1m $1.8m $1.8m 0.00% Reduced -1.6m -1,628,271
16 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 2,003,4002.0m $1.7m $1.7m 0.00% Reduced -4.8m -4,797,510
17 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 1,961,6292.0m $1.7m $1.7m 0.00% Reduced -2.2m -2,150,732
18 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 1,950,5212.0m $1.7m $1.7m 0.00% Added +1.9m +1,938,161
19 Rock Springs Capital Management LP 0.06% of their portfolio Baltimore, MD 1,917,1911.9m $1.6m $1.6m 0.06% Added +170.7k +170,742
20 Siren, L.L.C. 0.06% of their portfolio New York, NY 1,633,7681.6m $1.4m $1.4m 0.06% Unchanged
21 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,329,1491.3m $1.1m $1.1m 0.00% Added +1.1m +1,051,779
22 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 1,307,3811.3m $1.1m $1.1m 0.00% Added +773.4k +773,377
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,021,6071.0m $874.7k $874.7k 0.00% Added +203.8k +203,841
24 PERCEPTIVE ADVISORS LLC 0.02% of their portfolio NEW YORK, NY 860,000860.0k $736.3k $736.3k 0.02% Reduced -7.1m -7,145,000
25 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 774,317774.3k $663.0k $663.0k 0.00% Added +13.3k +13,257
26 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 727,626727.6k $623.0k $623.0k 0.00% Added +374.1k +374,143
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 700,836700.8k $600.1k $600.1k 0.00% Reduced -34.4k -34,381
28 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 556,001556.0k $476.0k $476.0k 0.00% Added +522.1k +522,150
29 UBS Group AG 0.00% of their portfolio ZURICH, V8 441,769441.8k $378.2k $378.2k 0.00% Added +158.1k +158,084
30 Windsor Advisory Group, LLC 0.41% of their portfolio COLUMBUS, OH 416,757416.8k $356.8k $356.8k 0.41% Added +217.8k +217,770
31 GROUP ONE TRADING LLC 0.01% of their portfolio CHICAGO, IL 321,312321.3k $275.1k $275.1k 0.01% Added +161.1k +161,148
32 Hennion & Walsh Asset Management, Inc. 0.01% of their portfolio Parsippany, NJ 313,355313.4k $268.3k $268.3k 0.01% Added +48.0k +47,983
33 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 293,810293.8k $251.6k $251.6k 0.00% New
34 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 281,028281.0k $240.6k $240.6k 0.00% Added +19.6k +19,608
35 Jefferies Financial Group Inc. 0.00% of their portfolio NEW YORK, NY 276,700276.7k $236.9k $236.9k 0.00% New
36 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 257,277257.3k $220.3k $220.3k 0.00% Added +10.8k +10,831
37 Jain Global LLC 0.01% of their portfolio NEW YORK, NY 254,019254.0k $217.5k $217.5k 0.01% First filing
38 NORGES BANK 0.00% of their portfolio OSLO, Q8 243,200243.2k $208.2k $208.2k 0.00% Not comparable
39 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 242,878242.9k $207.0k $207.0k 0.00% New
40 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 237,850237.8k $203.6k $203.6k 0.00% Added +35.9k +35,884
41 Caption Management, LLC 0.01% of their portfolio OKLAHOMA CITY, OK 191,800191.8k $164.2k $164.2k 0.01% Added +91.8k +91,800
42 FMR LLC 0.00% of their portfolio BOSTON, MA 176,036176.0k $150.7k $150.7k 0.00% Added +173.6k +173,635
43 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 174,651174.7k $149.5k $149.5k 0.00% Added +39.4k +39,379
44 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 173,568173.6k $148.6k $148.6k 0.01% Added +111.1k +111,128
45 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 172,015172.0k $147.3k $147.3k 0.00% Reduced -28.0k -27,997
46 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 167,415167.4k $143.3k $143.3k 0.00% Reduced -147.5k -147,491
47 Aristides Capital LLC 0.04% of their portfolio LOUISVILLE, KY 156,507156.5k $134.0k $134.0k 0.04% New
48 Swiss National Bank 0.00% of their portfolio ZURICH, V8 146,900146.9k $125.8k $125.8k 0.00% New
49 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 134,335134.3k $115.0k $115.0k 0.00% Added +988 +988
50 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 119,035119.0k $101.9k $101.9k 0.00% New
51 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 100,840100.8k $86.3k $86.3k 0.00% Unchanged
52 Legal & General Group Plc 0.00% of their portfolio London, X0 84,01884.0k $71.9k $71.9k 0.00% Added +62.7k +62,686
53 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 79,84579.8k $68.4k $68.4k 0.00% Added +10.2k +10,178
54 Scientech Research LLC 0.02% of their portfolio JERSEY CITY, NJ 76,51176.5k $65.5k $65.5k 0.02% New
55 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 71,28271.3k $61.0k $61.0k 0.00% Added +64.3k +64,316
56 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 57,45457.5k $49.2k $49.2k 0.00% New
57 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 55,10855.1k $47.2k $47.2k 0.00% Reduced -3.9k -3,914
58 DARK FOREST CAPITAL MANAGEMENT LP 0.01% of their portfolio NEW YORK, NY 53,71853.7k $46.0k $46.0k 0.01% Added +18.9k +18,949
59 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 53,49953.5k $45.8k $45.8k 0.00% Reduced -506.1k -506,118
60 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 52,63152.6k $45.1k $45.1k 0.00% Added +33.6k +33,567
61 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 51,55051.5k $44.1k $44.1k 0.00% Reduced -45.1k -45,076
62 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 51,52651.5k $44.1k $44.1k 0.00% Added +15.7k +15,695
63 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 51,04951.0k $43.7k $43.7k 0.00% Reduced -32.7k -32,711
64 GSA CAPITAL PARTNERS LLP 0.00% of their portfolio LONDON, X0 50,99451.0k $44.0k $44.0k 0.00% New
65 Laurion Capital Management LP 0.00% of their portfolio NEW YORK, NY 50,00050.0k $42.8k $42.8k 0.00% Unchanged
66 SPHERA FUNDS MANAGEMENT LTD. 0.01% of their portfolio TEL AVIV, L3 50,00050.0k $42.8k $42.8k 0.01% Reduced -261.6k -261,572
67 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 49,45749.5k $42.3k $42.3k 0.00% Added +13.7k +13,721
68 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 47,79847.8k $40.9k $40.9k 0.00% Reduced -3.6k -3,608
69 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 40,74740.7k $35.0k $35.0k 0.00% Added +25.6k +25,601
70 Private Advisor Group, LLC 0.00% of their portfolio MORRISTOWN, NJ 40,30040.3k $34.5k $34.5k 0.00% New
71 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 35,79135.8k $30.8k $30.8k 0.00% Reduced -10.5m -10,505,737
72 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 34,76334.8k $30.0k $30.0k 0.00% Reduced -986.1k -986,108
73 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 32,58832.6k $27.9k $27.9k 0.00% Added +14.4k +14,420
74 Ground Swell Capital, LLC 0.06% of their portfolio FOLLY BEACH, SC 31,63631.6k $27.1k $27.1k 0.06% New
75 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,11529.1k $24.9k $24.9k 0.00% Reduced -2.8k -2,758
76 Woodline Partners LP 0.00% of their portfolio San Francisco, CA 26,78626.8k $22.9k $22.9k 0.00% New
77 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 25,77825.8k $22.1k $22.1k 0.00% New
78 CANTOR FITZGERALD, L. P. 0.00% of their portfolio NEW YORK, NY 25,00025.0k $21.4k $21.4k 0.00% New
79 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 24,67224.7k $21.1k $21.1k 0.00% New
80 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 24,42524.4k $20.9k $20.9k 0.00% Added +23.9k +23,893
81 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio AUSTIN, TX 23,20223.2k $20.0k $20.0k 0.00% New
82 CreativeOne Wealth, LLC 0.00% of their portfolio OVERLAND PARK, KS 21,71221.7k $18.6k $18.6k 0.00% New
83 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 21,64821.6k $18.5k $18.5k 0.00% Reduced -60.6k -60,632
84 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 21,61921.6k $18.5k $18.5k 0.00% New
85 Virtu Financial LLC 0.00% of their portfolio New York, NY 21,41421.4k $18.0k $18.0k 0.00% New
86 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 21,20021.2k $18.2k $18.2k 0.00% Unchanged
87 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 19,32919.3k $16.5k $16.5k 0.00% First filing
88 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 17,79917.8k $15.2k $15.2k 0.00% Reduced -19.4k -19,436
89 Pictet Asset Management Holding SA 0.00% of their portfolio CAROUGE, V8 16,96317.0k $14.5k $14.5k 0.00% New
90 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 16,90016.9k $14.5k $14.5k 0.00% Unchanged
91 WOLVERINE TRADING, LLC 0.00% of their portfolio CHICAGO, IL 16,57316.6k $13.5k $13.5k 0.00% New
92 KLP KAPITALFORVALTNING AS 0.00% of their portfolio OSLO, Q8 15,10015.1k $12.9k $12.9k 0.00% First filing
93 Mariner, LLC 0.00% of their portfolio Overland Park, KS 12,32812.3k $10.6k $10.6k 0.00% New
94 Perennial Investment Advisors, LLC 0.00% of their portfolio Los Angeles, CA 11,60011.6k $9.9k $9.9k 0.00% Unchanged
95 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 11,27211.3k $9.6k $9.6k 0.00% Reduced -501 -501
96 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 10,79410.8k $9.2k $9.2k 0.00% Reduced -358 -358
97 Adams Wealth Management 0.00% of their portfolio LOGAN, UT 10,25310.3k $8.8k $8.8k 0.00% New
98 CacheTech Inc. 0.00% of their portfolio LOGAN, UT 10,25310.3k $8.8k $8.8k 0.00% New
99 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 9,4279.4k $8.0k $8.0k 0.00% New
100 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 9,4199.4k $8.1k $8.1k 0.00% Unchanged