Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

140 institutional holders +0 vs Q2 2024
55,994,64156.0m shares reported held*
$3.3bnreported value*
24 new 47 added 46 reduced 24 sold out net bought ≈ $101.0m (+1.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $58.69. Options: 6 managers hold calls ($2.6m notional), 6 hold puts ($15.2m).

Trends to Q3 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140140Q3 23Q4 23Q1 24Q2 24Q3 24
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 52 bought or addedQ4 23: 17 cut or sold outQ4 23Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ1 24Q2 24: 79 bought or addedQ2 24: 73 cut or sold outQ2 24Q3 24: 71 bought or addedQ3 24: 70 cut or sold outQ3 24
Numbers
QuarterBought or addedCut or sold out
Q4 20235217
Q1 202411226
Q2 20247973
Q3 20247170

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15m$20mQ4 23 calls: $0Q4 23 puts: $0Q4 23P/C —Q1 24 calls: $4.5mQ1 24 puts: $338.9kQ1 24P/C 0.08Q2 24 calls: $86.6kQ2 24 puts: $652.5kQ2 24P/C 7.54Q3 24 calls: $2.6mQ3 24 puts: $15.2mQ3 24P/C 5.76
Numbers
QuarterCallsPutsP/C
Q4 2023$0$0—
Q1 2024$4.5m$338.9k0.08
Q2 2024$86.6k$652.5k7.54
Q3 2024$2.6m$15.2m5.76

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +1,267,451+1.3m
Waypoint Capital Advisors, LLC New +627,089+627.1k
JANUS HENDERSON GROUP PLC Added +458,157+458.2k
Point72 Asset Management, L.P. Added +438,036+438.0k
Driehaus Capital Management LLC Added +415,737+415.7k
Paradigm Biocapital Advisors LP Added +371,817+371.8k
FRONTIER CAPITAL MANAGEMENT CO LLC New +311,316+311.3k
BARCLAYS PLC Added +287,243+287.2k
Woodline Partners LP Added +229,996+230.0k
VICTORY CAPITAL MANAGEMENT INC Added +190,092+190.1k

Biggest sellers

BRAIDWELL LP Reduced -748,816-748.8k
Avidity Partners Management LP Reduced -333,000-333.0k
DEERFIELD MANAGEMENT COMPANY, L.P. Sold out -329,000-329.0k
First Turn Management, LLC Sold out -318,327-318.3k
Polar Capital Holdings Plc Sold out -250,000-250.0k
GOLDMAN SACHS GROUP INC Reduced -179,696-179.7k
Affinity Asset Advisors, LLC Reduced -172,085-172.1k
RENAISSANCE TECHNOLOGIES LLC Sold out -156,204-156.2k
STATE STREET CORP Reduced -149,723-149.7k
FRANKLIN RESOURCES INC Reduced -144,481-144.5k

Biggest calls

Caption Management, LLC New $1.5m25.0k shares
CITADEL ADVISORS LLC Added $487.5k8.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $387.7k6.6k shares
Ikarian Capital, LLC New $293.7k5.0k shares
SIMPLEX TRADING, LLC New $11.0k200 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC New $11.7m200.0k shares
JANE STREET GROUP, LLC New $2.9m50.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $522.8k8.9k shares
CITADEL ADVISORS LLC Reduced $29.4k500 shares
SIMPLEX TRADING, LLC Reduced $11.0k200 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17)

Holders, Q3 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 26.13% of their portfolio NEW YORK, NY 8,493,3218.5m $498.9m $498.9m 26.13% Unchanged
2 FMR LLC 0.03% of their portfolio BOSTON, MA 7,502,4827.5m $440.7m $440.7m 0.03% Reduced -3.4k -3,393
3 WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio Boston, MA 4,814,4004.8m $282.8m $282.8m 0.05% Added +1.3m +1,267,451
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 2,975,9173.0m $174.8m $174.8m 0.00% First filing
5 RTW INVESTMENTS, LP 2.31% of their portfolio NEW YORK, NY 2,712,0962.7m $159.3m $159.3m 2.31% Unchanged
6 Driehaus Capital Management LLC 1.28% of their portfolio Chicago, IL 2,533,6072.5m $148.8m $148.8m 1.28% Added +415.7k +415,737
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,127,0422.1m $124.9m $124.9m 0.00% Added +156.7k +156,722
8 Fairmount Funds Management LLC 9.76% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $120.3m $120.3m 9.76% Unchanged
9 PERCEPTIVE ADVISORS LLC 2.54% of their portfolio NEW YORK, NY 2,015,0072.0m $118.4m $118.4m 2.54% Reduced -90.6k -90,629
10 RA CAPITAL MANAGEMENT, L.P. 1.33% of their portfolio BOSTON, MA 1,961,8632.0m $115.2m $115.2m 1.33% Unchanged
11 BRAIDWELL LP 2.74% of their portfolio STAMFORD, CT 1,643,2261.6m $96.5m $96.5m 2.74% Reduced -748.8k -748,816
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,411,6391.4m $82.9m $82.9m 0.00% Reduced -149.7k -149,723
13 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 1,194,3631.2m $70.2m $70.2m 0.02% Added +62.1k +62,093
14 Deep Track Capital, LP 1.88% of their portfolio GREENWICH, CT 1,000,0001.0m $58.7m $58.7m 1.88% Unchanged
15 Woodline Partners LP 0.48% of their portfolio San Francisco, CA 976,155976.2k $57.3m $57.3m 0.48% Added +230.0k +229,996
16 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 860,989861.0k $48.1m $48.1m 0.01% Reduced -144.5k -144,481
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 823,839823.8k $48.4m $48.4m 0.00% Added +83.0k +82,978
18 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 758,081758.1k $44.5m $44.5m 0.01% Reduced -10.1k -10,140
19 Point72 Asset Management, L.P. 0.14% of their portfolio STAMFORD, CT 707,268707.3k $41.5m $41.5m 0.14% Added +438.0k +438,036
20 Paradigm Biocapital Advisors LP 1.44% of their portfolio NEW YORK, NY 701,817701.8k $41.2m $41.2m 1.44% Added +371.8k +371,817
21 Affinity Asset Advisors, LLC 6.05% of their portfolio NEW YORK, NY 664,198664.2k $39.0m $39.0m 6.05% Reduced -172.1k -172,085
22 Waypoint Capital Advisors, LLC 7.84% of their portfolio Minneapolis, MN 627,089627.1k $36.8m $36.8m 7.84% New
23 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 469,557469.6k $27.6m $27.6m 0.01% Added +458.2k +458,157
24 ORBIMED ADVISORS LLC 0.41% of their portfolio New York, NY 379,130379.1k $22.3m $22.3m 0.41% Unchanged
25 Jefferies Financial Group Inc. 0.35% of their portfolio NEW YORK, NY 369,197369.2k $21.7m $21.7m 0.35% Added +189.1k +189,120
26 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 365,046365.0k $21.4m $21.4m 0.01% Added +287.2k +287,243
27 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 346,358346.4k $20.3m $20.3m 0.02% Added +190.1k +190,092
28 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 312,611312.6k $18.4m $18.4m 0.01% Added +6.5k +6,533
29 FRONTIER CAPITAL MANAGEMENT CO LLC 0.17% of their portfolio Boston, MA 311,316311.3k $18.3m $18.3m 0.17% New
30 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 306,549306.5k $18.0m $18.0m 0.00% Reduced -4.7k -4,654
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 299,472299.5k $17.6m $17.6m 0.00% Reduced -50.1k -50,084
32 Commodore Capital LP 1.06% of their portfolio NEW YORK, NY 290,000290.0k $17.0m $17.0m 1.06% Unchanged
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 280,428280.4k $16.5m $16.5m 0.00% Added +41.7k +41,686
34 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 238,270238.3k $14.0m $14.0m 0.00% Added +3.5k +3,490
35 TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio NEW YORK, NY 199,308199.3k $11.7m $11.7m 0.03% Reduced -102.9k -102,914
36 Boxer Capital, LLC 0.52% of their portfolio San Diego, CA 179,000179.0k $10.5m $10.5m 0.52% New
37 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 157,457157.5k $9.2m $9.2m 0.00% Reduced -179.7k -179,696
38 Avidity Partners Management LP 0.46% of their portfolio DALLAS, TX 154,000154.0k $9.0m $9.0m 0.46% Reduced -333.0k -333,000
39 Vestal Point Capital, LP 0.63% of their portfolio NEW YORK, NY 136,500136.5k $8.0m $8.0m 0.63% New
40 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 135,346135.3k $8.0m $8.0m 0.00% Reduced -2.6k -2,552
41 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 132,166132.2k $7.8m $7.8m 0.00% Added +111.8k +111,783
42 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 112,601112.6k $6.6m $6.6m 0.00% Reduced -23.1k -23,146
43 ArrowMark Colorado Holdings LLC 0.08% of their portfolio Denver, CO 109,410109.4k $6.4m $6.4m 0.08% Unchanged
44 PLATINUM INVESTMENT MANAGEMENT LTD 0.29% of their portfolio SYDNEY AUSTRALIA 2000, C3 107,694107.7k $6.3m $6.3m 0.29% Reduced -39.8k -39,778
45 TANG CAPITAL MANAGEMENT LLC 0.42% of their portfolio SAN DIEGO, CA 100,000100.0k $5.9m $5.9m 0.42% Unchanged
46 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 98,29098.3k $5.8m $5.8m 0.00% Added +86.7k +86,710
47 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 93,44693.4k $5.4m $5.4m 0.00% Reduced -1.6k -1,560
48 Granahan Investment Management, LLC 0.21% of their portfolio WALTHAM, MA 91,75791.8k $5.4m $5.4m 0.21% New
49 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 90,00990.0k $5.3m $5.3m 0.00% Reduced -7.1k -7,056
50 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 90,00090.0k $5.3m $5.3m 0.03% Unchanged
51 Cubist Systematic Strategies, LLC 0.07% of their portfolio STAMFORD, CT 83,97784.0k $4.9m $4.9m 0.07% Reduced -66.2k -66,158
52 Blackstone Inc. 0.02% of their portfolio NEW YORK, NY 80,00080.0k $4.7m $4.7m 0.02% Unchanged
53 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 69,75069.8k $4.1m $4.1m 0.01% Unchanged
54 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 67,98868.0k $4.0m $4.0m 0.00% Reduced -3.7k -3,655
55 HighVista Strategies LLC 1.25% of their portfolio BOSTON, MA 61,78861.8k $3.6m $3.6m 1.25% Reduced -17.2k -17,154
56 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 59,11059.1k $3.5m $3.5m 0.00% Added +2.4k +2,424
57 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 58,46658.5k $3.4m $3.4m 0.00% Reduced -54.4k -54,392
58 ADAR1 Capital Management, LLC 0.56% of their portfolio AUSTIN, TX 57,18357.2k $3.4m $3.4m 0.56% Added +16.3k +16,308
59 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 56,51756.5k $3.3m $3.3m 0.00% Added +31.0k +30,957
60 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 54,56354.6k $3.2m $3.2m 0.01% Reduced -20.3k -20,275
61 UBS Group AG 0.00% of their portfolio ZURICH, V8 51,82051.8k $3.0m $3.0m 0.00% Added +1.3k +1,330
62 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 51,53051.5k $3.0m $3.0m 0.01% Added +36.4k +36,407
63 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 50,97051.0k $3.0m $3.0m 0.00% Added +1.5k +1,535
64 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 49,66249.7k $2.9m $2.9m 0.00% Reduced -2.4k -2,364
65 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 47,20047.2k $2.8m $2.8m 0.01% Reduced -5.2k -5,200
66 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio JUPITER, FL 41,74741.7k $2.5m $2.5m 0.01% Reduced -133.1k -133,067
67 KENNEDY CAPITAL MANAGEMENT LLC 0.05% of their portfolio ST LOUIS, MO 41,19441.2k $2.4m $2.4m 0.05% Added +8.8k +8,755
68 Swiss National Bank 0.00% of their portfolio ZURICH, V8 37,70037.7k $2.2m $2.2m 0.00% Reduced -4.5k -4,500
69 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 35,48535.5k $2.1m $2.1m 0.01% Added +418 +418
70 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 32,24132.2k $1.9m $1.9m 0.00% Reduced -2.2k -2,162
71 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 28,13428.1k $1.7m $1.7m 0.00% Added +10.0k +10,023
72 COMERICA BANK 0.01% of their portfolio DALLAS, TX 28,05828.1k $1.6m $1.6m 0.01% Added +28.0k +27,952
73 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 24,53524.5k $1.4m $1.4m 0.00% Added +55 +55
74 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 22,90422.9k $1.3m $1.3m 0.00% Reduced -1.1k -1,065
75 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 21,11521.1k $1.2m $1.2m 0.01% Added +80 +80
76 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 21,03021.0k $1.2m $1.2m 0.00% Added +4.8k +4,836
77 Legal & General Group Plc 0.00% of their portfolio London, X0 20,87020.9k $1.2m $1.2m 0.00% Reduced -218 -218
78 Corebridge Financial, Inc. 0.01% of their portfolio HOUSTON, TX 20,26120.3k $1.2m $1.2m 0.01% Added +803 +803
79 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 19,60919.6k $1.2m $1.2m 0.00% Reduced -2.4k -2,407
80 Point72 (DIFC) Ltd 0.09% of their portfolio DUBAI, C0 19,20719.2k $1.1m $1.1m 0.09% Added +2.4k +2,428
81 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 19,04319.0k $1.1m $1.1m 0.00% Reduced -25.0k -24,979
82 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 18,37518.4k $1.1m $1.1m 0.00% Reduced -55.5k -55,518
83 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 14,96815.0k $879.0k $879.0k 0.00% New
84 DARK FOREST CAPITAL MANAGEMENT LP 0.11% of their portfolio NEW YORK, NY 14,23014.2k $835.9k $835.9k 0.11% Added +147 +147
85 Bayesian Capital Management, LP 0.08% of their portfolio Brooklyn, NY 11,87811.9k $697.7k $697.7k 0.08% New
86 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 11,64411.6k $684.0k $684.0k 0.01% Reduced -3.2k -3,163
87 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 11,18711.2k $657.1k $657.1k 0.00% Reduced -5.2k -5,200
88 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 11,11211.1k $652.7k $652.7k 0.02% Reduced -2.9k -2,898
89 Exane Asset Management 0.47% of their portfolio PARIS, I0 10,10010.1k $593.3k $593.3k 0.47% New
90 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 9,8209.8k $576.8k $576.8k 0.00% Added +1.5k +1,504
91 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 9,3509.3k $549.2k $549.2k 0.00% Unchanged
92 Handelsbanken Fonder AB 0.00% of their portfolio STOCKHOLM, V7 8,8008.8k $517.0k $517.0k 0.00% Added +1.8k +1,800
93 China Universal Asset Management Co., Ltd. 0.06% of their portfolio SHANGHAI, F4 8,6558.7k $508.4k $508.4k 0.06% Added +3.4k +3,371
94 AlphaCentric Advisors LLC 0.37% of their portfolio SAN JUAN, PR 8,5008.5k $499.3k $499.3k 0.37% New
95 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 8,1928.2k $481.2k $481.2k 0.00% Reduced -1.2k -1,233
96 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 8,0948.1k $475.0k $475.0k 0.00% New
97 Family Manage LLC 0.08% of their portfolio NEW YORK, NY 8,0798.1k $474.6k $474.6k 0.08% Added +1.1k +1,126
98 Global Endowment Management, LP 0.05% of their portfolio CHARLOTTE, NC 7,7977.8k $458.0k $458.0k 0.05% Unchanged
99 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 7,7307.7k $454.1k $454.1k 0.00% Reduced -943 -943
100 Caption Management, LLC 0.05% of their portfolio OKLAHOMA CITY, OK 7,5407.5k $442.9k $442.9k 0.05% New