Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

225 institutional holders +17 vs Q4 2025
78,993,84879.0m shares reported held*
$6.6bnreported value*
42 new 104 added 53 reduced 29 sold out net bought ≈ $618.2m (+7.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $83.97. Options: 11 managers hold calls ($78.5m notional), 11 hold puts ($36.7m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140Q4 24: 159Q1 25: 170Q2 25: 184Q3 25: 174Q4 25: 208Q1 26: 225225Q3 23Q1 24Q3 24Q1 25Q3 25Q1 26
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140
Q4 2024159
Q1 2025170
Q2 2025184
Q3 2025174
Q4 2025208
Q1 2026225

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 24: 79 bought or addedQ2 24: 73 cut or sold outQ3 24: 71 bought or addedQ3 24: 70 cut or sold outQ3 24Q4 24: 84 bought or addedQ4 24: 62 cut or sold outQ1 25: 83 bought or addedQ1 25: 78 cut or sold outQ1 25Q2 25: 91 bought or addedQ2 25: 87 cut or sold outQ3 25: 86 bought or addedQ3 25: 89 cut or sold outQ3 25Q4 25: 129 bought or addedQ4 25: 65 cut or sold outQ1 26: 146 bought or addedQ1 26: 82 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 20247973
Q3 20247170
Q4 20248462
Q1 20258378
Q2 20259187
Q3 20258689
Q4 202512965
Q1 202614682

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60m$80mQ2 25 calls: $18.5mQ2 25 puts: $34.4mQ2 25P/C 1.86Q3 25 calls: $12.8mQ3 25 puts: $5.3mQ3 25P/C 0.41Q4 25 calls: $27.8mQ4 25 puts: $13.5mQ4 25P/C 0.49Q1 26 calls: $78.5mQ1 26 puts: $36.7mQ1 26P/C 0.47
Numbers
QuarterCallsPutsP/C
Q2 2025$18.5m$34.4m1.86
Q3 2025$12.8m$5.3m0.41
Q4 2025$27.8m$13.5m0.49
Q1 2026$78.5m$36.7m0.47

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +6,012,541+6.0m
FMR LLC Added +1,037,253+1.0m
FRONTIER CAPITAL MANAGEMENT CO LLC Added +584,030+584.0k
Vestal Point Capital, LP Added +550,000+550.0k
STATE STREET CORP Added +472,778+472.8k
Balyasny Asset Management L.P. New +438,654+438.7k
FEDERATED HERMES, INC. Added +314,807+314.8k
BlackRock, Inc. Added +301,657+301.7k
JANUS HENDERSON GROUP PLC Added +297,992+298.0k
First Light Asset Management, LLC Added +291,693+291.7k

Biggest sellers

Fairmount Funds Management LLC Reduced -1,750,000-1.8m
PERCEPTIVE ADVISORS LLC Reduced -790,267-790.3k
Sofinnova Investments, Inc. Sold out -534,845-534.8k
Avoro Capital Advisors LLC Sold out -500,000-500.0k
WELLINGTON MANAGEMENT GROUP LLP Reduced -370,882-370.9k
MORGAN STANLEY Reduced -295,232-295.2k
Driehaus Capital Management LLC Reduced -262,904-262.9k
JPMORGAN CHASE & CO Reduced -262,596-262.6k
Trails Edge Capital Partners, LP Sold out -192,000-192.0k
CITADEL ADVISORS LLC Reduced -168,079-168.1k

Biggest calls

Caption Management, LLC New $30.5m362.6k shares
DIADEMA PARTNERS LP Added $18.7m222.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $16.1m190.8k shares
CITADEL ADVISORS LLC Added $2.8m33.7k shares
JANE STREET GROUP, LLC Added $2.7m32.0k shares
Persistent Asset Partners Ltd Unchanged $1.9m566 shares
GROUP ONE TRADING LLC Added $1.7m19.7k shares
NOMURA HOLDINGS INC Unchanged $1.5m18.2k shares
Point72 Asset Management, L.P. New $1.2m13.8k shares
BARCLAYS PLC New $841.7k10.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.4m111.5k shares
BARCLAYS PLC New $8.5m100.8k shares
JANE STREET GROUP, LLC Added $4.7m55.8k shares
SIMPLEX TRADING, LLC Added $3.6m42.3k shares
Caption Management, LLC New $2.8m32.8k shares
NOMURA HOLDINGS INC New $2.2m26.6k shares
GROUP ONE TRADING LLC Added $1.7m20.0k shares
CITADEL ADVISORS LLC Added $1.7m20.0k shares
JPMORGAN CHASE & CO New $1.2m14.9k shares
LMR Partners LLP New $841.7k10.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 T. Rowe Price Investment Management, Inc. 0.60% of their portfolio BALTIMORE, MD 10,300,98410.3m $867.0m $867.0m 0.60% Added +6.0m +6,012,541
2 FMR LLC 0.04% of their portfolio BOSTON, MA 9,262,2919.3m $779.6m $779.6m 0.04% Added +1.0m +1,037,253
3 Venrock Adviser, LLC 26.68% of their portfolio NEW YORK, NY 8,493,3218.5m $714.9m $714.9m 26.68% Unchanged
4 WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio Boston, MA 4,375,7034.4m $368.3m $368.3m 0.07% Reduced -370.9k -370,882
5 BlackRock, Inc. 0.01% of their portfolio New York, NY 4,085,6514.1m $343.9m $343.9m 0.01% Added +301.7k +301,657
6 RTW INVESTMENTS, LP 2.33% of their portfolio NEW YORK, NY 2,782,0972.8m $234.2m $234.2m 2.33% Added +70.0k +70,000
7 VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 2,502,0952.5m $210.6m $210.6m 0.01% First filing
8 JANUS HENDERSON GROUP PLC 0.09% of their portfolio LONDON, X0 2,360,5962.4m $198.8m $198.8m 0.09% Added +298.0k +297,992
9 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,162,9642.2m $182.1m $182.1m 0.01% Added +472.8k +472,778
10 Driehaus Capital Management LLC 1.19% of their portfolio Chicago, IL 1,920,8001.9m $161.7m $161.7m 1.19% Reduced -262.9k -262,904
11 PERCEPTIVE ADVISORS LLC 2.56% of their portfolio NEW YORK, NY 1,540,3841.5m $129.7m $129.7m 2.56% Reduced -790.3k -790,267
12 Paradigm Biocapital Advisors LP 2.32% of their portfolio NEW YORK, NY 1,348,2431.3m $113.5m $113.5m 2.32% Added +225.0k +225,000
13 Affinity Asset Advisors, LLC 6.34% of their portfolio NEW YORK, NY 1,284,9261.3m $108.2m $108.2m 6.34% Added +50.0k +50,000
14 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,217,2891.2m $102.5m $102.5m 0.01% Added +158.2k +158,204
15 UBS Group AG 0.02% of their portfolio ZURICH, V8 1,144,3281.1m $96.3m $96.3m 0.02% Added +169.5k +169,502
16 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,143,1521.1m $96.2m $96.2m 0.01% Reduced -94.0k -93,983
17 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,110,4701.1m $87.4m $87.4m 0.01% Reduced -262.6k -262,596
18 Vestal Point Capital, LP 2.59% of their portfolio NEW YORK, NY 1,100,0001.1m $92.6m $92.6m 2.59% Added +550.0k +550,000
19 FRONTIER CAPITAL MANAGEMENT CO LLC 0.92% of their portfolio Boston, MA 1,064,4831.1m $89.6m $89.6m 0.92% Added +584.0k +584,030
20 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 990,297990.3k $74.7m $74.7m 0.02% Reduced -103.4k -103,360
21 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 900,871900.9k $75.8m $75.8m 0.01% Added +107.2k +107,176
22 MERCER GLOBAL ADVISORS INC /ADV 0.10% of their portfolio DENVER, CO 831,428831.4k $70.0m $70.0m 0.10% Reduced -59.2k -59,237
23 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 652,590652.6k $54.9m $54.9m 0.01% Added +87.2k +87,180
24 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 598,902598.9k $50.4m $50.4m 0.04% Reduced -168.1k -168,079
25 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 595,032595.0k $50.1m $50.1m 0.00% Reduced -295.2k -295,232
26 JENNISON ASSOCIATES LLC 0.03% of their portfolio NEW YORK, NY 585,016585.0k $49.2m $49.2m 0.03% Added +6.4k +6,389
27 Remedium Capital Partners, LLC 17.47% of their portfolio WEST PALM BEACH, FL 583,591583.6k $49.1m $49.1m 17.47% Unchanged
28 First Light Asset Management, LLC 4.35% of their portfolio Edina, MN 576,684576.7k $48.5m $48.5m 4.35% Added +291.7k +291,693
29 EVENTIDE ASSET MANAGEMENT, LLC 0.78% of their portfolio Boston, MA 557,423557.4k $46.9m $46.9m 0.78% Added +121.4k +121,408
30 Polar Capital Holdings Plc 0.20% of their portfolio London, X0 539,177539.2k $45.4m $45.4m 0.20% Added +35.6k +35,638
31 First Turn Management, LLC 4.83% of their portfolio DEL MAR, CA 513,770513.8k $43.2m $43.2m 4.83% Added +38.9k +38,931
32 BRAIDWELL LP 1.34% of their portfolio STAMFORD, CT 478,667478.7k $40.3m $40.3m 1.34% Reduced -96.4k -96,400
33 NOVO HOLDINGS A/S 3.07% of their portfolio HELLERUP, G7 450,000450.0k $37.9m $37.9m 3.07% Reduced -120.0k -120,000
34 FEDERATED HERMES, INC. 0.06% of their portfolio PITTSBURGH, PA 442,738442.7k $37.3m $37.3m 0.06% Added +314.8k +314,807
35 Balyasny Asset Management L.P. 0.07% of their portfolio Chicago, IL 438,654438.7k $36.9m $36.9m 0.07% New
36 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 420,684420.7k $35.4m $35.4m 0.01% Added +39.3k +39,322
37 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 405,538405.5k $34.1m $34.1m 0.01% Reduced -45.5k -45,464
38 VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 396,330396.3k $33.4m $33.4m 0.00% First filing
39 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 390,879390.9k $32.9m $32.9m 0.00% Added +63.5k +63,503
40 Opaleye Management Inc. 4.33% of their portfolio BOSTON, MA 390,000390.0k $32.8m $32.8m 4.33% Added +1.7k +1,743
41 GREAT POINT PARTNERS LLC 7.71% of their portfolio Greenwich, CT 374,000374.0k $31.5m $31.5m 7.71% Unchanged
42 VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio MALVERN, PA 368,961369.0k $31.1m $31.1m 0.01% First filing
43 LOOMIS SAYLES & CO L P 0.04% of their portfolio BOSTON, MA 362,781362.8k $30.5m $30.5m 0.04% Added +107.3k +107,342
44 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 348,674348.7k $29.3m $29.3m 0.00% Added +221.1k +221,056
45 Fairmount Funds Management LLC 1.82% of their portfolio WEST CONSHOHOCKEN, PA 298,647298.6k $25.1m $25.1m 1.82% Reduced -1.8m -1,750,000
46 Deep Track Capital, LP 0.49% of their portfolio GREENWICH, CT 285,000285.0k $24.0m $24.0m 0.49% New
47 TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio NEW YORK, NY 281,386281.4k $23.7m $23.7m 0.02% Added +176.1k +176,145
48 Woodline Partners LP 0.08% of their portfolio San Francisco, CA 261,120261.1k $22.0m $22.0m 0.08% Added +50.7k +50,654
49 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 261,050261.1k $22.0m $22.0m 0.02% Reduced -51.8k -51,833
50 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 250,000250.0k $21.0m $21.0m 0.03% Added +10.0k +10,000
51 Candriam S.C.A. 0.10% of their portfolio STRASSEN, N4 223,541223.5k $18.8m $18.8m 0.10% Added +32.2k +32,223
52 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 220,099220.1k $18.5m $18.5m 0.01% Added +210.1k +210,134
53 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 184,792184.8k $15.6m $15.6m 0.01% Added +55.5k +55,502
54 Aberdeen Group plc 0.02% of their portfolio EDINBURGH, X0 143,379143.4k $12.1m $12.1m 0.02% Added +107.3k +107,276
55 Nicholas Investment Partners, LP 0.80% of their portfolio RANCHO SANTA FE, CA 130,992131.0k $11.0m $11.0m 0.80% Added +18.1k +18,068
56 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 128,115128.1k $10.8m $10.8m 0.00% Added +7.1k +7,065
57 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 128,015128.0k $10.8m $10.8m 0.02% Added +386 +386
58 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 126,757126.8k $10.7m $10.7m 0.00% Added +8.7k +8,673
59 KENNEDY CAPITAL MANAGEMENT LLC 0.22% of their portfolio ST LOUIS, MO 122,669122.7k $10.3m $10.3m 0.22% Reduced -2.3k -2,310
60 ArrowMark Colorado Holdings LLC 0.24% of their portfolio Denver, CO 109,410109.4k $9.2m $9.2m 0.24% Unchanged
61 SEVEN GRAND MANAGERS, LLC 0.56% of their portfolio BRONXVILLE, NY 100,000100.0k $8.4m $8.4m 0.56% Added +50.0k +50,000
62 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 96,65696.7k $7.6m $7.6m 0.01% Reduced -8.3k -8,344
63 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 95,13795.1k $8.0m $8.0m 0.01% Reduced -13.1k -13,130
64 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 92,59292.6k $7.8m $7.8m 0.01% Reduced -48.1k -48,135
65 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 91,42191.4k $7.7m $7.7m 0.00% Added +12.1k +12,060
66 NOMURA HOLDINGS INC 0.06% of their portfolio TOKYO, M0 88,56188.6k $7.5m $7.5m 0.06% Added +11.7k +11,663
67 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 82,30082.3k $6.9m $6.9m 0.01% Added +80.0k +80,050
68 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 80,20180.2k $6.8m $6.8m 0.01% Added +29.5k +29,457
69 SIMPLEX TRADING, LLC 0.20% of their portfolio CHICAGO, IL 77,80877.8k $6.5m $6.5m 0.20% Added +15.0k +15,009
70 Parkman Healthcare Partners LLC 0.68% of their portfolio STAMFORD, CT 77,68677.7k $6.5m $6.5m 0.68% Reduced -52.4k -52,383
71 WCM INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio LAGUNA BEACH, CA 76,03076.0k $6.0m $6.0m 0.01% New
72 Swiss National Bank 0.00% of their portfolio ZURICH, V8 75,60075.6k $6.4m $6.4m 0.00% Added +12.7k +12,700
73 Granahan Investment Management, LLC 0.31% of their portfolio WALTHAM, MA 75,08675.1k $6.3m $6.3m 0.31% Reduced -19.6k -19,634
74 Alyeska Investment Group, L.P. 0.02% of their portfolio CHICAGO, IL 75,00075.0k $6.3m $6.3m 0.02% New
75 Rhenman & Partners Asset Management AB 0.78% of their portfolio Stockholm, V7 75,00075.0k $6.3m $6.3m 0.78% New
76 Boxer Capital Management, LLC 0.77% of their portfolio San Diego, CA 70,00070.0k $5.9m $5.9m 0.77% Unchanged
77 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 69,88869.9k $5.9m $5.9m 0.00% Reduced -53.0k -53,012
78 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 68,69668.7k $5.8m $5.8m 0.00% Reduced -12.1k -12,136
79 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 63,90063.9k $5.4m $5.4m 0.01% Added +9.6k +9,600
80 FIFTH THIRD BANCORP 0.01% of their portfolio CINCINNATI, OH 63,80063.8k $5.4m $5.4m 0.01% New
81 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 60,39760.4k $5.1m $5.1m 0.02% Added +11.8k +11,778
82 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 58,83558.8k $5.0m $5.0m 0.00% Reduced -4.4k -4,415
83 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 58,48458.5k $4.9m $4.9m 0.01% Added +8.5k +8,485
84 PLATINUM INVESTMENT MANAGEMENT LTD 1.24% of their portfolio SYDNEY AUSTRALIA 2000, C3 58,31458.3k $4.9m $4.9m 1.24% Reduced -10.9k -10,898
85 Holocene Advisors, LP 0.01% of their portfolio New York, NY 57,47357.5k $4.8m $4.8m 0.01% New
86 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 56,35256.4k $4.7m $4.7m 0.00% Added +6.5k +6,547
87 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.01% of their portfolio Paris, I0 54,43754.4k $4.6m $4.6m 0.01% Added +14.6k +14,591
88 Lisanti Capital Growth, LLC 1.11% of their portfolio NEW YORK, NY 52,26052.3k $4.4m $4.4m 1.11% New
89 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 50,39650.4k $4.2m $4.2m 0.00% Reduced -82.8k -82,797
90 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 48,67848.7k $4.1m $4.1m 0.00% Added +2.7k +2,707
91 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 45,58645.6k $3.8m $3.8m 0.02% Added +664 +664
92 XTX Topco Ltd 0.06% of their portfolio LONDON, X0 42,89942.9k $3.6m $3.6m 0.06% Added +23.9k +23,873
93 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 42,20342.2k $3.6m $3.6m 0.00% Added +25.9k +25,874
94 Man Group plc 0.01% of their portfolio LONDON, X0 41,81541.8k $3.5m $3.5m 0.01% Added +30.7k +30,652
95 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 40,77640.8k $3.4m $3.4m 0.00% Added +37.4k +37,358
96 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 38,76338.8k $3.3m $3.3m 0.00% Reduced -31.9k -31,924
97 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 38,34838.3k $3.2m $3.2m 0.01% New
98 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 38,16138.2k $3.2m $3.2m 0.00% Added +7.4k +7,403
99 KBC Group NV 0.01% of their portfolio Brussels, C9 37,84337.8k $3.2m $3.2m 0.01% New
100 HighVista Strategies LLC 0.83% of their portfolio BOSTON, MA 35,76135.8k $3.0m $3.0m 0.83% Reduced -53.5k -53,468