ACHIEVE LIFE SCIENCES INC ACHV
COM · Common Stock · CUSIP 004468500
- SectorHealth care
- IndustryIn Vitro & In Vivo Diagnostic Substances
- HeadquartersSeattle, WA
- Founded2015
- Websiteachievelifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.0m this quarter). Holder counts are more reliable. Shares outstanding: 34.3m as of 2024-08-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.24. Options: 8 managers hold calls ($2.7m notional), 3 hold puts ($115.6k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 29 |
| Q4 2022 | 29 |
| Q1 2023 | 32 |
| Q2 2023 | 40 |
| Q3 2023 | 36 |
| Q4 2023 | 30 |
| Q1 2024 | 42 |
| Q2 2024 | 57 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 12 | 13 |
| Q1 2023 | 20 | 11 |
| Q2 2023 | 25 | 13 |
| Q3 2023 | 13 | 21 |
| Q4 2023 | 13 | 17 |
| Q1 2024 | 25 | 16 |
| Q2 2024 | 37 | 17 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $110.9k | $251.6k | 2.27 |
| Q4 2023 | $119.7k | $209.3k | 1.75 |
| Q1 2024 | $1.6m | $225.5k | 0.14 |
| Q2 2024 | $2.7m | $115.6k | 0.04 |
Biggest buyers
| BlackRock Inc. | Added | +1.9m |
| Nantahala Capital Management, LLC | Added | +654.0k |
| VANGUARD GROUP INC | Added | +557.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +493.9k |
| STATE STREET CORP | Added | +348.9k |
| Bank of New York Mellon Corp | New | +102.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | New | +95.9k |
| FRANKLIN RESOURCES INC | Added | +88.3k |
| Nuveen Asset Management, LLC | New | +46.7k |
| RHUMBLINE ADVISERS | New | +41.8k |
Biggest sellers
| Altium Capital Management LLC | Reduced | -619.2k |
| CVI Holdings, LLC | Reduced | -495.4k |
| ADAR1 Capital Management, LLC | Reduced | -332.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -175.3k |
| Sofinnova Investments, Inc. | Reduced | -129.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Sold out | -44.7k |
| Balyasny Asset Management L.P. | Sold out | -27.7k |
| Virtu Financial LLC | Sold out | -12.9k |
| OMERS ADMINISTRATION Corp | Sold out | -12.0k |
| Jefferies Financial Group Inc. | Sold out | -11.5k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $861.0k183.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $592.2k126.0k shares |
| Caption Management, LLC | New | $506.2k107.7k shares |
| CITADEL ADVISORS LLC | Added | $305.5k65.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $283.0k60.3k shares |
| JANE STREET GROUP, LLC | New | $94.0k20.0k shares |
| HAP Trading, LLC | New | $32.0k80.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| GROUP ONE TRADING LLC | Reduced | $94.0k20.0k shares |
| CITADEL ADVISORS LLC | Reduced | $21.6k4.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TPG GP A, LLC
13D · may seek influence
new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing |
12.6% |
| Logos Global Management LP 13G · institution new · filed 2026-08-17 | 10.0% |
venBio Global Strategic Fund V, L.P.
13D · may seek influence
new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing |
10.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 | 9.2% |
| FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 | 8.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 | 6.5% |
| Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 | 5.6% |
| Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 | 5.4% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 | 5.2% |
| BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 | 5.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 | 5.0% |
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 1 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 1 | $27.5k | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 2 | $45.9k | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 6.1m $19.6m | Added +88.3k |
| Propel Bio Management, LLC 7.48% of their portfolio | 2.5m $11.5m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 2.0m $9.2m | Added +1.9m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.5m $7.1m | Added +557.3k |
| Sofinnova Investments, Inc. 0.41% of their portfolio | 1.4m $6.5m | Reduced -129.9k |
| Nantahala Capital Management, LLC 0.31% of their portfolio | 1.3m $6.1m | Added +654.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 700.6k $3.3m | Added +493.9k |
| ADAR1 Capital Management, LLC 0.51% of their portfolio | 542.2k $2.5m | Reduced -332.8k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 471.0k $2.2m | Unchanged |
| Shay Capital LLC 0.59% of their portfolio | 450.0k $2.1m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 404.1k $1.9m | Added +348.9k |
| Long Focus Capital Management, LLC 0.12% of their portfolio | 248.1k $1.2m | Unchanged |
| Simplify Asset Management Inc. 0.09% of their portfolio | 217.8k $1.0m | Unchanged |
| Altium Capital Management LLC 0.42% of their portfolio | 216.3k $1.0m | Reduced -619.2k |
| LPL Financial LLC 0.00% of their portfolio | 188.0k $883.6k | Added +5.5k |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 150.4k $707.1k | Reduced -1.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 126.3k $593.5k | Added +27.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 102.6k $482.0k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 95.9k $450.7k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 75.9k $356.6k | Added +7.1k |
| CVI Holdings, LLC 0.29% of their portfolio | 71.7k $337.2k | Reduced -495.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 46.7k $219.3k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 41.8k $196.5k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 34.5k $162.3k | Added +12.3k |
| MORGAN STANLEY 0.00% of their portfolio | 32.8k $154.1k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 29.4k $138.0k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 26.3k $123.8k | Added +4.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 25.1k $117.8k | Added +14.4k |
| J. Goldman & Co LP 0.00% of their portfolio | 24.5k $115.4k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 22.9k $107.5k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 21.6k $101.5k | New |
| MANCHESTER FINANCIAL INC 0.02% of their portfolio | 19.6k $92.3k | Added +530 |
| Corebridge Financial, Inc. 0.00% of their portfolio | 18.5k $87.3k | First filing |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 18.3k $86.0k | Reduced -175.3k |
| BERKSHIRE ASSET MANAGEMENT LLC/PA 0.00% of their portfolio | 17.7k $83.2k | New |
| Invesco Ltd. 0.00% of their portfolio | 16.2k $76.2k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 14.6k $68.8k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.2k $62.2k | New |
| BARCLAYS PLC 0.00% of their portfolio | 11.8k $55.6k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 11.1k $0 | New |
| UBS Group AG 0.00% of their portfolio | 10.4k $49.1k | Added +10.4k |
| Madison Park Capital Advisors, LLC 0.04% of their portfolio | 10.0k $47.0k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 9.1k $42.6k | New |
| CITIGROUP INC 0.00% of their portfolio | 7.6k $35.7k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 7.3k $34.2k | Reduced -2.6k |
| STRS OHIO 0.00% of their portfolio | 6.4k $30.1k | New |
| Legal & General Group Plc 0.00% of their portfolio | 3.5k $16.4k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.4k $15.9k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 3.2k $15.0k | New |
| Allworth Financial LP 0.00% of their portfolio | 3.0k $13.9k | New |
| Stephens Consulting, LLC 0.00% of their portfolio | 3.0k $14.1k | Unchanged |
| COMERICA BANK 0.00% of their portfolio | 2.5k $11.8k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 2.5k $11.7k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 1.2k $6.0k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 293 $1.4k | Reduced -2.8k |
| Cornerstone Planning Group LLC 0.00% of their portfolio | 100 $447 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |