Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

208 institutional holders +34 vs Q3 2025
71,270,13471.3m shares reported held*
$5.4bnreported value*
44 new 85 added 47 reduced 18 sold out net bought ≈ $741.3m (+9.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $75.48. Options: 8 managers hold calls ($27.8m notional), 6 hold puts ($13.5m).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140Q4 24: 159Q1 25: 170Q2 25: 184Q3 25: 174Q4 25: 208208Q3 23Q1 24Q3 24Q1 25Q3 25Q4 25
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140
Q4 2024159
Q1 2025170
Q2 2025184
Q3 2025174
Q4 2025208

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ2 24: 79 bought or addedQ2 24: 73 cut or sold outQ2 24Q3 24: 71 bought or addedQ3 24: 70 cut or sold outQ4 24: 84 bought or addedQ4 24: 62 cut or sold outQ4 24Q1 25: 83 bought or addedQ1 25: 78 cut or sold outQ2 25: 91 bought or addedQ2 25: 87 cut or sold outQ2 25Q3 25: 86 bought or addedQ3 25: 89 cut or sold outQ4 25: 129 bought or addedQ4 25: 65 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 202411226
Q2 20247973
Q3 20247170
Q4 20248462
Q1 20258378
Q2 20259187
Q3 20258689
Q4 202512965

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ1 25 calls: $14.3mQ1 25 puts: $9.5mQ1 25P/C 0.67Q2 25 calls: $18.5mQ2 25 puts: $34.4mQ2 25P/C 1.86Q3 25 calls: $12.8mQ3 25 puts: $5.3mQ3 25P/C 0.41Q4 25 calls: $27.8mQ4 25 puts: $13.5mQ4 25P/C 0.49
Numbers
QuarterCallsPutsP/C
Q1 2025$14.3m$9.5m0.67
Q2 2025$18.5m$34.4m1.86
Q3 2025$12.8m$5.3m0.41
Q4 2025$27.8m$13.5m0.49

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +4,287,002+4.3m
JANUS HENDERSON GROUP PLC Added +1,576,626+1.6m
FMR LLC Added +1,308,576+1.3m
BlackRock, Inc. Added +1,097,968+1.1m
PERCEPTIVE ADVISORS LLC Added +978,662+978.7k
VANGUARD GROUP INC Added +612,193+612.2k
JENNISON ASSOCIATES LLC New +578,627+578.6k
Avoro Capital Advisors LLC New +500,000+500.0k
PRICE T ROWE ASSOCIATES INC /MD/ Added +486,606+486.6k
EVENTIDE ASSET MANAGEMENT, LLC New +436,015+436.0k

Biggest sellers

JPMORGAN CHASE & CO Reduced -902,396-902.4k
BRAIDWELL LP Reduced -863,678-863.7k
Jefferies Financial Group Inc. Sold out -568,084-568.1k
BARCLAYS PLC Reduced -509,123-509.1k
CITADEL ADVISORS LLC Reduced -402,263-402.3k
Paradigm Biocapital Advisors LP Reduced -398,514-398.5k
ALLIANCEBERNSTEIN L.P. Reduced -325,475-325.5k
Commodore Capital LP Sold out -290,000-290.0k
MILLENNIUM MANAGEMENT LLC Reduced -289,736-289.7k
FRANKLIN RESOURCES INC Reduced -279,759-279.8k

Biggest calls

DIADEMA PARTNERS LP Added $15.9m211.1k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $6.0m79.4k shares
Persistent Asset Partners Ltd Added $1.6m566 shares
NOMURA HOLDINGS INC New $1.4m18.2k shares
CITADEL ADVISORS LLC Reduced $1.1m14.2k shares
GROUP ONE TRADING LLC Added $928.4k12.3k shares
JANE STREET GROUP, LLC Added $483.1k6.4k shares
SIMPLEX TRADING, LLC Reduced $347.2k4.6k shares

Biggest puts

Hudson Bay Capital Management LP New $6.0m79.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $3.1m41.7k shares
SIMPLEX TRADING, LLC Added $2.6m35.1k shares
CITADEL ADVISORS LLC Added $1.2m15.8k shares
JANE STREET GROUP, LLC Reduced $430.2k5.7k shares
GROUP ONE TRADING LLC Reduced $90.6k1.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 31.67% of their portfolio NEW YORK, NY 8,493,3218.5m $641.1m $641.1m 31.67% Unchanged
2 FMR LLC 0.03% of their portfolio BOSTON, MA 8,225,0388.2m $620.8m $620.8m 0.03% Added +1.3m +1,308,576
3 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 4,746,5854.7m $358.3m $358.3m 0.06% Added +22.9k +22,884
4 T. Rowe Price Investment Management, Inc. 0.13% of their portfolio BALTIMORE, MD 4,288,4434.3m $323.7m $323.7m 0.13% Added +4.3m +4,287,002
5 BlackRock, Inc. 0.00% of their portfolio New York, NY 3,783,9943.8m $285.6m $285.6m 0.00% Added +1.1m +1,097,968
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,857,8242.9m $215.7m $215.7m 0.00% Added +612.2k +612,193
7 RTW INVESTMENTS, LP 2.05% of their portfolio NEW YORK, NY 2,712,0972.7m $204.7m $204.7m 2.05% Unchanged
8 PERCEPTIVE ADVISORS LLC 3.22% of their portfolio NEW YORK, NY 2,330,6512.3m $175.9m $175.9m 3.22% Added +978.7k +978,662
9 Driehaus Capital Management LLC 1.12% of their portfolio Chicago, IL 2,183,7042.2m $164.8m $164.8m 1.12% Added +25.2k +25,202
10 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 2,062,6042.1m $155.7m $155.7m 0.07% Added +1.6m +1,576,626
11 Fairmount Funds Management LLC 11.77% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $154.6m $154.6m 11.77% Unchanged
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,690,1861.7m $127.6m $127.6m 0.00% Added +34.6k +34,638
13 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,373,0661.4m $103.6m $103.6m 0.01% Reduced -902.4k -902,396
14 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,237,1351.2m $93.4m $93.4m 0.01% Added +486.6k +486,606
15 Affinity Asset Advisors, LLC 6.70% of their portfolio NEW YORK, NY 1,234,9261.2m $93.2m $93.2m 6.70% Added +61.5k +61,500
16 Paradigm Biocapital Advisors LP 2.27% of their portfolio NEW YORK, NY 1,123,2431.1m $84.8m $84.8m 2.27% Reduced -398.5k -398,514
17 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,093,6571.1m $82.5m $82.5m 0.03% Reduced -325.5k -325,475
18 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,059,0851.1m $80.0m $80.0m 0.00% Added +166.9k +166,882
19 UBS Group AG 0.01% of their portfolio ZURICH, V8 974,826974.8k $73.6m $73.6m 0.01% Added +175.4k +175,361
20 MERCER GLOBAL ADVISORS INC /ADV 0.10% of their portfolio DENVER, CO 890,665890.7k $67.2m $67.2m 0.10% Reduced -79.9k -79,916
21 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 890,264890.3k $67.2m $67.2m 0.00% Added +425.3k +425,301
22 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 793,695793.7k $59.9m $59.9m 0.00% Added +399.8k +399,783
23 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 766,981767.0k $57.9m $57.9m 0.04% Reduced -402.3k -402,263
24 Remedium Capital Partners, LLC 25.88% of their portfolio WEST PALM BEACH, FL 583,591583.6k $44.0m $44.0m 25.88% First filing
25 JENNISON ASSOCIATES LLC 0.03% of their portfolio NEW YORK, NY 578,627578.6k $43.7m $43.7m 0.03% New
26 BRAIDWELL LP 1.39% of their portfolio STAMFORD, CT 575,067575.1k $43.4m $43.4m 1.39% Reduced -863.7k -863,678
27 NOVO HOLDINGS A/S 3.34% of their portfolio HELLERUP, G7 570,000570.0k $43.0m $43.0m 3.34% Added +70.0k +70,000
28 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 565,410565.4k $42.7m $42.7m 0.01% Reduced -34.2k -34,206
29 Vestal Point Capital, LP 1.52% of their portfolio NEW YORK, NY 550,000550.0k $41.5m $41.5m 1.52% Added +125.0k +125,000
30 Sofinnova Investments, Inc. 1.74% of their portfolio Menlo Park, CA 534,845534.8k $40.4m $40.4m 1.74% Reduced -30.6k -30,572
31 Polar Capital Holdings Plc 0.17% of their portfolio London, X0 503,539503.5k $38.0m $38.0m 0.17% Reduced -20.6k -20,555
32 Avoro Capital Advisors LLC 0.37% of their portfolio NEW YORK, NY 500,000500.0k $37.7m $37.7m 0.37% New
33 FRONTIER CAPITAL MANAGEMENT CO LLC 0.38% of their portfolio Boston, MA 480,453480.5k $36.3m $36.3m 0.38% Added +106.0k +106,046
34 First Turn Management, LLC 4.10% of their portfolio DEL MAR, CA 474,839474.8k $35.8m $35.8m 4.10% Added +72.0k +72,028
35 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 451,002451.0k $34.0m $34.0m 0.01% Reduced -279.8k -279,759
36 EVENTIDE ASSET MANAGEMENT, LLC 0.51% of their portfolio Boston, MA 436,015436.0k $32.9m $32.9m 0.51% New
37 Opaleye Management Inc. 3.87% of their portfolio BOSTON, MA 388,257388.3k $29.3m $29.3m 3.87% Added +25.0k +25,000
38 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 381,362381.4k $28.8m $28.8m 0.00% Added +61.5k +61,459
39 GREAT POINT PARTNERS LLC 9.15% of their portfolio Greenwich, CT 374,000374.0k $28.2m $28.2m 9.15% Added +70.0k +70,000
40 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 327,376327.4k $24.7m $24.7m 0.00% Added +42.9k +42,893
41 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 312,883312.9k $23.6m $23.6m 0.02% New
42 First Light Asset Management, LLC 1.64% of their portfolio Edina, MN 284,991285.0k $21.5m $21.5m 1.64% New
43 LOOMIS SAYLES & CO L P 0.02% of their portfolio BOSTON, MA 255,439255.4k $19.3m $19.3m 0.02% New
44 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 240,000240.0k $18.1m $18.1m 0.03% Added +5.0k +5,000
45 Woodline Partners LP 0.06% of their portfolio San Francisco, CA 210,466210.5k $15.9m $15.9m 0.06% Added +153.1k +153,145
46 Trails Edge Capital Partners, LP 3.58% of their portfolio ATLANTA, GA 192,000192.0k $14.5m $14.5m 3.58% First filing
47 Candriam S.C.A. 0.07% of their portfolio STRASSEN, N4 191,318191.3k $14.4m $14.4m 0.07% Added +65.2k +65,237
48 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 140,727140.7k $10.6m $10.6m 0.01% Reduced -289.7k -289,736
49 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 133,193133.2k $10.1m $10.1m 0.00% Reduced -509.1k -509,123
50 Parkman Healthcare Partners LLC 0.93% of their portfolio STAMFORD, CT 130,069130.1k $9.8m $9.8m 0.93% Added +24.2k +24,238
51 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 129,290129.3k $9.8m $9.8m 0.01% Added +46.0k +46,050
52 FEDERATED HERMES, INC. 0.02% of their portfolio PITTSBURGH, PA 127,931127.9k $9.7m $9.7m 0.02% New
53 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 127,629127.6k $9.6m $9.6m 0.02% Reduced -3.8k -3,807
54 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 127,618127.6k $9.6m $9.6m 0.00% Unchanged
55 KENNEDY CAPITAL MANAGEMENT LLC 0.20% of their portfolio ST LOUIS, MO 124,979125.0k $9.4m $9.4m 0.20% Added +928 +928
56 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 122,900122.9k $9.3m $9.3m 0.00% Added +19.7k +19,748
57 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 121,050121.0k $9.1m $9.1m 0.00% Added +37.8k +37,759
58 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 118,084118.1k $8.9m $8.9m 0.00% Added +10.5k +10,544
59 Nicholas Investment Partners, LP 0.62% of their portfolio RANCHO SANTA FE, CA 112,924112.9k $8.5m $8.5m 0.62% New
60 ArrowMark Colorado Holdings LLC 0.18% of their portfolio Denver, CO 109,410109.4k $8.3m $8.3m 0.18% Unchanged
61 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 108,267108.3k $8.2m $8.2m 0.00% Reduced -108.9k -108,946
62 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 105,241105.2k $7.9m $7.9m 0.01% Reduced -17.1k -17,134
63 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 105,000105.0k $8.0m $8.0m 0.01% Reduced -110.8k -110,846
64 NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio NEW YORK, NY 99,64899.6k $7.5m $7.5m 0.01% New
65 Granahan Investment Management, LLC 0.31% of their portfolio WALTHAM, MA 94,72094.7k $7.1m $7.1m 0.31% Reduced -37.7k -37,680
66 HighVista Strategies LLC 1.73% of their portfolio BOSTON, MA 89,22989.2k $6.7m $6.7m 1.73% Reduced -17.9k -17,878
67 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 80,83280.8k $6.1m $6.1m 0.01% Added +17.6k +17,607
68 STEMPOINT CAPITAL LP 1.04% of their portfolio NEW YORK, NY 80,57480.6k $6.1m $6.1m 1.04% New
69 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 79,36179.4k $6.0m $6.0m 0.00% Added +2.8k +2,814
70 NOMURA HOLDINGS INC 0.02% of their portfolio TOKYO, M0 76,89876.9k $5.8m $5.8m 0.02% New
71 SG Americas Securities, LLC 0.01% of their portfolio NEW YORK, NY 73,26273.3k $5.5m $5.5m 0.01% Reduced -61.0k -60,964
72 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 70,68770.7k $5.3m $5.3m 0.00% Added +41.5k +41,549
73 Boxer Capital Management, LLC 1.16% of their portfolio San Diego, CA 70,00070.0k $5.3m $5.3m 1.16% Added +20.0k +20,000
74 PLATINUM INVESTMENT MANAGEMENT LTD 1.21% of their portfolio SYDNEY AUSTRALIA 2000, C3 69,21269.2k $5.2m $5.2m 1.21% Reduced -24.5k -24,516
75 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 63,25063.2k $4.8m $4.8m 0.00% Reduced -37.3k -37,320
76 Swiss National Bank 0.00% of their portfolio ZURICH, V8 62,90062.9k $4.7m $4.7m 0.00% Added +19.5k +19,500
77 SIMPLEX TRADING, LLC 0.13% of their portfolio CHICAGO, IL 62,79962.8k $4.7m $4.7m 0.13% New
78 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 54,30054.3k $4.1m $4.1m 0.00% Added +41.4k +41,440
79 Blackstone Inc. 0.02% of their portfolio NEW YORK, NY 51,82751.8k $3.9m $3.9m 0.02% Reduced -138.5k -138,525
80 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 50,74450.7k $3.8m $3.8m 0.00% Added +43.7k +43,717
81 SEVEN GRAND MANAGERS, LLC 0.29% of their portfolio BRONXVILLE, NY 50,00050.0k $3.8m $3.8m 0.29% New
82 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 49,99950.0k $3.8m $3.8m 0.00% Added +6.3k +6,326
83 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 49,80549.8k $3.8m $3.8m 0.00% Added +18.6k +18,642
84 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 48,61948.6k $3.7m $3.7m 0.01% Reduced -17.2k -17,177
85 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 45,97146.0k $3.5m $3.5m 0.00% Reduced -1.8k -1,828
86 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 44,92244.9k $3.4m $3.4m 0.02% Added +22.4k +22,416
87 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 42,49942.5k $3.2m $3.2m 0.00% Added +20.5k +20,509
88 BANQUE PICTET & CIE SA 0.03% of their portfolio GENEVA 73, V8 41,80041.8k $3.2m $3.2m 0.03% New
89 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% of their portfolio Paris, I0 39,84639.8k $3.0m $3.0m 0.00% Added +39.6k +39,644
90 Aberdeen Group plc 0.00% of their portfolio EDINBURGH, X0 36,10336.1k $2.7m $2.7m 0.00% Reduced -18.7k -18,657
91 COMERICA BANK 0.01% of their portfolio DALLAS, TX 35,87235.9k $2.7m $2.7m 0.01% Added +338 +338
92 Cinctive Capital Management LP 0.14% of their portfolio New York, NY 33,26433.3k $2.5m $2.5m 0.14% New
93 Legal & General Group Plc 0.00% of their portfolio London, X0 32,85632.9k $2.5m $2.5m 0.00% Added +5.2k +5,193
94 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 30,75830.8k $2.3m $2.3m 0.00% Added +9.4k +9,371
95 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 30,03930.0k $2.3m $2.3m 0.01% New
96 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 29,14529.1k $2.2m $2.2m 0.01% New
97 Erste Asset Management GmbH 0.02% of their portfolio VIENNA, C4 24,00024.0k $1.8m $1.8m 0.02% Unchanged
98 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 22,48422.5k $1.7m $1.7m 0.00% Added +12.6k +12,597
99 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 21,31121.3k $1.6m $1.6m 0.01% Added +2.1k +2,073
100 SummitTX Capital, L.P. 0.05% of their portfolio FORT WORTH, TX 20,97221.0k $1.6m $1.6m 0.05% Reduced -5.6k -5,635