Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

84 institutional holders +28 vs Q3 2023
58,658,10558.7m shares reported held*
$196.5mreported value*
27 new 27 added 11 reduced 4 sold out net bought ≈ $27.2m (+8.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $3.35. Options: 9 managers hold calls ($26.4m notional), 6 hold puts ($510.2k).

Trends to Q4 2023

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 45Q4 22: 39Q1 23: 37Q2 23: 41Q3 23: 56Q4 23: 8484Q3 22Q4 22Q1 23Q2 23Q3 23Q4 23
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337
Q2 202341
Q3 202356
Q4 202384

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 11 bought or addedQ4 22: 29 cut or sold outQ4 22Q1 23: 19 bought or addedQ1 23: 18 cut or sold outQ1 23Q2 23: 21 bought or addedQ2 23: 12 cut or sold outQ2 23Q3 23: 36 bought or addedQ3 23: 14 cut or sold outQ3 23Q4 23: 54 bought or addedQ4 23: 15 cut or sold outQ4 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221129
Q1 20231918
Q2 20232112
Q3 20233614
Q4 20235415

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30mQ1 23 calls: $3.5mQ1 23 puts: $0Q1 23P/C 0.00Q2 23 calls: $9.7mQ2 23 puts: $5.8kQ2 23P/C 0.00Q3 23 calls: $19.9mQ3 23 puts: $9.5kQ3 23P/C 0.00Q4 23 calls: $26.4mQ4 23 puts: $510.2kQ4 23P/C 0.02
Numbers
QuarterCallsPutsP/C
Q1 2023$3.5m$00.00
Q2 2023$9.7m$5.8k0.00
Q3 2023$19.9m$9.5k0.00
Q4 2023$26.4m$510.2k0.02

Biggest buyers

PERCEPTIVE ADVISORS LLC New +4,080,249+4.1m
JANUS HENDERSON GROUP PLC New +2,148,463+2.1m
VANGUARD GROUP INC Added +1,801,827+1.8m
Logos Global Management LP New +1,660,000+1.7m
AIGH Capital Management LLC Added +865,689+865.7k
MILLENNIUM MANAGEMENT LLC New +600,038+600.0k
Venrock Adviser, LLC Added +591,966+592.0k
ACUTA CAPITAL PARTNERS, LLC New +525,100+525.1k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added +473,653+473.7k
Knoll Capital Management, LLC Added +312,599+312.6k

Biggest sellers

ARMISTICE CAPITAL, LLC Sold out -3,400,000-3.4m
Alyeska Investment Group, L.P. Reduced -1,615,941-1.6m
FRANKLIN RESOURCES INC Reduced -929,100-929.1k
Soleus Capital Management, L.P. Reduced -731,833-731.8k
Parkman Healthcare Partners LLC Reduced -730,844-730.8k
FMR LLC Reduced -212,100-212.1k
Informed Momentum Co LLC Reduced -208,725-208.7k
Walleye Capital LLC Reduced -122,381-122.4k
JANE STREET GROUP, LLC Reduced -71,273-71.3k
PRELUDE CAPITAL MANAGEMENT, LLC Sold out -63,508-63.5k

Biggest calls

Alyeska Investment Group, L.P. Unchanged $25.1m7.5m shares
PERCEPTIVE ADVISORS LLC New $500.0k500.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $281.7k84.1k shares
CITADEL ADVISORS LLC Added $216.1k64.5k shares
GROUP ONE TRADING LLC Reduced $154.4k46.1k shares
WOLVERINE TRADING, LLC New $77.0k23.0k shares
SIMPLEX TRADING, LLC Reduced $67.0k20.2k shares
Belvedere Trading LLC New $8.4k2.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

LMR Partners LLP New $400.3k119.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $54.9k16.4k shares
CITADEL ADVISORS LLC Added $46.9k14.0k shares
GROUP ONE TRADING LLC Added $4.0k1.2k shares
SIMPLEX TRADING, LLC Reduced $4.0k1.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q4 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 7,017,9127.0m $23.5m $23.5m 0.01% Reduced -929.1k -929,100
2 Venrock Adviser, LLC 1.44% of their portfolio NEW YORK, NY 6,250,0006.2m $20.9m $20.9m 1.44% Added +592.0k +591,966
3 Knoll Capital Management, LLC 15.19% of their portfolio MIAMI, FL 5,474,6875.5m $18.3m $18.3m 15.19% Added +312.6k +312,599
4 Propel Bio Management, LLC 14.93% of their portfolio Los Angeles, CA 5,374,9825.4m $18.0m $18.0m 14.93% First filing
5 Vestal Point Capital, LP 1.47% of their portfolio NEW YORK, NY 4,155,0004.2m $13.9m $13.9m 1.47% First filing
6 PERCEPTIVE ADVISORS LLC 0.31% of their portfolio NEW YORK, NY 4,080,2494.1m $13.7m $13.7m 0.31% New
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,230,4813.2m $10.8m $10.8m 0.00% Added +1.8m +1,801,827
8 Alyeska Investment Group, L.P. 0.06% of their portfolio CHICAGO, IL 2,604,7192.6m $8.7m $8.7m 0.06% Reduced -1.6m -1,615,941
9 FMR LLC 0.00% of their portfolio BOSTON, MA 2,427,4362.4m $8.1m $8.1m 0.00% Reduced -212.1k -212,100
10 Simplify Asset Management Inc. 1.26% of their portfolio Las Vegas, NV 2,417,5052.4m $8.1m $8.1m 1.26% Unchanged
11 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 2,148,4632.1m $7.2m $7.2m 0.00% New
12 Logos Global Management LP 0.62% of their portfolio San Francisco, CA 1,660,0001.7m $5.6m $5.6m 0.62% New
13 AIGH Capital Management LLC 2.20% of their portfolio BALTIMORE, MD 1,659,0391.7m $5.6m $5.6m 2.20% Added +865.7k +865,689
14 Opaleye Management Inc. 0.97% of their portfolio BOSTON, MA 1,092,5001.1m $3.7m $3.7m 0.97% Added +199.5k +199,500
15 Parkman Healthcare Partners LLC 0.48% of their portfolio STAMFORD, CT 1,019,1561.0m $3.4m $3.4m 0.48% Reduced -730.8k -730,844
16 STEMPOINT CAPITAL LP 0.87% of their portfolio NEW YORK, NY 907,152907.2k $3.0m $3.0m 0.87% First filing
17 Rock Springs Capital Management LP 0.07% of their portfolio Baltimore, MD 895,195895.2k $3.0m $3.0m 0.07% Added +86.4k +86,386
18 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 653,087653.1k $2.2m $2.2m 0.00% Added +237.6k +237,609
19 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 600,038600.0k $2.0m $2.0m 0.00% New
20 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 577,671577.7k $1.9m $1.9m 0.00% Added +134.2k +134,199
21 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 567,445567.4k $1.9m $1.9m 0.00% Added +473.7k +473,653
22 BlackRock Inc. 0.00% of their portfolio New York, NY 527,886527.9k $1.8m $1.8m 0.00% Added +143.9k +143,893
23 ACUTA CAPITAL PARTNERS, LLC 0.99% of their portfolio REDWOOD CITY, CA 525,100525.1k $1.8m $1.8m 0.99% New
24 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 491,491491.5k $1.6m $1.6m 0.01% Added +34.1k +34,091
25 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 474,929474.9k $1.6m $1.6m 0.00% Unchanged
26 Soleus Capital Management, L.P. 0.17% of their portfolio GREENWICH, CT 460,793460.8k $1.5m $1.5m 0.17% Reduced -731.8k -731,833
27 Laurion Capital Management LP 0.05% of their portfolio NEW YORK, NY 431,006431.0k $1.4m $1.4m 0.05% Added +85.1k +85,106
28 Worth Venture Partners, LLC 0.75% of their portfolio FORT LEE, NJ 412,981413.0k $1.4m $1.4m 0.75% Added +219.0k +219,008
29 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 285,997286.0k $958.1k $958.1k 0.00% Added +216.6k +216,646
30 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 258,144258.1k $864.8k $864.8k 0.00% New
31 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 219,926219.9k $736.8k $736.8k 0.00% Added +153.9k +153,950
32 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 193,800193.8k $649.2k $649.2k 0.01% Added +50.0k +50,000
33 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 193,673193.7k $648.8k $648.8k 0.00% Added +186.1k +186,123
34 Informed Momentum Co LLC 0.11% of their portfolio SOLANA BEACH, CA 182,870182.9k $612.6k $612.6k 0.11% Reduced -208.7k -208,725
35 Man Group plc 0.00% of their portfolio LONDON, X0 166,550166.6k $557.9k $557.9k 0.00% New
36 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 140,669140.7k $471.2k $471.2k 0.00% Added +3.4k +3,400
37 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 131,906131.9k $441.9k $441.9k 0.00% Reduced -71.3k -71,273
38 Richmond Brothers, Inc. 0.72% of their portfolio JACKSON, MI 123,654123.7k $414.2k $414.2k 0.72% Unchanged
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 120,207120.2k $402.7k $402.7k 0.00% Added +11.8k +11,826
40 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 107,246107.2k $359.3k $359.3k 0.00% Added +55.9k +55,875
41 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 106,597106.6k $357.1k $357.1k 0.00% Added +7.7k +7,650
42 683 Capital Management, LLC 0.03% of their portfolio NEW YORK, NY 100,806100.8k $337.7k $337.7k 0.03% New
43 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 93,86693.9k $314.5k $314.5k 0.00% Added +93.5k +93,478
44 XTX Topco Ltd 0.06% of their portfolio LONDON, X0 81,37181.4k $272.6k $272.6k 0.06% New
45 Connective Capital Management, LLC 0.23% of their portfolio PALO ALTO, CA 79,24279.2k $265.5k $265.5k 0.23% New
46 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 77,61277.6k $260.0k $260.0k 0.00% Added +77.2k +77,239
47 SIMPLEX TRADING, LLC 0.01% of their portfolio CHICAGO, IL 71,99172.0k $241.0k $241.0k 0.01% New
48 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 58,59758.6k $196.3k $196.3k 0.00% Added +54.1k +54,085
49 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 51,00051.0k $170.8k $170.8k 0.00% Added +35.4k +35,400
50 Maven Securities LTD 0.02% of their portfolio ST HELIER, Y9 50,00050.0k $167.5k $167.5k 0.02% New
51 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 44,63144.6k $149.5k $149.5k 0.00% Added +44.4k +44,403
52 WealthTrust Axiom LLC 0.05% of their portfolio WAYNE, PA 43,00043.0k $144.1k $144.1k 0.05% Unchanged
53 Relyea Zuckerberg Hanson LLC 0.03% of their portfolio STAMFORD, CT 40,00040.0k $134.0k $134.0k 0.03% Unchanged
54 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 26,96027.0k $90.3k $90.3k 0.00% New
55 Susquehanna Portfolio Strategies, LLC 0.00% of their portfolio Bala Cynwyd, PA 25,09525.1k $84.1k $84.1k 0.00% First filing
56 BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 24,96425.0k $83.6k $83.6k 0.00% New
57 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 24,50424.5k $82.1k $82.1k 0.00% Unchanged
58 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 24,17124.2k $81.0k $81.0k 0.00% New
59 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 23,17523.2k $77.6k $77.6k 0.00% Reduced -12.3k -12,268
60 TWO SIGMA SECURITIES, LLC 0.00% of their portfolio NEW YORK, NY 18,68718.7k $62.6k $62.6k 0.00% New
61 Belvedere Trading LLC 0.01% of their portfolio CHICAGO, IL 18,23618.2k $61.1k $61.1k 0.01% New
62 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 18,09118.1k $60.6k $60.6k 0.00% Unchanged
63 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 17,00017.0k $57.0k $57.0k 0.00% Reduced -122.4k -122,381
64 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 16,75216.8k $56.1k $56.1k 0.00% New
65 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 16,44516.4k $55.1k $55.1k 0.00% New
66 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 13,91513.9k $46.6k $46.6k 0.00% New
67 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 13,68913.7k $45.0k $45.0k 0.00% New
68 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 13,55013.6k $45.0k $45.0k 0.00% Unchanged
69 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 13,10013.1k $43.9k $43.9k 0.00% New
70 Perennial Investment Advisors, LLC 0.01% of their portfolio Los Angeles, CA 11,60011.6k $38.9k $38.9k 0.01% Unchanged
71 Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio HONG KONG, K3 11,04811.0k $37.0k $37.0k 0.00% New
72 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 10,60510.6k $35.5k $35.5k 0.00% New
73 WOLVERINE TRADING, LLC 0.00% of their portfolio CHICAGO, IL 10,10510.1k $33.9k $33.9k 0.00% New
74 Intrua Financial, LLC 0.01% of their portfolio Houston, TX 10,04010.0k $33.6k $33.6k 0.01% New
75 Essex Financial Services, Inc. 0.00% of their portfolio ESSEX, CT 10,00010.0k $33.5k $33.5k 0.00% Unchanged
76 Vontobel Holding Ltd. 0.00% of their portfolio ZURICH, V8 10,00010.0k $33.5k $33.5k 0.00% New
77 Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio SINGAPORE, U0 2,9002.9k $9.7k $9.7k 0.00% First filing
78 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2,1412.1k $7.0k $7.0k 0.00% Added +2.1k +2,059
79 COMERICA BANK 0.00% of their portfolio DALLAS, TX 2,0002.0k $6.7k $6.7k 0.00% Unchanged
80 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 544544 $1.8k $1.8k 0.00% Unchanged
81 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 428428 $1.4k $1.4k 0.00% Reduced -76 -76
82 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 8484 $281 $281 0.00% Unchanged
83 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 11 $3 $3 0.00% Reduced -1.6k -1,632
84 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged