ALUMIS INC ALMS
COM · Common Stock · CUSIP 022307102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($38.7k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $3.99. Options: 4 managers hold calls ($154.6k notional), 7 hold puts ($10.5m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2024 | 30 |
| Q3 2024 | 53 |
| Q4 2024 | 65 |
| Q1 2025 | 73 |
| Q2 2025 | 113 |
| Q3 2025 | 130 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 38 | 16 |
| Q4 2024 | 36 | 10 |
| Q1 2025 | 46 | 14 |
| Q2 2025 | 100 | 15 |
| Q3 2025 | 71 | 45 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $0 | $0 | — |
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $4.3m | $8.3m | 1.92 |
| Q3 2025 | $154.6k | $10.5m | 67.76 |
Biggest buyers
| Woodline Partners LP | Added | +1.6m |
| VANGUARD GROUP INC | Added | +625.4k |
| Trium Capital LLP | Added | +474.1k |
| Exome Asset Management LLC | New | +292.8k |
| GOLDMAN SACHS GROUP INC | Added | +285.0k |
| JPMORGAN CHASE & CO | Added | +245.2k |
| CITADEL ADVISORS LLC | Added | +232.2k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +225.5k |
| BANK OF AMERICA CORP /DE/ | Added | +222.2k |
| WELLINGTON MANAGEMENT GROUP LLP | New | +165.5k |
Biggest sellers
| Madison Avenue Partners, LP | Reduced | -1.4m |
| TANG CAPITAL MANAGEMENT LLC | Reduced | -829.8k |
| Velan Capital Investment Management LP | Reduced | -674.2k |
| CANTOR FITZGERALD, L. P. | Sold out | -559.2k |
| UBS Group AG | Reduced | -444.9k |
| Balyasny Asset Management L.P. | Sold out | -351.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -246.4k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -184.1k |
| Palo Alto Investors LP | Sold out | -143.4k |
| CREDIT INDUSTRIEL ET COMMERCIAL | Reduced | -140.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $63.4k15.9k shares |
| CITADEL ADVISORS LLC | Reduced | $42.3k10.6k shares |
| GROUP ONE TRADING LLC | Reduced | $37.9k9.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $11.0k2.8k shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $3.5m865.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.7m672.8k shares |
| GROUP ONE TRADING LLC | Added | $1.7m419.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.2m292.5k shares |
| CITADEL ADVISORS LLC | Added | $771.1k193.2k shares |
| SIG BROKERAGE, LP | Unchanged | $725.8k181.9k shares |
| HAP Trading, LLC | First filing | $272340.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Foresite Capital Fund VI LP
13D · may seek influence
-1.4 pts · filed 2026-04-03
Stated purposeThe Reporting Persons hold their securities of the Issuer for investment purposes. Depending on the factors discussed herein, the Reporting Persons may, from time to time, acquire additional shares of Common Stock and/or retain and/or sell all or a portion of the Common Stock held by the Reporting Persons in the open market or in privately negotiated transactions, and/or may distribute the Common Stock held by the Reporting Persons to their respective members or limited partners. Any actions the Reporting Persons might undertake will be dependent upon the Reporting Persons' review of numerous factors, including, among other things, the price levels of the Common Stock; general market and economic conditions; ongoing evaluation of the Issuer's business, financial condition, operations and p… Full filing |
12.7% |
| AyurMaya Capital Management Company, LP 13D · may seek influence -3.5 pts · filed 2026-07-02 | 12.3% |
| Deep Track Capital, LP 13G · passive investor new · filed 2026-04-07 | 6.0% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-27 | 5.7% |
| FMR LLC 13G · institution new · filed 2026-08-06 | 5.5% |
| Samsara BioCapital, L.P. 13D · may seek influence +0.1 pts · filed 2026-01-13 | 5.4% |
Fell to 5% or below in the last year: venBio Global Strategic Fund IV, L.P. (4.8%, 2025-11-17)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 2 | $65.0m | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 4 | $1.9m | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
None reported in Q3 2025.
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| AyurMaya Capital Management Company, LP 100.00% of their portfolio | 15.1m $60.4m | Reduced -1 |
| Foresite Capital Management V, LLC 21.21% of their portfolio | 5.8m $23.1m | Unchanged |
| SAMSARA BIOCAPITAL, LLC 2.50% of their portfolio | 4.8m $19.2m | Unchanged |
| venBio Partners LLC 10.45% of their portfolio | 4.6m $18.4m | Unchanged |
| Foresite Capital Management VI LLC 6.55% of their portfolio | 4.2m $16.9m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 4.2m $16.7m | Added +17.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.0m $16.1m | Added +625.4k |
| Trium Capital LLP 4.89% of their portfolio | 3.1m $12.5m | Added +474.1k |
| Nextech Invest Ltd. 1.77% of their portfolio | 2.9m $11.6m | Unchanged |
| Cormorant Asset Management, LP 0.59% of their portfolio | 2.1m $8.6m | Unchanged |
| SR One Capital Management, LP 1.13% of their portfolio | 2.0m $7.8m | Unchanged |
| ORBIMED ADVISORS LLC 0.18% of their portfolio | 1.9m $7.7m | Unchanged |
| Woodline Partners LP 0.03% of their portfolio | 1.8m $7.0m | Added +1.6m |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 1.6m $6.2m | Unchanged |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 18.05% of their portfolio | 1.4m $5.6m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $5.6m | Added +225.5k |
| GENERAL ATLANTIC, L.P. 0.16% of their portfolio | 1.3m $5.2m | Unchanged |
| BML Capital Management, LLC 4.44% of their portfolio | 1.2m $4.8m | Unchanged |
| TANG CAPITAL MANAGEMENT LLC 0.18% of their portfolio | 1.2m $4.7m | Reduced -829.8k |
| STATE STREET CORP 0.00% of their portfolio | 1.1m $4.4m | Reduced -7.2k |
| Velan Capital Investment Management LP 3.55% of their portfolio | 946.7k $3.8m | Reduced -674.2k |
| Yu Fan 4.10% of their portfolio | 789.6k $3.2m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 762.7k $3.0m | Reduced -444.9k |
| Opaleye Management Inc. 0.38% of their portfolio | 665.0k $2.7m | Reduced -110.0k |
| Omega Fund Management, LLC 1.17% of their portfolio | 653.2k $2.6m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 537.3k $2.1m | Added +245.2k |
| TOWERVIEW LLC 1.44% of their portfolio | 495.0k $2.0m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 491.0k $2.0m | Added +112.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 439.0k $1.8m | Added +60.7k |
| Madison Avenue Partners, LP 0.10% of their portfolio | 417.8k $1.7m | Reduced -1.4m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 417.1k $1.7m | Added +285.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 362.6k $1.4m | Reduced -246.4k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 339.3k $1.4m | Added +232.2k |
| MORGAN STANLEY 0.00% of their portfolio | 332.4k $1.3m | Reduced -6.7k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 317.0k $1.3m | Reduced -184.1k |
| Stonepine Capital Management, LLC 0.97% of their portfolio | 300.0k $1.2m | Reduced -49.6k |
| Exome Asset Management LLC 0.77% of their portfolio | 292.8k $1.2m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 263.9k $1.1m | Added +222.2k |
| LMR Partners LLP 0.01% of their portfolio | 258.4k $1.0m | Added +25.5k |
| CREDIT INDUSTRIEL ET COMMERCIAL 0.16% of their portfolio | 247.0k $985.5k | Reduced -140.0k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 209.7k $836.8k | Added +60 |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 166.8k $665.4k | Added +122.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 165.5k $660.4k | New |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 158.8k $633.4k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 151.6k $604.8k | Reduced -75.2k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 140.9k $562.3k | Added +114.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 136.7k $545.5k | Added +13.9k |
| Invesco Ltd. 0.00% of their portfolio | 129.6k $517.0k | Added +26.7k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 122.7k $489.6k | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 100.7k $401.9k | Reduced -23.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 89.3k $356.2k | Added +30.9k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio | 87.8k $350.4k | Added +76.8k |
| Quantinno Capital Management LP 0.00% of their portfolio | 87.6k $349.6k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 86.1k $343.5k | New |
| Mariner, LLC 0.00% of their portfolio | 84.9k $338.6k | Added +54.3k |
| BARCLAYS PLC 0.00% of their portfolio | 83.4k $332.6k | Reduced -6.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 80.9k $322.8k | Reduced -7.4k |
| Walleye Capital LLC 0.00% of their portfolio | 77.5k $309.4k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 74.0k $295.4k | Added +4.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 73.7k $294.2k | Unchanged |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 66.7k $266.2k | Unchanged |
| ADAR1 Capital Management, LLC 0.02% of their portfolio | 61.3k $244.6k | Added +23.5k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 40.2k $160.2k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 33.5k $133.6k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 32.7k $131.0k | Added +23.3k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 32.6k $130.0k | New |
| STONERIDGE INVESTMENT PARTNERS LLC 0.08% of their portfolio | 29.5k $118.0k | Added +2.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 28.3k $113.0k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 27.1k $108.2k | Reduced -83.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 26.0k $103.6k | Reduced -410 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 24.7k $98.7k | Reduced -2.3k |
| XTX Topco Ltd 0.01% of their portfolio | 24.6k $98.2k | New |
| Atom Investors LP 0.01% of their portfolio | 24.2k $96.5k | New |
| STRS OHIO 0.00% of their portfolio | 23.8k $95.1k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 23.5k $93.9k | Reduced -7.8k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 22.6k $90.1k | Reduced -47.2k |
| PharVision Advisers, LLC 0.05% of their portfolio | 20.7k $82.6k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 20.5k $81.9k | Reduced -1.0k |
| Inscription Capital, LLC 0.01% of their portfolio | 20.4k $81.5k | New |
| SIG BROKERAGE, LP 0.02% of their portfolio | 19.8k $79.0k | Unchanged |
| AXQ CAPITAL, LP 0.03% of their portfolio | 19.5k $77.6k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 17.3k $69.2k | Reduced -1.5k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 17.0k $67.8k | Reduced -2.2k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 16.7k $66.8k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 15.3k $61.2k | Added +4.6k |
| Arax Advisory Partners 0.00% of their portfolio | 13.7k $54.5k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 13.0k $51.9k | Reduced -452 |
| Western Wealth Management, LLC 0.00% of their portfolio | 12.0k $48.0k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 11.8k $47.0k | Added +6.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 11.8k $47.0k | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 11.3k $45.1k | Reduced -23.9k |
| Kera Capital Partners, Inc. 0.01% of their portfolio | 11.0k $43.8k | Added +451 |
| CWM, LLC 0.00% of their portfolio | 10.4k $41.0k | Added +9.5k |
| Birchview Capital, LP 0.03% of their portfolio | 10.0k $39.9k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 8.8k $35.0k | Reduced -82.9k |
| FMR LLC 0.00% of their portfolio | 6.9k $27.7k | Added +2.1k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 6.4k $25.6k | Added +4.9k |
| Legal & General Group Plc 0.00% of their portfolio | 5.3k $21.2k | Added +969 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 4.8k $19.3k | Unchanged |
| Quarry LP 0.00% of their portfolio | 3.9k $15.7k | New |