Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

170 institutional holders +11 vs Q4 2024
61,478,97761.5m shares reported held*
$2.3bnreported value*
33 new 50 added 57 reduced 21 sold out net bought ≈ $137.1m (+3.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $37.43. Options: 8 managers hold calls ($14.3m notional), 10 hold puts ($9.5m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140Q4 24: 159Q1 25: 170170Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140
Q4 2024159
Q1 2025170

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 52 bought or addedQ4 23: 17 cut or sold outQ4 23Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ1 24Q2 24: 79 bought or addedQ2 24: 73 cut or sold outQ2 24Q3 24: 71 bought or addedQ3 24: 70 cut or sold outQ3 24Q4 24: 84 bought or addedQ4 24: 62 cut or sold outQ4 24Q1 25: 83 bought or addedQ1 25: 78 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q4 20235217
Q1 202411226
Q2 20247973
Q3 20247170
Q4 20248462
Q1 20258378

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15m$20mQ2 24 calls: $86.6kQ2 24 puts: $652.5kQ2 24P/C 7.54Q3 24 calls: $2.6mQ3 24 puts: $15.2mQ3 24P/C 5.76Q4 24 calls: $1.7mQ4 24 puts: $3.3mQ4 24P/C 1.97Q1 25 calls: $14.3mQ1 25 puts: $9.5mQ1 25P/C 0.67
Numbers
QuarterCallsPutsP/C
Q2 2024$86.6k$652.5k7.54
Q3 2024$2.6m$15.2m5.76
Q4 2024$1.7m$3.3m1.97
Q1 2025$14.3m$9.5m0.67

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +968,391+968.4k
JPMORGAN CHASE & CO Added +925,376+925.4k
MERCER GLOBAL ADVISORS INC /ADV Added +920,079+920.1k
JANUS HENDERSON GROUP PLC Added +658,733+658.7k
Polar Capital Holdings Plc New +550,000+550.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +486,800+486.8k
BANK OF AMERICA CORP /DE/ Added +320,340+320.3k
MORGAN STANLEY Added +310,405+310.4k
Affinity Asset Advisors, LLC Added +219,471+219.5k
UBS Group AG Added +160,623+160.6k

Biggest sellers

Jefferies Financial Group Inc. Reduced -465,701-465.7k
Paradigm Biocapital Advisors LP Reduced -322,059-322.1k
Logos Global Management LP Sold out -300,000-300.0k
Driehaus Capital Management LLC Reduced -265,747-265.7k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -230,745-230.7k
STATE STREET CORP Reduced -153,364-153.4k
Siren, L.L.C. Reduced -152,331-152.3k
BlackRock, Inc. Reduced -134,129-134.1k
GOLDMAN SACHS GROUP INC Reduced -117,320-117.3k
Cubist Systematic Strategies, LLC Sold out -91,213-91.2k

Biggest calls

Caption Management, LLC Added $5.7m151.3k shares
DIADEMA PARTNERS LP New $4.7m126.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $3.2m84.6k shares
CITADEL ADVISORS LLC Added $291.4k7.8k shares
SIMPLEX TRADING, LLC New $242.0k6.5k shares
Persistent Asset Partners Ltd Added $232.9k293 shares
GROUP ONE TRADING LLC New $37.4k1.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $3.3m89.3k shares
Ikarian Capital, LLC New $2.6m70.7k shares
Caption Management, LLC New $1.4m37.5k shares
BOOTHBAY FUND MANAGEMENT, LLC New $844.3k22.6k shares
CITADEL ADVISORS LLC Added $750.9k20.1k shares
JANE STREET GROUP, LLC Reduced $369.9k9.9k shares
GROUP ONE TRADING LLC Added $127.0k3.4k shares
BANK OF AMERICA CORP /DE/ New $63.5k1.7k shares
SIMPLEX TRADING, LLC Unchanged $3.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 27.00% of their portfolio NEW YORK, NY 8,493,3218.5m $317.3m $317.3m 27.00% Unchanged
2 FMR LLC 0.02% of their portfolio BOSTON, MA 7,493,6267.5m $280.0m $280.0m 0.02% Reduced -5.8k -5,756
3 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 5,485,7545.5m $204.9m $204.9m 0.04% Added +968.4k +968,391
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 2,910,8292.9m $108.7m $108.7m 0.00% Reduced -134.1k -134,129
5 RTW INVESTMENTS, LP 1.55% of their portfolio NEW YORK, NY 2,712,0972.7m $101.3m $101.3m 1.55% Unchanged
6 Driehaus Capital Management LLC 0.84% of their portfolio Chicago, IL 2,339,5632.3m $87.4m $87.4m 0.84% Reduced -265.7k -265,747
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,082,6062.1m $77.8m $77.8m 0.00% Reduced -15.0k -14,991
8 Fairmount Funds Management LLC 11.87% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $76.5m $76.5m 11.87% Unchanged
9 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 1,793,8331.8m $71.3m $71.3m 0.04% Added +658.7k +658,733
10 MERCER GLOBAL ADVISORS INC /ADV 0.14% of their portfolio DENVER, CO 1,640,1801.6m $61.3m $61.3m 0.14% Added +920.1k +920,079
11 RA CAPITAL MANAGEMENT, L.P. 0.98% of their portfolio BOSTON, MA 1,569,4911.6m $58.6m $58.6m 0.98% Unchanged
12 BRAIDWELL LP 2.02% of their portfolio STAMFORD, CT 1,540,3621.5m $57.5m $57.5m 2.02% Unchanged
13 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,313,7501.3m $49.1m $49.1m 0.00% Reduced -153.4k -153,364
14 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 1,280,9501.3m $47.9m $47.9m 0.02% Reduced -74.2k -74,235
15 Affinity Asset Advisors, LLC 6.73% of their portfolio NEW YORK, NY 1,151,1991.2m $43.0m $43.0m 6.73% Added +219.5k +219,471
16 PERCEPTIVE ADVISORS LLC 1.49% of their portfolio NEW YORK, NY 1,122,7671.1m $41.9m $41.9m 1.49% Added +75.5k +75,535
17 Woodline Partners LP 0.26% of their portfolio San Francisco, CA 1,061,0531.1m $39.6m $39.6m 0.26% Added +45.4k +45,445
18 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 962,631962.6k $36.0m $36.0m 0.00% Added +925.4k +925,376
19 Paradigm Biocapital Advisors LP 1.65% of their portfolio NEW YORK, NY 961,707961.7k $35.9m $35.9m 1.65% Reduced -322.1k -322,059
20 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 876,076876.1k $32.7m $32.7m 0.01% Added +9.9k +9,888
21 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 835,695835.7k $31.2m $31.2m 0.00% Added +19.6k +19,582
22 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 821,850821.9k $30.7m $30.7m 0.00% Reduced -230.7k -230,745
23 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio Boston, MA 727,000727.0k $27.2m $27.2m 0.05% Added +486.8k +486,800
24 UBS Group AG 0.01% of their portfolio ZURICH, V8 701,909701.9k $26.2m $26.2m 0.01% Added +160.6k +160,623
25 Siren, L.L.C. 1.25% of their portfolio New York, NY 594,994595.0k $22.2m $22.2m 1.25% Reduced -152.3k -152,331
26 Polar Capital Holdings Plc 0.13% of their portfolio London, X0 550,000550.0k $20.5m $20.5m 0.13% New
27 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 519,939519.9k $19.4m $19.4m 0.00% Added +310.4k +310,405
28 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 498,625498.6k $18.6m $18.6m 0.01% Added +21.9k +21,865
29 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 425,880425.9k $15.9m $15.9m 0.00% Added +320.3k +320,340
30 Jefferies Financial Group Inc. 0.27% of their portfolio NEW YORK, NY 421,796421.8k $15.8m $15.8m 0.27% Reduced -465.7k -465,701
31 Point72 Asset Management, L.P. 0.04% of their portfolio STAMFORD, CT 392,488392.5k $14.7m $14.7m 0.04% Added +89.8k +89,753
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 314,478314.5k $11.7m $11.7m 0.00% Reduced -12.8k -12,814
33 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 293,757293.8k $11.0m $11.0m 0.01% Reduced -18.6k -18,634
34 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 290,699290.7k $10.9m $10.9m 0.00% Reduced -117.3k -117,320
35 Commodore Capital LP 0.80% of their portfolio NEW YORK, NY 290,000290.0k $10.8m $10.8m 0.80% Unchanged
36 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 271,879271.9k $10.2m $10.2m 0.00% Reduced -5.6k -5,613
37 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 260,335260.3k $9.7m $9.7m 0.01% Added +130.2k +130,164
38 TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio NEW YORK, NY 252,135252.1k $9.4m $9.4m 0.02% Reduced -14.3k -14,347
39 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 232,983233.0k $8.7m $8.7m 0.01% Added +9.9k +9,921
40 First Turn Management, LLC 1.73% of their portfolio DEL MAR, CA 229,675229.7k $8.6m $8.6m 1.73% Reduced -23.1k -23,050
41 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 214,231214.2k $8.0m $8.0m 0.00% Added +103.4k +103,404
42 TANG CAPITAL MANAGEMENT LLC 0.41% of their portfolio SAN DIEGO, CA 200,000200.0k $7.5m $7.5m 0.41% Added +100.0k +100,000
43 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 193,895193.9k $7.2m $7.2m 0.00% Reduced -11.2k -11,205
44 Blackstone Inc. 0.03% of their portfolio NEW YORK, NY 183,747183.7k $6.9m $6.9m 0.03% Added +103.7k +103,747
45 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 167,991168.0k $6.3m $6.3m 0.02% Added +126.9k +126,885
46 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 127,208127.2k $4.8m $4.8m 0.01% Reduced -16.7k -16,744
47 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 112,730112.7k $4.2m $4.2m 0.01% New
48 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 110,855110.9k $4.1m $4.1m 0.00% First filing
49 Allostery Investments LP 5.93% of their portfolio Stamford, CT 110,000110.0k $4.1m $4.1m 5.93% Added +10.0k +10,000
50 ArrowMark Colorado Holdings LLC 0.07% of their portfolio Denver, CO 109,410109.4k $4.1m $4.1m 0.07% Unchanged
51 FRONTIER CAPITAL MANAGEMENT CO LLC 0.04% of their portfolio Boston, MA 108,817108.8k $4.1m $4.1m 0.04% Reduced -63.9k -63,894
52 Granahan Investment Management, LLC 0.20% of their portfolio WALTHAM, MA 108,340108.3k $4.0m $4.0m 0.20% Added +15.5k +15,486
53 ADAR1 Capital Management, LLC 0.75% of their portfolio AUSTIN, TX 104,853104.9k $3.9m $3.9m 0.75% Added +63.6k +63,579
54 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 101,388101.4k $3.8m $3.8m 0.00% Reduced -25.1k -25,058
55 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 96,99297.0k $3.9m $3.9m 0.00% Added +38.5k +38,526
56 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 96,32696.3k $3.6m $3.6m 0.00% Added +90.6k +90,616
57 PLATINUM INVESTMENT MANAGEMENT LTD 0.21% of their portfolio SYDNEY AUSTRALIA 2000, C3 95,64695.6k $3.6m $3.6m 0.21% Unchanged
58 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 87,34787.3k $3.3m $3.3m 0.00% Reduced -606 -606
59 KENNEDY CAPITAL MANAGEMENT LLC 0.07% of their portfolio ST LOUIS, MO 78,39778.4k $2.9m $2.9m 0.07% Added +6.1k +6,090
60 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 70,33870.3k $2.6m $2.6m 0.00% Added +39.0k +39,050
61 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 67,70067.7k $2.5m $2.5m 0.01% Reduced -3.8k -3,800
62 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 66,18266.2k $2.5m $2.5m 0.00% Reduced -6.5k -6,542
63 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 61,36261.4k $2.3m $2.3m 0.00% Added +5.3k +5,260
64 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 54,38554.4k $2.0m $2.0m 0.00% Added +1.7k +1,665
65 Parkman Healthcare Partners LLC 0.21% of their portfolio STAMFORD, CT 46,66346.7k $1.7m $1.7m 0.21% Reduced -38.3k -38,337
66 Swiss National Bank 0.00% of their portfolio ZURICH, V8 43,60043.6k $1.6m $1.6m 0.00% Reduced -700 -700
67 HighVista Strategies LLC 0.62% of their portfolio BOSTON, MA 43,19043.2k $1.6m $1.6m 0.62% Unchanged
68 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 43,00143.0k $1.6m $1.6m 0.01% Reduced -14.7k -14,672
69 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 42,85442.9k $1.6m $1.6m 0.00% Reduced -3.1k -3,106
70 DIADEMA PARTNERS LP 1.19% of their portfolio MORRISTOWN, NJ 40,00040.0k $1.5m $1.5m 1.19% Reduced -10.6k -10,620
71 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 35,72635.7k $1.3m $1.3m 0.00% Added +3.5k +3,465
72 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 33,09633.1k $1.2m $1.2m 0.01% Reduced -3.3k -3,314
73 B Group, Inc. 0.97% of their portfolio DALLAS, TX 30,00030.0k $1.1m $1.1m 0.97% Added +15.0k +15,000
74 DARK FOREST CAPITAL MANAGEMENT LP 0.05% of their portfolio NEW YORK, NY 29,87129.9k $1.1m $1.1m 0.05% New
75 Polymer Capital Management (HK) LTD 0.19% of their portfolio HONG KONG, K3 29,26829.3k $1.1m $1.1m 0.19% New
76 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 28,86928.9k $1.1m $1.1m 0.00% Reduced -2.9k -2,870
77 Legal & General Group Plc 0.00% of their portfolio London, X0 25,78225.8k $963.2k $963.2k 0.00% Reduced -91 -91
78 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 24,90524.9k $930.5k $930.5k 0.00% Added +370 +370
79 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 24,52924.5k $921.1k $921.1k 0.00% Added +694 +694
80 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 24,31024.3k $908.2k $908.2k 0.00% Added +3.1k +3,054
81 TWINBEECH CAPITAL LP 0.02% of their portfolio PURCHASE, NY 24,29824.3k $907.8k $907.8k 0.02% New
82 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 24,00024.0k $953.3k $953.3k 0.01% Unchanged
83 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 22,60522.6k $844.5k $844.5k 0.00% Reduced -355 -355
84 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 22,17822.2k $828.6k $828.6k 0.00% Unchanged
85 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 18,56318.6k $693.5k $693.5k 0.00% Reduced -276 -276
86 INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio WEST PALM BEACH, FL 18,41718.4k $688.1k $688.1k 0.01% Added +1.5k +1,483
87 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 18,10418.1k $676.4k $676.4k 0.00% Added +399 +399
88 XTX Topco Ltd 0.03% of their portfolio LONDON, X0 17,18817.2k $642.1k $642.1k 0.03% Added +10.8k +10,840
89 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 16,23216.2k $606.4k $606.4k 0.00% Reduced -20.1k -20,112
90 Soleus Capital Management, L.P. 0.05% of their portfolio GREENWICH, CT 16,00016.0k $597.8k $597.8k 0.05% Reduced -54.0k -54,000
91 COMERICA BANK 0.00% of their portfolio DALLAS, TX 15,36015.4k $573.9k $573.9k 0.00% Reduced -5.2k -5,180
92 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 15,01615.0k $561.0k $561.0k 0.00% Added +238 +238
93 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 13,74213.7k $513.4k $513.4k 0.00% Added +8.2k +8,174
94 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 12,18712.2k $455.3k $455.3k 0.00% Unchanged
95 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.00% of their portfolio FRANKFORT, KY 11,64411.6k $435.0k $435.0k 0.00% Unchanged
96 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 11,59911.6k $433.3k $433.3k 0.00% Reduced -64.2k -64,250
97 Jain Global LLC 0.01% of their portfolio NEW YORK, NY 11,58611.6k $432.9k $432.9k 0.01% New
98 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 10,23510.2k $382.4k $382.4k 0.00% Reduced -2.6k -2,570
99 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 9,3509.3k $349.3k $349.3k 0.00% Unchanged
100 PROFUND ADVISORS LLC 0.01% of their portfolio BETHESDA, MD 9,2159.2k $344.3k $344.3k 0.01% Reduced -2.2k -2,221