Vault-13

ACHIEVE LIFE SCIENCES INC ACHV

COM · Common Stock · CUSIP 004468500

81 institutional holders +4 vs Q4 2025
21,524,08121.5m shares reported held*
40.4% of all shares outstanding*
$63.6mreported value*
14 new 17 added 23 reduced 11 sold out net sold ≈ $5.1m (-1.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.2m as of 2026-03-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.95. Options: 7 managers hold calls ($2.5m notional), 2 hold puts ($144.6k).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 29Q4 22: 29Q1 23: 32Q2 23: 40Q3 23: 36Q4 23: 30Q1 24: 42Q2 24: 57Q3 24: 65Q4 24: 71Q1 25: 73Q2 25: 67Q3 25: 66Q4 25: 77Q1 26: 8181Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 202229
Q4 202229
Q1 202332
Q2 202340
Q3 202336
Q4 202330
Q1 202442
Q2 202457
Q3 202465
Q4 202471
Q1 202573
Q2 202567
Q3 202566
Q4 202577
Q1 202681

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q2 24: 37 bought or addedQ2 24: 17 cut or sold outQ3 24: 29 bought or addedQ3 24: 15 cut or sold outQ3 24Q4 24: 35 bought or addedQ4 24: 16 cut or sold outQ1 25: 29 bought or addedQ1 25: 26 cut or sold outQ1 25Q2 25: 40 bought or addedQ2 25: 40 cut or sold outQ3 25: 39 bought or addedQ3 25: 41 cut or sold outQ3 25Q4 25: 45 bought or addedQ4 25: 23 cut or sold outQ1 26: 31 bought or addedQ1 26: 34 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 20243717
Q3 20242915
Q4 20243516
Q1 20252926
Q2 20254040
Q3 20253941
Q4 20254523
Q1 20263134

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ2 25 calls: $480.0kQ2 25 puts: $94.4kQ2 25P/C 0.20Q3 25 calls: $2.4mQ3 25 puts: $239.3kQ3 25P/C 0.10Q4 25 calls: $1.4mQ4 25 puts: $214.2kQ4 25P/C 0.15Q1 26 calls: $2.5mQ1 26 puts: $144.6kQ1 26P/C 0.06
Numbers
QuarterCallsPutsP/C
Q2 2025$480.0k$94.4k0.20
Q3 2025$2.4m$239.3k0.10
Q4 2025$1.4m$214.2k0.15
Q1 2026$2.5m$144.6k0.06

Biggest buyers

Lakeside Advisors, INC. New +111,101+111.1k
LPL Financial LLC Added +95,300+95.3k
Brevan Howard Capital Management LP New +54,508+54.5k
BANK OF AMERICA CORP /DE/ Added +46,630+46.6k
RAYMOND JAMES FINANCIAL INC Added +42,246+42.2k
UBS Group AG Added +41,041+41.0k
WELLS FARGO & COMPANY/MN Added +31,912+31.9k
BCV Asset Management Inc. New +26,365+26.4k
GEODE CAPITAL MANAGEMENT, LLC Added +23,174+23.2k
CHARLES SCHWAB INVESTMENT MANAGEMENT INC Added +23,000+23.0k

Biggest sellers

Pathstone Holdings, LLC Sold out -416,667-416.7k
GOLDMAN SACHS GROUP INC Reduced -297,976-298.0k
MILLENNIUM MANAGEMENT LLC Reduced -281,778-281.8k
TWO SIGMA ADVISERS, LP Sold out -209,900-209.9k
JANE STREET GROUP, LLC Reduced -205,611-205.6k
BNP PARIBAS FINANCIAL MARKETS Reduced -167,691-167.7k
TWO SIGMA INVESTMENTS, LP Reduced -160,065-160.1k
Squarepoint Ops LLC Reduced -144,947-144.9k
RENAISSANCE TECHNOLOGIES LLC Reduced -124,508-124.5k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -112,667-112.7k

Biggest calls

CITADEL ADVISORS LLC Added $596.2k202.8k shares
SIMPLEX TRADING, LLC Added $419.2k142.6k shares
Foundations Investment Advisors, LLC New $391.9k133.3k shares
SLT Holdings LLC New $391.9k133.3k shares
GROUP ONE TRADING LLC Added $367.8k125.1k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $249.6k84.9k shares
Caption Management, LLC Unchanged $88.2k30.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $124.4k42.3k shares
SIMPLEX TRADING, LLC Added $20.3k6.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
TPG GP A, LLC 13D · may seek influence new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing
12.6% new 13.8m≈ $89.8m 2026-04-24
Logos Global Management LP 13G · institution new · filed 2026-08-17 10.0% new 10.5m≈ $68.8m 2026-08-17
venBio Global Strategic Fund V, L.P. 13D · may seek influence new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing
10.0% new 10.7m≈ $70.1m 2026-04-27
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 9.2% new 9.9m≈ $64.7m 2026-04-24
FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 8.3% +2.1 pts 8.9m≈ $58.0m 2026-07-28
Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 6.5% new 6.6m≈ $43.3m 2026-04-24
Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 5.6% -4.3 pts 3.0m≈ $19.5m 2025-11-14
Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 5.4% new 5.5m≈ $35.9m 2026-08-13
Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 5.2% new 5.5m≈ $35.9m 2026-04-24
BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 5.1% +4.5 pts 5.3m≈ $34.4m 2026-07-27
Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 5.0% new 5.3m≈ $34.6m 2026-07-08

Fell to 5% or below in the last year: Contrarian Alpha, LP (4.9%, 2025-11-14)

Insider purchases and sales in Q1 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q2 24: 0 buyingQ2 24: 0 sellingQ3 24: 0 buyingQ3 24: 0 sellingQ3 24Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 2 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 6 sellingQ3 25Q4 25: 0 buyingQ4 25: 0 sellingQ1 26: 0 buyingQ1 26: 0 sellingQ1 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20240—0——
Q3 20240—0——
Q4 20240—0——
Q1 20252$57.5k0——
Q2 20250—0——
Q3 20250—6$1.1m—
Q4 20250—0——
Q1 20260—0——

None reported in Q1 2026.

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 4,369,1934.4m $12.8m $12.8m 0.00% Unchanged
2 Propel Bio Management, LLC 7.17% of their portfolio Los Angeles, CA 3,786,4253.8m $11.4m $11.4m 7.17% Unchanged
3 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 2,204,7142.2m $6.5m $6.5m 0.00% First filing
4 Simplify Asset Management Inc. 0.05% of their portfolio Las Vegas, NV 1,184,5121.2m $3.5m $3.5m 0.05% Unchanged
5 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,077,3381.1m $3.2m $3.2m 0.00% Reduced -281.8k -281,778
6 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 1,019,2811.0m $3.0m $3.0m 0.00% Unchanged
7 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 728,448728.4k $2.1m $2.1m 0.00% Added +95.3k +95,300
8 Nantahala Capital Management, LLC 0.12% of their portfolio NEW CANAAN, CT 648,885648.9k $1.9m $1.9m 0.12% Unchanged
9 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 641,925641.9k $1.9m $1.9m 0.00% Added +42.2k +42,246
10 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 622,785622.8k $1.8m $1.8m 0.00% Added +23.2k +23,174
11 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 588,551588.6k $1.7m $1.7m 0.00% Reduced -160.1k -160,065
12 KVP Capital Advisors, LP 1.02% of their portfolio SAN FRANCISCO, CA 462,355462.4k $1.4m $1.4m 1.02% Unchanged
13 BlackRock, Inc. 0.00% of their portfolio New York, NY 439,360439.4k $1.3m $1.3m 0.00% Added +20.2k +20,227
14 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 383,683383.7k $1.1m $1.1m 0.00% Reduced -112.7k -112,667
15 UBS Group AG 0.00% of their portfolio ZURICH, V8 326,270326.3k $959.2k $959.2k 0.00% Added +41.0k +41,041
16 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 316,177316.2k $929.6k $929.6k 0.00% First filing
17 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 254,457254.5k $748.1k $748.1k 0.00% Added +20.2k +20,200
18 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 224,742224.7k $660.7k $660.7k 0.00% Reduced -5.1k -5,137
19 Shay Capital LLC 0.09% of their portfolio NEW YORK, NY 205,114205.1k $603.0k $603.0k 0.09% Reduced -29.8k -29,823
20 683 Capital Management, LLC 0.05% of their portfolio NEW YORK, NY 200,000200.0k $588.0k $588.0k 0.05% Reduced -14.9k -14,897
21 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 176,600176.6k $519.2k $519.2k 0.00% Reduced -205.6k -205,611
22 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 152,952153.0k $449.7k $449.7k 0.00% Reduced -298.0k -297,976
23 Lakeside Advisors, INC. 0.22% of their portfolio SEATTLE, WA 111,101111.1k $326.6k $326.6k 0.22% New
24 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 101,971102.0k $299.8k $299.8k 0.00% Added +31.9k +31,912
25 Blue Trust, Inc. 0.00% of their portfolio BRENTWOOD, TN 85,88885.9k $252.5k $252.5k 0.00% Unchanged
26 Hudson Bay Capital Management LP 0.00% of their portfolio STAMFORD, CT 84,89684.9k $249.6k $249.6k 0.00% Added +17.2k +17,233
27 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 70,68470.7k $207.8k $207.8k 0.00% Added +46.6k +46,630
28 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 70,37870.4k $206.9k $206.9k 0.00% Reduced -8.7k -8,683
29 MANCHESTER FINANCIAL INC 0.04% of their portfolio Westlake Village, CA 66,22266.2k $194.7k $194.7k 0.04% Added +7.1k +7,138
30 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 56,11856.1k $165.0k $165.0k 0.00% Added +2.1k +2,135
31 Brevan Howard Capital Management LP 0.00% of their portfolio ST. HELIER, Y9 54,50854.5k $160.3k $160.3k 0.00% New
32 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 52,42052.4k $154.1k $154.1k 0.00% Unchanged
33 Alpine Global Management, LLC 0.02% of their portfolio NEW YORK, NY 50,00050.0k $147.0k $147.0k 0.02% Reduced -33.5k -33,481
34 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 48,06748.1k $141.3k $141.3k 0.00% Reduced -62.0k -61,965
35 ADAR1 Capital Management, LLC 0.01% of their portfolio AUSTIN, TX 47,80047.8k $140.5k $140.5k 0.01% Unchanged
36 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 43,00043.0k $126.4k $126.4k 0.00% Added +23.0k +23,000
37 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 37,76037.8k $111.0k $111.0k 0.00% Reduced -37.4k -37,409
38 Next Capital Management LLC 0.03% of their portfolio NEW YORK, NY 34,99535.0k $102.9k $102.9k 0.03% Added +18.9k +18,865
39 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 31,57931.6k $92.0k $92.0k 0.00% Added +12.7k +12,721
40 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 30,00030.0k $88.2k $88.2k 0.00% Unchanged
41 MEMBERS WEALTH LLC 0.08% of their portfolio MEDIA, PA 30,00030.0k $126.9k $126.9k 0.08% Unchanged
42 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 27,95228.0k $82.2k $82.2k 0.00% Reduced -124.5k -124,508
43 BCV Asset Management Inc. 0.00% of their portfolio WINNIPEG, A2 26,36526.4k $77.5k $77.5k 0.00% New
44 Keating Financial Advisory Services, Inc. 0.01% of their portfolio MANHATTAN, KS 24,91124.9k $73.2k $73.2k 0.01% Unchanged
45 Goldstone Financial Group, LLC 0.01% of their portfolio OAKBROOK TERRACE, IL 24,16324.2k $71.0k $71.0k 0.01% Unchanged
46 MAGNOLIA CAPITAL ADVISORS LLC 0.01% of their portfolio RIDGELAND, MS 24,10024.1k $70.9k $70.9k 0.01% Added +11.2k +11,250
47 Vanguard Global Advisers, LLC 0.00% of their portfolio MALVERN, PA 22,60322.6k $66.5k $66.5k 0.00% First filing
48 Scientech Research LLC 0.05% of their portfolio JERSEY CITY, NJ 21,71821.7k $63.9k $63.9k 0.05% New
49 Robertson Stephens Wealth Management, LLC 0.00% of their portfolio San Francisco, CA 20,00020.0k $58.8k $58.8k 0.00% Unchanged
50 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 19,65819.7k $57.8k $57.8k 0.00% Reduced -144.9k -144,947
51 Diametric Capital, LP 0.01% of their portfolio BOSTON, MA 18,65118.7k $54.8k $54.8k 0.01% New
52 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 18,21818.2k $53.6k $53.6k 0.00% Reduced -874 -874
53 Catalyst Funds Management Pty Ltd 0.01% of their portfolio SYDNEY NSW, C3 18,00018.0k $52.9k $52.9k 0.01% New
54 AXQ CAPITAL, LP 0.01% of their portfolio JERSEY CITY, NJ 15,20115.2k $44.7k $44.7k 0.01% New
55 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 14,38914.4k $42.3k $42.3k 0.00% New
56 nVerses Capital, LLC 0.04% of their portfolio WELLINGTON, FL 14,19514.2k $41.7k $41.7k 0.04% New
57 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 14,10914.1k $41.5k $41.5k 0.00% Added +68 +68
58 Jefferies Financial Group Inc. 0.00% of their portfolio NEW YORK, NY 12,57212.6k $37.0k $37.0k 0.00% Reduced -4.2k -4,241
59 Foundations Investment Advisors, LLC 0.00% of their portfolio PHOENIX, AZ 11,70211.7k $34.4k $34.4k 0.00% New
60 Windsor Capital Management, LLC 0.01% of their portfolio Phoenix, AZ 10,81710.8k $31.8k $31.8k 0.01% Unchanged
61 Madison Park Capital Advisors, LLC 0.02% of their portfolio SEATTLE, WA 10,00010.0k $29.4k $29.4k 0.02% Unchanged
62 SLT Holdings LLC 0.02% of their portfolio SCOTTSDALE, AZ 9,5009.5k $27.9k $27.9k 0.02% New
63 FMR LLC 0.00% of their portfolio BOSTON, MA 5,8955.9k $17.3k $17.3k 0.00% Reduced -618 -618
64 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 5,4485.4k $16.0k $16.0k 0.00% Reduced -27.5k -27,520
65 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 3,0003.0k $8.8k $8.8k 0.00% Unchanged
66 FIFTH THIRD BANCORP 0.00% of their portfolio CINCINNATI, OH 2,2902.3k $6.7k $6.7k 0.00% New
67 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 2,0002.0k $5.9k $5.9k 0.00% Unchanged
68 CWM, LLC 0.00% of their portfolio OMAHA, NE 1,7021.7k $5.0k $5.0k 0.00% Unchanged
69 Capital Analysts, LLC 0.00% of their portfolio FORT WASHINGTON, PA 700700 $2.0k $2.0k 0.00% Unchanged
70 SITTNER & NELSON, LLC 0.00% of their portfolio EUGENE, OR 673673 $2.0k $2.0k 0.00% Unchanged
71 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 500500 $1.3k $1.3k 0.00% Added +300 +300
72 Avion Wealth 0.00% of their portfolio THE WOODLANDS, TX 500500 $1.0k $1.0k 0.00% New
73 Optiver Holding B.V. 0.00% of their portfolio AMSTERDAM, P7 490490 $1.4k $1.4k 0.00% Unchanged
74 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 254254 $747 $747 0.00% Reduced -167.7k -167,691
75 Steward Partners Investment Advisory, LLC 0.00% of their portfolio STAMFORD, CT 215215 $632 $632 0.00% Reduced -4.4k -4,425
76 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 150150 $441 $441 0.00% Unchanged
77 Caption Management, LLC 0.00% of their portfolio OKLAHOMA CITY, OK 138138 $406 $406 0.00% Reduced -37.6k -37,557
78 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 126126 $0 $0 0.00% Reduced -1.4k -1,410
79 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1919 $51 $51 0.00% Unchanged
80 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 22 $6 $6 0.00% New
81 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 11 $29 $29 0.00% Reduced -9 -9