TALPHERA INC TLPH
COM NEW · Common Stock · CUSIP 00444T209
Company in Redwood City, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Mateo, CA
- Founded2005
- Websiteacelrx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 51.9m as of 2026-08-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.03. Options: 5 managers hold calls ($114.8k notional), 3 hold puts ($111.4k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 37 |
| Q1 2023 | 33 |
| Q2 2023 | 28 |
| Q3 2023 | 32 |
| Q4 2023 | 34 |
| Q1 2024 | 32 |
| Q2 2024 | 31 |
| Q3 2024 | 30 |
| Q4 2024 | 36 |
| Q1 2025 | 33 |
| Q2 2025 | 33 |
| Q3 2025 | 34 |
| Q4 2025 | 38 |
| Q1 2026 | 45 |
| Q2 2026 | 49 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 6 | 13 |
| Q4 2024 | 12 | 11 |
| Q1 2025 | 13 | 13 |
| Q2 2025 | 7 | 13 |
| Q3 2025 | 17 | 9 |
| Q4 2025 | 20 | 12 |
| Q1 2026 | 22 | 11 |
| Q2 2026 | 26 | 14 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $247.1k | $0 | 0.00 |
| Q4 2025 | $979.4k | $1.0m | 1.06 |
| Q1 2026 | $78.3k | $86.5k | 1.10 |
| Q2 2026 | $114.8k | $111.4k | 0.97 |
Biggest buyers
| Nantahala Capital Management, LLC | Added | +3.5m |
| Rosalind Advisors, Inc. | Added | +1.8m |
| CANTOR FITZGERALD, L. P. | Added | +887.5k |
| Dauntless Investment Group, LLC | Added | +310.8k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +260.3k |
| Shay Capital LLC | Added | +155.7k |
| UBS Group AG | Added | +116.1k |
| GSA CAPITAL PARTNERS LLP | Added | +115.6k |
| Universal- Beteiligungs- und Servicegesellschaft mbH | New | +50.0k |
| VANGUARD FIDUCIARY TRUST CO | Added | +30.0k |
Biggest sellers
| Empery Asset Management, LP | Sold out | -590.5k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -124.5k |
| CITADEL ADVISORS LLC | Sold out | -106.2k |
| AIGH Capital Management LLC | Reduced | -60.0k |
| Caption Management, LLC | Reduced | -46.9k |
| AlphaCore Capital LLC | Sold out | -20.7k |
| HRT FINANCIAL LP | Sold out | -19.1k |
| MAI Capital Management | Sold out | -3.3k |
| TWO SIGMA SECURITIES, LLC | Reduced | -2.9k |
| Values First Advisors, Inc. | Reduced | -1.8k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $60.6k58.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $22.7k22.0k shares |
| JANE STREET GROUP, LLC | Reduced | $20.1k19.5k shares |
| SIMPLEX TRADING, LLC | Added | $7.6k7.4k shares |
| GROUP ONE TRADING LLC | Reduced | $3.9k3.8k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $61.6k59.8k shares |
| JANE STREET GROUP, LLC | Added | $29.1k28.3k shares |
| SIMPLEX TRADING, LLC | Added | $20.7k20.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
CorMedix Inc.
13D · may seek influence
new · filed 2025-09-12
Stated purposeOn September 7, 2025, the Issuer entered into a securities purchase agreement (the "Purchase Agreement") with the Reporting Person, pursuant to which the Reporting Person purchased from the Issuer in a private placement 9,090,909 Shares at a purchase price of $0.55 per share upon the First Closing (as defined in the Purchase Agreement). The First Closing occurred on September 10, 2025. Upon the First Closing, the Reporting Person has the right, subject to compliance with the applicable rules and regulations of The Nasdaq Capital Market, to designate one member of the Issuer's board of directors as long as the Reporting Person or its affiliates beneficially own at least 25% of the Shares the Reporting Person purchased at the First Closing. Additionally, pursuant to the Purchase Agreement,… Full filing |
19.9% |
| Nantahala Capital Management, LLC 13D · may seek influence no change · filed 2025-04-03 | 11.7% |
| Rosalind Advisors, Inc. 13G · exempt (held before listing) no change · filed 2026-08-12 | 9.9% |
| HIRSCHMAN ORIN 13G · institution +0.1 pts · filed 2026-01-30 | 9.8% |
| Rock Springs Capital Management LP 13G · passive investor new · filed 2025-09-12 | 7.9% |
Fell to 5% or below in the last year: LYTTON LAURENCE W (2.5%, 2026-05-15)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $6.8k | 1 | $119 | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 1 | $125.9k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 4 | $276.0k | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Nantahala Capital Management, LLC 0.22% of their portfolio | 7.0m $7.2m | Added +3.5m |
| Rosalind Advisors, Inc. 2.00% of their portfolio | 5.2m $5.3m | Added +1.8m |
| AIGH Capital Management LLC 0.43% of their portfolio | 4.6m $4.7m | Reduced -60.0k |
| Rock Springs Capital Management LP 0.18% of their portfolio | 3.6m $3.7m | Unchanged |
| CANTOR FITZGERALD, L. P. 0.02% of their portfolio | 1.8m $1.8m | Added +887.5k |
| Bleichroeder LP 0.24% of their portfolio | 1.3m $1.3m | Unchanged |
| Dauntless Investment Group, LLC 1.33% of their portfolio | 746.1k $768.4k | Added +310.8k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 701.9k $722.9k | Added +260.3k |
| Caption Management, LLC 0.02% of their portfolio | 515.0k $530.4k | Reduced -46.9k |
| Almitas Capital LLC 0.12% of their portfolio | 467.2k $481.2k | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 429.1k $442.0k | Added +9.1k |
| Shay Capital LLC 0.05% of their portfolio | 405.8k $417.9k | Added +155.7k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 222.4k $229.0k | Added +30.0k |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 209.4k $216.0k | Added +115.6k |
| DIADEMA PARTNERS LP 0.06% of their portfolio | 153.6k $158.2k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 129.9k $133.8k | Added +116.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 113.3k $116.7k | Reduced -124.5k |
| Mariner, LLC 0.00% of their portfolio | 100.0k $103.0k | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 91.5k $94.3k | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 88.3k $90.9k | Unchanged |
| Values First Advisors, Inc. 0.04% of their portfolio | 79.7k $82.1k | Reduced -1.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 75.7k $78.0k | Added +25.1k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 50.0k $51.5k | New |
| Persistent Asset Partners Ltd 0.01% of their portfolio | 39.0k $40.1k | Unchanged |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 29.7k $30.6k | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 28.4k $29.3k | New |
| XTX Topco Ltd 0.00% of their portfolio | 28.2k $29.0k | Added +2.4k |
| STATE STREET CORP 0.00% of their portfolio | 22.2k $22.8k | Unchanged |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 15.8k $16.3k | Reduced -2.9k |
| STEPHENS INC /AR/ 0.00% of their portfolio | 15.1k $15.6k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 12.5k $18.2k | New |
| Onyx Bridge Wealth Group LLC 0.00% of their portfolio | 11.5k $11.8k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 10.7k $11.0k | New |
| Virtu Financial LLC 0.00% of their portfolio | 10.1k $10.0k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 8.2k $8.5k | Added +1.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 4.5k $4.8k | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 1.0k $1.0k | New |
| BARCLAYS PLC 0.00% of their portfolio | 961 $990 | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 600 $618 | Reduced -383 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 285 $293 | Unchanged |
| NewEdge Advisors, LLC 0.00% of their portfolio | 201 $207 | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 136 $140 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 115 $118 | Added +2 |
| Arax Advisory Partners 0.00% of their portfolio | 81 $83 | Unchanged |
| Larson Financial Group LLC 0.00% of their portfolio | 30 $31 | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 10 $10 | Unchanged |
| BESSEMER GROUP INC 0.00% of their portfolio | 5 $0 | New |
| FLAGSHIP WEALTH ADVISORS, LLC 0.00% of their portfolio | 5 $5 | New |
| Global Retirement Partners, LLC 0.00% of their portfolio | 1 $1 | First filing |