ACADIA PHARMACEUTICALS INC ACAD
COM · Common Stock · CUSIP 004225108 · ISIN US0042251084
Pharmaceutical company, which developed Nuplazid, based in San Diego, California.
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- Founded1993
- Websiteacadia-pharm.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.4m this quarter). Holder counts are more reliable. Shares outstanding: 171.2m as of 2026-04-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $22.26. Options: 10 managers hold calls ($12.9m notional), 9 hold puts ($8.3m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 223 |
| Q4 2022 | 227 |
| Q1 2023 | 233 |
| Q2 2023 | 236 |
| Q3 2023 | 250 |
| Q4 2023 | 277 |
| Q1 2024 | 269 |
| Q2 2024 | 267 |
| Q3 2024 | 259 |
| Q4 2024 | 297 |
| Q1 2025 | 321 |
| Q2 2025 | 313 |
| Q3 2025 | 335 |
| Q4 2025 | 337 |
| Q1 2026 | 344 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 143 | 118 |
| Q3 2024 | 122 | 123 |
| Q4 2024 | 161 | 104 |
| Q1 2025 | 159 | 136 |
| Q2 2025 | 146 | 175 |
| Q3 2025 | 183 | 136 |
| Q4 2025 | 156 | 161 |
| Q1 2026 | 151 | 161 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $19.9m | $7.8m | 0.39 |
| Q3 2025 | $34.2m | $26.1m | 0.76 |
| Q4 2025 | $7.7m | $5.7m | 0.74 |
| Q1 2026 | $12.9m | $8.3m | 0.65 |
Biggest buyers
| Artisan Partners Limited Partnership | New | +1.3m |
| FIRST TRUST ADVISORS LP | Added | +1.1m |
| JANE STREET GROUP, LLC | New | +803.3k |
| BlackRock, Inc. | Added | +795.5k |
| Woodline Partners LP | New | +676.4k |
| STEMPOINT CAPITAL LP | New | +485.1k |
| Pictet Asset Management Holding SA | Added | +478.9k |
| BRAIDWELL LP | Added | +439.2k |
| STATE STREET CORP | Added | +422.0k |
| Allianz Asset Management GmbH | Added | +411.2k |
Biggest sellers
| Trails Edge Capital Partners, LP | Sold out | -1.4m |
| Point72 Asset Management, L.P. | Reduced | -799.4k |
| EMERALD ADVISERS, LLC | Reduced | -782.6k |
| CITADEL ADVISORS LLC | Reduced | -744.7k |
| ALGERT GLOBAL LLC | Reduced | -473.9k |
| EMERALD MUTUAL FUND ADVISERS TRUST | Reduced | -467.9k |
| MARSHALL WACE, LLP | Reduced | -417.2k |
| FMR LLC | Reduced | -376.6k |
| TWO SIGMA ADVISERS, LP | Sold out | -370.2k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -344.0k |
Biggest calls
| Caption Management, LLC | Added | $4.0m180.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.3m149.7k shares |
| Stonepine Capital Management, LLC | New | $2.2m100.0k shares |
| JANE STREET GROUP, LLC | Added | $868.1k39.0k shares |
| SIMPLEX TRADING, LLC | Added | $683.4k30.7k shares |
| NOMURA HOLDINGS INC | Added | $667.8k30.0k shares |
| CITADEL ADVISORS LLC | Added | $445.2k20.0k shares |
| Point72 Asset Management, L.P. | New | $305.0k13.7k shares |
| Walleye Capital LLC | Added | $215.9k9.7k shares |
| GROUP ONE TRADING LLC | Added | $126.9k5.7k shares |
Biggest puts
| Caption Management, LLC | Added | $4.9m220.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.1m48.2k shares |
| JANE STREET GROUP, LLC | Added | $870.4k39.1k shares |
| NOMURA HOLDINGS INC | Added | $667.8k30.0k shares |
| CITADEL ADVISORS LLC | Reduced | $353.9k15.9k shares |
| Point72 Asset Management, L.P. | New | $305.0k13.7k shares |
| GROUP ONE TRADING LLC | Added | $124.7k5.6k shares |
| Walleye Capital LLC | Reduced | $49.0k2.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $8.9k400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BAKER BROS. ADVISORS LP 13D · may seek influence filed 2026-02-26 | 25.4% |
| BlackRock, Inc. 13G · institution filed 2025-02-07 | 11.9% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-28 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), RTW INVESTMENTS, LP (4.2%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 4 | $950.0k | — |
| Q3 2024 | 0 | — | 3 | $779.5k | — |
| Q4 2024 | 0 | — | 3 | $414.6k | — |
| Q1 2025 | 0 | — | 3 | $187.3k | — |
| Q2 2025 | 0 | — | 3 | $530.4k | $90.0k |
| Q3 2025 | 0 | — | 2 | $678.3k | $554.0k |
| Q4 2025 | 0 | — | 3 | $1.0m | — |
| Q1 2026 | 0 | — | 5 | $769.7k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-26 | Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER | Sold | $69.5k3.2k shares |
| 2026-03-26 | Kihara James PRINCIPAL ACCOUNTING OFFICER | Sold | $24.0k1.1k shares |
| 2026-03-25 | Owen Adams Catherine Chief Executive Officer, director | Sold | $249.9k11.6k shares |
| 2026-03-25 | Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER | Sold | $89.7k4.2k shares |
| 2026-03-25 | Rhodes Jennifer J EVP, CHIEF LEGAL OFFICER, SEC | Sold | $82.5k3.8k shares |
| 2026-03-25 | Thompson Elizabeth H.Z. EVP, Head of Research & Dev | Sold | $73.7k3.4k shares |
| 2026-03-25 | Kihara James PRINCIPAL ACCOUNTING OFFICER | Sold | $17.9k833 shares |
| 2026-02-09 | Rhodes Jennifer J EVP, CHIEF LEGAL OFFICER, SEC | Sold | $162.5k7.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 5.48% of their portfolio | 42.9m $954.9m | Unchanged |
| BlackRock, Inc. 0.01% of their portfolio | 21.6m $479.7m | Added +795.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 8.7m $193.0m | First filing |
| STATE STREET CORP 0.01% of their portfolio | 8.3m $185.5m | Added +422.0k |
| RTW INVESTMENTS, LP 1.58% of their portfolio | 7.1m $159.0m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 5.7m $126.0m | First filing |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.5m $77.1m | Added +225.2k |
| FIRST TRUST ADVISORS LP 0.05% of their portfolio | 3.3m $74.4m | Added +1.1m |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 3.2m $70.2m | Added +234.2k |
| Palo Alto Investors LP 9.78% of their portfolio | 2.9m $63.9m | Added +388.7k |
| Point72 Asset Management, L.P. 0.10% of their portfolio | 2.6m $57.4m | Reduced -799.4k |
| BRAIDWELL LP 1.84% of their portfolio | 2.5m $55.0m | Added +439.2k |
| Pictet Asset Management Holding SA 0.05% of their portfolio | 2.0m $44.7m | Added +478.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.06% of their portfolio | 1.7m $38.4m | Added +191.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio | 1.6m $34.9m | Added +66.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.6m $34.7m | Reduced -12.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.6m $34.6m | Added +332.3k |
| Frazier Life Sciences Management, L.P. 0.82% of their portfolio | 1.4m $32.0m | Added +141.0k |
| Artisan Partners Limited Partnership 0.05% of their portfolio | 1.3m $29.6m | New |
| FRED ALGER MANAGEMENT, LLC 0.12% of their portfolio | 1.3m $28.4m | Reduced -282.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.3m $28.3m | Added +36.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.2m $26.1m | Added +1.2k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $24.3m | Reduced -48.8k |
| Nuveen, LLC 0.01% of their portfolio | 1.0m $23.1m | Reduced -20.5k |
| Rockefeller Capital Management L.P. 0.04% of their portfolio | 1.0m $22.9m | Reduced -85.7k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 1.0m $22.7m | Reduced -52.7k |
| Allspring Global Investments Holdings, LLC 0.04% of their portfolio | 954.9k $21.3m | Added +296.0k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 950.3k $21.2m | Reduced -252.3k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 875.7k $19.5m | First filing |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 840.4k $18.7m | Added +11.8k |
| Invesco Ltd. 0.00% of their portfolio | 836.5k $18.6m | Reduced -11.5k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 803.3k $17.9m | New |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 775.1k $17.3m | Reduced -344.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 768.2k $17.1m | Added +22.9k |
| Logos Global Management LP 0.86% of their portfolio | 750.0k $16.7m | Reduced -100.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 736.6k $16.4m | Reduced -15.4k |
| Fisher Asset Management, LLC 0.01% of their portfolio | 732.9k $16.3m | Added +67.8k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 729.8k $16.2m | Reduced -296.9k |
| Allianz Asset Management GmbH 0.02% of their portfolio | 706.7k $15.7m | Added +411.2k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 705.5k $15.7m | Added +151.8k |
| PANAGORA ASSET MANAGEMENT INC 0.06% of their portfolio | 688.6k $15.3m | Added +7.5k |
| Woodline Partners LP 0.06% of their portfolio | 676.4k $15.1m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 634.7k $14.1m | Added +19.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 624.3k $13.9m | Reduced -38.0k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 622.8k $13.9m | Reduced -744.7k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.77% of their portfolio | 617.5k $13.7m | Added +13.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 613.8k $13.7m | Reduced -27.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 571.8k $12.7m | Added +39.2k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 527.9k $11.8m | Reduced -76.8k |
| JUPITER ASSET MANAGEMENT LTD 0.06% of their portfolio | 491.1k $10.9m | Reduced -130.0k |
| STEMPOINT CAPITAL LP 1.05% of their portfolio | 485.1k $10.8m | New |
| UBS Group AG 0.00% of their portfolio | 448.5k $10.0m | Reduced -320.8k |
| Public Sector Pension Investment Board 0.03% of their portfolio | 447.9k $10.0m | Added +14.7k |
| Hudson Bay Capital Management LP 0.06% of their portfolio | 445.5k $9.9m | Added +375.5k |
| GLENMEDE TRUST CO NA 0.04% of their portfolio | 405.9k $9.0m | Reduced -47.8k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 387.6k $8.6m | Reduced -98.2k |
| Squarepoint Ops LLC 0.02% of their portfolio | 370.5k $8.2m | Added +329.7k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 355.5k $7.9m | Reduced -5.6k |
| FMR LLC 0.00% of their portfolio | 350.3k $7.8m | Reduced -376.6k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 313.0k $7.0m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio | 294.3k $6.6m | Reduced -286.7k |
| Legal & General Group Plc 0.00% of their portfolio | 287.4k $6.4m | Reduced -27.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 263.1k $5.5m | Reduced -7.7k |
| SPHERA FUNDS MANAGEMENT LTD. 0.98% of their portfolio | 256.2k $5.7m | Added +44.0k |
| LAZARD ASSET MANAGEMENT LLC 0.01% of their portfolio | 246.3k $5.5m | Added +20.1k |
| GREAT LAKES ADVISORS, LLC 0.04% of their portfolio | 241.8k $5.4m | Reduced -71.7k |
| Trexquant Investment LP 0.04% of their portfolio | 235.9k $5.3m | Reduced -61.9k |
| Swiss National Bank 0.00% of their portfolio | 234.4k $5.2m | Added +1.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 230.1k $5.1m | Added +58.6k |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 228.1k $4.9m | Reduced -9.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 223.2k $5.0m | Reduced -67.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 206.9k $4.6m | Added +1.5k |
| Edgestream Partners, L.P. 0.14% of their portfolio | 191.3k $4.3m | Reduced -124.9k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 181.7k $4.0m | Reduced -16.6k |
| Birchview Capital, LP 2.17% of their portfolio | 171.0k $3.8m | Unchanged |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 170.0k $3.8m | Added +17.8k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.81% of their portfolio | 168.0k $3.7m | Added +21.0k |
| ALPS ADVISORS INC 0.02% of their portfolio | 162.8k $3.6m | Added +4.6k |
| CONGRESS ASSET MANAGEMENT CO 0.03% of their portfolio | 160.8k $3.6m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 156.4k $3.5m | Added +6.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 153.1k $3.4m | Added +101.0k |
| Axecap Investments, LLC 2.34% of their portfolio | 152.9k $3.4m | Added +16.2k |
| BESSEMER GROUP INC 0.01% of their portfolio | 150.5k $3.4m | Added +149.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 149.3k $4.0m | Reduced -6.9k |
| Tetragon Partners GP Ltd 0.63% of their portfolio | 144.6k $3.2m | New |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 143.5k $3.2m | Reduced -34.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 142.7k $3.2m | Reduced -228.3k |
| Bridgewater Associates, LP 0.01% of their portfolio | 141.8k $3.2m | Added +3.6k |
| ALGERT GLOBAL LLC 0.05% of their portfolio | 140.5k $3.1m | Reduced -473.9k |
| MARTINGALE ASSET MANAGEMENT L P 0.08% of their portfolio | 140.0k $3.1m | Added +30.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 138.2k $3.1m | Added +11.4k |
| Erste Asset Management GmbH 0.03% of their portfolio | 133.7k $2.8m | Unchanged |
| Man Group plc 0.01% of their portfolio | 129.4k $2.9m | Reduced -218.8k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.01% of their portfolio | 128.7k $2.9m | Unchanged |
| Ishara Investments LP 2.77% of their portfolio | 123.0k $2.7m | Reduced -37.0k |
| SEGALL BRYANT & HAMILL, LLC 0.04% of their portfolio | 121.0k $2.7m | Reduced -5.0k |
| Caption Management, LLC 0.13% of their portfolio | 120.9k $2.7m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 118.5k $2.6m | Reduced -90.7k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 114.1k $2.5m | First filing |
| Emerald Investment Advisers, LLC 0.22% of their portfolio | 110.0k $2.4m | First filing |