ACTUATE THERAPEUTICS INC ACTU
COM · Common Stock · CUSIP 005083100
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersFort Worth, TX
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.0k this quarter). Holder counts are more reliable. Shares outstanding: 24.0m as of 2026-08-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.53.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 11 |
| Q4 2024 | 20 |
| Q1 2025 | 26 |
| Q2 2025 | 39 |
| Q3 2025 | 43 |
| Q4 2025 | 45 |
| Q1 2026 | 61 |
| Q2 2026 | 64 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 13 | 6 |
| Q1 2025 | 19 | 4 |
| Q2 2025 | 32 | 10 |
| Q3 2025 | 24 | 13 |
| Q4 2025 | 29 | 15 |
| Q1 2026 | 38 | 14 |
| Q2 2026 | 34 | 34 |
Biggest buyers
| AQR CAPITAL MANAGEMENT LLC | Added | +100.4k |
| MILLENNIUM MANAGEMENT LLC | New | +96.7k |
| JANE STREET GROUP, LLC | New | +39.1k |
| HighTower Advisors, LLC | New | +36.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | +28.2k |
| ABS Direct Equity Fund LLC | Added | +23.2k |
| GOLDMAN SACHS GROUP INC | Added | +23.1k |
| Mariner, LLC | New | +21.1k |
| Qube Research & Technologies Ltd | New | +15.3k |
| Virtu Financial LLC | New | +14.6k |
Biggest sellers
| BlackRock, Inc. | Reduced | -337.1k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -115.8k |
| Connective Capital Management, LLC | Sold out | -113.3k |
| NORTHERN TRUST CORP | Reduced | -76.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Sold out | -55.5k |
| STATE STREET CORP | Reduced | -44.2k |
| DEUTSCHE BANK AG\ | Reduced | -24.2k |
| ROYAL BANK OF CANADA | Reduced | -21.7k |
| Bank of New York Mellon Corp | Sold out | -15.4k |
| XTX Topco Ltd | Sold out | -15.1k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BIOS Fund I, LP 13D · may seek influence -2.6 pts · filed 2025-06-30 | 49.8% |
| Voss Capital, LP 13G · passive investor +2.4 pts · filed 2026-04-22 | 7.7% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 3 | $500.0k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 1 | $1.6m | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BIOS Capital Management, LP 36.90% of their portfolio | 10.0m $15.4m | Unchanged |
| Voss Capital, LP 0.13% of their portfolio | 1.7m $2.6m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 393.4k $602.0k | Reduced -7.1k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 127.5k $195.1k | Added +100.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 112.6k $172.2k | Reduced -115.8k |
| Texas Capital Bank Wealth Management Services Inc 0.01% of their portfolio | 102.6k $157.0k | Added +8.0k |
| Palogic Value Management, L.P. 0.05% of their portfolio | 100.0k $153.0k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 96.7k $147.9k | New |
| BlackRock, Inc. 0.00% of their portfolio | 90.0k $137.8k | Reduced -337.1k |
| ABS Investment Management LLC 0.07% of their portfolio | 73.2k $112.0k | First filing |
| ABS Direct Equity Fund LLC 0.07% of their portfolio | 73.2k $112.0k | Added +23.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 54.5k $83.4k | Reduced -8.1k |
| Rock Creek Group LLC 0.01% of their portfolio | 39.3k $60.1k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 39.1k $59.9k | New |
| HighTower Advisors, LLC 0.00% of their portfolio | 36.5k $55.8k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 35.5k $54.3k | Added +23.1k |
| SFMG, LLC 0.00% of their portfolio | 33.0k $50.5k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 28.2k $43.1k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 23.5k $35.9k | Reduced -7.5k |
| STATE STREET CORP 0.00% of their portfolio | 21.9k $33.4k | Reduced -44.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 21.2k $32.5k | Reduced -76.6k |
| Mariner, LLC 0.00% of their portfolio | 21.1k $32.3k | New |
| Gleason Group, Inc. 0.00% of their portfolio | 19.0k $29.1k | Unchanged |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 18.5k $28.3k | Reduced -12.9k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 15.3k $23.3k | New |
| Virtu Financial LLC 0.00% of their portfolio | 14.6k $22.0k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 14.0k $21.0k | New |
| Apollon Wealth Management, LLC 0.00% of their portfolio | 14.0k $21.4k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 13.9k $21.3k | New |
| ACT Advisors, LLC. 0.01% of their portfolio | 12.9k $19.7k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 12.2k $18.7k | Reduced -24.2k |
| LPL Financial LLC 0.00% of their portfolio | 12.0k $18.3k | Reduced -1.0k |
| Sowell Financial Services LLC 0.00% of their portfolio | 11.0k $16.8k | New |
| Green Ridge Wealth Planning LLC 0.01% of their portfolio | 10.0k $15.3k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 7.6k $12.0k | Added +3.8k |
| Global Retirement Partners, LLC 0.00% of their portfolio | 6.2k $9.6k | First filing |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 5.1k $7.8k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.6k $5.6k | Reduced -2.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 3.6k $5.5k | Reduced -5.7k |
| UBS Group AG 0.00% of their portfolio | 3.5k $5.4k | Added +1.6k |
| MORGAN STANLEY 0.00% of their portfolio | 3.5k $5.3k | Reduced -3.4k |
| FMR LLC 0.00% of their portfolio | 3.3k $5.0k | Reduced -5.7k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 2.5k $3.8k | Added +2.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.4k $3.7k | Reduced -3.4k |
| Arax Advisory Partners 0.00% of their portfolio | 1.3k $2.0k | Added +1.3k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.0k $1.5k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 990 $1.5k | Reduced -1.5k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 673 $1.0k | Added +89 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 483 $1.0k | Reduced -21.7k |
| BARCLAYS PLC 0.00% of their portfolio | 421 $645 | Reduced -1.8k |
| CITIGROUP INC 0.00% of their portfolio | 395 $604 | Reduced -103 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 334 $511 | Added +247 |
| Allworth Financial LP 0.00% of their portfolio | 286 $438 | Added +246 |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 265 $406 | Added +230 |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 181 $278 | New |
| Essential Partners LLC 0.00% of their portfolio | 167 $256 | Added +119 |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 124 $190 | Added +111 |
| IFP Advisors, Inc 0.00% of their portfolio | 73 $112 | Added +72 |
| GAMMA Investing LLC 0.00% of their portfolio | 65 $99 | Reduced -221 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 46 $70 | Added +39 |
| Fortitude Family Office, LLC 0.00% of their portfolio | 30 $46 | New |
| True Wealth Design, LLC 0.00% of their portfolio | 29 $45 | Added +15 |
| SJS Investment Consulting Inc. 0.00% of their portfolio | 10 $16 | Added +9 |
| JPL Wealth Management, LLC 0.00% of their portfolio | 1 $2 | New |