ACRIVON THERAPEUTICS INC ACRV
COMMON STOCK · Common Stock · CUSIP 004890109
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 42.9m as of 2026-08-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.78.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 19 |
| Q1 2023 | 40 |
| Q2 2023 | 41 |
| Q3 2023 | 44 |
| Q4 2023 | 43 |
| Q1 2024 | 49 |
| Q2 2024 | 56 |
| Q3 2024 | 56 |
| Q4 2024 | 64 |
| Q1 2025 | 64 |
| Q2 2025 | 54 |
| Q3 2025 | 48 |
| Q4 2025 | 48 |
| Q1 2026 | 44 |
| Q2 2026 | 46 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 23 | 21 |
| Q4 2024 | 25 | 20 |
| Q1 2025 | 24 | 27 |
| Q2 2025 | 26 | 41 |
| Q3 2025 | 17 | 30 |
| Q4 2025 | 24 | 18 |
| Q1 2026 | 18 | 24 |
| Q2 2026 | 27 | 13 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | Added | +3.9m |
| ACADIAN ASSET MANAGEMENT LLC | Added | +319.1k |
| TWO SIGMA INVESTMENTS, LP | Added | +252.1k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +230.0k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +220.0k |
| Sands Capital Alternatives, LLC | Added | +166.7k |
| XTX Topco Ltd | Added | +111.4k |
| VANGUARD FIDUCIARY TRUST CO | Added | +76.6k |
| CITADEL ADVISORS LLC | New | +41.3k |
| BlackRock, Inc. | Added | +30.2k |
Biggest sellers
| JANE STREET GROUP, LLC | Reduced | -165.0k |
| PANAGORA ASSET MANAGEMENT INC | Sold out | -33.8k |
| MORGAN STANLEY | Reduced | -31.4k |
| MARSHALL WACE, LLP | Reduced | -28.6k |
| Squarepoint Ops LLC | Reduced | -14.2k |
| TWO SIGMA SECURITIES, LLC | Sold out | -11.7k |
| Marex Group Ltd | Reduced | -10.0k |
| Vanguard Global Advisers, LLC | Sold out | -4.5k |
| WELLS FARGO & COMPANY/MN | Sold out | -3.0k |
| Tower Research Capital LLC (TRC) | Reduced | -2.8k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence +7.2 pts · filed 2026-04-23 | 28.8% |
| Sands Capital Life Sciences Pulse Fund II, L.P. 13G · passive investor -1.5 pts · filed 2026-08-13 | 5.3% |
Fell to 5% or below in the last year: CITADEL ADVISORS LLC (0.0%, 2026-05-15)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 3 | $114.5k | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 6 | $39.9k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-25 | Blume-Jensen Peter +1 President and CEO, director | Sold | $31.0k14.0k shares |
| 2026-08-18 | Blume-Jensen Peter +1 President and CEO, director | Sold | $2.5k1.2k shares |
| 2026-08-18 | Devroe Eric Chief Operating Officer | Sold | $1.2k604 shares |
| 2026-08-18 | Blume-Jensen Peter +1 President and CEO, director | Sold | $973484 shares |
| 2026-08-18 | Gamelin Erick Chief Development Officer | Sold | $804400 shares |
| 2026-08-18 | Miller Mary Chief Legal Officer | Sold | $372185 shares |
| 2026-08-18 | Peterson Katharine Chief Accounting Officer | Sold | $203101 shares |
| 2026-08-04 | Levy Adam D. Chief Financial Officer | Sold | $1.8k1.1k shares |
| 2026-07-21 | Miller Mary Chief Legal Officer | Sold | $1.0k573 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.19% of their portfolio | 12.2m $21.8m | Added +3.9m |
| Sands Capital Alternatives, LLC 0.66% of their portfolio | 2.3m $4.1m | Added +166.7k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.2m $2.1m | Added +319.1k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 952.0k $1.7m | Added +230.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 888.1k $1.6m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 758.9k $1.4m | Added +423 |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 641.5k $1.1m | Added +252.1k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 531.9k $946.7k | Reduced -28.6k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 378.9k $674.4k | Added +220.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 265.2k $472.3k | Added +28.9k |
| BlackRock, Inc. 0.00% of their portfolio | 239.1k $425.6k | Added +30.2k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 200.4k $357.0k | Added +13.7k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 184.1k $327.7k | Added +76.6k |
| XTX Topco Ltd 0.00% of their portfolio | 178.2k $317.3k | Added +111.4k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 74.6k $132.9k | Reduced -165.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 67.2k $119.6k | Added +18.3k |
| STATE STREET CORP 0.00% of their portfolio | 67.1k $119.5k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 43.9k $78.1k | Added +9.2k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 41.3k $73.5k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 29.3k $52.2k | Added +11.0k |
| Spark Investment Management LLC 0.10% of their portfolio | 28.3k $50.4k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 24.0k $42.7k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 16.4k $29.2k | Reduced -106 |
| Verdad Advisers, LP 0.03% of their portfolio | 15.1k $26.8k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 14.9k $26.6k | Added +178 |
| Squarepoint Ops LLC 0.00% of their portfolio | 13.3k $23.7k | Reduced -14.2k |
| AAF Wealth Management, LLC 0.01% of their portfolio | 10.7k $19.0k | Unchanged |
| HRT FINANCIAL LP 0.00% of their portfolio | 10.3k $18.0k | New |
| Marex Group Ltd 0.00% of their portfolio | 10.0k $17.8k | Reduced -10.0k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 7.9k $14.1k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 7.4k $13.1k | Added +1.4k |
| FMR LLC 0.00% of their portfolio | 7.0k $12.4k | Reduced -2.5k |
| MORGAN STANLEY 0.00% of their portfolio | 5.2k $9.3k | Reduced -31.4k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.7k $3.0k | Reduced -2.8k |
| Crews Bank & Trust 0.00% of their portfolio | 1.0k $1.9k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 751 $1.3k | Added +113 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 584 $1.0k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 537 $956 | Reduced -97 |
| Redwood Park Advisors LLC 0.00% of their portfolio | 500 $890 | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 481 $856 | Unchanged |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 400 $712 | Unchanged |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 326 $580 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 75 $134 | Added +1 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 50 $89 | Added +46 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 30 $0 | Added +5 |
| CITIGROUP INC 0.00% of their portfolio | 6 $11 | New |