ACADIA PHARMACEUTICALS INC ACAD
COM · Common Stock · CUSIP 004225108 · ISIN US0042251084
Pharmaceutical company, which developed Nuplazid, based in San Diego, California.
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- Founded1993
- Websiteacadia-pharm.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($16.8m this quarter). Holder counts are more reliable. Shares outstanding: 168.7m as of 2025-07-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.57. Options: 15 managers hold calls ($19.9m notional), 10 hold puts ($7.8m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 223 |
| Q4 2022 | 227 |
| Q1 2023 | 233 |
| Q2 2023 | 236 |
| Q3 2023 | 250 |
| Q4 2023 | 277 |
| Q1 2024 | 269 |
| Q2 2024 | 267 |
| Q3 2024 | 259 |
| Q4 2024 | 297 |
| Q1 2025 | 321 |
| Q2 2025 | 313 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 133 | 99 |
| Q4 2023 | 156 | 100 |
| Q1 2024 | 149 | 129 |
| Q2 2024 | 143 | 118 |
| Q3 2024 | 122 | 123 |
| Q4 2024 | 161 | 104 |
| Q1 2025 | 159 | 136 |
| Q2 2025 | 146 | 175 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $16.4m | $6.8m | 0.41 |
| Q4 2024 | $18.4m | $7.7m | 0.42 |
| Q1 2025 | $30.3m | $5.8m | 0.19 |
| Q2 2025 | $19.9m | $7.8m | 0.39 |
Biggest buyers
| CITADEL ADVISORS LLC | Added | +2.7m |
| MARSHALL WACE, LLP | Added | +1.6m |
| Rockefeller Capital Management L.P. | Added | +1.2m |
| Pictet Asset Management Holding SA | Added | +1.1m |
| DIMENSIONAL FUND ADVISORS LP | Added | +740.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +603.8k |
| Woodline Partners LP | Added | +542.0k |
| VOYA INVESTMENT MANAGEMENT LLC | Added | +535.7k |
| RTW INVESTMENTS, LP | Added | +455.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +336.4k |
Biggest sellers
| Assenagon Asset Management S.A. | Reduced | -2.0m |
| Point72 Asset Management, L.P. | Reduced | -1.5m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -1.2m |
| STATE STREET CORP | Reduced | -815.5k |
| TWO SIGMA ADVISERS, LP | Reduced | -772.6k |
| BlackRock, Inc. | Reduced | -714.1k |
| GOLDMAN SACHS GROUP INC | Reduced | -710.3k |
| MORGAN STANLEY | Reduced | -568.9k |
| Frazier Life Sciences Management, L.P. | Sold out | -470.3k |
| Nuveen, LLC | Reduced | -460.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.5m210.2k shares |
| J. Goldman & Co LP | New | $2.3m105.0k shares |
| GROUP ONE TRADING LLC | Added | $2.0m93.9k shares |
| Exome Asset Management LLC | New | $2.0m93.2k shares |
| GOLDMAN SACHS GROUP INC | Unchanged | $1.9m89.8k shares |
| DIADEMA PARTNERS LP | New | $1.9m88.9k shares |
| CITIGROUP INC | Added | $1.3m59.9k shares |
| JANE STREET GROUP, LLC | Added | $1.2m53.6k shares |
| CITADEL ADVISORS LLC | Reduced | $1.1m53.1k shares |
| Caption Management, LLC | New | $647.1k30.0k shares |
Biggest puts
| GOLDMAN SACHS GROUP INC | Unchanged | $1.9m89.8k shares |
| CITADEL ADVISORS LLC | Added | $1.4m65.1k shares |
| CITIGROUP INC | Added | $1.3m59.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.1m52.8k shares |
| Caption Management, LLC | Added | $647.1k30.0k shares |
| NOMURA HOLDINGS INC | New | $519.8k24.1k shares |
| GROUP ONE TRADING LLC | Added | $375.3k17.4k shares |
| JANE STREET GROUP, LLC | Reduced | $258.8k12.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $232.0k10.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BAKER BROS. ADVISORS LP 13D · may seek influence filed 2026-02-26 | 25.4% |
| BlackRock, Inc. 13G · institution filed 2025-02-07 | 11.9% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-28 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), RTW INVESTMENTS, LP (4.2%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 3 | $5.1m | $5.1m |
| Q4 2023 | 0 | — | 5 | $1.8m | $56.6k |
| Q1 2024 | 0 | — | 5 | $841.5k | — |
| Q2 2024 | 0 | — | 4 | $950.0k | — |
| Q3 2024 | 0 | — | 3 | $779.5k | — |
| Q4 2024 | 0 | — | 3 | $414.6k | — |
| Q1 2025 | 0 | — | 3 | $187.3k | — |
| Q2 2025 | 0 | — | 3 | $530.4k | $90.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-04 | Brege Laura Director | Sold | $314.6k14.4k shares |
| 2025-05-16 | Kihara James PRINCIPAL ACCOUNTING OFFICER | Sold plan | $90.0k4.0k shares |
| 2025-05-16 | Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER | Sold plan | $50.0k2.0k shares |
| 2025-05-02 | Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER | Sold | $51.1k3.5k shares |
| 2025-05-02 | Kihara James PRINCIPAL ACCOUNTING OFFICER | Sold | $19.4k1.3k shares |
| 2025-04-08 | Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER | Sold | $40.1k2.7k shares |
| 2025-04-08 | Kihara James PRINCIPAL ACCOUNTING OFFICER | Sold | $15.2k1.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 8.98% of their portfolio | 42.9m $925.3m | Added +18.8k |
| BlackRock, Inc. 0.01% of their portfolio | 20.7m $445.5m | Reduced -714.1k |
| VANGUARD GROUP INC 0.01% of their portfolio | 15.3m $329.2m | Added +61.0k |
| RTW INVESTMENTS, LP 2.76% of their portfolio | 9.0m $194.0m | Added +455.4k |
| STATE STREET CORP 0.00% of their portfolio | 6.2m $133.3m | Reduced -815.5k |
| MORGAN STANLEY 0.01% of their portfolio | 4.1m $88.7m | Reduced -568.9k |
| Point72 Asset Management, L.P. 0.16% of their portfolio | 3.2m $68.4m | Reduced -1.5m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.0m $65.2m | Added +69.6k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 3.0m $65.0m | Added +2.7m |
| Palo Alto Investors LP 11.76% of their portfolio | 2.6m $55.3m | Reduced -100.7k |
| FIRST TRUST ADVISORS LP 0.04% of their portfolio | 2.4m $52.5m | Added +65.9k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 2.4m $51.7m | Added +740.2k |
| FRED ALGER MANAGEMENT, LLC 0.23% of their portfolio | 2.4m $51.5m | Reduced -382.4k |
| Rockefeller Capital Management L.P. 0.06% of their portfolio | 2.3m $50.2m | Added +1.2m |
| MARSHALL WACE, LLP 0.05% of their portfolio | 2.0m $42.5m | Added +1.6m |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 2.0m $42.4m | Reduced -384.9k |
| Assenagon Asset Management S.A. 0.06% of their portfolio | 1.7m $36.9m | Reduced -2.0m |
| CITIGROUP INC 0.02% of their portfolio | 1.7m $36.0m | Reduced -185.5k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 1.6m $34.4m | Added +1.1m |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 1.6m $33.8m | Reduced -65.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.04% of their portfolio | 1.5m $33.4m | Added +70.7k |
| TANG CAPITAL MANAGEMENT LLC 1.64% of their portfolio | 1.5m $32.4m | Unchanged |
| NORGES BANK 0.00% of their portfolio | 1.5m $31.7m | Added +48.0k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.5m $31.7m | Reduced -710.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.3m $28.1m | Reduced -72.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.2m $25.7m | Reduced -11.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 928.8k $20.0m | Added +279.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 878.3k $18.9m | Added +158.0k |
| Invesco Ltd. 0.00% of their portfolio | 858.0k $18.5m | Added +126.4k |
| Nuveen, LLC 0.01% of their portfolio | 842.3k $18.2m | Reduced -460.0k |
| Woodline Partners LP 0.10% of their portfolio | 837.2k $18.1m | Added +542.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 806.4k $17.4m | Added +2.0k |
| GREAT LAKES ADVISORS, LLC 0.14% of their portfolio | 788.0k $17.0m | Added +175.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.02% of their portfolio | 787.5k $17.0m | Reduced -16.6k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 783.8k $16.9m | Added +134.6k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.06% of their portfolio | 761.2k $16.4m | Reduced -1.2m |
| UBS Group AG 0.00% of their portfolio | 736.2k $15.9m | Reduced -320.6k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 734.6k $15.8m | Reduced -26.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.28% of their portfolio | 728.4k $15.7m | Reduced -124.4k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 710.2k $15.3m | Reduced -44.6k |
| PRUDENTIAL FINANCIAL INC 0.02% of their portfolio | 685.5k $14.8m | Added +330.9k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.78% of their portfolio | 669.8k $14.4m | Reduced -2.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 658.8k $14.2m | Added +535.7k |
| PANAGORA ASSET MANAGEMENT INC 0.06% of their portfolio | 654.2k $14.1m | Added +435 |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 642.4k $13.9m | Added +70.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 636.5k $13.7m | Reduced -60.4k |
| JUPITER ASSET MANAGEMENT LTD 0.11% of their portfolio | 636.4k $13.7m | Added +229.3k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 603.8k $13.0m | New |
| EMERALD ADVISERS, LLC 0.47% of their portfolio | 592.4k $12.8m | Reduced -223.5k |
| Trexquant Investment LP 0.12% of their portfolio | 509.9k $11.0m | Added +215.7k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 483.1k $10.4m | Reduced -333.6k |
| Allspring Global Investments Holdings, LLC 0.02% of their portfolio | 431.0k $9.2m | Added +120.6k |
| BARCLAYS PLC 0.00% of their portfolio | 427.5k $9.2m | Added +179.0k |
| Public Sector Pension Investment Board 0.04% of their portfolio | 422.3k $9.1m | Added +31.8k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 367.1k $7.9m | Added +14.4k |
| Cubist Systematic Strategies, LLC 0.08% of their portfolio | 355.6k $7.7m | Reduced -167.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 342.9k $7.4m | Added +91.8k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 336.4k $7.3m | New |
| Legal & General Group Plc 0.00% of their portfolio | 331.5k $7.1m | Added +5.9k |
| EMERALD MUTUAL FUND ADVISERS TRUST 0.42% of their portfolio | 319.3k $6.9m | Reduced -175.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 311.9k $6.7m | Reduced -12.8k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 310.3k $6.7m | Reduced -44.7k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 291.7k $6.3m | Added +224.0k |
| Man Group plc 0.01% of their portfolio | 286.9k $6.2m | Added +90.6k |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 277.7k $6.1m | Added +2.6k |
| Stonepine Capital Management, LLC 4.78% of their portfolio | 225.0k $4.9m | Added +131.6k |
| LSV ASSET MANAGEMENT 0.01% of their portfolio | 210.0k $4.5m | Added +133.8k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 209.9k $4.5m | Reduced -79.6k |
| Swiss National Bank 0.00% of their portfolio | 207.0k $4.5m | Reduced -2.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 201.3k $4.3m | Reduced -224.2k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 199.0k $4.3m | New |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 194.9k $4.2m | Reduced -772.6k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 190.0k $4.1m | Reduced -121.0k |
| Birchview Capital, LP 4.02% of their portfolio | 187.8k $4.1m | Reduced -75.6k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 186.4k $4.0m | Reduced -6.2k |
| Erste Asset Management GmbH 0.03% of their portfolio | 180.3k $4.0m | Reduced -62.0k |
| SPHERA FUNDS MANAGEMENT LTD. 0.99% of their portfolio | 174.9k $3.8m | New |
| FMR LLC 0.00% of their portfolio | 169.4k $3.7m | Reduced -4.9k |
| J. Goldman & Co LP 0.11% of their portfolio | 164.3k $3.5m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 162.6k $3.5m | Added +20.0k |
| Tetragon Partners GP Ltd 0.63% of their portfolio | 161.4k $3.5m | Added +54.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 155.2k $3.3m | Reduced -17.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 155.1k $3.3m | Added +9.8k |
| Privium Fund Management B.V. 0.68% of their portfolio | 148.4k $3.2m | Unchanged |
| Hennion & Walsh Asset Management, Inc. 0.12% of their portfolio | 140.1k $3.0m | Added +9.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 138.7k $3.0m | Reduced -61.1k |
| Point72 Europe (London) LLP 0.15% of their portfolio | 135.0k $2.9m | Reduced -154.8k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 134.1k $2.9m | Reduced -18.5k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.01% of their portfolio | 132.3k $2.9m | Added +97.7k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 125.7k $2.7m | Reduced -74.6k |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 125.1k $2.7m | Reduced -150.3k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 121.1k $2.6m | Reduced -2.1k |
| HOHIMER WEALTH MANAGEMENT, LLC 0.45% of their portfolio | 117.9k $2.5m | Reduced -42.8k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 117.1k $2.5m | Added +36.6k |
| BURNEY CO/ 0.08% of their portfolio | 113.8k $2.5m | Reduced -284.3k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 112.0k $2.4m | Added +5.1k |
| ALPS ADVISORS INC 0.01% of their portfolio | 111.9k $2.4m | Reduced -28.3k |
| Edgestream Partners, L.P. 0.07% of their portfolio | 111.1k $2.4m | Reduced -48.0k |
| Nan Fung Group Holdings Ltd 3.50% of their portfolio | 103.0k $2.2m | Unchanged |
| Phocas Financial Corp. 0.32% of their portfolio | 102.2k $2.2m | Added +15 |