ANAPTYSBIO INC ANAB
COM · Common Stock · CUSIP 032724106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($620.9k this quarter). Holder counts are more reliable. Shares outstanding: 28.0m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $22.20. Options: 6 managers hold calls ($5.3m notional), 6 hold puts ($2.9m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 114 |
| Q4 2022 | 119 |
| Q1 2023 | 114 |
| Q2 2023 | 117 |
| Q3 2023 | 117 |
| Q4 2023 | 120 |
| Q1 2024 | 134 |
| Q2 2024 | 136 |
| Q3 2024 | 161 |
| Q4 2024 | 137 |
| Q1 2025 | 154 |
| Q2 2025 | 149 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 48 | 52 |
| Q4 2023 | 45 | 56 |
| Q1 2024 | 65 | 52 |
| Q2 2024 | 66 | 68 |
| Q3 2024 | 95 | 42 |
| Q4 2024 | 68 | 86 |
| Q1 2025 | 84 | 70 |
| Q2 2025 | 71 | 85 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $28.5m | $36.9m | 1.30 |
| Q4 2024 | $21.0m | $34.3m | 1.63 |
| Q1 2025 | $5.7m | $5.1m | 0.90 |
| Q2 2025 | $5.3m | $2.9m | 0.55 |
Biggest buyers
| MORGAN STANLEY | Added | +1.4m |
| UBS Group AG | Added | +782.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +352.0k |
| 683 Capital Management, LLC | Added | +304.4k |
| Nuveen, LLC | Added | +267.5k |
| JPMORGAN CHASE & CO | Added | +233.3k |
| Soleus Capital Management, L.P. | Added | +219.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +185.7k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +150.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +145.0k |
Biggest sellers
| FMR LLC | Reduced | -1.8m |
| Boxer Capital Management, LLC | Sold out | -1.3m |
| First Light Asset Management, LLC | Reduced | -1.1m |
| Camber Capital Management LP | Reduced | -625.0k |
| BlackRock, Inc. | Reduced | -389.7k |
| 5AM Venture Management, LLC | Sold out | -357.7k |
| Woodline Partners LP | Reduced | -290.0k |
| CITADEL ADVISORS LLC | Reduced | -254.3k |
| Opaleye Management Inc. | Sold out | -250.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -241.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.1m140.1k shares |
| CITADEL ADVISORS LLC | Added | $990.1k44.6k shares |
| GROUP ONE TRADING LLC | Reduced | $495.1k22.3k shares |
| SIMPLEX TRADING, LLC | Added | $379.0k17.1k shares |
| JANE STREET GROUP, LLC | New | $301.9k13.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.2m97.1k shares |
| CITADEL ADVISORS LLC | Added | $432.9k19.5k shares |
| JANE STREET GROUP, LLC | New | $242.0k10.9k shares |
| GROUP ONE TRADING LLC | Reduced | $31.1k1.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $28.0k1.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.2 pts · filed 2025-04-17 | 6.2% |
| Sirenia Capital Management LP 13G · institution -1.7 pts · filed 2026-08-14 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (0.2%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-26), MORGAN STANLEY (3.6%, 2026-02-11), MILLENNIUM MANAGEMENT LLC (2.9%, 2026-01-16), First Light Asset Management, LLC (3.1%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 3 | $116.3k | — |
| Q4 2023 | 0 | — | 1 | $12.5k | — |
| Q1 2024 | 0 | — | 4 | $3.9m | $125.0k |
| Q2 2024 | 0 | — | 3 | $125.9k | $80.8k |
| Q3 2024 | 0 | — | 4 | $1.4m | $1.4m |
| Q4 2024 | 1 | $1.0m | 1 | $250.0k | $250.0k |
| Q1 2025 | 1 | $86.1k | 0 | — | — |
| Q2 2025 | 0 | — | 2 | $72.3k | $72.3k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-18 | RENTON HOLLINGS Director | Sold plan | $72.3k3.0k shares |
| 2025-06-18 | FENTON DENNIS M Director | Sold plan | $72.3k3.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| EcoR1 Capital, LLC 10.37% of their portfolio | 7.9m $174.9m | Unchanged |
| First Light Asset Management, LLC 10.19% of their portfolio | 3.5m $78.6m | Reduced -1.1m |
| Point72 Asset Management, L.P. 0.13% of their portfolio | 2.5m $54.9m | Added +106.5k |
| MORGAN STANLEY 0.00% of their portfolio | 1.9m $41.5m | Added +1.4m |
| BlackRock, Inc. 0.00% of their portfolio | 1.8m $39.7m | Reduced -389.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.5m $34.1m | Added +20.2k |
| TANG CAPITAL MANAGEMENT LLC 1.49% of their portfolio | 1.3m $29.5m | Reduced -214.3k |
| UBS Group AG 0.01% of their portfolio | 1.3m $28.2m | Added +782.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $23.9m | Reduced -67.2k |
| CITIGROUP INC 0.02% of their portfolio | 1.0m $23.2m | Reduced -24.8k |
| Sofinnova Investments, Inc. 1.56% of their portfolio | 1.0m $22.9m | Reduced -127.7k |
| Sanofi 10.38% of their portfolio | 821.9k $18.2m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 821.0k $18.2m | Reduced -39.7k |
| Palo Alto Investors LP 3.84% of their portfolio | 812.8k $18.0m | Reduced -207.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 673.2k $14.9m | Reduced -241.9k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 532.1k $11.8m | Added +125.7k |
| Woodline Partners LP 0.06% of their portfolio | 501.0k $11.1m | Reduced -290.0k |
| 683 Capital Management, LLC 1.13% of their portfolio | 500.0k $11.1m | Added +304.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 463.4k $10.3m | Reduced -27.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.03% of their portfolio | 368.4k $8.2m | Added +352.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 354.5k $7.9m | Added +117 |
| Nuveen, LLC 0.00% of their portfolio | 323.5k $7.2m | Added +267.5k |
| Soleus Capital Management, L.P. 0.49% of their portfolio | 321.0k $7.1m | Added +219.0k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 290.4k $6.4m | Added +22.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 279.8k $6.2m | Reduced -742 |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 263.1k $5.8m | Reduced -75.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 247.6k $5.5m | Added +233.3k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 231.4k $5.1m | Reduced -34.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 215.5k $4.8m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 203.5k $4.5m | Added +185.7k |
| Trexquant Investment LP 0.05% of their portfolio | 199.2k $4.4m | Added +45.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 196.3k $4.4m | Reduced -16.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 189.3k $4.2m | Added +145.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 157.1k $3.5m | Added +3.8k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 150.8k $3.3m | New |
| HighMark Wealth Management LLC 1.58% of their portfolio | 145.6k $3.2m | Added +53.5k |
| Granahan Investment Management, LLC 0.12% of their portfolio | 131.7k $2.9m | Reduced -14.8k |
| Camber Capital Management LP 0.39% of their portfolio | 125.0k $2.8m | Reduced -625.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 118.3k $2.6m | Reduced -254.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 112.3k $2.5m | Reduced -17.3k |
| Squarepoint Ops LLC 0.01% of their portfolio | 109.4k $2.4m | New |
| BARCLAYS PLC 0.00% of their portfolio | 100.0k $2.2m | Added +43.8k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 93.7k $2.1m | Unchanged |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 92.9k $2.1m | Added +60.8k |
| SECTORAL ASSET MANAGEMENT INC 1.23% of their portfolio | 83.9k $1.9m | New |
| Invesco Ltd. 0.00% of their portfolio | 83.2k $1.8m | Added +61.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 80.2k $1.8m | Added +4.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 73.0k $1.6m | Reduced -120.9k |
| FMR LLC 0.00% of their portfolio | 72.1k $1.6m | Reduced -1.8m |
| GSA CAPITAL PARTNERS LLP 0.11% of their portfolio | 69.8k $1.6m | New |
| Aquatic Capital Management LLC 0.03% of their portfolio | 65.8k $1.5m | New |
| Moody Aldrich Partners LLC 0.26% of their portfolio | 60.1k $1.3m | Reduced -23.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 59.2k $1.3m | Reduced -2.0k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 58.9k $1.3m | Added +21 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 49.8k $1.1m | Added +14.9k |
| DCF Advisers, LLC 0.51% of their portfolio | 48.0k $1.1m | Added +13.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 44.7k $991.6k | New |
| PDT Partners, LLC 0.06% of their portfolio | 44.5k $987.1k | Reduced -64 |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 38.5k $855.3k | Reduced -8.5k |
| Bleakley Financial Group, LLC 0.02% of their portfolio | 37.6k $833.6k | New |
| FMB WEALTH MANAGEMENT 0.38% of their portfolio | 35.6k $790.1k | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 33.5k $744.2k | Unchanged |
| SummitTX Capital, L.P. 0.03% of their portfolio | 33.4k $742.2k | Reduced -23.7k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 33.4k $740.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 33.3k $739.9k | Added +22.0k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 32.8k $728.2k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 30.7k $681.6k | Reduced -198 |
| XTX Topco Ltd 0.03% of their portfolio | 30.6k $680.3k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 30.5k $677.5k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.7k $615.4k | Reduced -2.3k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 26.8k $595.6k | Reduced -4.4k |
| Swiss National Bank 0.00% of their portfolio | 26.4k $586.1k | Reduced -6.0k |
| Engineers Gate Manager LP 0.01% of their portfolio | 24.7k $549.3k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 23.8k $528.2k | New |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 23.8k $527.0k | Added +1.8k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 23.0k $509.6k | Added +8.8k |
| Legal & General Group Plc 0.00% of their portfolio | 19.5k $433.0k | Reduced -859 |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 17.0k $376.5k | Reduced -225.5k |
| Creative Planning 0.00% of their portfolio | 16.9k $374.2k | Added +3.6k |
| ALPS ADVISORS INC 0.00% of their portfolio | 15.9k $352.2k | Reduced -7.3k |
| Ikarian Capital, LLC 0.12% of their portfolio | 15.7k $347.7k | New |
| Nebula Research & Development LLC 0.03% of their portfolio | 15.5k $344.8k | Added +28 |
| Allianz Asset Management GmbH 0.00% of their portfolio | 15.2k $337.4k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 15.0k $333.6k | New |
| Exome Asset Management LLC 0.28% of their portfolio | 15.0k $333.0k | Reduced -101.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 14.2k $315.6k | Reduced -373 |
| Cresset Asset Management, LLC 0.00% of their portfolio | 13.0k $289.3k | Reduced -1.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 12.7k $281.5k | Reduced -3.1k |
| Corton Capital Inc. 0.31% of their portfolio | 12.0k $266.5k | Added +1.3k |
| NEOS Investment Management LLC 0.00% of their portfolio | 11.4k $253.2k | New |
| Tema ETFs LLC 0.07% of their portfolio | 11.4k $253.2k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 10.8k $239.6k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 9.4k $209.1k | Reduced -775 |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 8.3k $183.7k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 7.9k $175.9k | Unchanged |
| Glenmede Investment Management, LP 0.00% of their portfolio | 7.5k $167.5k | First filing |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 6.5k $144.3k | Added +4.4k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 5.9k $131.0k | Reduced -250 |
| US BANCORP \DE\ 0.00% of their portfolio | 5.9k $130.9k | Added +4.1k |
| SG Americas Securities, LLC 0.00% of their portfolio | 4.9k $109.0k | Reduced -7.2k |