Vault-13

ACHIEVE LIFE SCIENCES INC ACHV

COM · Common Stock · CUSIP 004468500

77 institutional holders +11 vs Q3 2025
22,055,03322.1m shares reported held*
41.4% of all shares outstanding*
$109.4mreported value*
21 new 24 added 13 reduced 10 sold out net bought ≈ $36.0m (+7.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.9m this quarter). Holder counts are more reliable. Shares outstanding: 53.2m as of 2025-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.96. Options: 6 managers hold calls ($1.4m notional), 4 hold puts ($214.2k).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 29Q4 22: 29Q1 23: 32Q2 23: 40Q3 23: 36Q4 23: 30Q1 24: 42Q2 24: 57Q3 24: 65Q4 24: 71Q1 25: 73Q2 25: 67Q3 25: 66Q4 25: 7777Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202229
Q4 202229
Q1 202332
Q2 202340
Q3 202336
Q4 202330
Q1 202442
Q2 202457
Q3 202465
Q4 202471
Q1 202573
Q2 202567
Q3 202566
Q4 202577

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q1 24: 25 bought or addedQ1 24: 16 cut or sold outQ2 24: 37 bought or addedQ2 24: 17 cut or sold outQ2 24Q3 24: 29 bought or addedQ3 24: 15 cut or sold outQ4 24: 35 bought or addedQ4 24: 16 cut or sold outQ4 24Q1 25: 29 bought or addedQ1 25: 26 cut or sold outQ2 25: 40 bought or addedQ2 25: 40 cut or sold outQ2 25Q3 25: 39 bought or addedQ3 25: 41 cut or sold outQ4 25: 45 bought or addedQ4 25: 23 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20242516
Q2 20243717
Q3 20242915
Q4 20243516
Q1 20252926
Q2 20254040
Q3 20253941
Q4 20254523

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ1 25 calls: $31.5kQ1 25 puts: $5.1kQ1 25P/C 0.16Q2 25 calls: $480.0kQ2 25 puts: $94.4kQ2 25P/C 0.20Q3 25 calls: $2.4mQ3 25 puts: $239.3kQ3 25P/C 0.10Q4 25 calls: $1.4mQ4 25 puts: $214.2kQ4 25P/C 0.15
Numbers
QuarterCallsPutsP/C
Q1 2025$31.5k$5.1k0.16
Q2 2025$480.0k$94.4k0.20
Q3 2025$2.4m$239.3k0.10
Q4 2025$1.4m$214.2k0.15

Biggest buyers

FRANKLIN RESOURCES INC Added +4,346,011+4.3m
MILLENNIUM MANAGEMENT LLC Added +1,121,614+1.1m
JANE STREET GROUP, LLC New +382,211+382.2k
TWO SIGMA INVESTMENTS, LP Added +309,552+309.6k
LPL Financial LLC Added +301,850+301.9k
MARSHALL WACE, LLP Added +244,428+244.4k
GOLDMAN SACHS GROUP INC Added +227,095+227.1k
683 Capital Management, LLC New +214,897+214.9k
UBS Group AG Added +206,087+206.1k
BNP PARIBAS FINANCIAL MARKETS Added +167,635+167.6k

Biggest sellers

Clearline Capital LP Sold out -451,219-451.2k
Squarepoint Ops LLC Reduced -208,474-208.5k
Alyeska Investment Group, L.P. Sold out -178,389-178.4k
RENAISSANCE TECHNOLOGIES LLC Reduced -158,304-158.3k
ROYAL BANK OF CANADA Reduced -153,184-153.2k
Pathstone Holdings, LLC Reduced -85,333-85.3k
XTX Topco Ltd Reduced -66,763-66.8k
Shay Capital LLC Reduced -54,608-54.6k
Qube Research & Technologies Ltd Reduced -36,261-36.3k
Sender Co & Partners, Inc. Sold out -25,000-25.0k

Biggest calls

CITADEL ADVISORS LLC Added $466.7k93.9k shares
SIMPLEX TRADING, LLC Reduced $339.0k68.2k shares
GROUP ONE TRADING LLC Reduced $194.8k39.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $170.0k34.2k shares
Caption Management, LLC Reduced $149.1k30.0k shares
JANE STREET GROUP, LLC Reduced $67.6k13.6k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $117.8k23.7k shares
CITADEL ADVISORS LLC Reduced $84.5k17.0k shares
GROUP ONE TRADING LLC Reduced $8.0k1.6k shares
SIMPLEX TRADING, LLC Reduced $4.0k800 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
TPG GP A, LLC 13D · may seek influence new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing
12.6% new 13.8m≈ $89.8m 2026-04-24
Logos Global Management LP 13G · institution new · filed 2026-08-17 10.0% new 10.5m≈ $68.8m 2026-08-17
venBio Global Strategic Fund V, L.P. 13D · may seek influence new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing
10.0% new 10.7m≈ $70.1m 2026-04-27
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 9.2% new 9.9m≈ $64.7m 2026-04-24
FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 8.3% +2.1 pts 8.9m≈ $58.0m 2026-07-28
Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 6.5% new 6.6m≈ $43.3m 2026-04-24
Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 5.6% -4.3 pts 3.0m≈ $19.5m 2025-11-14
Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 5.4% new 5.5m≈ $35.9m 2026-08-13
Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 5.2% new 5.5m≈ $35.9m 2026-04-24
BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 5.1% +4.5 pts 5.3m≈ $34.4m 2026-07-27
Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 5.0% new 5.3m≈ $34.6m 2026-07-08

Insider purchases and sales in Q4 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q1 24: 2 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 0 buyingQ4 24: 0 sellingQ4 24Q1 25: 2 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25Q3 25: 0 buyingQ3 25: 6 sellingQ4 25: 0 buyingQ4 25: 0 sellingQ4 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20242$45.9k0——
Q2 20240—0——
Q3 20240—0——
Q4 20240—0——
Q1 20252$57.5k0——
Q2 20250—0——
Q3 20250—6$1.1m—
Q4 20250—0——

None reported in Q4 2025.

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 4,369,1934.4m $21.7m $21.7m 0.01% Added +4.3m +4,346,011
2 Propel Bio Management, LLC 16.07% of their portfolio Los Angeles, CA 3,786,4253.8m $18.8m $18.8m 16.07% Unchanged
3 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,474,3122.5m $12.3m $12.3m 0.00% Added +12.5k +12,510
4 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,359,1161.4m $6.8m $6.8m 0.00% Added +1.1m +1,121,614
5 Simplify Asset Management Inc. 0.10% of their portfolio Las Vegas, NV 1,184,5121.2m $5.9m $5.9m 0.10% Unchanged
6 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 1,019,2811.0m $5.1m $5.1m 0.00% Added +244.4k +244,428
7 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 748,616748.6k $3.7m $3.7m 0.01% Added +309.6k +309,552
8 Nantahala Capital Management, LLC 0.19% of their portfolio NEW CANAAN, CT 648,885648.9k $3.2m $3.2m 0.19% Unchanged
9 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 633,148633.1k $3.1m $3.1m 0.00% Added +301.9k +301,850
10 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 599,679599.7k $3.0m $3.0m 0.00% Added +143.3k +143,307
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 599,611599.6k $3.0m $3.0m 0.00% Added +92.6k +92,634
12 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 496,350496.4k $2.5m $2.5m 0.00% Added +130.0k +129,987
13 KVP Capital Advisors, LP 2.37% of their portfolio SAN FRANCISCO, CA 462,355462.4k $2.3m $2.3m 2.37% First filing
14 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 450,928450.9k $2.2m $2.2m 0.00% Added +227.1k +227,095
15 BlackRock, Inc. 0.00% of their portfolio New York, NY 419,133419.1k $2.1m $2.1m 0.00% Added +27.9k +27,893
16 Pathstone Holdings, LLC 0.01% of their portfolio ENGLEWOOD, NJ 416,667416.7k $1.9m $1.9m 0.01% Reduced -85.3k -85,333
17 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 382,211382.2k $1.9m $1.9m 0.00% New
18 UBS Group AG 0.00% of their portfolio ZURICH, V8 285,229285.2k $1.4m $1.4m 0.00% Added +206.1k +206,087
19 Shay Capital LLC 0.19% of their portfolio NEW YORK, NY 234,937234.9k $1.2m $1.2m 0.19% Reduced -54.6k -54,608
20 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 234,257234.3k $1.2m $1.2m 0.00% Added +13.9k +13,873
21 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 229,879229.9k $1.1m $1.1m 0.00% Added +10.4k +10,434
22 683 Capital Management, LLC 0.09% of their portfolio NEW YORK, NY 214,897214.9k $1.1m $1.1m 0.09% New
23 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 209,900209.9k $1.0m $1.0m 0.00% Added +99.6k +99,600
24 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 167,945167.9k $834.7k $834.7k 0.00% Added +167.6k +167,635
25 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 164,605164.6k $818.1k $818.1k 0.00% Reduced -208.5k -208,474
26 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 152,460152.5k $757.7k $757.7k 0.00% Reduced -158.3k -158,304
27 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 110,032110.0k $546.9k $546.9k 0.00% Added +110.0k +110,031
28 Blue Trust, Inc. 0.00% of their portfolio BRENTWOOD, TN 85,88885.9k $426.9k $426.9k 0.00% Reduced -13.2k -13,242
29 Alpine Global Management, LLC 0.09% of their portfolio NEW YORK, NY 83,48183.5k $414.9k $414.9k 0.09% New
30 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 79,06179.1k $392.9k $392.9k 0.00% Added +45.4k +45,414
31 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 75,16975.2k $373.6k $373.6k 0.00% New
32 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 70,05970.1k $348.2k $348.2k 0.00% Reduced -1.5k -1,537
33 Hudson Bay Capital Management LP 0.00% of their portfolio STAMFORD, CT 67,66367.7k $336.3k $336.3k 0.00% New
34 MANCHESTER FINANCIAL INC 0.05% of their portfolio Westlake Village, CA 59,08459.1k $293.6k $293.6k 0.05% Added +12.4k +12,410
35 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 53,98354.0k $268.3k $268.3k 0.00% Added +25.6k +25,550
36 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 52,42052.4k $260.5k $260.5k 0.00% Unchanged
37 ADAR1 Capital Management, LLC 0.02% of their portfolio AUSTIN, TX 47,80047.8k $237.6k $237.6k 0.02% Unchanged
38 Graham Capital Management, L.P. 0.01% of their portfolio ROWAYTON, CT 42,72342.7k $212.3k $212.3k 0.01% New
39 Caption Management, LLC 0.01% of their portfolio OKLAHOMA CITY, OK 37,69537.7k $187.3k $187.3k 0.01% New
40 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 32,96833.0k $163.9k $163.9k 0.00% New
41 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 30,00030.0k $149.1k $149.1k 0.00% Unchanged
42 MEMBERS WEALTH LLC 0.10% of their portfolio MEDIA, PA 30,00030.0k $152.7k $152.7k 0.10% New
43 Keating Financial Advisory Services, Inc. 0.02% of their portfolio MANHATTAN, KS 24,91124.9k $123.8k $123.8k 0.02% First filing
44 Goldstone Financial Group, LLC 0.01% of their portfolio OAKBROOK TERRACE, IL 24,16324.2k $120.1k $120.1k 0.01% New
45 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 24,05424.1k $119.5k $119.5k 0.00% Reduced -23.4k -23,355
46 Lighthouse Investment Partners, LLC 0.00% of their portfolio Palm Beach Gardens, FL 23,70023.7k $117.8k $117.8k 0.00% New
47 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 21,00021.0k $104.4k $104.4k 0.00% New
48 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 20,00020.0k $99.4k $99.4k 0.00% New
49 Robertson Stephens Wealth Management, LLC 0.00% of their portfolio San Francisco, CA 20,00020.0k $99.4k $99.4k 0.00% Added +10.0k +10,000
50 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 19,09219.1k $94.9k $94.9k 0.00% Reduced -66.8k -66,763
51 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 18,85818.9k $93.0k $93.0k 0.00% New
52 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 17,33817.3k $86.2k $86.2k 0.00% New
53 Jefferies Financial Group Inc. 0.00% of their portfolio NEW YORK, NY 16,81316.8k $83.6k $83.6k 0.00% New
54 Next Capital Management LLC 0.03% of their portfolio NEW YORK, NY 16,13016.1k $80.2k $80.2k 0.03% Unchanged
55 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 14,04114.0k $69.8k $69.8k 0.00% Added +1 +1
56 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 13,40513.4k $66.6k $66.6k 0.00% Reduced -36.3k -36,261
57 MAGNOLIA CAPITAL ADVISORS LLC 0.01% of their portfolio RIDGELAND, MS 12,85012.8k $63.9k $63.9k 0.01% New
58 Windsor Capital Management, LLC 0.01% of their portfolio Phoenix, AZ 10,81710.8k $53.8k $53.8k 0.01% Unchanged
59 Madison Park Capital Advisors, LLC 0.04% of their portfolio SEATTLE, WA 10,00010.0k $49.7k $49.7k 0.04% Unchanged
60 FMR LLC 0.00% of their portfolio BOSTON, MA 6,5136.5k $32.4k $32.4k 0.00% Reduced -473 -473
61 Steward Partners Investment Advisory, LLC 0.00% of their portfolio STAMFORD, CT 4,6404.6k $23.1k $23.1k 0.00% New
62 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 3,0003.0k $14.9k $14.9k 0.00% Unchanged
63 Torren Management, LLC 0.01% of their portfolio SAN DIEGO, CA 2,8702.9k $14.3k $14.3k 0.01% First filing
64 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 2,8262.8k $14.0k $14.0k 0.00% New
65 COMERICA BANK 0.00% of their portfolio DALLAS, TX 2,3822.4k $11.8k $11.8k 0.00% Reduced -31 -31
66 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 2,0002.0k $9.9k $9.9k 0.00% Unchanged
67 CWM, LLC 0.00% of their portfolio OMAHA, NE 1,7021.7k $8.0k $8.0k 0.00% Unchanged
68 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 1,5361.5k $8.0k $8.0k 0.00% Reduced -153.2k -153,184
69 Capital Analysts, LLC 0.00% of their portfolio FORT WASHINGTON, PA 700700 $3.0k $3.0k 0.00% Added +190 +190
70 SITTNER & NELSON, LLC 0.00% of their portfolio EUGENE, OR 673673 $2.9k $2.9k 0.00% Unchanged
71 Optiver Holding B.V. 0.00% of their portfolio AMSTERDAM, P7 490490 $2.4k $2.4k 0.00% Unchanged
72 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 200200 $994 $994 0.00% New
73 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 150150 $746 $746 0.00% Unchanged
74 Cornerstone Planning Group LLC 0.00% of their portfolio FAIRFIELD, NJ 100100 $436 $436 0.00% Added +87 +87
75 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1919 $94 $94 0.00% Reduced -19 -19
76 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 1010 $50 $50 0.00% Unchanged
77 Parkside Financial Bank & Trust 0.00% of their portfolio SAINT LOUIS, MO 55 $25 $25 0.00% New