AN2 THERAPEUTICS INC ANTX
COM · Common Stock · CUSIP 037326105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersMenlo Park, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 37.7m as of 2026-08-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.84.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 37 |
| Q1 2023 | 39 |
| Q2 2023 | 32 |
| Q3 2023 | 38 |
| Q4 2023 | 52 |
| Q1 2024 | 55 |
| Q2 2024 | 46 |
| Q3 2024 | 32 |
| Q4 2024 | 38 |
| Q1 2025 | 38 |
| Q2 2025 | 37 |
| Q3 2025 | 35 |
| Q4 2025 | 37 |
| Q1 2026 | 52 |
| Q2 2026 | 66 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 15 | 29 |
| Q4 2024 | 21 | 13 |
| Q1 2025 | 13 | 16 |
| Q2 2025 | 17 | 14 |
| Q3 2025 | 10 | 14 |
| Q4 2025 | 13 | 12 |
| Q1 2026 | 35 | 17 |
| Q2 2026 | 43 | 28 |
Biggest buyers
| BlackRock, Inc. | Added | +1.3m |
| CITADEL ADVISORS LLC | Added | +796.8k |
| Commodore Capital LP | Added | +600.0k |
| SummitTX Capital, L.P. | New | +597.5k |
| Balyasny Asset Management L.P. | New | +556.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +411.3k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +227.6k |
| STATE STREET CORP | Added | +196.4k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | New | +179.6k |
| NORTHERN TRUST CORP | Added | +171.7k |
Biggest sellers
| Woodline Partners LP | Reduced | -533.9k |
| BANK OF NOVA SCOTIA | Sold out | -459.2k |
| JANE STREET GROUP, LLC | Sold out | -303.6k |
| BANK OF MONTREAL /CAN/ | Sold out | -260.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -247.9k |
| CANTOR FITZGERALD, L. P. | Sold out | -200.0k |
| MORGAN STANLEY | Reduced | -184.8k |
| Stonepine Capital Management, LLC | Reduced | -162.2k |
| AMERIPRISE FINANCIAL INC | Reduced | -159.1k |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | Reduced | -130.7k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Commodore Capital LP 13G · passive investor new · filed 2026-03-16 | 9.9% |
| Coastlands Capital Partners LP 13G · institution new · filed 2025-06-04 | 9.3% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-03-13 | 8.0% |
| Easom Eric 13G · exempt (held before listing) +1.7 pts · filed 2026-02-13 | 7.9% |
| Adjuvant Global Health Technology Fund, L.P. 13G · exempt (held before listing) filed 2025-02-28 | 7.9% |
| INTEGRATED CORE STRATEGIES (US) LLC 13G · passive investor new · filed 2026-03-13 | 6.3% |
Fell to 5% or below in the last year: Almitas Capital LLC (4.1%, 2026-05-15)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 3 | $483.4k | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $19.6k | — |
| Q2 2025 | 2 | $20.9k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 2 | $4.1k | — |
| Q1 2026 | 0 | — | 5 | $46.6k | — |
| Q2 2026 | 0 | — | 1 | $1.2k | — |
| Q3 2026 | 1 | $11.6k | 3 | $343.1k | $316.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-09 | Readnour Robin Shane Director · See footnotes | Sold plan | $6.7k1.1k shares |
| 2026-09-08 | Readnour Robin Shane Director · See footnotes | Sold plan | $60.3k10.0k shares |
| 2026-09-03 | Readnour Robin Shane Director · See footnotes | Sold plan | $37.0k6.1k shares |
| 2026-09-01 | FitzPatrick Margaret M Director | Bought | $11.6k2.1k shares |
| 2026-09-01 | Williams Sarah Joanne Principal Accounting Officer | Sold | $1.5k272 shares |
| 2026-08-17 | Readnour Robin Shane Director · See footnotes | Sold plan | $212.8k35.4k shares |
| 2026-07-08 | Eizen Joshua M Officer | Sold | $24.8k5.9k shares |
| 2026-05-29 | Williams Sarah Joanne Principal Accounting Officer | Sold | $1.2k265 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Vivo Capital, LLC 1.39% of their portfolio | 3.2m $15.3m | Unchanged |
| Commodore Capital LP 0.85% of their portfolio | 2.9m $14.2m | Added +600.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 2.3m $11.2m | Added +96.2k |
| BlackRock, Inc. 0.00% of their portfolio | 1.7m $8.1m | Added +1.3m |
| Spruce Street Capital LP 1.58% of their portfolio | 1.7m $8.0m | Unchanged |
| Almitas Capital LLC 1.70% of their portfolio | 1.5m $7.1m | Reduced -10.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.2m $6.0m | Added +227.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 1.0m $4.8m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 952.0k $4.6m | Added +796.8k |
| Boxer Capital Management, LLC 0.27% of their portfolio | 749.0k $3.6m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 697.8k $3.4m | Added +411.3k |
| SummitTX Capital, L.P. 0.08% of their portfolio | 597.5k $2.9m | New |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 556.0k $2.7m | New |
| Stonepine Capital Management, LLC 2.03% of their portfolio | 551.7k $2.7m | Reduced -162.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 537.1k $2.6m | Reduced -159.1k |
| Sio Capital Management, LLC 0.44% of their portfolio | 529.9k $2.6m | Reduced -127.3k |
| Ally Bridge Group (NY) LLC 3.28% of their portfolio | 526.3k $2.5m | Unchanged |
| Prosight Management, LP 0.40% of their portfolio | 474.6k $2.3m | Reduced -41.1k |
| Woodline Partners LP 0.01% of their portfolio | 459.8k $2.2m | Reduced -533.9k |
| STATE STREET CORP 0.00% of their portfolio | 311.6k $1.5m | Added +196.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 214.9k $1.0m | Added +171.7k |
| Seven Fleet Capital Management LP 0.17% of their portfolio | 208.9k $1.0m | Added +9.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 196.9k $953.1k | Added +59.2k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 179.6k $869.2k | New |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.05% of their portfolio | 167.4k $810.4k | Reduced -130.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 145.8k $705.7k | Reduced -247.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 129.7k $627.7k | Reduced -69.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 87.9k $425.6k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 76.0k $368.1k | New |
| UBS Group AG 0.00% of their portfolio | 74.1k $358.6k | Added +12.7k |
| Walleye Capital LLC 0.00% of their portfolio | 72.1k $349.2k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 67.7k $327.6k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 64.2k $310.8k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 59.9k $289.9k | Unchanged |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 58.8k $284.6k | Added +44.9k |
| MORGAN STANLEY 0.00% of their portfolio | 49.4k $239.0k | Reduced -184.8k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 40.2k $194.4k | Added +165 |
| Velan Capital Investment Management LP 0.12% of their portfolio | 40.0k $193.6k | New |
| Nuveen, LLC 0.00% of their portfolio | 35.3k $171.0k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 25.8k $125.1k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 24.3k $117.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.4k $108.4k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 22.0k $107.0k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 15.9k $77.0k | New |
| Invesco Ltd. 0.00% of their portfolio | 13.8k $67.0k | New |
| LPL Financial LLC 0.00% of their portfolio | 12.3k $59.8k | New |
| CITIGROUP INC 0.00% of their portfolio | 12.3k $59.4k | Reduced -6.8k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 12.2k $59.0k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 11.0k $55.2k | New |
| Bronte Capital Management Pty Ltd. 0.01% of their portfolio | 10.9k $52.7k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 10.2k $49.3k | Reduced -19.9k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 8.6k $41.7k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 7.3k $35.5k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 5.5k $26.6k | Added +5.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 5.0k $24.2k | New |
| Legal & General Group Plc 0.00% of their portfolio | 2.6k $12.4k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.4k $11.6k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 2.1k $10.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.8k $8.7k | Added +1.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 938 $5.0k | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 484 $2.3k | New |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 449 $2.2k | Reduced -7.9k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 300 $1.5k | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 274 $1.3k | Reduced -2.3k |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 201 $973 | Unchanged |
| FMR LLC 0.00% of their portfolio | 61 $295 | New |