ATYR PHARMA INC ATYR
COM NEW · Common Stock · CUSIP 002120202 · ISIN US0021202025
Company in San Diego, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded2005
- Websiteatyrpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.7k this quarter). Holder counts are more reliable. Shares outstanding: 98.1m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.60. Options: 6 managers hold calls ($573.1k notional), 8 hold puts ($136.5k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 34 |
| Q4 2022 | 37 |
| Q1 2023 | 38 |
| Q2 2023 | 42 |
| Q3 2023 | 42 |
| Q4 2023 | 48 |
| Q1 2024 | 57 |
| Q2 2024 | 48 |
| Q3 2024 | 57 |
| Q4 2024 | 78 |
| Q1 2025 | 88 |
| Q2 2025 | 111 |
| Q3 2025 | 103 |
| Q4 2025 | 84 |
| Q1 2026 | 111 |
| Q2 2026 | 90 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 29 | 17 |
| Q4 2024 | 51 | 20 |
| Q1 2025 | 60 | 27 |
| Q2 2025 | 75 | 52 |
| Q3 2025 | 67 | 62 |
| Q4 2025 | 39 | 59 |
| Q1 2026 | 57 | 40 |
| Q2 2026 | 45 | 65 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $3.9m | $10.0m | 2.53 |
| Q4 2025 | $770.0k | $499.2k | 0.65 |
| Q1 2026 | $766.3k | $280.0k | 0.37 |
| Q2 2026 | $573.1k | $136.5k | 0.24 |
Biggest buyers
| Kalehua Capital Management LLC | New | +3.6m |
| AQR CAPITAL MANAGEMENT LLC | Added | +2.1m |
| GSA CAPITAL PARTNERS LLP | Added | +1.8m |
| JANE STREET GROUP, LLC | Added | +1.7m |
| CITADEL ADVISORS LLC | Added | +1.2m |
| GOLDMAN SACHS GROUP INC | Added | +358.0k |
| MARSHALL WACE, LLP | Added | +230.0k |
| Qube Research & Technologies Ltd | New | +127.0k |
| HRT FINANCIAL LP | New | +126.7k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +124.7k |
Biggest sellers
| FMR LLC | Reduced | -12.2m |
| BlackRock, Inc. | Reduced | -4.6m |
| UBS Group AG | Reduced | -2.3m |
| FEDERATED HERMES, INC. | Reduced | -2.0m |
| STATE STREET CORP | Reduced | -1.3m |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -1.2m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -985.2k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Sold out | -569.2k |
| NORTHERN TRUST CORP | Reduced | -491.0k |
| Nuveen, LLC | Sold out | -229.3k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $148.6k249.0k shares |
| GROUP ONE TRADING LLC | Added | $125.7k210.6k shares |
| JANE STREET GROUP, LLC | Reduced | $106.6k178.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $92.9k154.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $92.1k154.2k shares |
| TORONTO DOMINION BANK | New | $7.3k12.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $69.9k116.5k shares |
| CITADEL ADVISORS LLC | Added | $34.1k57.2k shares |
| GROUP ONE TRADING LLC | Reduced | $10.3k17.3k shares |
| JANE STREET GROUP, LLC | New | $9.0k15.0k shares |
| DIADEMA PARTNERS LP | Unchanged | $7.5k12.5k shares |
| Persistent Asset Partners Ltd | Unchanged | $5.2k27 shares |
| SIMPLEX TRADING, LLC | Reduced | $477800 shares |
| FNY Investment Advisers, LLC | Unchanged | $015 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FEDERATED HERMES, INC. 13G · institution -3.6 pts · filed 2026-10-07 | 5.1% |
Fell to 5% or below in the last year: FMR LLC (2.5%, 2026-08-06), BlackRock, Inc. (1.8%, 2026-07-27), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 1 | $15.0k | 2 | $8.1k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $912.7k | 0 | — | — |
| Q1 2026 | 0 | — | 3 | $6.3k | — |
| Q2 2026 | 1 | $50.0k | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-05-27 | SCHIMMEL PAUL Director · See Footnote | Bought | $50.0k100.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FEDERATED HERMES, INC. 0.01% of their portfolio | 8.5m $5.1m | Reduced -2.0m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.8m $2.3m | Reduced -4.0k |
| Kalehua Capital Management LLC 0.68% of their portfolio | 3.6m $2.1m | New |
| GSA CAPITAL PARTNERS LLP 0.13% of their portfolio | 3.5m $2.1m | Added +1.8m |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.6m $1.6m | Added +2.1m |
| FMR LLC 0.00% of their portfolio | 2.5m $1.5m | Reduced -12.2m |
| BlackRock, Inc. 0.00% of their portfolio | 1.8m $1.1m | Reduced -4.6m |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 1.7m $1.0m | Added +1.7m |
| UBS Group AG 0.00% of their portfolio | 1.5m $914.1k | Reduced -2.3m |
| MORGAN STANLEY 0.00% of their portfolio | 1.3m $801.9k | Added +118.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 1.2m $743.1k | Added +100.6k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.2m $741.3k | Added +1.2m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.2m $702.7k | Reduced -1.2m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 747.0k $445.8k | Reduced -119.7k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 656.1k $391.5k | Reduced -985.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 641.2k $382.7k | Added +358.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 576.1k $343.9k | Reduced -75.7k |
| STATE STREET CORP 0.00% of their portfolio | 495.0k $295.4k | Reduced -1.3m |
| MARSHALL WACE, LLP 0.00% of their portfolio | 368.1k $220.9k | Added +230.0k |
| XTX Topco Ltd 0.00% of their portfolio | 226.7k $135.3k | Added +115.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 220.1k $131.4k | Reduced -491.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 207.5k $123.7k | Reduced -96.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 165.2k $98.6k | Added +124.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 150.7k $85.3k | Added +108.7k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 138.9k $82.9k | Reduced -45.1k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 127.0k $75.8k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 126.7k $75.0k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 90.9k $54.1k | Reduced -1.0k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 66.2k $38.4k | Added +48.0k |
| Mariner, LLC 0.00% of their portfolio | 58.7k $35.0k | New |
| HOHIMER WEALTH MANAGEMENT, LLC 0.00% of their portfolio | 55.0k $32.8k | Reduced -45.0k |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 53.5k $31.9k | Added +38.3k |
| KINGSWOOD WEALTH ADVISORS, LLC 0.00% of their portfolio | 52.0k $31.0k | Unchanged |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 50.9k $30.4k | New |
| ADAR1 Capital Management, LLC 0.00% of their portfolio | 50.7k $30.2k | Unchanged |
| Alpha Wealth Funds, LLC 0.02% of their portfolio | 50.0k $29.9k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 48.8k $29.1k | Added +31.3k |
| Virtu Financial LLC 0.00% of their portfolio | 46.9k $28.0k | Added +6.9k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 43.9k $23.9k | Added +28.4k |
| Creative Planning 0.00% of their portfolio | 41.6k $24.8k | Added +31.1k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 37.3k $22.2k | New |
| Hobbs Group Advisors, LLC 0.01% of their portfolio | 36.0k $21.5k | Added +16.6k |
| LPL Financial LLC 0.00% of their portfolio | 35.5k $21.2k | Unchanged |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 33.9k $20.3k | Added +18.0k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 33.4k $19.9k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 31.0k $18.5k | Reduced -14.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 30.4k $18.2k | Reduced -72.7k |
| Cerity Partners LLC 0.00% of their portfolio | 29.2k $17.4k | New |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 28.1k $16.8k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 25.1k $15.0k | Reduced -223 |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 23.0k $13.7k | Added +12.7k |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 22.4k $13.4k | New |
| Abel Hall, LLC 0.00% of their portfolio | 22.1k $13.2k | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 19.6k $11.7k | Added +3.0k |
| MAI Capital Management 0.00% of their portfolio | 16.8k $10.1k | Added +3.3k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 16.8k $10.0k | Added +200 |
| TRUST CO OF TOLEDO NA /OH/ 0.00% of their portfolio | 16.6k $9.9k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 16.6k $9.9k | New |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 14.9k $8.9k | Reduced -1.8k |
| TrinityBridge Ltd 0.00% of their portfolio | 12.3k $7.0k | Reduced -3.9k |
| BRIGHTON JONES LLC 0.00% of their portfolio | 11.5k $6.8k | New |
| Gladstone Institutional Advisory LLC 0.00% of their portfolio | 11.3k $6.7k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 6.5k $3.9k | Reduced -40.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.0k $3.0k | Reduced -5.2k |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 6.0k $3.6k | New |
| Allworth Financial LP 0.00% of their portfolio | 3.6k $2.2k | Added +3.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 2.0k $1.2k | Unchanged |
| Ares Financial Consulting, LLC 0.00% of their portfolio | 2.0k $1.2k | Unchanged |
| NFSG Corp 0.00% of their portfolio | 2.0k $1.2k | Reduced -100 |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 1.5k $791 | Unchanged |
| FNY Investment Advisers, LLC 0.00% of their portfolio | 1.5k $0 | Unchanged |
| Vision Retirement, LLC 0.00% of their portfolio | 1.5k $895 | Unchanged |
| MCF Advisors LLC 0.00% of their portfolio | 1.4k $836 | Added +1.0k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.3k $762 | Reduced -6.9k |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 1.1k $685 | Added +734 |
| CITIGROUP INC 0.00% of their portfolio | 900 $537 | Reduced -5.0k |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 885 $528 | Added +598 |
| Clearstead Advisors, LLC 0.00% of their portfolio | 861 $515 | New |
| Essential Partners LLC 0.00% of their portfolio | 815 $486 | Reduced -803 |
| GAMMA Investing LLC 0.00% of their portfolio | 659 $393 | Reduced -7.1k |
| True Wealth Design, LLC 0.00% of their portfolio | 464 $277 | Added +392 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 372 $222 | Reduced -948 |
| SJS Investment Consulting Inc. 0.00% of their portfolio | 208 $125 | Added +166 |
| Larson Financial Group LLC 0.00% of their portfolio | 150 $90 | Unchanged |
| IFP Advisors, Inc 0.00% of their portfolio | 143 $85 | Reduced -5.9k |
| CALDWELL SUTTER CAPITAL, INC. 0.00% of their portfolio | 52 $31 | Unchanged |
| IFG Advisory, LLC 0.00% of their portfolio | 50 $30 | New |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 25 $15 | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 8 $5 | Reduced -966 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $1 | Unchanged |