ATYR PHARMA INC ATYR
COM NEW · Common Stock · CUSIP 002120202 · ISIN US0021202025
Company in San Diego, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded2005
- Websiteatyrpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($100.7k this quarter). Holder counts are more reliable. Shares outstanding: 98.0m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.07. Options: 8 managers hold calls ($5.9m notional), 12 hold puts ($3.8m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 34 |
| Q4 2022 | 37 |
| Q1 2023 | 38 |
| Q2 2023 | 42 |
| Q3 2023 | 42 |
| Q4 2023 | 48 |
| Q1 2024 | 57 |
| Q2 2024 | 48 |
| Q3 2024 | 57 |
| Q4 2024 | 78 |
| Q1 2025 | 88 |
| Q2 2025 | 111 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 14 | 26 |
| Q4 2023 | 24 | 14 |
| Q1 2024 | 36 | 16 |
| Q2 2024 | 28 | 28 |
| Q3 2024 | 29 | 17 |
| Q4 2024 | 51 | 20 |
| Q1 2025 | 60 | 27 |
| Q2 2025 | 75 | 52 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $53.2k | $5.5k | 0.10 |
| Q4 2024 | $195.0k | $237.4k | 1.22 |
| Q1 2025 | $778.3k | $2.3m | 2.98 |
| Q2 2025 | $5.9m | $3.8m | 0.65 |
Biggest buyers
| BlackRock, Inc. | Added | +4.2m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +1.2m |
| STATE STREET CORP | Added | +872.4k |
| VANGUARD GROUP INC | Added | +648.3k |
| Invesco Ltd. | New | +598.0k |
| NORTHERN TRUST CORP | Added | +494.3k |
| FMR LLC | Added | +457.1k |
| Integral Health Asset Management, LLC | Added | +350.0k |
| Octagon Capital Advisors LP | Added | +268.0k |
| Ensign Peak Advisors, Inc | New | +235.7k |
Biggest sellers
| Point72 Asset Management, L.P. | Reduced | -1.9m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -1.5m |
| Ally Bridge Group (NY) LLC | Reduced | -489.3k |
| Qube Research & Technologies Ltd | Sold out | -414.6k |
| GOLDMAN SACHS GROUP INC | Reduced | -346.0k |
| MARSHALL WACE, LLP | Reduced | -327.0k |
| MAI Capital Management | Reduced | -289.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -246.0k |
| Squarepoint Ops LLC | Sold out | -235.2k |
| Balyasny Asset Management L.P. | Sold out | -227.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.3m263.9k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m250.0k shares |
| GROUP ONE TRADING LLC | Added | $1.1m208.9k shares |
| CITADEL ADVISORS LLC | Added | $965.3k190.4k shares |
| DIADEMA PARTNERS LP | Added | $652.5k128.7k shares |
| JANE STREET GROUP, LLC | New | $513.1k101.2k shares |
| Persistent Asset Partners Ltd | Added | $81.6k297 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $775.2k152.9k shares |
| Persistent Asset Partners Ltd | Added | $697.9k64.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $605.9k119.5k shares |
| DIADEMA PARTNERS LP | Added | $386.3k76.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $292.0k57.7k shares |
| Rosalind Advisors, Inc. | New | $271.1k223.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $253.5k50.0k shares |
| ADAR1 Capital Management, LLC | New | $253.5k50.0k shares |
| GROUP ONE TRADING LLC | Reduced | $174.4k34.4k shares |
| JANE STREET GROUP, LLC | Reduced | $92.3k18.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FEDERATED HERMES, INC. 13G · institution -3.6 pts · filed 2026-10-07 | 5.1% |
Fell to 5% or below in the last year: FMR LLC (2.5%, 2026-08-06), BlackRock, Inc. (1.8%, 2026-07-27), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 1 | $30.1k | 0 | — | — |
| Q4 2023 | 1 | $34.4k | 0 | — | — |
| Q1 2024 | 0 | — | 1 | $2.7k | — |
| Q2 2024 | 4 | $141.9k | 0 | — | — |
| Q3 2024 | 1 | $184.5k | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 1 | $15.0k | 2 | $8.1k | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FEDERATED HERMES, INC. 0.14% of their portfolio | 14.7m $74.4m | Unchanged |
| FMR LLC 0.00% of their portfolio | 13.4m $67.7m | Added +457.1k |
| BlackRock, Inc. 0.00% of their portfolio | 5.8m $29.3m | Added +4.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.7m $23.6m | Added +648.3k |
| Octagon Capital Advisors LP 4.25% of their portfolio | 3.8m $19.4m | Added +268.0k |
| Tikvah Management LLC 4.02% of their portfolio | 2.5m $12.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.1m $10.6m | Added +1.2m |
| UBS Group AG 0.00% of their portfolio | 1.7m $8.9m | Added +108.5k |
| Woodline Partners LP 0.05% of their portfolio | 1.7m $8.5m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.6m $8.1m | Added +1.2k |
| Alyeska Investment Group, L.P. 0.03% of their portfolio | 1.4m $7.2m | Added +134.9k |
| STATE STREET CORP 0.00% of their portfolio | 1.2m $6.3m | Added +872.4k |
| Integral Health Asset Management, LLC 0.50% of their portfolio | 1.1m $5.3m | Added +350.0k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 988.7k $5.0m | Reduced -1.9m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 680.9k $3.5m | Added +494.3k |
| TANG CAPITAL MANAGEMENT LLC 0.17% of their portfolio | 671.1k $3.4m | Unchanged |
| Erste Asset Management GmbH 0.03% of their portfolio | 600.0k $3.0m | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 598.0k $3.0m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 518.4k $2.6m | Added +38.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 511.4k $2.6m | Reduced -327.0k |
| GSA CAPITAL PARTNERS LLP 0.18% of their portfolio | 496.3k $2.5m | Added +164.0k |
| MAI Capital Management 0.01% of their portfolio | 369.1k $1.9m | Reduced -289.2k |
| BARCLAYS PLC 0.00% of their portfolio | 296.6k $1.5m | Added +59.5k |
| Ally Bridge Group (NY) LLC 1.28% of their portfolio | 287.7k $1.5m | Reduced -489.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 277.4k $1.4m | Added +109.2k |
| MORGAN STANLEY 0.00% of their portfolio | 260.0k $1.3m | Reduced -2.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 258.6k $1.3m | Added +218.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 254.0k $1.3m | Reduced -1.5m |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 235.7k $1.2m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 214.9k $1.1m | Added +46.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 214.5k $1.1m | Reduced -13.5k |
| THOROUGHBRED FINANCIAL SERVICES, LLC 0.07% of their portfolio | 210.8k $1.1m | New |
| Nuveen, LLC 0.00% of their portfolio | 194.1k $984.1k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 192.3k $974.0k | Added +167.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 185.9k $942.5k | New |
| Dauntless Investment Group, LLC 3.77% of their portfolio | 158.4k $803.1k | Reduced -12.3k |
| Parkman Healthcare Partners LLC 0.09% of their portfolio | 150.0k $760.5k | New |
| Main Street Financial Solutions, LLC 0.05% of their portfolio | 143.6k $728.1k | Added +9.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 124.2k $629.5k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 119.1k $603.9k | Reduced -141.9k |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 92.5k $468.9k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 77.3k $391.7k | Reduced -25.4k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 70.8k $358.8k | Reduced -18.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 64.5k $326.9k | Added +12.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 60.3k $305.7k | New |
| AVANTAX ADVISORY SERVICES, INC. 0.00% of their portfolio | 57.7k $292.4k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 56.0k $282.9k | New |
| Knott David M Jr 0.12% of their portfolio | 50.4k $255.4k | Reduced -173.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 47.6k $241.6k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 44.7k $226.5k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 43.5k $221.0k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 42.3k $214.7k | Reduced -246.0k |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.00% of their portfolio | 41.6k $210.7k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 41.1k $208.4k | New |
| Polar Asset Management Partners Inc. 0.01% of their portfolio | 40.5k $205.3k | New |
| Diametric Capital, LP 0.10% of their portfolio | 37.0k $187.7k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 36.4k $184.7k | Reduced -138.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 36.3k $183.9k | Reduced -346.0k |
| KINGSWOOD WEALTH ADVISORS, LLC 0.01% of their portfolio | 36.0k $182.5k | Reduced -1.0k |
| CITIGROUP INC 0.00% of their portfolio | 33.3k $169.0k | Added +33.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 32.5k $164.7k | New |
| Virtu Financial LLC 0.01% of their portfolio | 32.0k $162.0k | New |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 31.8k $161.2k | Reduced -116.3k |
| D.A. DAVIDSON & CO. 0.00% of their portfolio | 31.6k $160.5k | Reduced -8.6k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 31.3k $158.8k | Added +9.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 27.5k $139.4k | New |
| LPL Financial LLC 0.00% of their portfolio | 26.3k $133.5k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 24.8k $125.9k | Added +11.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 24.6k $124.8k | New |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 24.6k $127.7k | New |
| Atom Investors LP 0.01% of their portfolio | 21.8k $110.5k | New |
| KENNEDY CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 21.5k $109.1k | New |
| Apollon Wealth Management, LLC 0.00% of their portfolio | 20.5k $103.9k | Reduced -3.0k |
| Focus Partners Wealth 0.00% of their portfolio | 20.0k $101.4k | New |
| Three Magnolias Financial Advisors, LLC 0.07% of their portfolio | 20.0k $101.4k | New |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 19.9k $101.0k | Reduced -4.5k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 19.9k $100.7k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 19.6k $99.1k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 17.8k $90.4k | New |
| UNITED BANK 0.01% of their portfolio | 16.8k $85.3k | Added +3.0k |
| NORTH STAR ASSET MANAGEMENT INC 0.00% of their portfolio | 16.8k $85.2k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 15.3k $77.5k | New |
| Creative Planning 0.00% of their portfolio | 14.5k $73.6k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 14.5k $73.4k | Reduced -6.8k |
| OXFORD ASSET MANAGEMENT LLP 0.02% of their portfolio | 13.7k $69.6k | Not comparable |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 12.4k $62.8k | New |
| Gladstone Institutional Advisory LLC 0.00% of their portfolio | 10.8k $54.8k | New |
| CIBC WORLD MARKETS CORP 0.00% of their portfolio | 10.7k $54.3k | New |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 10.7k $54.2k | Reduced -7.3k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 10.3k $52.4k | Reduced -17.2k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 10.3k $52.0k | New |
| Legal & General Group Plc 0.00% of their portfolio | 9.6k $48.5k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 9.2k $46.0k | Reduced -87.6k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 8.9k $45.0k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 5.4k $27.5k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 3.0k $15.0k | New |
| Leonteq Securities AG 0.00% of their portfolio | 2.5k $12.7k | Unchanged |
| Caitong International Asset Management Co., Ltd 0.01% of their portfolio | 1.9k $9.7k | Added +524 |
| TWIN PEAKS WEALTH ADVISORS, LLC 0.00% of their portfolio | 1.8k $9.5k | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.2k $6.1k | New |