SPYRE THERAPEUTICS INC SYRE
COM NEW · Common Stock · CUSIP 00773J202
Business enterprise in United States of America
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- Founded2013
- Websiteaegleabio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($286.8k this quarter). Holder counts are more reliable. Shares outstanding: 86.8m as of 2026-04-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $50.37. Options: 2 managers hold calls ($16.4m notional), 3 hold puts ($1.6m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2023 | 28 |
| Q4 2023 | 55 |
| Q1 2024 | 103 |
| Q2 2024 | 109 |
| Q3 2024 | 121 |
| Q4 2024 | 133 |
| Q1 2025 | 131 |
| Q2 2025 | 131 |
| Q3 2025 | 138 |
| Q4 2025 | 154 |
| Q1 2026 | 199 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 74 | 40 |
| Q3 2024 | 71 | 40 |
| Q4 2024 | 87 | 42 |
| Q1 2025 | 71 | 54 |
| Q2 2025 | 81 | 43 |
| Q3 2025 | 66 | 56 |
| Q4 2025 | 102 | 41 |
| Q1 2026 | 118 | 59 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $1.0m | $602.8k | 0.57 |
| Q3 2025 | $1.6m | $838.0k | 0.52 |
| Q4 2025 | $14.6m | $2.2m | 0.15 |
| Q1 2026 | $16.4m | $1.6m | 0.10 |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +916.3k |
| Caligan Partners LP | New | +878.1k |
| BANK OF AMERICA CORP /DE/ | Added | +808.4k |
| PERCEPTIVE ADVISORS LLC | Added | +714.0k |
| Paradigm Biocapital Advisors LP | Added | +490.0k |
| Capital World Investors | Added | +466.4k |
| SAMLYN CAPITAL, LLC | New | +396.7k |
| STATE STREET CORP | Added | +344.2k |
| ADAR1 Capital Management, LLC | Added | +304.3k |
| STEMPOINT CAPITAL LP | Added | +302.8k |
Biggest sellers
| Capital International Investors | Reduced | -1.7m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold out | -710.6k |
| BRAIDWELL LP | Reduced | -701.8k |
| Point72 Asset Management, L.P. | Sold out | -662.4k |
| Commodore Capital LP | Reduced | -475.9k |
| Pictet Asset Management Holding SA | Reduced | -422.3k |
| FRANKLIN RESOURCES INC | Reduced | -226.4k |
| Blackstone Inc. | Reduced | -208.2k |
| JANUS HENDERSON GROUP PLC | Reduced | -172.8k |
| Affinity Asset Advisors, LLC | Reduced | -153.5k |
Biggest calls
| Caption Management, LLC | Reduced | $12.0m237.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.4m86.4k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $771.7k15.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $660.8k13.1k shares |
| GROUP ONE TRADING LLC | Added | $121.1k2.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-10-09 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-07-16 | 6.6% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-10-01 | 5.1% |
Fell to 5% or below in the last year: PERCEPTIVE ADVISORS LLC (4.9%, 2026-08-14), RTW INVESTMENTS, LP (4.8%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27), TANG CAPITAL MANAGEMENT LLC (2.4%, 2026-02-17)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 1 | $522.0k | — |
| Q4 2024 | 0 | — | 1 | $257.2k | $257.2k |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $299.6k | — |
| Q4 2025 | 0 | — | 1 | $1.5m | $1.5m |
| Q1 2026 | 0 | — | 2 | $1.7m | $1.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-03 | Burrows Scott L Chief Financial Officer | Sold plan | $101.6k2.5k shares |
| 2026-03-02 | Turtle Cameron Chief Executive Officer, director | Sold plan | $632.9k15.0k shares |
| 2026-02-02 | Turtle Cameron Chief Executive Officer, director | Sold plan | $492.0k15.0k shares |
| 2026-01-02 | Turtle Cameron Chief Executive Officer, director | Sold plan | $460.1k15.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.03% of their portfolio | 11.8m $594.2m | Added +142.2k |
| BlackRock, Inc. 0.00% of their portfolio | 5.5m $278.5m | Reduced -880 |
| RTW INVESTMENTS, LP 2.09% of their portfolio | 4.2m $210.4m | Unchanged |
| Fairmount Funds Management LLC 14.64% of their portfolio | 4.0m $202.7m | Unchanged |
| PERCEPTIVE ADVISORS LLC 3.77% of their portfolio | 3.8m $190.8m | Added +714.0k |
| Venrock Adviser, LLC 6.94% of their portfolio | 3.7m $185.9m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.1m $154.2m | First filing |
| Driehaus Capital Management LLC 1.03% of their portfolio | 2.8m $140.8m | Reduced -91.6k |
| STATE STREET CORP 0.00% of their portfolio | 2.6m $131.5m | Added +344.2k |
| Paradigm Biocapital Advisors LP 2.02% of their portfolio | 2.0m $98.7m | Added +490.0k |
| Commodore Capital LP 5.58% of their portfolio | 1.9m $96.5m | Reduced -475.9k |
| TCG Crossover Management, LLC 2.74% of their portfolio | 1.9m $95.9m | Unchanged |
| TANG CAPITAL MANAGEMENT LLC 4.85% of their portfolio | 1.9m $95.4m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 1.8m $92.0m | Added +275.5k |
| Capital International Investors 0.02% of their portfolio | 1.7m $88.1m | Reduced -1.7m |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.7m $86.8m | Added +61.8k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 1.7m $83.6m | Reduced -172.8k |
| RA CAPITAL MANAGEMENT, L.P. 0.87% of their portfolio | 1.6m $81.8m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.6m $80.6m | Reduced -3.2k |
| Remedium Capital Partners, LLC 26.13% of their portfolio | 1.5m $73.5m | Unchanged |
| Affinity Asset Advisors, LLC 3.78% of their portfolio | 1.3m $64.5m | Reduced -153.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.2m $61.9m | Added +808.4k |
| BAKER BROS. ADVISORS LP 0.29% of their portfolio | 1.0m $50.4m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 979.3k $44.5m | Added +916.3k |
| BRAIDWELL LP 1.57% of their portfolio | 932.8k $47.1m | Reduced -701.8k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 882.8k $44.5m | Reduced -226.4k |
| Caligan Partners LP 3.13% of their portfolio | 878.1k $44.3m | New |
| Siren, L.L.C. 1.14% of their portfolio | 818.6k $41.3m | Unchanged |
| Polar Capital Holdings Plc 0.17% of their portfolio | 792.8k $40.0m | Added +52.5k |
| UBS Group AG 0.01% of their portfolio | 671.2k $33.9m | Reduced -9.3k |
| Capital World Investors 0.00% of their portfolio | 666.6k $33.6m | Added +466.4k |
| EMERALD ADVISERS, LLC 0.98% of their portfolio | 613.4k $30.9m | Reduced -22.7k |
| Candriam S.C.A. 0.16% of their portfolio | 610.3k $30.8m | Added +184.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 585.1k $29.5m | First filing |
| NORTHERN TRUST CORP 0.00% of their portfolio | 578.9k $29.2m | Added +17.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 562.7k $28.4m | Reduced -12.0k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 491.6k $24.8m | Reduced -422.3k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 464.7k $23.4m | First filing |
| EMERALD MUTUAL FUND ADVISERS TRUST 1.00% of their portfolio | 408.1k $20.6m | Reduced -4.3k |
| SAMLYN CAPITAL, LLC 0.34% of their portfolio | 396.7k $20.0m | New |
| ADAR1 Capital Management, LLC 1.03% of their portfolio | 338.3k $17.1m | Added +304.3k |
| STEMPOINT CAPITAL LP 1.64% of their portfolio | 335.2k $16.9m | Added +302.8k |
| Blackstone Inc. 0.06% of their portfolio | 292.8k $14.8m | Reduced -208.2k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 292.1k $14.7m | Added +146.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 269.9k $13.6m | Reduced -5.1k |
| Woodline Partners LP 0.05% of their portfolio | 265.9k $13.4m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 246.7k $12.4m | Added +64.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 207.3k $10.5m | Added +145.1k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.23% of their portfolio | 193.0k $9.7m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 191.4k $9.7m | Reduced -1.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.11% of their portfolio | 186.6k $9.4m | Reduced -1.1k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 178.4k $9.0m | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio | 170.4k $8.6m | Reduced -830 |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 159.2k $8.0m | Added +121.0k |
| Nuveen, LLC 0.00% of their portfolio | 153.9k $7.8m | Added +2.9k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 148.5k $7.5m | New |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 146.6k $7.4m | Added +70.4k |
| HighVista Strategies LLC 2.04% of their portfolio | 146.3k $7.4m | Reduced -41.9k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 139.3k $7.0m | New |
| TD Asset Management Inc 0.01% of their portfolio | 137.4k $6.9m | Reduced -12.4k |
| Invesco Ltd. 0.00% of their portfolio | 132.4k $6.7m | Reduced -18.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 129.2k $6.5m | Added +7.3k |
| ARMISTICE CAPITAL, LLC 0.20% of their portfolio | 120.9k $6.1m | Reduced -75.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 112.8k $5.7m | Reduced -16.2k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 108.1k $5.5m | Added +44.2k |
| SEVEN GRAND MANAGERS, LLC 0.34% of their portfolio | 100.0k $5.0m | Unchanged |
| B Group, Inc. 3.74% of their portfolio | 100.0k $5.0m | Unchanged |
| F/m Investments LLC 0.33% of their portfolio | 99.5k $5.0m | Reduced -4.3k |
| Swiss National Bank 0.00% of their portfolio | 96.5k $4.9m | Unchanged |
| ExodusPoint Capital Management, LP 0.04% of their portfolio | 87.1k $4.4m | Added +49.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 85.1k $4.3m | Added +2.2k |
| MERCER GLOBAL ADVISORS INC /ADV 0.01% of their portfolio | 71.1k $3.6m | Reduced -35.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 70.9k $2.3m | Added +3.4k |
| Rockefeller Capital Management L.P. 0.01% of their portfolio | 64.0k $3.2m | Added +63.5k |
| ALPS ADVISORS INC 0.02% of their portfolio | 63.9k $3.2m | Added +231 |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 63.7k $2.9m | Added +2.1k |
| Atle Fund Management AB 1.13% of their portfolio | 62.7k $3.5m | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 59.6k $3.0m | New |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 59.5k $3.0m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 59.2k $3.0m | Added +11.2k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 56.9k $2.9m | Added +3.5k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 55.5k $2.8m | Reduced -18.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 54.0k $2.7m | Added +26.7k |
| Susquehanna Portfolio Strategies, LLC 0.04% of their portfolio | 53.1k $2.7m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 47.7k $2.4m | Reduced -29.6k |
| BARCLAYS PLC 0.00% of their portfolio | 45.8k $2.3m | Reduced -136.7k |
| Legal & General Group Plc 0.00% of their portfolio | 44.8k $2.3m | Reduced -11.7k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 38.4k $1.9m | Added +396 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 36.3k $1.8m | Added +1.2k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 33.2k $1.7m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 33.2k $1.7m | Reduced -49.2k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 31.1k $1.6m | First filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 29.0k $1.5m | Added +22.9k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% of their portfolio | 27.6k $1.4m | Added +2.6k |
| Cinctive Capital Management LP 0.09% of their portfolio | 27.4k $1.4m | Reduced -8.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 26.5k $1.3m | Reduced -729 |
| PROFUND ADVISORS LLC 0.05% of their portfolio | 26.0k $1.3m | Added +5.5k |
| Waverly Advisors, LLC 0.01% of their portfolio | 26.0k $1.3m | Added +12 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 25.8k $1.3m | Unchanged |
| XTX Topco Ltd 0.02% of their portfolio | 24.4k $1.2m | New |