ACHIEVE LIFE SCIENCES INC ACHV
COM · Common Stock · CUSIP 004468500
- SectorHealth care
- IndustryIn Vitro & In Vivo Diagnostic Substances
- HeadquartersSeattle, WA
- Founded2015
- Websiteachievelifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.2m as of 2026-03-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.95. Options: 7 managers hold calls ($2.5m notional), 2 hold puts ($144.6k).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 29 |
| Q4 2022 | 29 |
| Q1 2023 | 32 |
| Q2 2023 | 40 |
| Q3 2023 | 36 |
| Q4 2023 | 30 |
| Q1 2024 | 42 |
| Q2 2024 | 57 |
| Q3 2024 | 65 |
| Q4 2024 | 71 |
| Q1 2025 | 73 |
| Q2 2025 | 67 |
| Q3 2025 | 66 |
| Q4 2025 | 77 |
| Q1 2026 | 81 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 37 | 17 |
| Q3 2024 | 29 | 15 |
| Q4 2024 | 35 | 16 |
| Q1 2025 | 29 | 26 |
| Q2 2025 | 40 | 40 |
| Q3 2025 | 39 | 41 |
| Q4 2025 | 45 | 23 |
| Q1 2026 | 31 | 34 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $480.0k | $94.4k | 0.20 |
| Q3 2025 | $2.4m | $239.3k | 0.10 |
| Q4 2025 | $1.4m | $214.2k | 0.15 |
| Q1 2026 | $2.5m | $144.6k | 0.06 |
Biggest buyers
| Lakeside Advisors, INC. | New | +111.1k |
| LPL Financial LLC | Added | +95.3k |
| Brevan Howard Capital Management LP | New | +54.5k |
| BANK OF AMERICA CORP /DE/ | Added | +46.6k |
| RAYMOND JAMES FINANCIAL INC | Added | +42.2k |
| UBS Group AG | Added | +41.0k |
| WELLS FARGO & COMPANY/MN | Added | +31.9k |
| BCV Asset Management Inc. | New | +26.4k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +23.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Added | +23.0k |
Biggest sellers
| Pathstone Holdings, LLC | Sold out | -416.7k |
| GOLDMAN SACHS GROUP INC | Reduced | -298.0k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -281.8k |
| TWO SIGMA ADVISERS, LP | Sold out | -209.9k |
| JANE STREET GROUP, LLC | Reduced | -205.6k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -167.7k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -160.1k |
| Squarepoint Ops LLC | Reduced | -144.9k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -124.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -112.7k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $596.2k202.8k shares |
| SIMPLEX TRADING, LLC | Added | $419.2k142.6k shares |
| Foundations Investment Advisors, LLC | New | $391.9k133.3k shares |
| SLT Holdings LLC | New | $391.9k133.3k shares |
| GROUP ONE TRADING LLC | Added | $367.8k125.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $249.6k84.9k shares |
| Caption Management, LLC | Unchanged | $88.2k30.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $124.4k42.3k shares |
| SIMPLEX TRADING, LLC | Added | $20.3k6.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TPG GP A, LLC
13D · may seek influence
new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing |
12.6% |
| Logos Global Management LP 13G · institution new · filed 2026-08-17 | 10.0% |
venBio Global Strategic Fund V, L.P.
13D · may seek influence
new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing |
10.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 | 9.2% |
| FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 | 8.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 | 6.5% |
| Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 | 5.6% |
| Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 | 5.4% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 | 5.2% |
| BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 | 5.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 | 5.0% |
Fell to 5% or below in the last year: Contrarian Alpha, LP (4.9%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 2 | $57.5k | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 6 | $1.1m | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
None reported in Q1 2026.
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 4.4m $12.8m | Unchanged |
| Propel Bio Management, LLC 7.17% of their portfolio | 3.8m $11.4m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.2m $6.5m | First filing |
| Simplify Asset Management Inc. 0.05% of their portfolio | 1.2m $3.5m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.1m $3.2m | Reduced -281.8k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.0m $3.0m | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 728.4k $2.1m | Added +95.3k |
| Nantahala Capital Management, LLC 0.12% of their portfolio | 648.9k $1.9m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 641.9k $1.9m | Added +42.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 622.8k $1.8m | Added +23.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 588.6k $1.7m | Reduced -160.1k |
| KVP Capital Advisors, LP 1.02% of their portfolio | 462.4k $1.4m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 439.4k $1.3m | Added +20.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 383.7k $1.1m | Reduced -112.7k |
| UBS Group AG 0.00% of their portfolio | 326.3k $959.2k | Added +41.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 316.2k $929.6k | First filing |
| STATE STREET CORP 0.00% of their portfolio | 254.5k $748.1k | Added +20.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 224.7k $660.7k | Reduced -5.1k |
| Shay Capital LLC 0.09% of their portfolio | 205.1k $603.0k | Reduced -29.8k |
| 683 Capital Management, LLC 0.05% of their portfolio | 200.0k $588.0k | Reduced -14.9k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 176.6k $519.2k | Reduced -205.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 153.0k $449.7k | Reduced -298.0k |
| Lakeside Advisors, INC. 0.22% of their portfolio | 111.1k $326.6k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 102.0k $299.8k | Added +31.9k |
| Blue Trust, Inc. 0.00% of their portfolio | 85.9k $252.5k | Unchanged |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 84.9k $249.6k | Added +17.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 70.7k $207.8k | Added +46.6k |
| MORGAN STANLEY 0.00% of their portfolio | 70.4k $206.9k | Reduced -8.7k |
| MANCHESTER FINANCIAL INC 0.04% of their portfolio | 66.2k $194.7k | Added +7.1k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 56.1k $165.0k | Added +2.1k |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 54.5k $160.3k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 52.4k $154.1k | Unchanged |
| Alpine Global Management, LLC 0.02% of their portfolio | 50.0k $147.0k | Reduced -33.5k |
| BARCLAYS PLC 0.00% of their portfolio | 48.1k $141.3k | Reduced -62.0k |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 47.8k $140.5k | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 43.0k $126.4k | Added +23.0k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 37.8k $111.0k | Reduced -37.4k |
| Next Capital Management LLC 0.03% of their portfolio | 35.0k $102.9k | Added +18.9k |
| HRT FINANCIAL LP 0.00% of their portfolio | 31.6k $92.0k | Added +12.7k |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 30.0k $88.2k | Unchanged |
| MEMBERS WEALTH LLC 0.08% of their portfolio | 30.0k $126.9k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 28.0k $82.2k | Reduced -124.5k |
| BCV Asset Management Inc. 0.00% of their portfolio | 26.4k $77.5k | New |
| Keating Financial Advisory Services, Inc. 0.01% of their portfolio | 24.9k $73.2k | Unchanged |
| Goldstone Financial Group, LLC 0.01% of their portfolio | 24.2k $71.0k | Unchanged |
| MAGNOLIA CAPITAL ADVISORS LLC 0.01% of their portfolio | 24.1k $70.9k | Added +11.2k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 22.6k $66.5k | First filing |
| Scientech Research LLC 0.05% of their portfolio | 21.7k $63.9k | New |
| Robertson Stephens Wealth Management, LLC 0.00% of their portfolio | 20.0k $58.8k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 19.7k $57.8k | Reduced -144.9k |
| Diametric Capital, LP 0.01% of their portfolio | 18.7k $54.8k | New |
| XTX Topco Ltd 0.00% of their portfolio | 18.2k $53.6k | Reduced -874 |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 18.0k $52.9k | New |
| AXQ CAPITAL, LP 0.01% of their portfolio | 15.2k $44.7k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 14.4k $42.3k | New |
| nVerses Capital, LLC 0.04% of their portfolio | 14.2k $41.7k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 14.1k $41.5k | Added +68 |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 12.6k $37.0k | Reduced -4.2k |
| Foundations Investment Advisors, LLC 0.00% of their portfolio | 11.7k $34.4k | New |
| Windsor Capital Management, LLC 0.01% of their portfolio | 10.8k $31.8k | Unchanged |
| Madison Park Capital Advisors, LLC 0.02% of their portfolio | 10.0k $29.4k | Unchanged |
| SLT Holdings LLC 0.02% of their portfolio | 9.5k $27.9k | New |
| FMR LLC 0.00% of their portfolio | 5.9k $17.3k | Reduced -618 |
| CITIGROUP INC 0.00% of their portfolio | 5.4k $16.0k | Reduced -27.5k |
| Allworth Financial LP 0.00% of their portfolio | 3.0k $8.8k | Unchanged |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 2.3k $6.7k | New |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 2.0k $5.9k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 1.7k $5.0k | Unchanged |
| Capital Analysts, LLC 0.00% of their portfolio | 700 $2.0k | Unchanged |
| SITTNER & NELSON, LLC 0.00% of their portfolio | 673 $2.0k | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 500 $1.3k | Added +300 |
| Avion Wealth 0.00% of their portfolio | 500 $1.0k | New |
| Optiver Holding B.V. 0.00% of their portfolio | 490 $1.4k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 254 $747 | Reduced -167.7k |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 215 $632 | Reduced -4.4k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 150 $441 | Unchanged |
| Caption Management, LLC 0.00% of their portfolio | 138 $406 | Reduced -37.6k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 126 $0 | Reduced -1.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 19 $51 | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 2 $6 | New |
| Arax Advisory Partners 0.00% of their portfolio | 1 $29 | Reduced -9 |