ADAGENE INC ADAG
ADS · ADR · CUSIP 005329107
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $4.21.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 12 |
| Q4 2022 | 10 |
| Q1 2023 | 12 |
| Q2 2023 | 11 |
| Q3 2023 | 11 |
| Q4 2023 | 12 |
| Q1 2024 | 18 |
| Q2 2024 | 15 |
| Q3 2024 | 14 |
| Q4 2024 | 16 |
| Q1 2025 | 15 |
| Q2 2025 | 16 |
| Q3 2025 | 17 |
| Q4 2025 | 17 |
| Q1 2026 | 25 |
| Q2 2026 | 36 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 3 | 5 |
| Q4 2024 | 8 | 2 |
| Q1 2025 | 3 | 8 |
| Q2 2025 | 6 | 5 |
| Q3 2025 | 5 | 7 |
| Q4 2025 | 7 | 7 |
| Q1 2026 | 13 | 9 |
| Q2 2026 | 26 | 11 |
Biggest buyers
| DEERFIELD MANAGEMENT COMPANY, L.P. | New | +2.7m |
| Siren, L.L.C. | New | +2.7m |
| Squadron Capital Management LLC | New | +1.2m |
| AMERIPRISE FINANCIAL INC | Added | +1.1m |
| CITADEL ADVISORS LLC | New | +506.9k |
| Dauntless Investment Group, LLC | Added | +502.5k |
| Birchview Capital, LP | New | +240.0k |
| MONETA GROUP INVESTMENT ADVISORS LLC | New | +200.0k |
| Pathstone Holdings, LLC | New | +199.6k |
| UBS Group AG | Added | +120.1k |
Biggest sellers
| Exome Asset Management LLC | Reduced | -248.6k |
| MORGAN STANLEY | Reduced | -58.2k |
| Persistent Asset Partners Ltd | Sold out | -35.1k |
| Alyeska Investment Group, L.P. | Sold out | -20.7k |
| NOMURA HOLDINGS INC | Sold out | -14.7k |
| Invesco Ltd. | Reduced | -4.2k |
| JANE STREET GROUP, LLC | Reduced | -2.9k |
| EverSource Wealth Advisors, LLC | Sold out | -2.5k |
| BARCLAYS PLC | Sold out | -400 |
| JPMORGAN CHASE & CO | Reduced | -260 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Luo Peter
13D · may seek influence
-4.4 pts · filed 2026-06-08
Stated purposeOn May 23, 2025, Mr. Luo received 191,667 ordinary shares from Great Han Fortune LP for the benefit of Peter Luo, and Xiaohong She received 23,333 ordinary shares from Great Han Fortune LP for the benefit of Xiaohong She. On May 23, 2025, Mr. Luo and Xiaohong She transferred 191,667 and 23,333 ordinary shares respectively to HAN 2020 Irrevocable Trust, for estate planning purpose. Due to the operation of the Concert Party Agreement dated December 14, 2020 among members of Peter Luo-Acting-in-Concert-Group, Peter Luo may be deemed to acquire or dispose additional beneficial ownership from time to time due to the acquisition or disposal of beneficial ownership by the members of Peter Luo-Acting-in-Concert-Group. The Reporting Persons acquired the ordinary shares reported herein for invest… Full filing |
11.2% |
| JANUS HENDERSON GROUP PLC 13G · institution new · filed 2026-05-07 | 10.1% |
| Smith Vincent C 13G · passive investor +1.8 pts · filed 2026-01-29 | 8.7% |
| Chernett Jorey 13G · passive investor new · filed 2026-03-18 | 5.1% |
Fell to 5% or below in the last year: WuXi PharmaTech Healthcare Fund I L.P. (3.5%, 2026-08-14), GENERAL ATLANTIC, L.P. (0.0%, 2026-02-17), Panacea Innovation Ltd (3.8%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 3 | $162.3k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-23 | Tam Man Kin Chief Financial Officer, director · American Depositary Shares (ADSs) | Bought | $6.0k2.0k shares |
| 2026-09-16 | Luo Peter Chief Executive Officer, director · American Depositary Shares (ADS) | Bought | $63.9k20.3k shares |
| 2026-08-14 | DO CUONG V Director · American Depositary Shares (ADS) | Bought | $7.5k2.0k shares |
| 2026-08-05 | Luo Peter Chief Executive Officer, director · American Depositary Shares (ADS) | Bought | $1.0k279 shares |
| 2026-08-04 | Luo Peter Chief Executive Officer, director · American Depositary Shares (ADS) | Bought | $83.8k23.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Jupiter Topco LLC 0.01% of their portfolio | 6.7m $28.1m | First filing |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.12% of their portfolio | 2.7m $11.2m | New |
| Siren, L.L.C. 0.23% of their portfolio | 2.7m $11.2m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 1.7m $7.2m | Added +1.1m |
| HSG Holding Ltd 0.47% of their portfolio | 1.3m $5.6m | Unchanged |
| Squadron Capital Management LLC 1.80% of their portfolio | 1.2m $5.2m | New |
| Dauntless Investment Group, LLC 3.91% of their portfolio | 537.2k $2.3m | Added +502.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 506.9k $2.1m | New |
| Exome Asset Management LLC 1.27% of their portfolio | 488.3k $2.1m | Reduced -248.6k |
| Birchview Capital, LP 0.47% of their portfolio | 240.0k $1.0m | New |
| MONETA GROUP INVESTMENT ADVISORS LLC 0.01% of their portfolio | 200.0k $840.0k | New |
| Pathstone Holdings, LLC 0.00% of their portfolio | 199.6k $838.4k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 146.5k $615.3k | Added +112.0k |
| UBS Group AG 0.00% of their portfolio | 124.1k $521.1k | Added +120.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 105.6k $443.5k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 80.5k $338.0k | Added +68.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 69.1k $290.2k | New |
| Invesco Ltd. 0.00% of their portfolio | 42.9k $180.4k | Reduced -4.2k |
| SmartHarvest Portfolios, LLC 0.06% of their portfolio | 41.7k $175.1k | Added +1.4k |
| Kamunting Street Capital Management, L.P. 0.09% of their portfolio | 38.1k $160.0k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 27.5k $115.4k | Reduced -2.9k |
| HRT FINANCIAL LP 0.00% of their portfolio | 21.7k $91.0k | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 18.0k $75.6k | Added +7.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 17.1k $72.0k | Added +220 |
| XTX Topco Ltd 0.00% of their portfolio | 12.3k $51.5k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 12.0k $50.2k | New |
| MORGAN STANLEY 0.00% of their portfolio | 8.0k $33.4k | Reduced -58.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 7.9k $33.2k | Added +4.2k |
| HUNTINGTON NATIONAL BANK 0.00% of their portfolio | 2.5k $10.3k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 1.5k $6.4k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.1k $4.4k | New |
| BlackRock, Inc. 0.00% of their portfolio | 635 $2.7k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 452 $1.9k | Reduced -260 |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 420 $1.8k | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 48 $202 | Added +20 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 13 $55 | Reduced -56 |