Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

266 institutional holders +7 vs Q2 2025
91,512,85591.5m shares reported held*
$4.3bnreported value*
44 new 75 added 91 reduced 36 sold out net sold ≈ $23.7m (-499.6k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($11.0m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $47.48. Options: 18 managers hold calls ($52.4m notional), 11 hold puts ($16.3m).

Trends to Q3 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 146Q4 22: 162Q1 23: 157Q2 23: 159Q3 23: 183Q4 23: 158Q1 24: 174Q2 24: 154Q3 24: 169Q4 24: 192Q1 25: 242Q2 25: 259Q3 25: 266266Q3 22Q2 23Q1 24Q4 24Q3 25
Numbers
QuarterHolders
Q3 2022146
Q4 2022162
Q1 2023157
Q2 2023159
Q3 2023183
Q4 2023158
Q1 2024174
Q2 2024154
Q3 2024169
Q4 2024192
Q1 2025242
Q2 2025259
Q3 2025266

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 81 bought or addedQ4 23: 99 cut or sold outQ1 24: 111 bought or addedQ1 24: 66 cut or sold outQ1 24Q2 24: 76 bought or addedQ2 24: 87 cut or sold outQ3 24: 78 bought or addedQ3 24: 74 cut or sold outQ3 24Q4 24: 90 bought or addedQ4 24: 69 cut or sold outQ1 25: 166 bought or addedQ1 25: 73 cut or sold outQ1 25Q2 25: 141 bought or addedQ2 25: 124 cut or sold outQ3 25: 119 bought or addedQ3 25: 127 cut or sold outQ3 25
Numbers
QuarterBought or addedCut or sold out
Q4 20238199
Q1 202411166
Q2 20247687
Q3 20247874
Q4 20249069
Q1 202516673
Q2 2025141124
Q3 2025119127

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150mQ4 24 calls: $17.2mQ4 24 puts: $16.3mQ4 24P/C 0.95Q1 25 calls: $51.2mQ1 25 puts: $36.6mQ1 25P/C 0.71Q2 25 calls: $100.1mQ2 25 puts: $48.2mQ2 25P/C 0.48Q3 25 calls: $52.4mQ3 25 puts: $16.3mQ3 25P/C 0.31
Numbers
QuarterCallsPutsP/C
Q4 2024$17.2m$16.3m0.95
Q1 2025$51.2m$36.6m0.71
Q2 2025$100.1m$48.2m0.48
Q3 2025$52.4m$16.3m0.31

Biggest buyers

Polar Capital Holdings Plc New +1,058,776+1.1m
Deep Track Capital, LP Added +958,380+958.4k
WELLINGTON MANAGEMENT GROUP LLP Added +841,915+841.9k
STATE STREET CORP Added +668,742+668.7k
AMERICAN CENTURY COMPANIES INC New +663,442+663.4k
BRAIDWELL LP New +475,400+475.4k
Weiss Asset Management LP Added +457,474+457.5k
Avoro Capital Advisors LLC Added +455,555+455.6k
Bellevue Group AG Added +404,042+404.0k
ORBIMED ADVISORS LLC Added +314,900+314.9k

Biggest sellers

Woodline Partners LP Reduced -1,827,752-1.8m
UBS Group AG Reduced -1,693,209-1.7m
Point72 Asset Management, L.P. Reduced -1,047,590-1.0m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -699,466-699.5k
CITADEL ADVISORS LLC Reduced -483,840-483.8k
JANUS HENDERSON GROUP PLC Reduced -458,251-458.3k
EcoR1 Capital, LLC Sold out -440,000-440.0k
READYSTATE ASSET MANAGEMENT LP Reduced -403,015-403.0k
MORGAN STANLEY Reduced -353,334-353.3k
Siren, L.L.C. Sold out -318,647-318.6k

Biggest calls

Point72 Asset Management, L.P. Unchanged $23.7m500.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $11.7m247.0k shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Added $3.9m82.2k shares
CITADEL ADVISORS LLC Reduced $2.0m41.9k shares
Ikarian Capital, LLC Reduced $2.0m41.6k shares
Caption Management, LLC Reduced $1.4m30.0k shares
GROUP ONE TRADING LLC Reduced $1.3m27.4k shares
JANE STREET GROUP, LLC Reduced $830.9k17.5k shares
SIMPLEX TRADING, LLC Reduced $764.0k16.1k shares
TUDOR INVESTMENT CORP ET AL Added $750.2k15.8k shares

Biggest puts

Caption Management, LLC Reduced $6.2m130.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.2m89.4k shares
CITADEL ADVISORS LLC Reduced $2.6m55.7k shares
JANE STREET GROUP, LLC Reduced $1.5m31.7k shares
TUDOR INVESTMENT CORP ET AL Added $735.9k15.5k shares
WOLVERINE TRADING, LLC New $352.4k7.4k shares
GROUP ONE TRADING LLC Reduced $294.4k6.2k shares
SIMPLEX TRADING, LLC Reduced $161.0k3.4k shares
Walleye Capital LLC New $109.2k2.3k shares
Walleye Trading LLC New $80.7k1.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10)

Holders, Q3 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.14% of their portfolio LONDON, X0 6,280,3056.3m $298.2m $298.2m 0.14% Reduced -458.3k -458,251
2 GENERAL ATLANTIC, L.P. 8.17% of their portfolio New York, NY 5,733,9895.7m $272.2m $272.2m 8.17% Unchanged
3 BlackRock, Inc. 0.00% of their portfolio New York, NY 5,702,6345.7m $270.8m $270.8m 0.00% Reduced -76.8k -76,778
4 RTW INVESTMENTS, LP 3.20% of their portfolio NEW YORK, NY 5,477,5615.5m $260.1m $260.1m 3.20% Unchanged
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,526,9204.5m $214.9m $214.9m 0.00% Reduced -2.7k -2,708
6 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 4,251,8614.3m $201.9m $201.9m 0.04% Added +841.9k +841,915
7 Deep Track Capital, LP 5.30% of their portfolio GREENWICH, CT 4,000,9784.0m $190.0m $190.0m 5.30% Added +958.4k +958,380
8 Avoro Capital Advisors LLC 2.43% of their portfolio NEW YORK, NY 3,955,5554.0m $187.8m $187.8m 2.43% Added +455.6k +455,555
9 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 3,809,8593.8m $180.9m $180.9m 0.02% Reduced -699.5k -699,466
10 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 3,414,3063.4m $162.1m $162.1m 0.01% Added +668.7k +668,742
11 Bellevue Group AG 2.36% of their portfolio ZURICH, V8 2,389,3142.4m $113.4m $113.4m 2.36% Added +404.0k +404,042
12 ALKEON CAPITAL MANAGEMENT LLC 0.40% of their portfolio New York, NY 1,850,9341.9m $87.9m $87.9m 0.40% Unchanged
13 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,785,5861.8m $84.8m $84.8m 0.01% Added +63.2k +63,181
14 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,689,6291.7m $80.2m $80.2m 0.03% Added +153.4k +153,429
15 Point72 Asset Management, L.P. 0.17% of their portfolio STAMFORD, CT 1,663,3391.7m $79.0m $79.0m 0.17% Reduced -1.0m -1,047,590
16 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,297,4381.3m $61.6m $61.6m 0.00% Reduced -23.0k -23,023
17 MARSHALL WACE, LLP 0.06% of their portfolio LONDON, X0 1,217,0441.2m $57.8m $57.8m 0.06% Reduced -201.2k -201,171
18 Logos Global Management LP 5.63% of their portfolio San Francisco, CA 1,200,0001.2m $57.0m $57.0m 5.63% Unchanged
19 PERCEPTIVE ADVISORS LLC 1.56% of their portfolio NEW YORK, NY 1,135,7661.1m $53.9m $53.9m 1.56% Added +219.9k +219,879
20 FMR LLC 0.00% of their portfolio BOSTON, MA 1,079,6571.1m $51.3m $51.3m 0.00% Added +147.7k +147,731
21 Polar Capital Holdings Plc 0.24% of their portfolio London, X0 1,058,7761.1m $50.3m $50.3m 0.24% New
22 Holocene Advisors, LP 0.12% of their portfolio New York, NY 1,055,1861.1m $50.1m $50.1m 0.12% Reduced -20.5k -20,456
23 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 926,441926.4k $44.0m $44.0m 0.04% Reduced -60.2k -60,192
24 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 855,766855.8k $40.6m $40.6m 0.01% Added +90.0k +90,025
25 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 810,568810.6k $38.5m $38.5m 0.01% Added +236.9k +236,880
26 Redmile Group, LLC 3.45% of their portfolio LARKSPUR, CA 747,818747.8k $35.5m $35.5m 3.45% Reduced -26.5k -26,493
27 Long Focus Capital Management, LLC 1.95% of their portfolio SAN JUAN, PR 720,000720.0k $34.2m $34.2m 1.95% Unchanged
28 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 685,842685.8k $32.6m $32.6m 0.03% Reduced -483.8k -483,840
29 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 663,442663.4k $31.5m $31.5m 0.02% New
30 SILVERARC CAPITAL MANAGEMENT, LLC 4.42% of their portfolio BOSTON, MA 643,636643.6k $30.6m $30.6m 4.42% Reduced -70.2k -70,175
31 Woodline Partners LP 0.14% of their portfolio San Francisco, CA 639,598639.6k $30.4m $30.4m 0.14% Reduced -1.8m -1,827,752
32 Rock Springs Capital Management LP 1.74% of their portfolio Baltimore, MD 626,526626.5k $29.7m $29.7m 1.74% Reduced -14.0k -14,000
33 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 626,019626.0k $29.7m $29.7m 0.00% Reduced -8.3k -8,307
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 612,126612.1k $29.1m $29.1m 0.00% Reduced -2.1k -2,140
35 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 577,940577.9k $27.4m $27.4m 0.00% Added +264.4k +264,447
36 LOOMIS SAYLES & CO L P 0.03% of their portfolio BOSTON, MA 527,175527.2k $25.0m $25.0m 0.03% Reduced -13.6k -13,613
37 ORBIMED ADVISORS LLC 0.60% of their portfolio New York, NY 526,200526.2k $25.0m $25.0m 0.60% Added +314.9k +314,900
38 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 502,913502.9k $23.9m $23.9m 0.04% Added +111.3k +111,313
39 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 487,230487.2k $23.1m $23.1m 0.01% Reduced -46.2k -46,186
40 Weiss Asset Management LP 0.33% of their portfolio BOSTON, MA 486,000486.0k $23.1m $23.1m 0.33% Added +457.5k +457,474
41 BRAIDWELL LP 0.67% of their portfolio STAMFORD, CT 475,400475.4k $22.6m $22.6m 0.67% New
42 Sofinnova Investments, Inc. 1.38% of their portfolio Menlo Park, CA 473,625473.6k $22.5m $22.5m 1.38% Reduced -75.2k -75,163
43 EVENTIDE ASSET MANAGEMENT, LLC 0.34% of their portfolio Boston, MA 435,293435.3k $20.7m $20.7m 0.34% Added +235.3k +235,293
44 Vivo Capital, LLC 1.66% of their portfolio Palo Alto, CA 434,689434.7k $20.6m $20.6m 1.66% Unchanged
45 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 418,975419.0k $19.9m $19.9m 0.01% Added +77.0k +76,977
46 VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio ATLANTA, GA 409,539409.5k $19.4m $19.4m 0.02% Reduced -7.9k -7,884
47 First Turn Management, LLC 2.83% of their portfolio DEL MAR, CA 397,010397.0k $18.9m $18.9m 2.83% Added +282.5k +282,456
48 PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio DES MOINES, IA 378,858378.9k $18.0m $18.0m 0.01% Reduced -11.3k -11,316
49 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 0.58% of their portfolio Boston, MA 377,152377.2k $17.9m $17.9m 0.58% Added +10.2k +10,155
50 Frazier Life Sciences Management, L.P. 0.52% of their portfolio PALO ALTO, CA 366,784366.8k $17.4m $17.4m 0.52% Unchanged
51 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 339,922339.9k $16.1m $16.1m 0.00% Reduced -353.3k -353,334
52 Hudson Bay Capital Management LP 0.10% of their portfolio STAMFORD, CT 338,500338.5k $16.1m $16.1m 0.10% Reduced -48.0k -48,023
53 UBS Group AG 0.00% of their portfolio ZURICH, V8 335,678335.7k $15.9m $15.9m 0.00% Reduced -1.7m -1,693,209
54 University of Wisconsin Foundation 13.21% of their portfolio MADISON, WI 328,504328.5k $15.6m $15.6m 13.21% Unchanged
55 Jain Global LLC 0.20% of their portfolio NEW YORK, NY 325,132325.1k $15.4m $15.4m 0.20% Reduced -20.2k -20,240
56 BAKER BROS. ADVISORS LP 0.11% of their portfolio NEW YORK, NY 324,630324.6k $15.4m $15.4m 0.11% Unchanged
57 Schonfeld Strategic Advisors LLC 0.10% of their portfolio NEW YORK, NY 303,814303.8k $14.4m $14.4m 0.10% Added +162.5k +162,508
58 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 291,593291.6k $13.8m $13.8m 0.00% Added +18.1k +18,148
59 PFM Health Sciences, LP 1.00% of their portfolio SAN FRANCISCO, CA 248,079248.1k $11.8m $11.8m 1.00% Reduced -18.1k -18,088
60 Foresite Capital Management VI LLC 4.49% of their portfolio WEST HOLLYWOOD, CA 244,900244.9k $11.6m $11.6m 4.49% Unchanged
61 READYSTATE ASSET MANAGEMENT LP 0.55% of their portfolio CHICAGO, IL 237,908237.9k $11.3m $11.3m 0.55% Reduced -403.0k -403,015
62 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 236,089236.1k $11.2m $11.2m 0.00% Reduced -1.6k -1,594
63 B Group, Inc. 10.55% of their portfolio DALLAS, TX 232,446232.4k $11.0m $11.0m 10.55% Unchanged
64 Rhenman & Partners Asset Management AB 1.21% of their portfolio Stockholm, V7 230,600230.6k $10.9m $10.9m 1.21% Added +33.0k +33,000
65 Propel Bio Management, LLC 10.88% of their portfolio Los Angeles, CA 228,884228.9k $10.9m $10.9m 10.88% Unchanged
66 Eagle Health Investments LP 2.82% of their portfolio Greenwich, CT 226,400226.4k $10.7m $10.7m 2.82% Unchanged
67 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 215,372215.4k $10.3m $10.3m 0.01% Added +65.9k +65,941
68 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 207,692207.7k $9.9m $9.9m 0.02% Added +19.3k +19,283
69 Ikarian Capital, LLC 1.99% of their portfolio DALLAS, TX 206,854206.9k $9.8m $9.8m 1.99% Reduced -13.1k -13,146
70 EMERALD ADVISERS, LLC 0.31% of their portfolio LEOLA, PA 206,771206.8k $9.8m $9.8m 0.31% Reduced -84.9k -84,921
71 Yiheng Capital Management, L.P. 3.00% of their portfolio SAN FRANCISCO, CA 191,076191.1k $9.1m $9.1m 3.00% Reduced -108.7k -108,715
72 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 189,194189.2k $9.0m $9.0m 0.01% Added +54.3k +54,255
73 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 188,844188.8k $9.0m $9.0m 0.01% Reduced -2.6k -2,604
74 CenterBook Partners LP 0.44% of their portfolio GREENWICH, CT 185,559185.6k $8.8m $8.8m 0.44% New
75 ExodusPoint Capital Management, LP 0.12% of their portfolio NEW YORK, NY 180,016180.0k $8.5m $8.5m 0.12% New
76 Hood River Capital Management LLC 0.10% of their portfolio PALM BEACH GARDENS, FL 178,549178.5k $8.5m $8.5m 0.10% New
77 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 164,529164.5k $7.8m $7.8m 0.00% Reduced -202.2k -202,240
78 Capricorn Fund Managers Ltd 2.38% of their portfolio LONDON, X0 149,200149.2k $7.1m $7.1m 2.38% New
79 Simplify Asset Management Inc. 0.14% of their portfolio Las Vegas, NV 145,609145.6k $6.9m $6.9m 0.14% Unchanged
80 FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 142,247142.2k $6.8m $6.8m 0.03% Reduced -168.3k -168,322
81 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 139,366139.4k $6.6m $6.6m 0.00% Added +62.5k +62,503
82 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 134,837134.8k $6.4m $6.4m 0.02% Added +41.7k +41,709
83 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 132,817132.8k $6.3m $6.3m 0.01% Reduced -6.0k -6,017
84 Trexquant Investment LP 0.06% of their portfolio STAMFORD, CT 123,352123.4k $5.9m $5.9m 0.06% Added +117.0k +116,969
85 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 121,477121.5k $5.8m $5.8m 0.01% Added +96.0k +96,030
86 STEMPOINT CAPITAL LP 1.16% of their portfolio NEW YORK, NY 121,410121.4k $5.8m $5.8m 1.16% Added +4.6k +4,631
87 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 118,100118.1k $5.6m $5.6m 0.01% Added +90.1k +90,100
88 EMERALD MUTUAL FUND ADVISERS TRUST 0.27% of their portfolio LEOLA, PA 110,747110.7k $5.3m $5.3m 0.27% Reduced -25.6k -25,550
89 NAN FUNG TRINITY (HK) LTD 0.52% of their portfolio CENTRAL, HONG KONG, K3 110,650110.7k $5.3m $5.3m 0.52% Unchanged
90 HighVista Strategies LLC 1.28% of their portfolio BOSTON, MA 110,079110.1k $5.2m $5.2m 1.28% Added +50.1k +50,086
91 Swiss National Bank 0.00% of their portfolio ZURICH, V8 108,100108.1k $5.1m $5.1m 0.00% Added +1.7k +1,700
92 GREAT POINT PARTNERS LLC 2.06% of their portfolio Greenwich, CT 103,848103.8k $4.9m $4.9m 2.06% Unchanged
93 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 103,239103.2k $4.9m $4.9m 0.00% Reduced -4.2k -4,199
94 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 99,91799.9k $4.7m $4.7m 0.00% Reduced -61.6k -61,648
95 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 97,25197.3k $4.6m $4.6m 0.00% Added +68.7k +68,678
96 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 79,24579.2k $3.8m $3.8m 0.00% Reduced -7.2k -7,245
97 Aquatic Capital Management LLC 0.07% of their portfolio CHICAGO, IL 76,56876.6k $3.6m $3.6m 0.07% First filing
98 AXA Investment Managers S.A. 0.01% of their portfolio PUTEAUX, I0 71,20071.2k $3.4m $3.4m 0.01% First filing
99 Soleus Capital Management, L.P. 0.18% of their portfolio GREENWICH, CT 71,00071.0k $3.4m $3.4m 0.18% Reduced -1.0k -1,000
100 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 65,96666.0k $3.1m $3.1m 0.00% Added +32.2k +32,219