ALX ONCOLOGY HLDGS INC ALXO
COM · Common Stock · CUSIP 00166B105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.6m as of 2025-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.43. Options: 4 managers hold calls ($48.5k notional), 3 hold puts ($6.9k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 88 |
| Q1 2023 | 87 |
| Q2 2023 | 76 |
| Q3 2023 | 77 |
| Q4 2023 | 94 |
| Q1 2024 | 107 |
| Q2 2024 | 114 |
| Q3 2024 | 93 |
| Q4 2024 | 88 |
| Q1 2025 | 86 |
| Q2 2025 | 62 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 35 | 32 |
| Q4 2023 | 62 | 30 |
| Q1 2024 | 51 | 40 |
| Q2 2024 | 66 | 50 |
| Q3 2024 | 56 | 58 |
| Q4 2024 | 48 | 46 |
| Q1 2025 | 33 | 38 |
| Q2 2025 | 19 | 66 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $363.9k | $61.7k | 0.17 |
| Q4 2024 | $427.4k | $190.6k | 0.45 |
| Q1 2025 | $24.0k | $56.5k | 2.35 |
| Q2 2025 | $48.5k | $6.9k | 0.14 |
Biggest buyers
| Almitas Capital LLC | Added | +1.2m |
| JANE STREET GROUP, LLC | New | +203.3k |
| GSA CAPITAL PARTNERS LLP | New | +81.3k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +71.1k |
| Squarepoint Ops LLC | New | +58.3k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +42.1k |
| NAN FUNG TRINITY (HK) LTD | New | +42.0k |
| UBS Group AG | Added | +32.2k |
| Point72 Asia (Singapore) Pte. Ltd. | New | +27.7k |
| TWO SIGMA ADVISERS, LP | Added | +22.3k |
Biggest sellers
| BlackRock, Inc. | Reduced | -1.6m |
| STATE STREET CORP | Reduced | -594.6k |
| MPM BIOIMPACT LLC | Sold out | -550.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -455.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -451.5k |
| BANK OF AMERICA CORP /DE/ | Reduced | -416.7k |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Sold out | -409.9k |
| JPMORGAN CHASE & CO | Reduced | -269.6k |
| Redmile Group, LLC | Reduced | -249.4k |
| MORGAN STANLEY | Reduced | -241.0k |
Biggest calls
| SIMPLEX TRADING, LLC | Added | $26.0k63.6k shares |
| CITADEL ADVISORS LLC | Added | $22.3k53.8k shares |
| GROUP ONE TRADING LLC | Reduced | $125300 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $4.9k11.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.0k4.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
venBio Global Strategic Fund, L.P.
13D · may seek influence
no change · filed 2026-10-16
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The responses to Items 3 and 6 of this Amendment No. 2 are incorporated by reference herein. Mr. Goodman resigned from the Issuer's board of directors effective June 29, 2026. Full filing |
10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-02-09 | 9.9% |
| HBM Healthcare Investments (Cayman) Ltd. 13G · passive investor -1.9 pts · filed 2026-05-15 | 6.5% |
| TANG CAPITAL PARTNERS LP 13G · passive investor filed 2025-02-14 | 6.3% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-27 | 5.4% |
Fell to 5% or below in the last year: TCG Crossover GP II, LLC (4.2%, 2026-08-14), LSV Associates, LLC (2.2%, 2026-05-27), Redmile Group, LLC (6.8%, 2026-05-15), MILLENNIUM MANAGEMENT LLC (1.5%, 2026-04-28)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 1 | $47.9k | — |
| Q4 2023 | 0 | — | 4 | $208.0k | — |
| Q1 2024 | 1 | $49.8k | 1 | $37.0k | — |
| Q2 2024 | 1 | $102.4k | 2 | $1.6m | $1.6m |
| Q3 2024 | 0 | — | 3 | $267.7k | $158.0k |
| Q4 2024 | 1 | $46.5k | 2 | $19.3k | — |
| Q1 2025 | 0 | — | 3 | $8.6k | — |
| Q2 2025 | 0 | — | 1 | $659 | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-30 | Pinto Shelly SVP, FINANCE AND CAO | Sold | $6591.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| venBio Partners LLC 3.51% of their portfolio | 9.7m $4.0m | Unchanged |
| Redmile Group, LLC 0.15% of their portfolio | 3.4m $1.4m | Reduced -249.4k |
| TANG CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 3.2m $1.3m | Unchanged |
| Almitas Capital LLC 0.27% of their portfolio | 2.5m $1.1m | Added +1.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.6m $664.3k | Reduced -237.1k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.3m $525.0k | Reduced -28.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.0m $429.6k | Reduced -416.7k |
| BlackRock, Inc. 0.00% of their portfolio | 716.3k $297.3k | Reduced -1.6m |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 703.3k $291.9k | Added +22.3k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 668.7k $277.6k | Reduced -13.6k |
| Privium Fund Management B.V. 0.05% of their portfolio | 509.1k $220.6k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 492.6k $204.5k | Reduced -451.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 477.9k $198.4k | Reduced -64.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 315.4k $131.0k | Reduced -455.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 289.7k $120.3k | Reduced -83.5k |
| UBS Group AG 0.00% of their portfolio | 288.7k $119.8k | Added +32.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 203.3k $84.4k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 163.8k $68.0k | Added +42.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 135.9k $56.4k | Reduced -182.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 133.4k $55.4k | Reduced -77.6k |
| STATE STREET CORP 0.00% of their portfolio | 124.2k $51.6k | Reduced -594.6k |
| MORGAN STANLEY 0.00% of their portfolio | 117.5k $48.8k | Reduced -241.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 106.3k $44.6k | Reduced -164.9k |
| BANK OF NOVA SCOTIA 0.00% of their portfolio | 105.9k $43.9k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 88.4k $36.7k | Reduced -269.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 85.4k $35.4k | Added +71.1k |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 81.3k $34.0k | New |
| XTX Topco Ltd 0.00% of their portfolio | 74.8k $31.0k | Reduced -17.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 58.3k $24.2k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 45.6k $18.9k | Reduced -73.5k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 44.1k $18.3k | Reduced -102.8k |
| NAN FUNG TRINITY (HK) LTD 0.00% of their portfolio | 42.0k $17.4k | New |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 41.0k $508.0k | Unchanged |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 39.3k $18.1k | Reduced -1.3k |
| Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio | 27.7k $11.5k | New |
| HC Advisors, LLC 0.01% of their portfolio | 20.5k $8.5k | Reduced -1.0k |
| Callan Family Office, LLC 0.00% of their portfolio | 19.8k $8.2k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 19.3k $8.0k | Reduced -134.5k |
| FMR LLC 0.00% of their portfolio | 18.0k $7.5k | Reduced -4.0k |
| JSF Financial, LLC 0.00% of their portfolio | 17.5k $7.3k | Unchanged |
| Abel Hall, LLC 0.00% of their portfolio | 15.2k $6.3k | New |
| MONETA GROUP INVESTMENT ADVISORS LLC 0.00% of their portfolio | 15.2k $6.3k | Unchanged |
| Lido Advisors, LLC 0.00% of their portfolio | 13.2k $5.5k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 12.3k $5.0k | Reduced -3.8k |
| BARCLAYS PLC 0.00% of their portfolio | 10.6k $4.4k | Reduced -37.5k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 10.3k $4.3k | Reduced -240 |
| CITIGROUP INC 0.00% of their portfolio | 9.0k $3.7k | Reduced -15.7k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 6.5k $2.7k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.0k $4.0k | Added +4.0k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 5.2k $2.2k | Reduced -11.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 1.7k $697 | Reduced -5.9k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.5k $611 | Added +771 |
| CWM, LLC 0.00% of their portfolio | 1.3k $1.0k | Reduced -5.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 1.0k $415 | New |
| Bradley & Co. Private Wealth Management, LLC 0.00% of their portfolio | 1.0k $415 | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 629 $261 | Added +99 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 447 $186 | Reduced -16.0k |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 422 $175 | Added +296 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 397 $165 | Reduced -450 |
| Clearstead Advisors, LLC 0.00% of their portfolio | 177 $74 | New |
| True Wealth Design, LLC 0.00% of their portfolio | 15 $7 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |