AGENUS INC AGEN
COM NEW · Common Stock · CUSIP 00847G804
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersLexington, MA
- Founded1994
- Websiteagenusbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($872 this quarter). Holder counts are more reliable. Shares outstanding: 45.0m as of 2026-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.06. Options: 5 managers hold calls ($336.6k notional), 4 hold puts ($203.8k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2024 | 10 |
| Q2 2024 | 89 |
| Q3 2024 | 98 |
| Q4 2024 | 85 |
| Q1 2025 | 89 |
| Q2 2025 | 93 |
| Q3 2025 | 87 |
| Q4 2025 | 96 |
| Q1 2026 | 87 |
| Q2 2026 | 102 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 55 | 43 |
| Q4 2024 | 39 | 49 |
| Q1 2025 | 40 | 37 |
| Q2 2025 | 52 | 57 |
| Q3 2025 | 40 | 52 |
| Q4 2025 | 45 | 40 |
| Q1 2026 | 23 | 52 |
| Q2 2026 | 63 | 33 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $2.2m | $664.5k | 0.31 |
| Q4 2025 | $745.4k | $102.4k | 0.14 |
| Q1 2026 | $651.0k | $218.1k | 0.34 |
| Q2 2026 | $336.6k | $203.8k | 0.61 |
Biggest buyers
| BlackRock, Inc. | Added | +2.0m |
| MACKENZIE FINANCIAL CORP | New | +714.2k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +686.6k |
| GLOBEFLEX CAPITAL L P | New | +418.6k |
| GOLDMAN SACHS GROUP INC | Added | +416.9k |
| STATE STREET CORP | Added | +256.2k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +235.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +232.5k |
| NORTHERN TRUST CORP | Added | +224.3k |
| RAYMOND JAMES FINANCIAL INC | Added | +190.5k |
Biggest sellers
| MARSHALL WACE, LLP | Reduced | -248.6k |
| UBS Group AG | Reduced | -215.2k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -190.0k |
| Walleye Capital LLC | Sold out | -120.6k |
| 683 Capital Management, LLC | Sold out | -114.3k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -72.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -66.8k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -57.3k |
| Jump Financial, LLC | Reduced | -53.2k |
| CITADEL ADVISORS LLC | Sold out | -52.0k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $90.3k29.5k shares |
| IMC-Chicago, LLC | Added | $82.3k26.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $77.4k25.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $54.8k17.9k shares |
| JANE STREET GROUP, LLC | New | $31.8k10.4k shares |
Biggest puts
| IMC-Chicago, LLC | Added | $73.7k24.1k shares |
| CITADEL ADVISORS LLC | Added | $62.7k20.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $56.9k18.6k shares |
| SIMPLEX TRADING, LLC | Added | $10.4k3.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Invus Global Management, LLC 13G · passive investor new · filed 2026-07-17 | 10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-07-20 | 9.9% |
| BlackRock, Inc. 13G · institution +4.2 pts · filed 2026-07-27 | 6.0% |
ZYNEXT VENTURES USA LLC
13D · may seek influence
new · filed 2026-01-23
Stated purposeThe acquisition of securities of the issuer is part of a strategic collaboration between Zydus and the issuer. At Zydus?s option, Zydus may appoint either a board observer or board member to issuer?s board of directors so long as Zydus retains significant ownership of issuer?s stock. Full filing |
5.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 2.6m $7.8m | Added +2.0m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.7m $5.1m | Added +235.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.4m $4.4m | Added +232.5k |
| Siren, L.L.C. 0.07% of their portfolio | 1.1m $3.3m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.0m $3.2m | Added +686.6k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 714.2k $2.2m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 448.4k $1.4m | Added +416.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 439.6k $1.3m | Reduced -248.6k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 430.1k $1.3m | Added +190.5k |
| GLOBEFLEX CAPITAL L P 0.16% of their portfolio | 418.6k $1.3m | New |
| STATE STREET CORP 0.00% of their portfolio | 412.4k $1.3m | Added +256.2k |
| Man Group plc 0.00% of their portfolio | 340.4k $1.0m | Added +61.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 314.1k $961.0k | Added +224.3k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 310.0k $948.7k | Added +111.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 271.6k $831.1k | Added +71.1k |
| MORGAN STANLEY 0.00% of their portfolio | 262.1k $801.9k | Reduced -33.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 228.3k $698.7k | Reduced -57.3k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 179.6k $549.5k | Added +16.4k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 158.7k $485.7k | New |
| Jump Financial, LLC 0.00% of their portfolio | 104.0k $318.2k | Reduced -53.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 101.8k $311.4k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 99.4k $304.1k | Added +84.4k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 98.7k $302.0k | Reduced -72.2k |
| STRS OHIO 0.00% of their portfolio | 76.9k $235.3k | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 67.1k $205.3k | Added +15.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 57.7k $177.0k | Added +33.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 52.0k $159.2k | Reduced -66.8k |
| Invesco Ltd. 0.00% of their portfolio | 50.9k $155.9k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 43.2k $132.2k | Added +33.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 42.0k $128.6k | Reduced -15.6k |
| Avestar Capital, LLC 0.01% of their portfolio | 41.0k $125.5k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 38.9k $119.0k | New |
| Claro Advisors Inc. 0.01% of their portfolio | 33.4k $102.1k | New |
| XTX Topco Ltd 0.00% of their portfolio | 31.6k $96.8k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 29.5k $90.2k | Added +28.9k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 29.0k $88.7k | Reduced -906 |
| Engineers Gate Manager LP 0.00% of their portfolio | 27.8k $85.1k | Reduced -6.5k |
| CITIGROUP INC 0.00% of their portfolio | 27.7k $84.8k | Added +27.7k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 25.0k $76.0k | Reduced -190.0k |
| LPL Financial LLC 0.00% of their portfolio | 24.2k $73.9k | Added +446 |
| Key Client Fiduciary Advisors, LLC 0.02% of their portfolio | 24.1k $73.8k | Reduced -1.1k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 23.5k $71.8k | Added +3.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 21.9k $67.0k | Added +21.8k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 19.8k $60.5k | Added +4.9k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 19.4k $59.4k | Added +6.9k |
| UBS Group AG 0.00% of their portfolio | 19.3k $59.0k | Reduced -215.2k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 19.2k $58.7k | Added +827 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 18.9k $57.8k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 18.3k $56.1k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 17.1k $53.9k | Added +16.7k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 15.9k $48.7k | Unchanged |
| DIVERSIFIED TRUST CO 0.00% of their portfolio | 15.6k $47.7k | New |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 15.5k $47.5k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 15.3k $46.9k | New |
| R Squared Ltd 0.02% of their portfolio | 13.4k $41.1k | New |
| FMR LLC 0.00% of their portfolio | 13.3k $40.6k | Added +7.9k |
| Virtu Financial LLC 0.00% of their portfolio | 12.9k $40.0k | New |
| Post Resch Tallon Group Inc. 0.03% of their portfolio | 12.8k $39.0k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 12.4k $41.3k | New |
| Abel Hall, LLC 0.01% of their portfolio | 11.8k $36.0k | New |
| Graham Capital Management, L.P. 0.00% of their portfolio | 11.5k $35.1k | Reduced -18.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 11.2k $34.8k | Reduced -3.7k |
| Values First Advisors, Inc. 0.02% of their portfolio | 11.0k $33.6k | Reduced -207 |
| StoneX Group Inc. 0.00% of their portfolio | 10.7k $36.8k | New |
| ZACKS INVESTMENT MANAGEMENT 0.00% of their portfolio | 10.6k $32.3k | New |
| EP Wealth Advisors, LLC 0.00% of their portfolio | 10.0k $30.6k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 9.2k $28.1k | Reduced -50.1k |
| Legal & General Group Plc 0.00% of their portfolio | 3.9k $11.8k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.6k $11.1k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 3.6k $11.1k | Added +3.2k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 3.4k $10.3k | New |
| Pinnacle Wealth Planning Services, Inc. 0.00% of their portfolio | 3.4k $10.3k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.3k $7.1k | New |
| CoreCap Advisors, LLC 0.00% of their portfolio | 2.0k $6.1k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.9k $6.0k | Added +1.9k |
| Atlantic Union Bankshares Corp 0.00% of their portfolio | 1.8k $5.4k | Added +1.5k |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1.6k $5.0k | New |
| Forum Finance Group S.A. 0.00% of their portfolio | 1.3k $3.0k | Unchanged |
| CHILTON CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.1k $3.2k | Unchanged |
| Covestor Ltd 0.00% of their portfolio | 915 $3.0k | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 847 $2.6k | Added +600 |
| Sterling Capital Management LLC 0.00% of their portfolio | 705 $2.2k | New |
| HUNTINGTON NATIONAL BANK 0.00% of their portfolio | 664 $2.0k | Added +164 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 633 $1.9k | Unchanged |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 621 $1.9k | Unchanged |
| Game Plan Financial Advisors, LLC 0.00% of their portfolio | 585 $1.8k | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 574 $1.8k | Added +96 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 561 $1.7k | Reduced -7.9k |
| Rialto Wealth Management, LLC 0.00% of their portfolio | 305 $934 | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 285 $872 | Unchanged |
| Bare Financial Services, Inc 0.00% of their portfolio | 173 $529 | New |
| Bogart Wealth, LLC 0.00% of their portfolio | 171 $523 | New |
| LifeSteps Financial, Inc. 0.00% of their portfolio | 100 $306 | New |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 100 $306 | Unchanged |
| Transamerica Financial Advisors, LLC 0.00% of their portfolio | 18 $55 | New |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 12 $36 | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 12 $37 | Unchanged |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 9 $28 | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 8 $25 | Reduced -50 |
| Arax Advisory Partners 0.00% of their portfolio | 5 $15 | Unchanged |