ACHIEVE LIFE SCIENCES INC ACHV
COM · Common Stock · CUSIP 004468500
- SectorHealth care
- IndustryIn Vitro & In Vivo Diagnostic Substances
- HeadquartersSeattle, WA
- Founded2015
- Websiteachievelifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.9m this quarter). Holder counts are more reliable. Shares outstanding: 53.2m as of 2025-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.96. Options: 6 managers hold calls ($1.4m notional), 4 hold puts ($214.2k).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 29 |
| Q4 2022 | 29 |
| Q1 2023 | 32 |
| Q2 2023 | 40 |
| Q3 2023 | 36 |
| Q4 2023 | 30 |
| Q1 2024 | 42 |
| Q2 2024 | 57 |
| Q3 2024 | 65 |
| Q4 2024 | 71 |
| Q1 2025 | 73 |
| Q2 2025 | 67 |
| Q3 2025 | 66 |
| Q4 2025 | 77 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 25 | 16 |
| Q2 2024 | 37 | 17 |
| Q3 2024 | 29 | 15 |
| Q4 2024 | 35 | 16 |
| Q1 2025 | 29 | 26 |
| Q2 2025 | 40 | 40 |
| Q3 2025 | 39 | 41 |
| Q4 2025 | 45 | 23 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $31.5k | $5.1k | 0.16 |
| Q2 2025 | $480.0k | $94.4k | 0.20 |
| Q3 2025 | $2.4m | $239.3k | 0.10 |
| Q4 2025 | $1.4m | $214.2k | 0.15 |
Biggest buyers
| FRANKLIN RESOURCES INC | Added | +4.3m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.1m |
| JANE STREET GROUP, LLC | New | +382.2k |
| TWO SIGMA INVESTMENTS, LP | Added | +309.6k |
| LPL Financial LLC | Added | +301.9k |
| MARSHALL WACE, LLP | Added | +244.4k |
| GOLDMAN SACHS GROUP INC | Added | +227.1k |
| 683 Capital Management, LLC | New | +214.9k |
| UBS Group AG | Added | +206.1k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +167.6k |
Biggest sellers
| Clearline Capital LP | Sold out | -451.2k |
| Squarepoint Ops LLC | Reduced | -208.5k |
| Alyeska Investment Group, L.P. | Sold out | -178.4k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -158.3k |
| ROYAL BANK OF CANADA | Reduced | -153.2k |
| Pathstone Holdings, LLC | Reduced | -85.3k |
| XTX Topco Ltd | Reduced | -66.8k |
| Shay Capital LLC | Reduced | -54.6k |
| Qube Research & Technologies Ltd | Reduced | -36.3k |
| Sender Co & Partners, Inc. | Sold out | -25.0k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $466.7k93.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $339.0k68.2k shares |
| GROUP ONE TRADING LLC | Reduced | $194.8k39.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $170.0k34.2k shares |
| Caption Management, LLC | Reduced | $149.1k30.0k shares |
| JANE STREET GROUP, LLC | Reduced | $67.6k13.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $117.8k23.7k shares |
| CITADEL ADVISORS LLC | Reduced | $84.5k17.0k shares |
| GROUP ONE TRADING LLC | Reduced | $8.0k1.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.0k800 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TPG GP A, LLC
13D · may seek influence
new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing |
12.6% |
| Logos Global Management LP 13G · institution new · filed 2026-08-17 | 10.0% |
venBio Global Strategic Fund V, L.P.
13D · may seek influence
new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing |
10.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 | 9.2% |
| FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 | 8.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 | 6.5% |
| Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 | 5.6% |
| Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 | 5.4% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 | 5.2% |
| BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 | 5.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 | 5.0% |
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 2 | $45.9k | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 2 | $57.5k | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 6 | $1.1m | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 4.4m $21.7m | Added +4.3m |
| Propel Bio Management, LLC 16.07% of their portfolio | 3.8m $18.8m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.5m $12.3m | Added +12.5k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.4m $6.8m | Added +1.1m |
| Simplify Asset Management Inc. 0.10% of their portfolio | 1.2m $5.9m | Unchanged |
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.0m $5.1m | Added +244.4k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 748.6k $3.7m | Added +309.6k |
| Nantahala Capital Management, LLC 0.19% of their portfolio | 648.9k $3.2m | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 633.1k $3.1m | Added +301.9k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 599.7k $3.0m | Added +143.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 599.6k $3.0m | Added +92.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 496.4k $2.5m | Added +130.0k |
| KVP Capital Advisors, LP 2.37% of their portfolio | 462.4k $2.3m | First filing |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 450.9k $2.2m | Added +227.1k |
| BlackRock, Inc. 0.00% of their portfolio | 419.1k $2.1m | Added +27.9k |
| Pathstone Holdings, LLC 0.01% of their portfolio | 416.7k $1.9m | Reduced -85.3k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 382.2k $1.9m | New |
| UBS Group AG 0.00% of their portfolio | 285.2k $1.4m | Added +206.1k |
| Shay Capital LLC 0.19% of their portfolio | 234.9k $1.2m | Reduced -54.6k |
| STATE STREET CORP 0.00% of their portfolio | 234.3k $1.2m | Added +13.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 229.9k $1.1m | Added +10.4k |
| 683 Capital Management, LLC 0.09% of their portfolio | 214.9k $1.1m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 209.9k $1.0m | Added +99.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 167.9k $834.7k | Added +167.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 164.6k $818.1k | Reduced -208.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 152.5k $757.7k | Reduced -158.3k |
| BARCLAYS PLC 0.00% of their portfolio | 110.0k $546.9k | Added +110.0k |
| Blue Trust, Inc. 0.00% of their portfolio | 85.9k $426.9k | Reduced -13.2k |
| Alpine Global Management, LLC 0.09% of their portfolio | 83.5k $414.9k | New |
| MORGAN STANLEY 0.00% of their portfolio | 79.1k $392.9k | Added +45.4k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 75.2k $373.6k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 70.1k $348.2k | Reduced -1.5k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 67.7k $336.3k | New |
| MANCHESTER FINANCIAL INC 0.05% of their portfolio | 59.1k $293.6k | Added +12.4k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 54.0k $268.3k | Added +25.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 52.4k $260.5k | Unchanged |
| ADAR1 Capital Management, LLC 0.02% of their portfolio | 47.8k $237.6k | Unchanged |
| Graham Capital Management, L.P. 0.01% of their portfolio | 42.7k $212.3k | New |
| Caption Management, LLC 0.01% of their portfolio | 37.7k $187.3k | New |
| CITIGROUP INC 0.00% of their portfolio | 33.0k $163.9k | New |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 30.0k $149.1k | Unchanged |
| MEMBERS WEALTH LLC 0.10% of their portfolio | 30.0k $152.7k | New |
| Keating Financial Advisory Services, Inc. 0.02% of their portfolio | 24.9k $123.8k | First filing |
| Goldstone Financial Group, LLC 0.01% of their portfolio | 24.2k $120.1k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 24.1k $119.5k | Reduced -23.4k |
| Lighthouse Investment Partners, LLC 0.00% of their portfolio | 23.7k $117.8k | New |
| Jump Financial, LLC 0.00% of their portfolio | 21.0k $104.4k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 20.0k $99.4k | New |
| Robertson Stephens Wealth Management, LLC 0.00% of their portfolio | 20.0k $99.4k | Added +10.0k |
| XTX Topco Ltd 0.00% of their portfolio | 19.1k $94.9k | Reduced -66.8k |
| HRT FINANCIAL LP 0.00% of their portfolio | 18.9k $93.0k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 17.3k $86.2k | New |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 16.8k $83.6k | New |
| Next Capital Management LLC 0.03% of their portfolio | 16.1k $80.2k | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 14.0k $69.8k | Added +1 |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 13.4k $66.6k | Reduced -36.3k |
| MAGNOLIA CAPITAL ADVISORS LLC 0.01% of their portfolio | 12.8k $63.9k | New |
| Windsor Capital Management, LLC 0.01% of their portfolio | 10.8k $53.8k | Unchanged |
| Madison Park Capital Advisors, LLC 0.04% of their portfolio | 10.0k $49.7k | Unchanged |
| FMR LLC 0.00% of their portfolio | 6.5k $32.4k | Reduced -473 |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 4.6k $23.1k | New |
| Allworth Financial LP 0.00% of their portfolio | 3.0k $14.9k | Unchanged |
| Torren Management, LLC 0.01% of their portfolio | 2.9k $14.3k | First filing |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.8k $14.0k | New |
| COMERICA BANK 0.00% of their portfolio | 2.4k $11.8k | Reduced -31 |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 2.0k $9.9k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 1.7k $8.0k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.5k $8.0k | Reduced -153.2k |
| Capital Analysts, LLC 0.00% of their portfolio | 700 $3.0k | Added +190 |
| SITTNER & NELSON, LLC 0.00% of their portfolio | 673 $2.9k | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 490 $2.4k | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 200 $994 | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 150 $746 | Unchanged |
| Cornerstone Planning Group LLC 0.00% of their portfolio | 100 $436 | Added +87 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 19 $94 | Reduced -19 |
| Arax Advisory Partners 0.00% of their portfolio | 10 $50 | Unchanged |
| Parkside Financial Bank & Trust 0.00% of their portfolio | 5 $25 | New |