Vault-13

SPYRE THERAPEUTICS INC SYRE

COM NEW · Common Stock · CUSIP 00773J202

Business enterprise in United States of America

109 institutional holders +6 vs Q1 2024
50,980,71551.0m shares reported held*
100.4% of all shares outstanding*
$1.2bnreported value*
27 new 47 added 17 reduced 23 sold out net bought ≈ $450.6m (+19.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 50.8m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $23.50. Options: 2 managers hold calls ($61.1k notional), 2 hold puts ($35.3k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 23: 28Q4 23: 55Q1 24: 103Q2 24: 109109Q3 23Q4 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202328
Q4 202355
Q1 2024103
Q2 2024109

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 23: 44 bought or addedQ4 23: 7 cut or sold outQ4 23Q1 24: 72 bought or addedQ1 24: 21 cut or sold outQ1 24Q2 24: 74 bought or addedQ2 24: 40 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 2023447
Q1 20247221
Q2 20247440

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20k$40k$60k$80kQ3 23 calls: $32.5kQ3 23 puts: $49Q3 23P/C 0.00Q4 23 calls: $44.3kQ4 23 puts: $86Q4 23P/C 0.00Q1 24 calls: $75.9kQ1 24 puts: $0Q1 24P/C 0.00Q2 24 calls: $61.1kQ2 24 puts: $35.3kQ2 24P/C 0.58
Numbers
QuarterCallsPutsP/C
Q3 2023$32.5k$490.00
Q4 2023$44.3k$860.00
Q1 2024$75.9k$00.00
Q2 2024$61.1k$35.3k0.58

Biggest buyers

Fairmount Funds Management LLC Added +3,639,680+3.6m
BRAIDWELL LP Added +1,999,538+2.0m
BlackRock Inc. Added +1,846,750+1.8m
VANGUARD GROUP INC Added +1,414,385+1.4m
STATE STREET CORP Added +1,275,233+1.3m
RTW INVESTMENTS, LP Added +1,025,600+1.0m
FMR LLC Added +924,228+924.2k
Logos Global Management LP Added +900,000+900.0k
JANUS HENDERSON GROUP PLC Added +659,890+659.9k
GOLDMAN SACHS GROUP INC Added +653,168+653.2k

Biggest sellers

MILLENNIUM MANAGEMENT LLC Sold out -319,563-319.6k
Cormorant Asset Management, LP Sold out -250,000-250.0k
MARSHALL WACE, LLP Sold out -161,921-161.9k
Invesco Ltd. Reduced -136,214-136.2k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Sold out -101,503-101.5k
Nicholas Investment Partners, LP Sold out -89,962-90.0k
HRT FINANCIAL LP Sold out -78,996-79.0k
Assenagon Asset Management S.A. Sold out -64,400-64.4k
MONTANOVA CAPITAL, LLC Reduced -55,085-55.1k
RENAISSANCE TECHNOLOGIES LLC Sold out -49,468-49.5k

Biggest calls

CITADEL ADVISORS LLC New $61.1k2.6k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC New $35.3k1.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-10-09 10.0% no change 10.2m≈ $860.2m 2026-10-09
BlackRock, Inc. 13G · institution filed 2025-07-16 6.6% 4.0m≈ $351.8m 2025-07-16
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-10-01 5.1% new 4.5m≈ $395.7m 2026-10-01

Fell to 5% or below in the last year: PERCEPTIVE ADVISORS LLC (4.9%, 2026-08-14), RTW INVESTMENTS, LP (4.8%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27), TANG CAPITAL MANAGEMENT LLC (2.4%, 2026-02-17)

Insider purchases and sales in Q2 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q3 22: 1 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23Q3 23: 0 buyingQ3 23: 0 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 0 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20221$50.4k0——
Q4 20220—0——
Q1 20230—0——
Q2 20230—0——
Q3 20230—0——
Q4 20230—0——
Q1 20240—0——
Q2 20240—0——

None reported in Q2 2024.

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.01% of their portfolio BOSTON, MA 7,507,9837.5m $176.5m $176.5m 0.01% Added +924.2k +924,228
2 Fairmount Funds Management LLC 10.67% of their portfolio WEST CONSHOHOCKEN, PA 4,018,1014.0m $94.5m $94.5m 10.67% Added +3.6m +3,639,680
3 RTW INVESTMENTS, LP 1.19% of their portfolio NEW YORK, NY 3,258,3603.3m $76.6m $76.6m 1.19% Added +1.0m +1,025,600
4 PERCEPTIVE ADVISORS LLC 1.72% of their portfolio NEW YORK, NY 3,031,0183.0m $71.3m $71.3m 1.72% Added +474.3k +474,339
5 Venrock Adviser, LLC 4.02% of their portfolio NEW YORK, NY 2,685,4482.7m $63.1m $63.1m 4.02% Added +513.7k +513,666
6 BRAIDWELL LP 1.85% of their portfolio STAMFORD, CT 2,514,5382.5m $59.1m $59.1m 1.85% Added +2.0m +1,999,538
7 BlackRock Inc. 0.00% of their portfolio New York, NY 2,403,4412.4m $56.5m $56.5m 0.00% Added +1.8m +1,846,750
8 Commodore Capital LP 3.19% of their portfolio NEW YORK, NY 1,988,0842.0m $46.7m $46.7m 3.19% Added +104.0k +104,000
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,911,5661.9m $44.9m $44.9m 0.00% Added +1.4m +1,414,385
10 Avoro Capital Advisors LLC 0.58% of their portfolio NEW YORK, NY 1,839,1381.8m $43.2m $43.2m 0.58% Unchanged
11 Deep Track Capital, LP 1.23% of their portfolio GREENWICH, CT 1,756,6671.8m $41.3m $41.3m 1.23% Added +543.2k +543,247
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,409,6591.4m $33.1m $33.1m 0.00% Added +1.3m +1,275,233
13 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio Boston, MA 1,152,4111.2m $27.1m $27.1m 0.05% Added +47.2k +47,211
14 Logos Global Management LP 1.57% of their portfolio San Francisco, CA 1,150,0001.1m $27.0m $27.0m 1.57% Added +900.0k +900,000
15 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 893,083893.1k $21.0m $21.0m 0.00% Added +653.2k +653,168
16 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 795,946795.9k $18.7m $18.7m 0.00% Reduced -16.9k -16,914
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 765,834765.8k $18.0m $18.0m 0.00% Added +435.6k +435,609
18 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 741,904741.9k $17.4m $17.4m 0.01% Unchanged
19 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 707,586707.6k $16.6m $16.6m 0.02% Reduced -4 -4
20 Boxer Capital, LLC 0.86% of their portfolio San Diego, CA 696,480696.5k $16.4m $16.4m 0.86% Added +446.5k +446,480
21 Driehaus Capital Management LLC 0.16% of their portfolio Chicago, IL 687,080687.1k $16.2m $16.2m 0.16% Unchanged
22 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 673,867673.9k $15.9m $15.9m 0.01% Added +659.9k +659,890
23 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.09% of their portfolio SAN FRANCISCO, CA 666,000666.0k $15.7m $15.7m 0.09% Added +200.0k +200,000
24 Affinity Asset Advisors, LLC 1.90% of their portfolio NEW YORK, NY 513,420513.4k $12.1m $12.1m 1.90% Added +103.4k +103,420
25 Polar Capital Holdings Plc 0.07% of their portfolio London, X0 500,000500.0k $11.8m $11.8m 0.07% Unchanged
26 First Turn Management, LLC 1.78% of their portfolio DEL MAR, CA 464,435464.4k $10.9m $10.9m 1.78% Unchanged
27 Darwin Global Management, Ltd. 1.19% of their portfolio ST. HELIER, Y9 452,040452.0k $10.3m $10.3m 1.19% Reduced -21.2k -21,160
28 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 408,853408.9k $9.6m $9.6m 0.00% Added +255.3k +255,289
29 Pictet Asset Management Holding SA 0.01% of their portfolio CAROUGE, V8 386,617386.6k $9.1m $9.1m 0.01% New
30 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 307,976308.0k $7.2m $7.2m 0.00% Added +229.4k +229,447
31 Blackstone Inc. 0.03% of their portfolio NEW YORK, NY 292,995293.0k $6.9m $6.9m 0.03% Added +273.0k +273,004
32 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 275,226275.2k $6.5m $6.5m 0.02% Added +87.2k +87,173
33 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 272,636272.6k $6.4m $6.4m 0.02% Added +240.2k +240,239
34 Woodline Partners LP 0.06% of their portfolio San Francisco, CA 262,616262.6k $6.2m $6.2m 0.06% Added +162.1k +162,089
35 Ghost Tree Capital, LLC 2.05% of their portfolio NEW YORK, NY 250,237250.2k $5.9m $5.9m 2.05% Added +150.2k +150,237
36 Avidity Partners Management LP 0.19% of their portfolio DALLAS, TX 195,000195.0k $4.6m $4.6m 0.19% New
37 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 191,169191.2k $4.5m $4.5m 0.00% Added +154.8k +154,837
38 Walleye Capital LLC 0.04% of their portfolio NEW YORK, NY 150,820150.8k $3.5m $3.5m 0.04% Added +39.3k +39,342
39 STEMPOINT CAPITAL LP 1.04% of their portfolio NEW YORK, NY 150,450150.4k $3.5m $3.5m 1.04% Added +88.2k +88,197
40 SOROS FUND MANAGEMENT LLC 0.08% of their portfolio NEW YORK, NY 145,000145.0k $3.4m $3.4m 0.08% Added +115.0k +114,962
41 ARMISTICE CAPITAL, LLC 0.08% of their portfolio NEW YORK, NY 136,000136.0k $3.2m $3.2m 0.08% New
42 GREAT POINT PARTNERS LLC 0.61% of their portfolio Greenwich, CT 134,612134.6k $3.2m $3.2m 0.61% Added +9.6k +9,612
43 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 117,686117.7k $2.8m $2.8m 0.00% Added +111.6k +111,636
44 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 117,140117.1k $2.8m $2.8m 0.00% New
45 HighVista Strategies LLC 0.98% of their portfolio BOSTON, MA 113,550113.5k $2.7m $2.7m 0.98% Reduced -40.8k -40,831
46 MONTANOVA CAPITAL, LLC 0.10% of their portfolio New York, NY 107,310107.3k $2.5m $2.5m 0.10% Reduced -55.1k -55,085
47 Candriam S.C.A. 0.01% of their portfolio STRASSEN, N4 105,000105.0k $2.5m $2.5m 0.01% Unchanged
48 Integral Health Asset Management, LLC 0.23% of their portfolio New York, NY 100,000100.0k $2.4m $2.4m 0.23% Unchanged
49 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 98,18198.2k $2.3m $2.3m 0.00% Added +83.2k +83,181
50 Jefferies Financial Group Inc. 0.05% of their portfolio NEW YORK, NY 97,57397.6k $2.3m $2.3m 0.05% New
51 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 85,58885.6k $2.0m $2.0m 0.00% Added +19.2k +19,248
52 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 82,47582.5k $1.9m $1.9m 0.00% New
53 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 78,50078.5k $1.8m $1.8m 0.01% Added +43.0k +43,000
54 NORGES BANK 0.00% of their portfolio OSLO, Q8 70,84370.8k $1.7m $1.7m 0.00% Not comparable
55 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 67,10967.1k $1.6m $1.6m 0.01% New
56 Jump Financial, LLC 0.03% of their portfolio Chicago, IL 64,90064.9k $1.5m $1.5m 0.03% Added +42.1k +42,100
57 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 64,04364.0k $1.5m $1.5m 0.00% Added +18.1k +18,081
58 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 51,89651.9k $1.2m $1.2m 0.00% New
59 SUPERSTRING CAPITAL MANAGEMENT LP 1.35% of their portfolio NEW YORK, NY 45,57145.6k $1.1m $1.1m 1.35% New
60 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 45,54445.5k $1.1m $1.1m 0.00% Added +45.5k +45,522
61 UBS Group AG 0.00% of their portfolio ZURICH, V8 44,50444.5k $1.0m $1.0m 0.00% Added +41.9k +41,903
62 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 37,78237.8k $888.3k $888.3k 0.00% Added +13.1k +13,125
63 EFG Asset Management (North America) Corp. 0.15% of their portfolio Portland, OR 36,78136.8k $868.8k $868.8k 0.15% Added +25.6k +25,630
64 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 36,23036.2k $851.8k $851.8k 0.00% New
65 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio HOUSTON, TX 36,10036.1k $848.7k $848.7k 0.02% New
66 Swiss National Bank 0.00% of their portfolio ZURICH, V8 36,10036.1k $848.7k $848.7k 0.00% Reduced -3.0k -3,000
67 ADAR1 Capital Management, LLC 0.17% of their portfolio AUSTIN, TX 35,18035.2k $827.1k $827.1k 0.17% Reduced -14.3k -14,320
68 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 35,16835.2k $826.8k $826.8k 0.00% Reduced -25.8k -25,800
69 NBW CAPITAL LLC 0.16% of their portfolio BOSTON, MA 34,36034.4k $807.8k $807.8k 0.16% Unchanged
70 Alpine Global Management, LLC 0.14% of their portfolio NEW YORK, NY 33,85833.9k $796.0k $796.0k 0.14% New
71 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 30,12130.1k $708.1k $708.1k 0.00% New
72 Legal & General Group Plc 0.00% of their portfolio London, X0 23,26323.3k $546.9k $546.9k 0.00% Added +6.2k +6,231
73 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 19,32019.3k $454.2k $454.2k 0.00% Reduced -12.4k -12,437
74 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 19,10519.1k $449.2k $449.2k 0.00% Added +1.3k +1,302
75 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 18,62518.6k $438.1k $438.1k 0.00% First filing
76 Global Endowment Management, LP 0.05% of their portfolio CHARLOTTE, NC 18,18418.2k $427.5k $427.5k 0.05% Unchanged
77 Informed Momentum Co LLC 0.07% of their portfolio SOLANA BEACH, CA 17,93817.9k $421.7k $421.7k 0.07% Unchanged
78 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 17,17517.2k $403.8k $403.8k 0.00% Added +14.9k +14,933
79 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 16,36416.4k $384.7k $384.7k 0.00% Reduced -136.2k -136,214
80 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 16,24516.2k $381.9k $381.9k 0.00% Added +15.9k +15,947
81 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 14,36514.4k $337.7k $337.7k 0.00% Reduced -305 -305
82 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 13,93213.9k $327.5k $327.5k 0.00% Reduced -700 -700
83 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 12,67212.7k $297.9k $297.9k 0.00% Reduced -45.0k -45,006
84 PROFUND ADVISORS LLC 0.01% of their portfolio BETHESDA, MD 12,60612.6k $296.4k $296.4k 0.01% New
85 Aquatic Capital Management LLC 0.01% of their portfolio CHICAGO, IL 11,80011.8k $277.4k $277.4k 0.01% New
86 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 11,60711.6k $272.9k $272.9k 0.00% New
87 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 11,55111.6k $271.6k $271.6k 0.00% Added +4.3k +4,341
88 Virtu Financial LLC 0.02% of their portfolio New York, NY 11,01611.0k $259.0k $259.0k 0.02% Reduced -5.2k -5,197
89 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 9,8429.8k $231.4k $231.4k 0.00% Reduced -3.5k -3,513
90 Carlyle Group Inc. 0.02% of their portfolio WASHINGTON, DC 9,6209.6k $226.9k $226.9k 0.02% Unchanged
91 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 9,0309.0k $212.3k $212.3k 0.00% New
92 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 8,7888.8k $206.6k $206.6k 0.00% New
93 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 5,5455.5k $130.0k $130.0k 0.00% New
94 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 3,3923.4k $79.7k $79.7k 0.00% New
95 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,3843.4k $79.6k $79.6k 0.00% Reduced -444 -444
96 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 3,2563.3k $77.0k $77.0k 0.00% Added +3.2k +3,200
97 VIRTUS ADVISERS, LLC 0.03% of their portfolio HARTFORD, CT 2,7972.8k $65.8k $65.8k 0.03% Reduced -3.0k -3,041
98 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 2,5262.5k $57.4k $57.4k 0.00% First filing
99 AlphaQuest LLC 0.00% of their portfolio New York, NY 1,5231.5k $35.8k $35.8k 0.00% New
100 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 1,1981.2k $28.0k $28.0k 0.00% New