Vault-13

ANNEXON INC ANNX

COM · Common Stock · CUSIP 03589W102

97 institutional holders -5 vs Q1 2023
54,125,34154.1m shares reported held*
$190.0mreported value*
27 new 38 added 18 reduced 32 sold out net bought ≈ $567.3k (+307.1k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $3.51. Options: 6 managers hold calls ($764.0k notional), 6 hold puts ($1.0m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 73Q4 22: 86Q1 23: 102Q2 23: 9797Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202273
Q4 202286
Q1 2023102
Q2 202397

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 37 bought or addedQ4 22: 26 cut or sold outQ4 22Q1 23: 64 bought or addedQ1 23: 31 cut or sold outQ1 23Q2 23: 65 bought or addedQ2 23: 50 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20223726
Q1 20236431
Q2 20236550

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3m$4mQ3 22 calls: $3.9mQ3 22 puts: $2.8mQ3 22P/C 0.70Q4 22 calls: $3.7mQ4 22 puts: $2.5mQ4 22P/C 0.66Q1 23 calls: $1.2mQ1 23 puts: $346.2kQ1 23P/C 0.28Q2 23 calls: $764.0kQ2 23 puts: $1.0mQ2 23P/C 1.37
Numbers
QuarterCallsPutsP/C
Q3 2022$3.9m$2.8m0.70
Q4 2022$3.7m$2.5m0.66
Q1 2023$1.2m$346.2k0.28
Q2 2023$764.0k$1.0m1.37

Biggest buyers

Logos Global Management LP New +3,500,000+3.5m
BlackRock Inc. Added +2,318,780+2.3m
FMR LLC Added +1,402,938+1.4m
GMT Capital Corp Added +1,055,874+1.1m
Bain Capital Life Sciences Investors, LLC Added +815,310+815.3k
PICTET ASSET MANAGEMENT SA Added +646,862+646.9k
STATE STREET CORP Added +638,445+638.4k
GEODE CAPITAL MANAGEMENT, LLC Added +496,427+496.4k
Octagon Capital Advisors LP Added +470,000+470.0k
SILVERARC CAPITAL MANAGEMENT, LLC New +389,911+389.9k

Biggest sellers

Venrock Adviser, LLC Sold out -3,220,050-3.2m
EVENTIDE ASSET MANAGEMENT, LLC Sold out -1,867,250-1.9m
CITADEL ADVISORS LLC Reduced -1,680,477-1.7m
Cormorant Asset Management, LP Sold out -1,250,000-1.2m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -1,200,000-1.2m
Artal Group S.A. Sold out -1,018,303-1.0m
Polar Capital Holdings Plc Sold out -1,000,000-1.0m
MILLENNIUM MANAGEMENT LLC Reduced -746,510-746.5k
MARSHALL WACE, LLP Sold out -464,819-464.8k
Point72 Asset Management, L.P. Sold out -461,284-461.3k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $369.6k105.0k shares
CITADEL ADVISORS LLC Reduced $178.8k50.8k shares
GROUP ONE TRADING LLC New $107.4k30.5k shares
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) Not comparable $91.2k350.0k shares
SIMPLEX TRADING, LLC Added $17.0k5.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $476.3k135.3k shares
GROUP ONE TRADING LLC New $298.1k84.7k shares
SIMPLEX TRADING, LLC Added $216.0k61.4k shares
CITADEL ADVISORS LLC Reduced $38.7k11.0k shares
Belvedere Trading LLC New $19.0k5.4k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +4.8 pts · filed 2026-07-08 11.9% +4.8 pts 19.5m≈ $111.5m 2026-07-08
Redmile Group, LLC 13G · passive investor no change · filed 2026-07-08 9.9% no change 17.9m≈ $102.3m 2026-07-08
BlackRock, Inc. 13G · institution +1.9 pts · filed 2026-07-27 8.0% +1.9 pts 13.1m≈ $75.0m 2026-07-27
Satter Muneer A 13D · may seek influence filed 2025-11-21 7.2% 10.4m≈ $59.6m 2025-11-21
STATE STREET CORP 13G · institution new · filed 2026-08-07 6.0% new 9.8m≈ $56.1m 2026-08-07
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2026-05-15 5.4% 8.7m≈ $49.7m 2026-05-15

Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 1 buyingQ2 22: 0 sellingQ2 22Q3 22: 1 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 1 buyingQ1 23: 3 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20221$147.0k0——
Q3 20221$9.4m0——
Q4 20220—0——
Q1 20231$18.0m3$61.0k—
Q2 20230—0——
DateInsiderTradeSharesPrice ValueTheir holding
2023-05-25 Bain Capital Life Sciences Fund, L.P. +3 10% owner · See footnotes Bought 300,000 $2.13 $639.0k300.0k shares +6%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Alerce Investment Management, L.P. 32.31% of their portfolio Chicago, IL 7,056,0247.1m $24.8m $24.8m 32.31% Unchanged
2 Bain Capital Life Sciences Investors, LLC 2.07% of their portfolio Boston, MA 5,701,9265.7m $20.1m $20.1m 2.07% Added +815.3k +815,310
3 Redmile Group, LLC 0.47% of their portfolio LARKSPUR, CA 3,503,1903.5m $12.3m $12.3m 0.47% Unchanged
4 Logos Global Management LP 1.70% of their portfolio San Francisco, CA 3,500,0003.5m $12.3m $12.3m 1.70% New
5 BlackRock Inc. 0.00% of their portfolio New York, NY 3,479,8963.5m $12.2m $12.2m 0.00% Added +2.3m +2,318,780
6 FEDERATED HERMES, INC. 0.03% of their portfolio PITTSBURGH, PA 3,057,8003.1m $10.8m $10.8m 0.03% Unchanged
7 GMT Capital Corp 0.33% of their portfolio ATLANTA, GA 2,464,5712.5m $8.7m $8.7m 0.33% Added +1.1m +1,055,874
8 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 2,349,9752.3m $8.3m $8.3m 0.02% Reduced -1.2m -1,200,000
9 PICTET ASSET MANAGEMENT SA 0.01% of their portfolio GENEVA 73, V8 1,879,5751.9m $6.6m $6.6m 0.01% Added +646.9k +646,862
10 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,749,7701.7m $6.2m $6.2m 0.00% Added +179.8k +179,799
11 Octagon Capital Advisors LP 0.82% of their portfolio NEW YORK, NY 1,660,0001.7m $5.8m $5.8m 0.82% Added +470.0k +470,000
12 FMR LLC 0.00% of their portfolio BOSTON, MA 1,405,2781.4m $4.9m $4.9m 0.00% Added +1.4m +1,402,938
13 Blackstone Inc. 0.01% of their portfolio NEW YORK, NY 910,494910.5k $3.2m $3.2m 0.01% Added +283 +283
14 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 883,510883.5k $3.1m $3.1m 0.00% Added +496.4k +496,427
15 ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio Boston, MA 820,566820.6k $2.9m $2.9m 0.01% Added +15.3k +15,287
16 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 794,244794.2k $2.8m $2.8m 0.00% Added +638.4k +638,445
17 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio Boston, MA 775,854775.9k $2.7m $2.7m 0.00% Reduced -8.2k -8,176
18 Driehaus Capital Management LLC 0.03% of their portfolio Chicago, IL 752,518752.5k $2.1m $2.1m 0.03% Reduced -338.5k -338,468
19 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 732,640732.6k $2.6m $2.6m 0.00% Reduced -1.7m -1,680,477
20 Woodline Partners LP 0.03% of their portfolio San Francisco, CA 704,623704.6k $2.5m $2.5m 0.03% Added +156.1k +156,149
21 SECTORAL ASSET MANAGEMENT INC 0.40% of their portfolio MONTREAL, A8 674,629674.6k $2.4m $2.4m 0.40% Added +347.8k +347,823
22 Vontobel Holding Ltd. 0.02% of their portfolio ZURICH, V8 674,629674.6k $2.4m $2.4m 0.02% Added +342.3k +342,323
23 Simplify Asset Management Inc. 0.42% of their portfolio Las Vegas, NV 653,483653.5k $2.3m $2.3m 0.42% Unchanged
24 Soleus Capital Management, L.P. 0.24% of their portfolio GREENWICH, CT 620,400620.4k $2.2m $2.2m 0.24% Reduced -295.0k -295,000
25 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 617,833617.8k $2.2m $2.2m 0.00% Reduced -746.5k -746,510
26 DEERFIELD MANAGEMENT COMPANY, L.P. 0.04% of their portfolio New York, NY 583,913583.9k $2.1m $2.1m 0.04% Unchanged
27 Board of Trustees of The Leland Stanford Junior University 0.17% of their portfolio STANFORD, CA 482,550482.6k $1.7m $1.7m 0.17% Unchanged
28 Velan Capital Investment Management LP 1.52% of their portfolio ALPHARETTA, GA 459,746459.7k $1.6m $1.6m 1.52% Added +359.7k +359,746
29 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 425,556425.6k $1.5m $1.5m 0.03% Added +258.6k +258,649
30 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 422,200422.2k $1.5m $1.5m 0.00% Added +65.1k +65,100
31 SILVERARC CAPITAL MANAGEMENT, LLC 0.46% of their portfolio BOSTON, MA 389,911389.9k $1.4m $1.4m 0.46% New
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 379,200379.2k $1.3m $1.3m 0.00% Added +298.5k +298,491
33 ExodusPoint Capital Management, LP 0.01% of their portfolio NEW YORK, NY 339,097339.1k $1.2m $1.2m 0.01% Added +120.0k +119,989
34 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 250,100250.1k $880.4k $880.4k 0.00% Added +147.1k +147,100
35 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 238,301238.3k $838.8k $838.8k 0.00% Added +141.4k +141,377
36 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 195,098195.1k $686.7k $686.7k 0.00% Reduced -29.4k -29,401
37 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 188,136188.1k $662.2k $662.2k 0.00% New
38 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 156,149156.1k $549.6k $549.6k 0.00% Reduced -4.3k -4,321
39 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 154,277154.3k $543.1k $543.1k 0.00% Added +116.6k +116,610
40 Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio VANCOUVER, A1 141,723141.7k $498.9k $498.9k 0.00% Added +81.0k +81,022
41 GSA CAPITAL PARTNERS LLP 0.05% of their portfolio LONDON, X0 130,042130.0k $458.0k $458.0k 0.05% New
42 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 126,812126.8k $446.4k $446.4k 0.00% Unchanged
43 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 123,668123.7k $435.3k $435.3k 0.00% Added +104.3k +104,336
44 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 107,337107.3k $377.8k $377.8k 0.00% Reduced -30.8k -30,767
45 OCCUDO QUANTITATIVE STRATEGIES LP 0.04% of their portfolio FORT LAUDERDALE, FL 99,69299.7k $350.9k $350.9k 0.04% New
46 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 92,50092.5k $325.6k $325.6k 0.01% New
47 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 87,40687.4k $307.7k $307.7k 0.00% Reduced -248.7k -248,710
48 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 79,32379.3k $279.2k $279.2k 0.00% Reduced -9.4k -9,375
49 DNB Asset Management AS 0.00% of their portfolio Oslo, Q8 59,53459.5k $209.6k $209.6k 0.00% New
50 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 58,50658.5k $205.9k $205.9k 0.00% Reduced -20 -20
51 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 55,03055.0k $193.7k $193.7k 0.00% New
52 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 51,30051.3k $180.6k $180.6k 0.01% New
53 SIMPLEX TRADING, LLC 0.01% of their portfolio CHICAGO, IL 50,02050.0k $176.0k $176.0k 0.01% Added +40.0k +40,002
54 CORNERCAP INVESTMENT COUNSEL INC 0.03% of their portfolio Atlanta, GA 47,26147.3k $166.4k $166.4k 0.03% Added +2.2k +2,204
55 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 47,10347.1k $165.8k $165.8k 0.00% Added +3.4k +3,360
56 GROUP ONE TRADING LLC 0.01% of their portfolio CHICAGO, IL 47,00447.0k $165.5k $165.5k 0.01% Added +45.0k +44,977
57 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 40,62040.6k $143.0k $143.0k 0.00% New
58 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 38,72438.7k $136.3k $136.3k 0.00% Reduced -29.3k -29,303
59 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 38,66038.7k $136.1k $136.1k 0.01% Added +4.3k +4,350
60 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 38,14138.1k $134.3k $134.3k 0.00% Added +36.4k +36,423
61 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 27,70027.7k $97.5k $97.5k 0.00% New
62 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 27,69527.7k $97.5k $97.5k 0.00% New
63 UBS Group AG 0.00% of their portfolio ZURICH, V8 26,93126.9k $94.8k $94.8k 0.00% New
64 Forefront Analytics, LLC 0.05% of their portfolio WEST CONSHOHOCKEN, PA 26,79026.8k $94.3k $94.3k 0.05% Added +11.5k +11,539
65 Kestra Advisory Services, LLC 0.00% of their portfolio AUSTIN, TX 25,00025.0k $88.0k $88.0k 0.00% Added +10.0k +10,000
66 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 24,36824.4k $85.8k $85.8k 0.00% New
67 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 22,50022.5k $79.2k $79.2k 0.00% Added +10.6k +10,589
68 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 21,96822.0k $77.3k $77.3k 0.00% New
69 Bayesian Capital Management, LP 0.01% of their portfolio Brooklyn, NY 21,23021.2k $74.7k $74.7k 0.01% New
70 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 20,02120.0k $70.5k $70.5k 0.00% New
71 NOMURA HOLDINGS INC 0.00% of their portfolio TOKYO, M0 20,00020.0k $70.4k $70.4k 0.00% New
72 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 19,12819.1k $67.3k $67.3k 0.00% Added +9.1k +9,061
73 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 18,77218.8k $66.1k $66.1k 0.00% New
74 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 18,46218.5k $65.0k $65.0k 0.00% New
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 17,38117.4k $61.2k $61.2k 0.00% Added +17.1k +17,104
76 Coastal Bridge Advisors, LLC 0.01% of their portfolio WESTPORT, CT 17,00017.0k $59.8k $59.8k 0.01% Unchanged
77 Graham Capital Management, L.P. 0.00% of their portfolio ROWAYTON, CT 16,84116.8k $59.3k $59.3k 0.00% New
78 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 15,18315.2k $53.4k $53.4k 0.00% New
79 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 14,91714.9k $52.5k $52.5k 0.00% Reduced -68.2k -68,157
80 Values First Advisors, Inc. 0.03% of their portfolio JOHNSON CITY, TN 12,30912.3k $43.3k $43.3k 0.03% Reduced -5.9k -5,887
81 Prospera Financial Services Inc 0.00% of their portfolio Dallas, TX 11,07811.1k $39.0k $39.0k 0.00% Reduced -1.6k -1,598
82 Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio FAIRFIELD, IA 10,00010.0k $35.0k $35.0k 0.00% Unchanged
83 Belvedere Trading LLC 0.01% of their portfolio CHICAGO, IL 9,3739.4k $33.0k $33.0k 0.01% New
84 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 5,7915.8k $20.4k $20.4k 0.00% Unchanged
85 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4,7734.8k $17.0k $17.0k 0.00% Added +4.8k +4,764
86 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 4,4394.4k $16.0k $16.0k 0.00% New
87 Legal & General Group Plc 0.00% of their portfolio London, X0 4,3724.4k $15.4k $15.4k 0.00% New
88 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,8583.9k $13.6k $13.6k 0.00% Reduced -4.1k -4,134
89 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 3,7693.8k $13.3k $13.3k 0.00% New
90 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 2,5252.5k $8.9k $8.9k 0.00% New
91 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 1,3901.4k $4.9k $4.9k 0.00% Added +1.1k +1,078
92 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 695695 $2.4k $2.4k 0.00% Added +49 +49
93 Red Tortoise LLC 0.00% of their portfolio ATLANTA, GA 583583 $2.1k $2.1k 0.00% Reduced -146 -146
94 HighMark Wealth Management LLC 0.00% of their portfolio ST. PAUL, MN 300300 $1.1k $1.1k 0.00% Unchanged
95 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 131131 $0 $0 0.00% Unchanged
96 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged
97 NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio TOKYO, M0 00 $0 $0 0.00% Unchanged