Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

90 institutional holders +6 vs Q4 2023
97,715,22697.7m shares reported held*
$664.1mreported value*
30 new 34 added 17 reduced 24 sold out net bought ≈ $265.0m (+39.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($19.2m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $6.80. Options: 11 managers hold calls ($45.8m notional), 7 hold puts ($1.7m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 45Q4 22: 39Q1 23: 37Q2 23: 41Q3 23: 56Q4 23: 84Q1 24: 9090Q3 22Q1 23Q3 23Q1 24
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337
Q2 202341
Q3 202356
Q4 202384
Q1 202490

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 11 bought or addedQ4 22: 29 cut or sold outQ4 22Q1 23: 19 bought or addedQ1 23: 18 cut or sold outQ1 23Q2 23: 21 bought or addedQ2 23: 12 cut or sold outQ2 23Q3 23: 36 bought or addedQ3 23: 14 cut or sold outQ3 23Q4 23: 54 bought or addedQ4 23: 15 cut or sold outQ4 23Q1 24: 64 bought or addedQ1 24: 41 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20221129
Q1 20231918
Q2 20232112
Q3 20233614
Q4 20235415
Q1 20246441

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ2 23 calls: $9.7mQ2 23 puts: $5.8kQ2 23P/C 0.00Q3 23 calls: $19.9mQ3 23 puts: $9.5kQ3 23P/C 0.00Q4 23 calls: $26.4mQ4 23 puts: $510.2kQ4 23P/C 0.02Q1 24 calls: $45.8mQ1 24 puts: $1.7mQ1 24P/C 0.04
Numbers
QuarterCallsPutsP/C
Q2 2023$9.7m$5.8k0.00
Q3 2023$19.9m$9.5k0.00
Q4 2023$26.4m$510.2k0.02
Q1 2024$45.8m$1.7m0.04

Biggest buyers

MORGAN STANLEY Added +9,474,910+9.5m
JANUS HENDERSON GROUP PLC Added +4,266,179+4.3m
PERCEPTIVE ADVISORS LLC Added +3,924,751+3.9m
FRANKLIN RESOURCES INC Added +3,546,433+3.5m
Venrock Adviser, LLC Added +2,825,000+2.8m
ADAGE CAPITAL PARTNERS GP, L.L.C. New +2,649,784+2.6m
TANG CAPITAL MANAGEMENT LLC New +2,230,000+2.2m
Frazier Life Sciences Management, L.P. New +1,952,857+2.0m
Schonfeld Strategic Advisors LLC Added +1,345,151+1.3m
STEMPOINT CAPITAL LP Added +1,109,864+1.1m

Biggest sellers

FMR LLC Sold out -2,427,436-2.4m
AIGH Capital Management LLC Sold out -1,659,039-1.7m
Alyeska Investment Group, L.P. Reduced -1,161,793-1.2m
RENAISSANCE TECHNOLOGIES LLC Reduced -477,287-477.3k
Point72 Asset Management, L.P. Sold out -474,929-474.9k
Worth Venture Partners, LLC Sold out -412,981-413.0k
Logos Global Management LP Reduced -310,000-310.0k
MARSHALL WACE, LLP Sold out -258,144-258.1k
VANGUARD GROUP INC Reduced -220,191-220.2k
TWO SIGMA INVESTMENTS, LP Reduced -130,839-130.8k

Biggest calls

Alyeska Investment Group, L.P. Reduced $27.2m4.0m shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.2m758.7k shares
PERCEPTIVE ADVISORS LLC Unchanged $3.4m500.0k shares
SIMPLEX TRADING, LLC Added $2.5m370.8k shares
J. Goldman & Co LP New $2.3m337.5k shares
GROUP ONE TRADING LLC Added $1.9m279.7k shares
JANE STREET GROUP, LLC New $1.7m253.7k shares
CITADEL ADVISORS LLC Added $813.3k119.6k shares
Parallax Volatility Advisers, L.P. New $653.5k96.1k shares
Belvedere Trading LLC Added $114.2k16.8k shares

Biggest puts

LMR Partners LLP Added $1.0m153.4k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $274.0k40.3k shares
ADAR1 Capital Management, LLC New $204.7k30.1k shares
SIMPLEX TRADING, LLC Added $125.0k18.5k shares
CITADEL ADVISORS LLC Reduced $48.3k7.1k shares
GROUP ONE TRADING LLC Added $19.0k2.8k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 10,564,34510.6m $71.8m $71.8m 0.02% Added +3.5m +3,546,433
2 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 9,582,1569.6m $65.2m $65.2m 0.00% Added +9.5m +9,474,910
3 Venrock Adviser, LLC 2.94% of their portfolio NEW YORK, NY 9,075,0009.1m $61.7m $61.7m 2.94% Added +2.8m +2,825,000
4 PERCEPTIVE ADVISORS LLC 0.96% of their portfolio NEW YORK, NY 8,005,0008.0m $54.4m $54.4m 0.96% Added +3.9m +3,924,751
5 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 6,414,6426.4m $43.6m $43.6m 0.02% Added +4.3m +4,266,179
6 Propel Bio Management, LLC 24.19% of their portfolio Los Angeles, CA 6,111,9066.1m $41.6m $41.6m 24.19% Added +736.9k +736,924
7 Knoll Capital Management, LLC 23.58% of their portfolio MIAMI, FL 5,574,6875.6m $37.9m $37.9m 23.58% Added +100.0k +100,000
8 Vestal Point Capital, LP 2.87% of their portfolio NEW YORK, NY 5,110,0005.1m $34.7m $34.7m 2.87% Added +955.0k +955,000
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,010,2903.0m $20.5m $20.5m 0.00% Reduced -220.2k -220,191
10 Simplify Asset Management Inc. 1.84% of their portfolio Las Vegas, NV 2,817,5052.8m $19.2m $19.2m 1.84% Added +400.0k +400,000
11 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 2,649,7842.6m $18.0m $18.0m 0.03% New
12 TANG CAPITAL MANAGEMENT LLC 1.58% of their portfolio SAN DIEGO, CA 2,230,0002.2m $15.2m $15.2m 1.58% New
13 STEMPOINT CAPITAL LP 3.66% of their portfolio NEW YORK, NY 2,017,0162.0m $13.7m $13.7m 3.66% Added +1.1m +1,109,864
14 Frazier Life Sciences Management, L.P. 0.56% of their portfolio PALO ALTO, CA 1,952,8572.0m $13.3m $13.3m 0.56% New
15 Parkman Healthcare Partners LLC 1.55% of their portfolio STAMFORD, CT 1,854,7631.9m $12.6m $12.6m 1.55% Added +835.6k +835,607
16 Schonfeld Strategic Advisors LLC 0.10% of their portfolio NEW YORK, NY 1,836,6421.8m $12.5m $12.5m 0.10% Added +1.3m +1,345,151
17 Opaleye Management Inc. 2.62% of their portfolio BOSTON, MA 1,770,0001.8m $12.0m $12.0m 2.62% Added +677.5k +677,500
18 Soleus Capital Management, L.P. 0.93% of their portfolio GREENWICH, CT 1,564,9161.6m $10.6m $10.6m 0.93% Added +1.1m +1,104,123
19 Rock Springs Capital Management LP 0.26% of their portfolio Baltimore, MD 1,497,9181.5m $10.2m $10.2m 0.26% Added +602.7k +602,723
20 Laurion Capital Management LP 0.28% of their portfolio NEW YORK, NY 1,481,0061.5m $10.1m $10.1m 0.28% Added +1.1m +1,050,000
21 Alyeska Investment Group, L.P. 0.06% of their portfolio CHICAGO, IL 1,442,9261.4m $9.8m $9.8m 0.06% Reduced -1.2m -1,161,793
22 Logos Global Management LP 0.94% of their portfolio San Francisco, CA 1,350,0001.4m $9.0m $9.0m 0.94% Reduced -310.0k -310,000
23 Artal Group S.A. 0.18% of their portfolio LUXEMBOURG, N4 1,009,5001.0m $6.9m $6.9m 0.18% New
24 BlackRock Inc. 0.00% of their portfolio New York, NY 989,277989.3k $6.7m $6.7m 0.00% Added +461.4k +461,391
25 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 926,425926.4k $6.3m $6.3m 0.01% Added +326.4k +326,387
26 ACUTA CAPITAL PARTNERS, LLC 3.50% of their portfolio REDWOOD CITY, CA 792,000792.0k $5.4m $5.4m 3.50% Added +266.9k +266,900
27 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 715,208715.2k $4.9m $4.9m 0.00% Added +698.5k +698,456
28 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 622,227622.2k $4.2m $4.2m 0.00% New
29 SPHERA FUNDS MANAGEMENT LTD. 0.68% of their portfolio TEL AVIV, L3 619,029619.0k $4.2m $4.2m 0.68% New
30 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 604,428604.4k $4.1m $4.1m 0.00% Added +26.8k +26,757
31 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 539,857539.9k $3.7m $3.7m 0.00% New
32 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 484,885484.9k $3.3m $3.3m 0.00% Reduced -82.6k -82,560
33 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 459,141459.1k $3.1m $3.1m 0.01% Added +265.5k +265,468
34 ADAR1 Capital Management, LLC 0.85% of their portfolio AUSTIN, TX 456,588456.6k $3.1m $3.1m 0.85% New
35 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 357,848357.8k $2.4m $2.4m 0.00% Added +264.0k +263,982
36 Walleye Capital LLC 0.02% of their portfolio NEW YORK, NY 308,316308.3k $2.1m $2.1m 0.02% Added +291.3k +291,316
37 Altitude Crest Partners Inc. 0.76% of their portfolio Stamford, CT 259,700259.7k $1.8m $1.8m 0.76% New
38 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 244,612244.6k $1.7m $1.7m 0.00% Added +112.7k +112,706
39 Checkpoint Capital L.P. 1.00% of their portfolio SAN FRANCISCO, CA 220,000220.0k $1.5m $1.5m 1.00% New
40 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 206,669206.7k $1.4m $1.4m 0.00% Added +66.0k +66,000
41 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 193,758193.8k $1.3m $1.3m 0.01% Added +179.8k +179,843
42 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 175,800175.8k $1.2m $1.2m 0.00% Reduced -477.3k -477,287
43 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio HOUSTON, TX 173,800173.8k $1.2m $1.2m 0.02% Reduced -20.0k -20,000
44 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 163,072163.1k $1.1m $1.1m 0.01% Added +104.5k +104,475
45 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 155,158155.2k $1.1m $1.1m 0.00% Reduced -130.8k -130,839
46 Man Group plc 0.00% of their portfolio LONDON, X0 154,636154.6k $1.1m $1.1m 0.00% Reduced -11.9k -11,914
47 UBS Group AG 0.00% of their portfolio ZURICH, V8 152,760152.8k $1.0m $1.0m 0.00% Added +32.6k +32,553
48 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 150,000150.0k $1.0m $1.0m 0.00% New
49 J. Goldman & Co LP 0.05% of their portfolio NEW YORK, NY 146,392146.4k $995.5k $995.5k 0.05% New
50 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 118,804118.8k $807.9k $807.9k 0.00% Reduced -101.1k -101,122
51 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 106,453106.5k $723.9k $723.9k 0.00% Reduced -144 -144
52 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 98,87998.9k $672.0k $672.0k 0.00% New
53 Informed Momentum Co LLC 0.10% of their portfolio SOLANA BEACH, CA 92,87292.9k $631.5k $631.5k 0.10% Reduced -90.0k -89,998
54 OMERS ADMINISTRATION Corp 0.01% of their portfolio TORONTO, A6 64,70064.7k $440.0k $440.0k 0.01% Added +51.6k +51,600
55 Richmond Brothers, Inc. 0.78% of their portfolio JACKSON, MI 61,82761.8k $420.4k $420.4k 0.78% Reduced -61.8k -61,827
56 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 61,27261.3k $416.6k $416.6k 0.00% New
57 ExodusPoint Capital Management, LP 0.01% of their portfolio NEW YORK, NY 60,79560.8k $413.0k $413.0k 0.01% New
58 Marathon Trading Investment Management LLC 0.16% of their portfolio RADNOR, PA 59,00059.0k $401.2k $401.2k 0.16% New
59 Brevan Howard Capital Management LP 0.03% of their portfolio ST. HELIER, Y9 47,35647.4k $322.0k $322.0k 0.03% New
60 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 43,56943.6k $296.3k $296.3k 0.01% Added +19.4k +19,398
61 EntryPoint Capital, LLC 0.24% of their portfolio NEW YORK, NY 40,07040.1k $272.5k $272.5k 0.24% New
62 Relyea Zuckerberg Hanson LLC 0.05% of their portfolio STAMFORD, CT 40,00040.0k $272.0k $272.0k 0.05% Unchanged
63 Engineers Gate Manager LP 0.01% of their portfolio NEW YORK, NY 39,63139.6k $269.5k $269.5k 0.01% New
64 Point72 Asia (Singapore) Pte. Ltd. 0.07% of their portfolio SINGAPORE, U0 37,14537.1k $252.6k $252.6k 0.07% Added +34.2k +34,245
65 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 35,54535.5k $241.7k $241.7k 0.00% Reduced -9.1k -9,086
66 DENALI ADVISORS LLC 0.07% of their portfolio SAN DIEGO, CA 33,60033.6k $228.5k $228.5k 0.07% New
67 Caption Management, LLC 0.02% of their portfolio OKLAHOMA CITY, OK 31,30031.3k $212.8k $212.8k 0.02% New
68 LMR Partners LLP 0.00% of their portfolio LONDON, X0 28,01328.0k $190.5k $190.5k 0.00% New
69 Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio HONG KONG, K3 27,01727.0k $183.7k $183.7k 0.01% Added +16.0k +15,969
70 Polymer Capital Management (HK) LTD 0.04% of their portfolio HONG KONG, K3 25,82625.8k $175.6k $175.6k 0.04% New
71 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 24,50424.5k $166.6k $166.6k 0.00% Unchanged
72 Jefferies Financial Group Inc. 0.00% of their portfolio NEW YORK, NY 22,20022.2k $151.0k $151.0k 0.00% New
73 GSA CAPITAL PARTNERS LLP 0.01% of their portfolio LONDON, X0 21,43121.4k $146.0k $146.0k 0.01% New
74 WealthTrust Axiom LLC 0.05% of their portfolio WAYNE, PA 21,00021.0k $142.8k $142.8k 0.05% Reduced -22.0k -22,000
75 Susquehanna Portfolio Strategies, LLC 0.00% of their portfolio Bala Cynwyd, PA 14,09914.1k $95.9k $95.9k 0.00% Reduced -11.0k -10,996
76 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 13,55013.6k $92.0k $92.0k 0.00% Unchanged
77 Perennial Investment Advisors, LLC 0.01% of their portfolio Los Angeles, CA 11,60011.6k $78.9k $78.9k 0.01% Unchanged
78 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 11,30011.3k $76.8k $76.8k 0.00% New
79 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 10,65810.7k $72.5k $72.5k 0.00% New
80 CTC Alternative Strategies, Ltd. 0.04% of their portfolio CHICAGO, IL 10,40010.4k $70.7k $70.7k 0.04% New
81 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 10,26110.3k $69.8k $69.8k 0.00% Reduced -12.9k -12,914
82 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 6,7366.7k $46 $46 0.00% New
83 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 3,1093.1k $21.1k $21.1k 0.00% Reduced -74.5k -74,503
84 COMERICA BANK 0.00% of their portfolio DALLAS, TX 2,0002.0k $13.6k $13.6k 0.00% Unchanged
85 Cutler Group LLC / CA 0.00% of their portfolio SAN FRANCISCO, CA 700700 $4.0k $4.0k 0.00% New
86 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 544544 $3.7k $3.7k 0.00% Unchanged
87 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 435435 $3.0k $3.0k 0.00% Added +7 +7
88 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 8484 $571 $571 0.00% Unchanged
89 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 11 $7 $7 0.00% Unchanged
90 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged