Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

242 institutional holders +50 vs Q4 2024
86,171,34886.2m shares reported held*
$3.5bnreported value*
75 new 91 added 48 reduced 25 sold out net bought ≈ $492.2m (+12.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($14.0m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $40.54. Options: 13 managers hold calls ($51.2m notional), 12 hold puts ($36.6m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 146Q4 22: 162Q1 23: 157Q2 23: 159Q3 23: 183Q4 23: 158Q1 24: 174Q2 24: 154Q3 24: 169Q4 24: 192Q1 25: 242242Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 2022146
Q4 2022162
Q1 2023157
Q2 2023159
Q3 2023183
Q4 2023158
Q1 2024174
Q2 2024154
Q3 2024169
Q4 2024192
Q1 2025242

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 23: 96 bought or addedQ2 23: 64 cut or sold outQ3 23: 115 bought or addedQ3 23: 50 cut or sold outQ3 23Q4 23: 81 bought or addedQ4 23: 99 cut or sold outQ1 24: 111 bought or addedQ1 24: 66 cut or sold outQ1 24Q2 24: 76 bought or addedQ2 24: 87 cut or sold outQ3 24: 78 bought or addedQ3 24: 74 cut or sold outQ3 24Q4 24: 90 bought or addedQ4 24: 69 cut or sold outQ1 25: 166 bought or addedQ1 25: 73 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 20239664
Q3 202311550
Q4 20238199
Q1 202411166
Q2 20247687
Q3 20247874
Q4 20249069
Q1 202516673

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ2 24 calls: $6.0mQ2 24 puts: $7.7mQ2 24P/C 1.29Q3 24 calls: $8.5mQ3 24 puts: $18.6mQ3 24P/C 2.18Q4 24 calls: $17.2mQ4 24 puts: $16.3mQ4 24P/C 0.95Q1 25 calls: $51.2mQ1 25 puts: $36.6mQ1 25P/C 0.71
Numbers
QuarterCallsPutsP/C
Q2 2024$6.0m$7.7m1.29
Q3 2024$8.5m$18.6m2.18
Q4 2024$17.2m$16.3m0.95
Q1 2025$51.2m$36.6m0.71

Biggest buyers

UBS Group AG Added +1,784,562+1.8m
Deep Track Capital, LP Added +1,720,270+1.7m
MARSHALL WACE, LLP Added +1,332,768+1.3m
Bellevue Group AG New +1,250,666+1.3m
JANUS HENDERSON GROUP PLC Added +1,034,409+1.0m
FMR LLC Added +970,403+970.4k
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New +580,000+580.0k
RTW INVESTMENTS, LP Added +559,517+559.5k
SG Americas Securities, LLC Added +557,794+557.8k
CITADEL ADVISORS LLC Added +554,437+554.4k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -1,440,721-1.4m
T. Rowe Price Investment Management, Inc. Sold out -670,048-670.0k
Balyasny Asset Management L.P. Sold out -649,134-649.1k
ALLIANCEBERNSTEIN L.P. Reduced -587,912-587.9k
Pfizer Inc Sold out -562,626-562.6k
BAKER BROS. ADVISORS LP Reduced -548,369-548.4k
MPM BIOIMPACT LLC Sold out -460,617-460.6k
PERCEPTIVE ADVISORS LLC Reduced -392,632-392.6k
Point72 Asset Management, L.P. Reduced -391,340-391.3k
Yiheng Capital Management, L.P. Reduced -306,354-306.4k

Biggest calls

Yiheng Capital Management, L.P. New $30.4m751.5k shares
SILVERARC CAPITAL MANAGEMENT, LLC Reduced $7.3m180.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $3.3m81.7k shares
SIMPLEX TRADING, LLC Added $2.6m65.1k shares
Caption Management, LLC New $2.1m52.0k shares
JANE STREET GROUP, LLC Added $2.0m48.4k shares
CITIGROUP INC New $1.7m42.0k shares
MILLENNIUM MANAGEMENT LLC New $607.2k15.0k shares
CITADEL ADVISORS LLC Reduced $421.0k10.4k shares
TUDOR INVESTMENT CORP ET AL New $271.2k6.7k shares

Biggest puts

JANE STREET GROUP, LLC Added $15.1m373.1k shares
CITIGROUP INC New $5.2m129.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $4.0m99.2k shares
SIMPLEX TRADING, LLC Added $3.1m77.8k shares
CITADEL ADVISORS LLC Added $2.9m71.4k shares
Caption Management, LLC New $1.7m41.0k shares
GROUP ONE TRADING LLC Added $1.6m39.7k shares
MILLENNIUM MANAGEMENT LLC New $1.2m30.0k shares
WOLVERINE TRADING, LLC New $948.4k22.2k shares
Squarepoint Ops LLC New $445.3k11.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10), PRICE T ROWE ASSOCIATES INC /MD/ (4.8%, 2025-11-14)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RTW INVESTMENTS, LP 4.59% of their portfolio NEW YORK, NY 7,419,3407.4m $300.3m $300.3m 4.59% Added +559.5k +559,517
2 JANUS HENDERSON GROUP PLC 0.17% of their portfolio LONDON, X0 7,068,6487.1m $301.9m $301.9m 0.17% Added +1.0m +1,034,409
3 BlackRock, Inc. 0.01% of their portfolio New York, NY 6,255,0246.3m $253.2m $253.2m 0.01% Added +330.8k +330,841
4 WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio Boston, MA 5,936,2405.9m $240.3m $240.3m 0.05% Reduced -1.4m -1,440,721
5 GENERAL ATLANTIC, L.P. 7.11% of their portfolio New York, NY 5,233,9895.2m $211.9m $211.9m 7.11% Unchanged
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 4,817,0914.8m $195.0m $195.0m 0.02% Added +495.1k +495,119
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,230,6444.2m $171.3m $171.3m 0.00% Added +526.2k +526,233
8 Deep Track Capital, LP 4.21% of their portfolio GREENWICH, CT 3,210,2703.2m $130.0m $130.0m 4.21% Added +1.7m +1,720,270
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,494,7432.5m $101.0m $101.0m 0.00% Added +158.8k +158,799
10 UBS Group AG 0.02% of their portfolio ZURICH, V8 2,156,4062.2m $87.3m $87.3m 0.02% Added +1.8m +1,784,562
11 CITADEL ADVISORS LLC 0.08% of their portfolio MIAMI, FL 1,909,3301.9m $77.3m $77.3m 0.08% Added +554.4k +554,437
12 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,749,1941.7m $70.8m $70.8m 0.01% Added +189.6k +189,563
13 MARSHALL WACE, LLP 0.09% of their portfolio LONDON, X0 1,607,8421.6m $65.1m $65.1m 0.09% Added +1.3m +1,332,768
14 ALKEON CAPITAL MANAGEMENT LLC 0.37% of their portfolio New York, NY 1,550,9341.6m $62.8m $62.8m 0.37% Reduced -210.3k -210,334
15 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 1,251,3691.3m $50.7m $50.7m 0.02% Reduced -587.9k -587,912
16 Bellevue Group AG 1.13% of their portfolio ZURICH, V8 1,250,6661.3m $50.6m $50.6m 1.13% New
17 Logos Global Management LP 8.64% of their portfolio San Francisco, CA 1,200,0001.2m $48.6m $48.6m 8.64% Added +400.0k +400,000
18 SG Americas Securities, LLC 0.16% of their portfolio NEW YORK, NY 1,155,7871.2m $46.8m $46.8m 0.16% Added +557.8k +557,794
19 FMR LLC 0.00% of their portfolio BOSTON, MA 1,009,1271.0m $40.8m $40.8m 0.00% Added +970.4k +970,403
20 Redmile Group, LLC 3.59% of their portfolio LARKSPUR, CA 939,277939.3k $38.0m $38.0m 3.59% Reduced -295.9k -295,932
21 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 802,854802.9k $32.5m $32.5m 0.00% Added +331.3k +331,319
22 PERCEPTIVE ADVISORS LLC 1.14% of their portfolio NEW YORK, NY 792,960793.0k $32.1m $32.1m 1.14% Reduced -392.6k -392,632
23 Long Focus Capital Management, LLC 2.01% of their portfolio SAN JUAN, PR 729,504729.5k $29.5m $29.5m 2.01% Added +9.9k +9,900
24 SILVERARC CAPITAL MANAGEMENT, LLC 6.09% of their portfolio BOSTON, MA 719,992720.0k $29.1m $29.1m 6.09% Reduced -19.6k -19,571
25 Rock Springs Capital Management LP 1.56% of their portfolio Baltimore, MD 672,759672.8k $27.2m $27.2m 1.56% Reduced -273.7k -273,740
26 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 656,733656.7k $26.6m $26.6m 0.00% Added +36.4k +36,412
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 582,254582.3k $23.6m $23.6m 0.00% Added +41.6k +41,562
28 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.13% of their portfolio Boston, MA 580,000580.0k $23.5m $23.5m 1.13% New
29 BAKER BROS. ADVISORS LP 0.25% of their portfolio NEW YORK, NY 548,713548.7k $22.2m $22.2m 0.25% Reduced -548.4k -548,369
30 LORD, ABBETT & CO. LLC 0.08% of their portfolio JERSEY CITY, NJ 527,004527.0k $21.3m $21.3m 0.08% New
31 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 526,642526.6k $21.3m $21.3m 0.01% Added +77.5k +77,532
32 FRED ALGER MANAGEMENT, LLC 0.12% of their portfolio NEW YORK, NY 515,324515.3k $20.9m $20.9m 0.12% Added +252.0k +251,971
33 Sofinnova Investments, Inc. 1.56% of their portfolio Menlo Park, CA 510,020510.0k $20.6m $20.6m 1.56% New
34 Point72 Asset Management, L.P. 0.06% of their portfolio STAMFORD, CT 508,340508.3k $20.6m $20.6m 0.06% Reduced -391.3k -391,340
35 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.08% of their portfolio JUPITER, FL 501,485501.5k $20.3m $20.3m 0.08% New
36 LOOMIS SAYLES & CO L P 0.03% of their portfolio BOSTON, MA 488,938488.9k $19.8m $19.8m 0.03% New
37 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 488,392488.4k $19.8m $19.8m 0.00% Added +30.9k +30,868
38 Woodline Partners LP 0.13% of their portfolio San Francisco, CA 480,736480.7k $19.5m $19.5m 0.13% Added +100.8k +100,769
39 EcoR1 Capital, LLC 1.06% of their portfolio San Francisco, CA 440,000440.0k $17.8m $17.8m 1.06% New
40 Aberdeen Group plc 0.03% of their portfolio EDINBURGH, X0 406,700406.7k $16.5m $16.5m 0.03% Added +136.9k +136,918
41 Foresite Capital Management VI LLC 8.09% of their portfolio WEST HOLLYWOOD, CA 365,000365.0k $14.8m $14.8m 8.09% Unchanged
42 Yiheng Capital Management, L.P. 5.12% of their portfolio SAN FRANCISCO, CA 359,791359.8k $14.6m $14.6m 5.12% Reduced -306.4k -306,354
43 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 332,383332.4k $13.5m $13.5m 0.00% Reduced -195.8k -195,824
44 University of Wisconsin Foundation 11.28% of their portfolio MADISON, WI 328,504328.5k $13.3m $13.3m 11.28% Reduced -82.1k -82,126
45 Pictet Asset Management Holding SA 0.01% of their portfolio CAROUGE, V8 314,711314.7k $12.7m $12.7m 0.01% New
46 Schonfeld Strategic Advisors LLC 0.09% of their portfolio NEW YORK, NY 313,931313.9k $12.7m $12.7m 0.09% Added +51.6k +51,636
47 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 308,326308.3k $1.7m $1.7m 0.00% First filing
48 Hudson Bay Capital Management LP 0.08% of their portfolio STAMFORD, CT 301,950301.9k $12.2m $12.2m 0.08% Added +127.0k +126,950
49 EMERALD ADVISERS, LLC 0.54% of their portfolio LEOLA, PA 294,402294.4k $11.9m $11.9m 0.54% Reduced -225.7k -225,712
50 Rheos Capital Works Inc. 0.91% of their portfolio Tokyo, M0 276,000276.0k $11.2m $11.2m 0.91% Unchanged
51 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 260,601260.6k $10.5m $10.5m 0.00% Added +194.3k +194,337
52 PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio DES MOINES, IA 257,025257.0k $10.4m $10.4m 0.01% New
53 Ikarian Capital, LLC 3.23% of their portfolio DALLAS, TX 245,000245.0k $9.9m $9.9m 3.23% New
54 B Group, Inc. 8.53% of their portfolio DALLAS, TX 242,500242.5k $9.8m $9.8m 8.53% Reduced -17.5k -17,500
55 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 234,172234.2k $9.5m $9.5m 0.01% Added +146.3k +146,255
56 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 234,130234.1k $9.5m $9.5m 0.00% Reduced -39.7k -39,681
57 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 230,864230.9k $9.3m $9.3m 0.01% Added +214.1k +214,128
58 Propel Bio Management, LLC 10.76% of their portfolio Los Angeles, CA 228,884228.9k $9.3m $9.3m 10.76% Reduced -114.8k -114,845
59 Eagle Health Investments LP 2.38% of their portfolio Greenwich, CT 226,400226.4k $9.2m $9.2m 2.38% New
60 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 212,665212.7k $8.6m $8.6m 0.00% Added +12.2k +12,235
61 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 208,848208.8k $8.5m $8.5m 0.01% Added +39.2k +39,194
62 EMERALD MUTUAL FUND ADVISERS TRUST 0.59% of their portfolio LEOLA, PA 207,035207.0k $8.4m $8.4m 0.59% Reduced -145.1k -145,145
63 Vivo Capital, LLC 1.08% of their portfolio Palo Alto, CA 201,168201.2k $8.1m $8.1m 1.08% New
64 EVENTIDE ASSET MANAGEMENT, LLC 0.16% of their portfolio Boston, MA 200,534200.5k $8.1m $8.1m 0.16% New
65 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 199,000199.0k $8.1m $8.1m 0.01% Added +178.2k +178,200
66 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio Boston, MA 195,000195.0k $7.9m $7.9m 0.01% New
67 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 182,457182.5k $7.4m $7.4m 0.01% Reduced -42.6k -42,562
68 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 180,390180.4k $7.3m $7.3m 0.01% Added +145.1k +145,122
69 ORBIMED ADVISORS LLC 0.17% of their portfolio New York, NY 179,900179.9k $7.3m $7.3m 0.17% Added +113.9k +113,900
70 Cubist Systematic Strategies, LLC 0.09% of their portfolio STAMFORD, CT 174,960175.0k $7.1m $7.1m 0.09% Added +144.8k +144,752
71 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 164,942164.9k $6.7m $6.7m 0.00% Added +144.5k +144,471
72 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 158,275158.3k $6.4m $6.4m 0.01% Added +156.2k +156,223
73 STEMPOINT CAPITAL LP 2.02% of their portfolio NEW YORK, NY 156,185156.2k $6.3m $6.3m 2.02% New
74 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 155,044155.0k $6.3m $6.3m 0.01% Unchanged
75 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 151,290151.3k $6.1m $6.1m 0.01% Added +26.7k +26,698
76 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 150,142150.1k $6.1m $6.1m 0.01% Added +142.1k +142,102
77 Simplify Asset Management Inc. 0.28% of their portfolio Las Vegas, NV 145,609145.6k $5.9m $5.9m 0.28% Reduced -119.1k -119,068
78 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 123,163123.2k $5.0m $5.0m 0.00% Reduced -9.7k -9,674
79 Jain Global LLC 0.10% of their portfolio NEW YORK, NY 122,897122.9k $5.0m $5.0m 0.10% New
80 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 117,121117.1k $4.7m $4.7m 0.00% Added +18.7k +18,658
81 Soleus Capital Management, L.P. 0.37% of their portfolio GREENWICH, CT 117,000117.0k $4.7m $4.7m 0.37% New
82 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 116,607116.6k $5.0m $5.0m 0.01% Added +91.0k +90,992
83 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 110,687110.7k $4.5m $4.5m 0.00% Added +5.0k +5,001
84 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 109,909109.9k $4.4m $4.4m 0.00% Added +38.5k +38,458
85 ExodusPoint Capital Management, LP 0.06% of their portfolio NEW YORK, NY 103,930103.9k $4.2m $4.2m 0.06% Added +48.7k +48,723
86 READYSTATE ASSET MANAGEMENT LP 0.20% of their portfolio CHICAGO, IL 100,500100.5k $4.1m $4.1m 0.20% New
87 Swiss National Bank 0.00% of their portfolio ZURICH, V8 94,70094.7k $3.8m $3.8m 0.00% Reduced -900 -900
88 Rhenman & Partners Asset Management AB 0.43% of their portfolio Stockholm, V7 92,50092.5k $3.7m $3.7m 0.43% New
89 Sio Capital Management, LLC 1.04% of their portfolio NEW YORK, NY 85,00085.0k $3.4m $3.4m 1.04% New
90 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 79,46779.5k $3.2m $3.2m 0.00% Added +64.3k +64,295
91 Exome Asset Management LLC 2.77% of their portfolio NEW YORK, NY 76,37976.4k $3.1m $3.1m 2.77% Added +7.8k +7,771
92 ALGERT GLOBAL LLC 0.08% of their portfolio SAN FRANCISCO, CA 74,92974.9k $3.0m $3.0m 0.08% Added +15.2k +15,195
93 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 74,08174.1k $3.0m $3.0m 0.01% Added +1.5k +1,477
94 Walleye Capital LLC 0.03% of their portfolio NEW YORK, NY 72,98473.0k $3.0m $3.0m 0.03% Reduced -61.7k -61,721
95 Aquatic Capital Management LLC 0.08% of their portfolio CHICAGO, IL 72,77472.8k $2.9m $2.9m 0.08% Added +54.7k +54,733
96 BOOTHBAY FUND MANAGEMENT, LLC 0.10% of their portfolio NEW YORK, NY 72,66672.7k $2.9m $2.9m 0.10% New
97 ADAR1 Capital Management, LLC 0.55% of their portfolio AUSTIN, TX 71,14371.1k $2.9m $2.9m 0.55% Added +55.8k +55,836
98 Informed Momentum Co LLC 0.46% of their portfolio SOLANA BEACH, CA 66,42266.4k $2.7m $2.7m 0.46% New
99 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 62,02062.0k $2.5m $2.5m 0.01% Reduced -65.3k -65,300
100 INTECH INVESTMENT MANAGEMENT LLC 0.02% of their portfolio WEST PALM BEACH, FL 58,52258.5k $2.4m $2.4m 0.02% Added +20.6k +20,620