Vault-13

AMBRX BIOPHARMA INC

SPONSORED ADS · CUSIP 02290A102

43 institutional holders +12 vs Q1 2023
47,920,40447.9m shares reported held*
$788.8mreported value*
18 new 13 added 9 reduced 6 sold out net bought ≈ $142.2m (+8.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $16.46. Options: 10 managers hold calls ($4.9m notional), 8 hold puts ($3.9m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 17Q4 22: 19Q1 23: 31Q2 23: 4343Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202217
Q4 202219
Q1 202331
Q2 202343

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 7 bought or addedQ4 22: 12 cut or sold outQ4 22Q1 23: 26 bought or addedQ1 23: 8 cut or sold outQ1 23Q2 23: 31 bought or addedQ2 23: 15 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 2022712
Q1 2023268
Q2 20233115

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ3 22 calls: $0Q3 22 puts: $0Q3 22P/C —Q4 22 calls: $60.8kQ4 22 puts: $232.7kQ4 22P/C 3.83Q1 23 calls: $13.1mQ1 23 puts: $2.3mQ1 23P/C 0.18Q2 23 calls: $4.9mQ2 23 puts: $3.9mQ2 23P/C 0.80
Numbers
QuarterCallsPutsP/C
Q3 2022$0$0—
Q4 2022$60.8k$232.7k3.83
Q1 2023$13.1m$2.3m0.18
Q2 2023$4.9m$3.9m0.80

Biggest buyers

Darwin Global Management, Ltd. Added +5,384,063+5.4m
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +1,908,000+1.9m
Paradigm Biocapital Advisors LP New +1,650,499+1.7m
Cormorant Asset Management, LP Added +1,116,155+1.1m
Holocene Advisors, LP New +913,754+913.8k
PRICE T ROWE ASSOCIATES INC /MD/ Added +718,690+718.7k
ExodusPoint Capital Management, LP Added +458,061+458.1k
Point72 Asset Management, L.P. New +349,938+349.9k
MILLENNIUM MANAGEMENT LLC Added +274,727+274.7k
JPMORGAN CHASE & CO New +157,858+157.9k

Biggest sellers

FMR LLC Reduced -2,210,618-2.2m
Commodore Capital LP Reduced -1,628,447-1.6m
Venrock Adviser, LLC Reduced -813,617-813.6k
Fosun International Ltd Sold out -249,190-249.2k
SIMPLEX TRADING, LLC Reduced -113,570-113.6k
NOMURA HOLDINGS INC Sold out -57,268-57.3k
UBS Group AG Sold out -56,868-56.9k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -30,156-30.2k
Tower Research Capital LLC (TRC) Sold out -20,440-20.4k
TOCQUEVILLE ASSET MANAGEMENT L.P. Sold out -12,500-12.5k

Biggest calls

UBS Group AG Reduced $1.6m95.4k shares
CITADEL ADVISORS LLC Added $1.0m61.1k shares
GROUP ONE TRADING LLC Added $831.2k50.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $464.2k28.2k shares
Belvedere Trading LLC Added $324.3k19.7k shares
JANE STREET GROUP, LLC Reduced $271.6k16.5k shares
SIMPLEX TRADING, LLC Added $209.0k12.7k shares
HAP Trading, LLC Unchanged $128.0k32.4k shares
Cutler Group LLC / CA Added $65.0k26.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $1.2m75.4k shares
SIMPLEX TRADING, LLC Added $834.0k50.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $793.4k48.2k shares
GROUP ONE TRADING LLC Added $424.7k25.8k shares
JANE STREET GROUP, LLC New $325.9k19.8k shares
Belvedere Trading LLC Added $294.6k17.9k shares
Cutler Group LLC / CA Added $6.0k6.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Darwin Global Management, Ltd. 44.91% of their portfolio ST. HELIER, Y9 16,688,63616.7m $274.7m $274.7m 44.91% Added +5.4m +5,384,063
2 Cormorant Asset Management, LP 9.01% of their portfolio BOSTON, MA 9,616,1559.6m $158.3m $158.3m 9.01% Added +1.1m +1,116,155
3 D. E. Shaw & Co., Inc. 0.10% of their portfolio New York, NY 4,015,9084.0m $66.1m $66.1m 0.10% Added +82.4k +82,356
4 Commodore Capital LP 5.87% of their portfolio NEW YORK, NY 3,175,0003.2m $52.3m $52.3m 5.87% Reduced -1.6m -1,628,447
5 Venrock Adviser, LLC 6.54% of their portfolio NEW YORK, NY 2,484,9602.5m $40.9m $40.9m 6.54% Reduced -813.6k -813,617
6 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.22% of their portfolio SAN FRANCISCO, CA 2,269,0002.3m $37.3m $37.3m 0.22% Added +1.9m +1,908,000
7 FMR LLC 0.00% of their portfolio BOSTON, MA 2,210,6182.2m $36.4m $36.4m 0.00% Reduced -2.2m -2,210,618
8 Paradigm Biocapital Advisors LP 2.20% of their portfolio NEW YORK, NY 1,650,4991.7m $27.2m $27.2m 2.20% New
9 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 929,317929.3k $15.3m $15.3m 0.00% Added +718.7k +718,690
10 Holocene Advisors, LP 0.07% of their portfolio New York, NY 913,754913.8k $15.0m $15.0m 0.07% New
11 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 727,022727.0k $12.0m $12.0m 0.01% Added +19.9k +19,889
12 Artal Group S.A. 0.37% of their portfolio LUXEMBOURG, N4 702,291702.3k $11.6m $11.6m 0.37% Unchanged
13 ExodusPoint Capital Management, LP 0.09% of their portfolio NEW YORK, NY 477,558477.6k $7.9m $7.9m 0.09% Added +458.1k +458,061
14 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 349,938349.9k $5.8m $5.8m 0.02% New
15 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 285,716285.7k $4.7m $4.7m 0.00% Added +274.7k +274,727
16 Ghost Tree Capital, LLC 1.42% of their portfolio NEW YORK, NY 238,225238.2k $3.9m $3.9m 1.42% Reduced -11.8k -11,775
17 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 157,858157.9k $2.6m $2.6m 0.00% New
18 HighVista Strategies LLC 1.16% of their portfolio BOSTON, MA 153,431153.4k $2.5m $2.5m 1.16% New
19 MOORE CAPITAL MANAGEMENT, LP 0.06% of their portfolio NEW YORK, NY 144,400144.4k $2.4m $2.4m 0.06% New
20 FIRST MANHATTAN CO. LLC. 0.01% of their portfolio NEW YORK, NY 135,003135.0k $2.2m $2.2m 0.01% New
21 SILVERARC CAPITAL MANAGEMENT, LLC 0.56% of their portfolio BOSTON, MA 100,000100.0k $1.6m $1.6m 0.56% New
22 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 98,60098.6k $1.6m $1.6m 0.01% Added +20.4k +20,400
23 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 63,72863.7k $1.0m $1.0m 0.00% Added +49.8k +49,828
24 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 59,19759.2k $973.8k $973.8k 0.00% Added +29.7k +29,674
25 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 51,29051.3k $844.2k $844.2k 0.00% Reduced -30.2k -30,156
26 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 40,59840.6k $668.2k $668.2k 0.01% New
27 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 39,43839.4k $649.1k $649.1k 0.00% New
28 Apis Capital Advisors, LLC 0.56% of their portfolio New York, NY 34,00034.0k $559.6k $559.6k 0.56% New
29 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 17,53817.5k $288.7k $288.7k 0.00% New
30 INNOVIS ASSET MANAGEMENT LLC 0.10% of their portfolio Chicago, IL 16,82616.8k $277.0k $277.0k 0.10% New
31 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 16,48016.5k $271.3k $271.3k 0.00% Reduced -1.0k -1,031
32 Belvedere Trading LLC 0.07% of their portfolio CHICAGO, IL 13,87213.9k $228.3k $228.3k 0.07% Reduced -2.9k -2,936
33 QP WEALTH MANAGEMENT, LLC 0.33% of their portfolio BOCA RATON, FL 12,67012.7k $208.5k $208.5k 0.33% New
34 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 9,8309.8k $161.7k $161.7k 0.00% New
35 VIRTUS ADVISERS, LLC 0.07% of their portfolio HARTFORD, CT 7,4687.5k $122.9k $122.9k 0.07% New
36 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 6,6346.6k $109.0k $109.0k 0.00% Reduced -113.6k -113,570
37 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 3,0703.1k $50.5k $50.5k 0.00% Added +3.0k +3,028
38 Cutler Group LLC / CA 0.01% of their portfolio SAN FRANCISCO, CA 1,8001.8k $29.0k $29.0k 0.01% Reduced -1.3k -1,300
39 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 1,0181.0k $16.8k $16.8k 0.00% New
40 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 558558 $9.2k $9.2k 0.00% Added +454 +454
41 Aquatic Capital Management LLC 0.00% of their portfolio CHICAGO, IL 400400 $7.0k $7.0k 0.00% New
42 BerganKDV Wealth Management, LLC 0.00% of their portfolio BLOOMINGTON, MN 100100 $1.6k $1.6k 0.00% Unchanged
43 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged