Vault-13

AEGLEA BIOTHERAPEUTICS INC AGLE

COM · Common Stock · CUSIP 00773J103

45 institutional holders -1 vs Q1 2023
70,897,64170.9m shares reported held*
$32.0mreported value*
14 new 6 added 9 reduced 15 sold out net bought ≈ $13.3m (+29.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.45. Options: 2 managers hold calls ($0 notional), 3 hold puts ($1.1k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 56Q4 22: 52Q1 23: 46Q2 23: 4545Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202256
Q4 202252
Q1 202346
Q2 202345

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 21 bought or addedQ4 22: 25 cut or sold outQ4 22Q1 23: 12 bought or addedQ1 23: 17 cut or sold outQ1 23Q2 23: 20 bought or addedQ2 23: 24 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20222125
Q1 20231217
Q2 20232024

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5k$10k$15kQ3 22 calls: $8.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $11.4kQ4 22 puts: $225Q4 22P/C 0.02Q1 23 calls: $0Q1 23 puts: $145Q1 23P/C —Q2 23 calls: $0Q2 23 puts: $1.1kQ2 23P/C —
Numbers
QuarterCallsPutsP/C
Q3 2022$8.0k$00.00
Q4 2022$11.4k$2250.02
Q1 2023$0$145—
Q2 2023$0$1.1k—

Biggest buyers

Fairmount Funds Management LLC New +9,460,540+9.5m
WELLINGTON MANAGEMENT GROUP LLP New +8,819,168+8.8m
Venrock Adviser, LLC New +6,343,221+6.3m
EcoR1 Capital, LLC New +5,000,000+5.0m
Affinity Asset Advisors, LLC New +4,900,000+4.9m
Driehaus Capital Management LLC New +4,643,357+4.6m
Logos Global Management LP New +3,142,880+3.1m
Commodore Capital LP New +2,908,100+2.9m
GOLDMAN SACHS GROUP INC New +558,650+558.6k
Avoro Capital Advisors LLC New +286,459+286.5k

Biggest sellers

Bain Capital Life Sciences Investors, LLC Sold out -5,347,689-5.3m
Sio Capital Management, LLC Sold out -3,004,959-3.0m
ORBIMED ADVISORS LLC Sold out -1,797,221-1.8m
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -1,500,000-1.5m
VANGUARD GROUP INC Reduced -1,349,544-1.3m
MILLENNIUM MANAGEMENT LLC Reduced -1,283,262-1.3m
SPHERA FUNDS MANAGEMENT LTD. Sold out -646,478-646.5k
Nantahala Capital Management, LLC Reduced -456,819-456.8k
TWO SIGMA INVESTMENTS, LP Sold out -320,498-320.5k
Assenagon Asset Management S.A. Sold out -318,451-318.5k

Biggest calls

CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC Unchanged $0200 shares

Biggest puts

SIMPLEX TRADING, LLC New $1.0k3.6k shares
GROUP ONE TRADING LLC Reduced $135300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Fairmount Funds Management LLC 0.60% of their portfolio WEST CONSHOHOCKEN, PA 9,460,5409.5m $4.3m $4.3m 0.60% New
2 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 8,819,1688.8m $4.0m $4.0m 0.00% New
3 Venrock Adviser, LLC 0.46% of their portfolio NEW YORK, NY 6,343,2216.3m $2.9m $2.9m 0.46% New
4 EcoR1 Capital, LLC 0.06% of their portfolio San Francisco, CA 5,000,0005.0m $2.3m $2.3m 0.06% New
5 Affinity Asset Advisors, LLC 0.87% of their portfolio NEW YORK, NY 4,900,0004.9m $2.2m $2.2m 0.87% New
6 Driehaus Capital Management LLC 0.03% of their portfolio Chicago, IL 4,643,3574.6m $2.1m $2.1m 0.03% New
7 Nantahala Capital Management, LLC 0.22% of their portfolio NEW CANAAN, CT 4,101,1934.1m $1.8m $1.8m 0.22% Reduced -456.8k -456,819
8 MONTANOVA CAPITAL, LLC 0.10% of their portfolio New York, NY 4,059,8944.1m $1.8m $1.8m 0.10% Unchanged
9 Rock Springs Capital Management LP 0.04% of their portfolio Baltimore, MD 3,413,9063.4m $1.5m $1.5m 0.04% Unchanged
10 BAKER BROS. ADVISORS LP 0.01% of their portfolio NEW YORK, NY 3,410,1063.4m $1.5m $1.5m 0.01% Unchanged
11 Logos Global Management LP 0.20% of their portfolio San Francisco, CA 3,142,8803.1m $1.4m $1.4m 0.20% New
12 Commodore Capital LP 0.15% of their portfolio NEW YORK, NY 2,908,1002.9m $1.3m $1.3m 0.15% New
13 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 2,453,2212.5m $1.1m $1.1m 0.00% Reduced -1.3m -1,283,262
14 Aisling Capital Management LP 0.37% of their portfolio NEW YORK, NY 1,691,1511.7m $761.9k $761.9k 0.37% Unchanged
15 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 1,391,3811.4m $625.0k $625.0k 0.00% Unchanged
16 SAMSARA BIOCAPITAL, LLC 0.07% of their portfolio PALO ALTO, CA 883,720883.7k $398.1k $398.1k 0.07% Unchanged
17 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 648,053648.1k $291.9k $291.9k 0.00% Reduced -1.3m -1,349,544
18 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 600,455600.5k $270.5k $270.5k 0.00% Unchanged
19 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 558,650558.6k $251.7k $251.7k 0.00% New
20 BlackRock Inc. 0.00% of their portfolio New York, NY 528,897528.9k $238.3k $238.3k 0.00% Reduced -119.8k -119,751
21 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 393,000393.0k $177.0k $177.0k 0.00% Added +211.9k +211,900
22 Avoro Capital Advisors LLC 0.00% of their portfolio NEW YORK, NY 286,459286.5k $129.1k $129.1k 0.00% New
23 UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 0.04% of their portfolio AUSTIN, TX 245,678245.7k $111.0k $111.0k 0.04% Unchanged
24 Carlyle Group Inc. 0.00% of their portfolio WASHINGTON, DC 240,500240.5k $108.2k $108.2k 0.00% Unchanged
25 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 195,089195.1k $87.9k $87.9k 0.00% Reduced -19.9k -19,900
26 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 164,528164.5k $74.0k $74.0k 0.00% New
27 Yu Fan 3.96% of their portfolio CENTRAL, HONG KONG, K3 112,044112.0k $50.5k $50.5k 3.96% Unchanged
28 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 97,92797.9k $44.1k $44.1k 0.00% Unchanged
29 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 54,27854.3k $24.5k $24.5k 0.00% Added +11.5k +11,515
30 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 36,17936.2k $16.3k $16.3k 0.00% New
31 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 31,36431.4k $14.1k $14.1k 0.00% Unchanged
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 23,23323.2k $10.5k $10.5k 0.00% Unchanged
33 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 22,74922.7k $10.3k $10.3k 0.00% Reduced -14.6k -14,632
34 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 8,7468.7k $3.9k $3.9k 0.00% Added +522 +522
35 UBS Group AG 0.00% of their portfolio ZURICH, V8 8,0918.1k $3.6k $3.6k 0.00% Added +8.1k +8,084
36 IFP Advisors, Inc 0.00% of their portfolio TAMPA, FL 5,7205.7k $29.9k $29.9k 0.00% Added +2.9k +2,860
37 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 5,0005.0k $2.3k $2.3k 0.00% New
38 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 3,3063.3k $1.5k $1.5k 0.00% Reduced -10.3k -10,350
39 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 2,8002.8k $1.0k $1.0k 0.00% Added +2.7k +2,744
40 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 1,3171.3k $1.0k $1.0k 0.00% New
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,0681.1k $481 $481 0.00% Unchanged
42 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 572572 $258 $258 0.00% Reduced -2.3k -2,310
43 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 9999 $45 $45 0.00% Unchanged
44 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 11 $0 $0 0.00% Reduced -395 -395
45 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged