AGENUS INC AGEN
COM NEW · Common Stock · CUSIP 00847G804
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersLexington, MA
- Founded1994
- Websiteagenusbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($952 this quarter). Holder counts are more reliable. Shares outstanding: 38.4m as of 2026-03-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.34. Options: 5 managers hold calls ($651.0k notional), 5 hold puts ($218.1k).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2024 | 10 |
| Q2 2024 | 89 |
| Q3 2024 | 98 |
| Q4 2024 | 85 |
| Q1 2025 | 89 |
| Q2 2025 | 93 |
| Q3 2025 | 87 |
| Q4 2025 | 96 |
| Q1 2026 | 87 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 82 | 9 |
| Q3 2024 | 55 | 43 |
| Q4 2024 | 39 | 49 |
| Q1 2025 | 40 | 37 |
| Q2 2025 | 52 | 57 |
| Q3 2025 | 40 | 52 |
| Q4 2025 | 45 | 40 |
| Q1 2026 | 23 | 52 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $1.5m | $1.5m | 1.02 |
| Q3 2025 | $2.2m | $664.5k | 0.31 |
| Q4 2025 | $745.4k | $102.4k | 0.14 |
| Q1 2026 | $651.0k | $218.1k | 0.34 |
Biggest buyers
| MARSHALL WACE, LLP | Added | +541.4k |
| Man Group plc | Added | +164.8k |
| Connor, Clark & Lunn Investment Management Ltd. | Added | +130.5k |
| UBS Group AG | Added | +115.6k |
| BANK OF AMERICA CORP /DE/ | Added | +105.5k |
| RAYMOND JAMES FINANCIAL INC | Added | +97.9k |
| TWO SIGMA INVESTMENTS, LP | Added | +53.8k |
| Hudson Bay Capital Management LP | New | +33.5k |
| AXQ CAPITAL, LP | New | +29.1k |
| STATE STREET CORP | Added | +18.8k |
Biggest sellers
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -407.4k |
| CITADEL ADVISORS LLC | Reduced | -371.2k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -257.9k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -181.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -176.0k |
| Point72 Asset Management, L.P. | Sold out | -108.2k |
| D. E. Shaw & Co., Inc. | Reduced | -94.4k |
| JANE STREET GROUP, LLC | Sold out | -73.6k |
| OMERS ADMINISTRATION Corp | Reduced | -65.8k |
| Susquehanna Portfolio Strategies, LLC | Sold out | -59.4k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $217.8k65.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $146.3k43.8k shares |
| GROUP ONE TRADING LLC | Reduced | $105.2k31.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $103.5k31.0k shares |
| IMC-Chicago, LLC | New | $78.2k23.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $111.2k33.3k shares |
| IMC-Chicago, LLC | New | $50.8k15.2k shares |
| CITADEL ADVISORS LLC | Added | $41.1k12.3k shares |
| SIMPLEX TRADING, LLC | Added | $10.7k3.2k shares |
| GROUP ONE TRADING LLC | Reduced | $4.3k1.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Invus Global Management, LLC 13G · passive investor new · filed 2026-07-17 | 10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-07-20 | 9.9% |
| BlackRock, Inc. 13G · institution +4.2 pts · filed 2026-07-27 | 6.0% |
ZYNEXT VENTURES USA LLC
13D · may seek influence
new · filed 2026-01-23
Stated purposeThe acquisition of securities of the issuer is part of a strategic collaboration between Zydus and the issuer. At Zydus?s option, Zydus may appoint either a board observer or board member to issuer?s board of directors so long as Zydus retains significant ownership of issuer?s stock. Full filing |
5.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q1 2026.
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.4m $4.8m | First filing |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.2m $4.0m | First filing |
| Siren, L.L.C. 0.10% of their portfolio | 1.1m $3.6m | Unchanged |
| MARSHALL WACE, LLP 0.00% of their portfolio | 688.2k $2.3m | Added +541.4k |
| BlackRock, Inc. 0.00% of their portfolio | 545.7k $1.8m | Reduced -12.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 348.4k $1.2m | Reduced -24.4k |
| MORGAN STANLEY 0.00% of their portfolio | 295.8k $988.0k | Added +10.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 285.6k $954.1k | Reduced -257.9k |
| Man Group plc 0.00% of their portfolio | 279.0k $931.8k | Added +164.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 239.6k $800.1k | Added +97.9k |
| UBS Group AG 0.00% of their portfolio | 234.4k $783.0k | Added +115.6k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 215.0k $713.0k | Reduced -407.4k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 200.5k $669.7k | First filing |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 198.5k $663.0k | Added +130.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 170.9k $570.9k | Added +53.8k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 163.1k $544.9k | Unchanged |
| Jump Financial, LLC 0.01% of their portfolio | 157.2k $525.0k | Reduced -13.2k |
| STATE STREET CORP 0.00% of their portfolio | 156.2k $521.7k | Added +18.8k |
| Walleye Capital LLC 0.00% of their portfolio | 120.6k $402.7k | Reduced -2.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 118.8k $396.7k | Added +105.5k |
| 683 Capital Management, LLC 0.04% of their portfolio | 114.3k $381.9k | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 89.7k $299.7k | Added +134 |
| BARCLAYS PLC 0.00% of their portfolio | 59.3k $198.2k | Added +13.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 57.7k $192.6k | Reduced -176.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 52.0k $173.7k | Reduced -371.2k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 51.8k $173.0k | Reduced -14.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 43.4k $145.0k | Reduced -181.9k |
| Avestar Capital, LLC 0.01% of their portfolio | 41.0k $136.9k | Unchanged |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 34.7k $115.9k | Reduced -65.8k |
| Engineers Gate Manager LP 0.00% of their portfolio | 34.3k $114.5k | Reduced -1.0k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 33.5k $112.0k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 33.3k $111.1k | Reduced -94.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 31.5k $105.1k | Reduced -30.3k |
| Graham Capital Management, L.P. 0.00% of their portfolio | 29.9k $99.9k | Reduced -1.8k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 29.9k $99.8k | Reduced -209 |
| AXQ CAPITAL, LP 0.01% of their portfolio | 29.1k $97.0k | New |
| Key Client Fiduciary Advisors, LLC 0.03% of their portfolio | 25.3k $84.4k | Reduced -2.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 24.5k $82.0k | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 23.7k $79.2k | Added +394 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 20.0k $66.8k | Reduced -7.1k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 18.4k $61.4k | Reduced -1.5k |
| TWO SIGMA SECURITIES, LLC 0.01% of their portfolio | 17.7k $59.3k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 15.9k $53.1k | First filing |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 15.5k $51.8k | Reduced -692 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 15.0k $50.1k | Reduced -61 |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 14.9k $49.8k | Added +400 |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 14.9k $50.2k | Reduced -19.2k |
| Redwood Family Wealth LLC 0.05% of their portfolio | 14.1k $47.2k | Unchanged |
| Post Resch Tallon Group Inc. 0.04% of their portfolio | 12.8k $43.7k | Unchanged |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 12.5k $41.7k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 12.4k $41.3k | Reduced -42.8k |
| Values First Advisors, Inc. 0.02% of their portfolio | 11.2k $37.4k | Added +126 |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 10.5k $35.0k | Reduced -29.4k |
| EP Wealth Advisors, LLC 0.00% of their portfolio | 10.0k $33.4k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 9.4k $31.3k | Reduced -821 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 8.5k $28.3k | Reduced -13.8k |
| FMR LLC 0.00% of their portfolio | 5.4k $18.1k | Reduced -24 |
| Pinnacle Wealth Planning Services, Inc. 0.00% of their portfolio | 3.4k $11.3k | Unchanged |
| CoreCap Advisors, LLC 0.00% of their portfolio | 2.0k $6.7k | Unchanged |
| Forum Finance Group S.A. 0.00% of their portfolio | 1.3k $4.0k | First filing |
| CHILTON CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.1k $3.5k | Unchanged |
| Covestor Ltd 0.00% of their portfolio | 915 $3.0k | Reduced -96 |
| CWM, LLC 0.00% of their portfolio | 820 $2.7k | Reduced -1.1k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 633 $2.1k | Unchanged |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 621 $2.1k | Unchanged |
| Game Plan Financial Advisors, LLC 0.00% of their portfolio | 585 $2.0k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 538 $1.8k | Unchanged |
| HUNTINGTON NATIONAL BANK 0.00% of their portfolio | 500 $1.7k | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 478 $1.6k | Reduced -895 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 433 $1.4k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 382 $1.2k | Unchanged |
| Rialto Wealth Management, LLC 0.00% of their portfolio | 305 $1.0k | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 285 $952 | New |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 274 $915 | Unchanged |
| Atlantic Union Bankshares Corp 0.00% of their portfolio | 250 $835 | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 247 $825 | Reduced -163 |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 100 $334 | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 96 $321 | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 58 $194 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 49 $0 | Reduced -2.1k |
| Root Financial Partners, LLC 0.00% of their portfolio | 25 $84 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 12 $40 | Added +7 |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 9 $30 | New |
| Advisory Services Network, LLC 0.00% of their portfolio | 5 $17 | New |
| Arax Advisory Partners 0.00% of their portfolio | 5 $17 | Unchanged |
| Parallel Advisors, LLC 0.00% of their portfolio | 5 $17 | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 1 $3 | New |