ANNEXON INC ANNX
COM · Common Stock · CUSIP 03589W102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBrisbane, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $3.51. Options: 6 managers hold calls ($764.0k notional), 6 hold puts ($1.0m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 73 |
| Q4 2022 | 86 |
| Q1 2023 | 102 |
| Q2 2023 | 97 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 37 | 26 |
| Q1 2023 | 64 | 31 |
| Q2 2023 | 65 | 50 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $3.9m | $2.8m | 0.70 |
| Q4 2022 | $3.7m | $2.5m | 0.66 |
| Q1 2023 | $1.2m | $346.2k | 0.28 |
| Q2 2023 | $764.0k | $1.0m | 1.37 |
Biggest buyers
| Logos Global Management LP | New | +3.5m |
| BlackRock Inc. | Added | +2.3m |
| FMR LLC | Added | +1.4m |
| GMT Capital Corp | Added | +1.1m |
| Bain Capital Life Sciences Investors, LLC | Added | +815.3k |
| PICTET ASSET MANAGEMENT SA | Added | +646.9k |
| STATE STREET CORP | Added | +638.4k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +496.4k |
| Octagon Capital Advisors LP | Added | +470.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | +389.9k |
Biggest sellers
| Venrock Adviser, LLC | Sold out | -3.2m |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -1.9m |
| CITADEL ADVISORS LLC | Reduced | -1.7m |
| Cormorant Asset Management, LP | Sold out | -1.2m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -1.2m |
| Artal Group S.A. | Sold out | -1.0m |
| Polar Capital Holdings Plc | Sold out | -1.0m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -746.5k |
| MARSHALL WACE, LLP | Sold out | -464.8k |
| Point72 Asset Management, L.P. | Sold out | -461.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $369.6k105.0k shares |
| CITADEL ADVISORS LLC | Reduced | $178.8k50.8k shares |
| GROUP ONE TRADING LLC | New | $107.4k30.5k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Not comparable | $91.2k350.0k shares |
| SIMPLEX TRADING, LLC | Added | $17.0k5.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $476.3k135.3k shares |
| GROUP ONE TRADING LLC | New | $298.1k84.7k shares |
| SIMPLEX TRADING, LLC | Added | $216.0k61.4k shares |
| CITADEL ADVISORS LLC | Reduced | $38.7k11.0k shares |
| Belvedere Trading LLC | New | $19.0k5.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +4.8 pts · filed 2026-07-08 | 11.9% |
| Redmile Group, LLC 13G · passive investor no change · filed 2026-07-08 | 9.9% |
| BlackRock, Inc. 13G · institution +1.9 pts · filed 2026-07-27 | 8.0% |
| Satter Muneer A 13D · may seek influence filed 2025-11-21 | 7.2% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 6.0% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2026-05-15 | 5.4% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 1 | $147.0k | 0 | — | — |
| Q3 2022 | 1 | $9.4m | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 1 | $18.0m | 3 | $61.0k | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-05-25 | Bain Capital Life Sciences Fund, L.P. +3 10% owner · See footnotes | Bought | $639.0k300.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| Alerce Investment Management, L.P. 32.31% of their portfolio | 7.1m $24.8m | Unchanged |
| Bain Capital Life Sciences Investors, LLC 2.07% of their portfolio | 5.7m $20.1m | Added +815.3k |
| Redmile Group, LLC 0.47% of their portfolio | 3.5m $12.3m | Unchanged |
| Logos Global Management LP 1.70% of their portfolio | 3.5m $12.3m | New |
| BlackRock Inc. 0.00% of their portfolio | 3.5m $12.2m | Added +2.3m |
| FEDERATED HERMES, INC. 0.03% of their portfolio | 3.1m $10.8m | Unchanged |
| GMT Capital Corp 0.33% of their portfolio | 2.5m $8.7m | Added +1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 2.3m $8.3m | Reduced -1.2m |
| PICTET ASSET MANAGEMENT SA 0.01% of their portfolio | 1.9m $6.6m | Added +646.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.7m $6.2m | Added +179.8k |
| Octagon Capital Advisors LP 0.82% of their portfolio | 1.7m $5.8m | Added +470.0k |
| FMR LLC 0.00% of their portfolio | 1.4m $4.9m | Added +1.4m |
| Blackstone Inc. 0.01% of their portfolio | 910.5k $3.2m | Added +283 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 883.5k $3.1m | Added +496.4k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 820.6k $2.9m | Added +15.3k |
| STATE STREET CORP 0.00% of their portfolio | 794.2k $2.8m | Added +638.4k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 775.9k $2.7m | Reduced -8.2k |
| Driehaus Capital Management LLC 0.03% of their portfolio | 752.5k $2.1m | Reduced -338.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 732.6k $2.6m | Reduced -1.7m |
| Woodline Partners LP 0.03% of their portfolio | 704.6k $2.5m | Added +156.1k |
| SECTORAL ASSET MANAGEMENT INC 0.40% of their portfolio | 674.6k $2.4m | Added +347.8k |
| Vontobel Holding Ltd. 0.02% of their portfolio | 674.6k $2.4m | Added +342.3k |
| Simplify Asset Management Inc. 0.42% of their portfolio | 653.5k $2.3m | Unchanged |
| Soleus Capital Management, L.P. 0.24% of their portfolio | 620.4k $2.2m | Reduced -295.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 617.8k $2.2m | Reduced -746.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.04% of their portfolio | 583.9k $2.1m | Unchanged |
| Board of Trustees of The Leland Stanford Junior University 0.17% of their portfolio | 482.6k $1.7m | Unchanged |
| Velan Capital Investment Management LP 1.52% of their portfolio | 459.7k $1.6m | Added +359.7k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 425.6k $1.5m | Added +258.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 422.2k $1.5m | Added +65.1k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.46% of their portfolio | 389.9k $1.4m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 379.2k $1.3m | Added +298.5k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 339.1k $1.2m | Added +120.0k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 250.1k $880.4k | Added +147.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 238.3k $838.8k | Added +141.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 195.1k $686.7k | Reduced -29.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 188.1k $662.2k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 156.1k $549.6k | Reduced -4.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 154.3k $543.1k | Added +116.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 141.7k $498.9k | Added +81.0k |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 130.0k $458.0k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 126.8k $446.4k | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 123.7k $435.3k | Added +104.3k |
| MORGAN STANLEY 0.00% of their portfolio | 107.3k $377.8k | Reduced -30.8k |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.04% of their portfolio | 99.7k $350.9k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 92.5k $325.6k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 87.4k $307.7k | Reduced -248.7k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 79.3k $279.2k | Reduced -9.4k |
| DNB Asset Management AS 0.00% of their portfolio | 59.5k $209.6k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 58.5k $205.9k | Reduced -20 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 55.0k $193.7k | New |
| Ergoteles LLC 0.01% of their portfolio | 51.3k $180.6k | New |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 50.0k $176.0k | Added +40.0k |
| CORNERCAP INVESTMENT COUNSEL INC 0.03% of their portfolio | 47.3k $166.4k | Added +2.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 47.1k $165.8k | Added +3.4k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 47.0k $165.5k | Added +45.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 40.6k $143.0k | New |
| BARCLAYS PLC 0.00% of their portfolio | 38.7k $136.3k | Reduced -29.3k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 38.7k $136.1k | Added +4.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 38.1k $134.3k | Added +36.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 27.7k $97.5k | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 27.7k $97.5k | New |
| UBS Group AG 0.00% of their portfolio | 26.9k $94.8k | New |
| Forefront Analytics, LLC 0.05% of their portfolio | 26.8k $94.3k | Added +11.5k |
| Kestra Advisory Services, LLC 0.00% of their portfolio | 25.0k $88.0k | Added +10.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 24.4k $85.8k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 22.5k $79.2k | Added +10.6k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 22.0k $77.3k | New |
| Bayesian Capital Management, LP 0.01% of their portfolio | 21.2k $74.7k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 20.0k $70.5k | New |
| NOMURA HOLDINGS INC 0.00% of their portfolio | 20.0k $70.4k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 19.1k $67.3k | Added +9.1k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 18.8k $66.1k | New |
| Invesco Ltd. 0.00% of their portfolio | 18.5k $65.0k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 17.4k $61.2k | Added +17.1k |
| Coastal Bridge Advisors, LLC 0.01% of their portfolio | 17.0k $59.8k | Unchanged |
| Graham Capital Management, L.P. 0.00% of their portfolio | 16.8k $59.3k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 15.2k $53.4k | New |
| CITIGROUP INC 0.00% of their portfolio | 14.9k $52.5k | Reduced -68.2k |
| Values First Advisors, Inc. 0.03% of their portfolio | 12.3k $43.3k | Reduced -5.9k |
| Prospera Financial Services Inc 0.00% of their portfolio | 11.1k $39.0k | Reduced -1.6k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 10.0k $35.0k | Unchanged |
| Belvedere Trading LLC 0.01% of their portfolio | 9.4k $33.0k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 5.8k $20.4k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 4.8k $17.0k | Added +4.8k |
| AMALGAMATED BANK 0.00% of their portfolio | 4.4k $16.0k | New |
| Legal & General Group Plc 0.00% of their portfolio | 4.4k $15.4k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.9k $13.6k | Reduced -4.1k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.8k $13.3k | New |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 2.5k $8.9k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.4k $4.9k | Added +1.1k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 695 $2.4k | Added +49 |
| Red Tortoise LLC 0.00% of their portfolio | 583 $2.1k | Reduced -146 |
| HighMark Wealth Management LLC 0.00% of their portfolio | 300 $1.1k | Unchanged |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 131 $0 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |
| NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio | 0 $0 | Unchanged |