ALX ONCOLOGY HLDGS INC ALXO
COM · Common Stock · CUSIP 00166B105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 50.2m as of 2024-02-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $11.15. Options: 7 managers hold calls ($1.6m notional), 5 hold puts ($399.9k).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 88 |
| Q1 2023 | 87 |
| Q2 2023 | 76 |
| Q3 2023 | 77 |
| Q4 2023 | 94 |
| Q1 2024 | 107 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 24 | 50 |
| Q1 2023 | 42 | 37 |
| Q2 2023 | 36 | 41 |
| Q3 2023 | 35 | 32 |
| Q4 2023 | 62 | 30 |
| Q1 2024 | 51 | 40 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $739.4k | $86.4k | 0.12 |
| Q3 2023 | $1.0m | $61.4k | 0.06 |
| Q4 2023 | $4.1m | $1.3m | 0.31 |
| Q1 2024 | $1.6m | $399.9k | 0.25 |
Biggest buyers
| Vestal Point Capital, LP | Added | +955.0k |
| Redmile Group, LLC | Added | +667.2k |
| MORGAN STANLEY | Added | +201.8k |
| MARSHALL WACE, LLP | Added | +110.0k |
| Squarepoint Ops LLC | New | +106.4k |
| GOLDMAN SACHS GROUP INC | Added | +66.3k |
| VANGUARD GROUP INC | Added | +64.1k |
| MILLENNIUM MANAGEMENT LLC | New | +60.2k |
| HRT FINANCIAL LP | New | +59.2k |
| STATE OF WISCONSIN INVESTMENT BOARD | New | +54.4k |
Biggest sellers
| Point72 Asset Management, L.P. | Sold out | -913.7k |
| Invesco Ltd. | Sold out | -385.2k |
| ORBIMED ADVISORS LLC | Reduced | -377.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -310.5k |
| Schonfeld Strategic Advisors LLC | Sold out | -104.6k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -83.9k |
| Cubist Systematic Strategies, LLC | Sold out | -65.8k |
| D. E. Shaw & Co., Inc. | Sold out | -50.2k |
| Walleye Capital LLC | Reduced | -39.6k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -36.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.0m92.6k shares |
| MILLENNIUM MANAGEMENT LLC | Reduced | $334.5k30.0k shares |
| CITADEL ADVISORS LLC | Reduced | $101.5k9.1k shares |
| SIMPLEX TRADING, LLC | Added | $81.0k7.3k shares |
| GROUP ONE TRADING LLC | Reduced | $25.6k2.3k shares |
| Walleye Capital LLC | New | $4.5k400 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $149.0k13.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $126.0k11.3k shares |
| CITADEL ADVISORS LLC | Reduced | $93.7k8.4k shares |
| GROUP ONE TRADING LLC | Reduced | $31.2k2.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
venBio Global Strategic Fund, L.P.
13D · may seek influence
no change · filed 2026-10-16
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The responses to Items 3 and 6 of this Amendment No. 2 are incorporated by reference herein. Mr. Goodman resigned from the Issuer's board of directors effective June 29, 2026. Full filing |
10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-02-09 | 9.9% |
| HBM Healthcare Investments (Cayman) Ltd. 13G · passive investor -1.9 pts · filed 2026-05-15 | 6.5% |
| TANG CAPITAL PARTNERS LP 13G · passive investor filed 2025-02-14 | 6.3% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-27 | 5.4% |
Fell to 5% or below in the last year: TCG Crossover GP II, LLC (4.2%, 2026-08-14), LSV Associates, LLC (2.2%, 2026-05-27), Redmile Group, LLC (6.8%, 2026-05-15), MILLENNIUM MANAGEMENT LLC (1.5%, 2026-04-28)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 4 | $68.9k | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 4 | $45.3k | — |
| Q3 2023 | 0 | — | 1 | $47.9k | — |
| Q4 2023 | 0 | — | 4 | $208.0k | — |
| Q1 2024 | 1 | $49.8k | 1 | $37.0k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-03-14 | Lettmann Jason CHIEF EXECUTIVE OFFICER, director | Bought | $49.8k4.4k shares |
| 2024-01-04 | Pinto Shelly SVP, Finance and CAO | Sold | $37.0k2.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| venBio Partners LLC 38.37% of their portfolio | 9.7m $108.2m | Unchanged |
| FMR LLC 0.01% of their portfolio | 7.5m $83.9m | Added +50.0k |
| Redmile Group, LLC 1.77% of their portfolio | 4.3m $48.2m | Added +667.2k |
| Vivo Capital, LLC 3.70% of their portfolio | 4.2m $47.1m | Unchanged |
| Cormorant Asset Management, LP 1.54% of their portfolio | 3.1m $35.0m | Unchanged |
| ORBIMED ADVISORS LLC 0.56% of their portfolio | 2.7m $30.3m | Reduced -377.0k |
| Vestal Point Capital, LP 2.41% of their portfolio | 2.6m $29.1m | Added +955.0k |
| BlackRock Inc. 0.00% of their portfolio | 2.2m $24.8m | Reduced -13.5k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.6m $17.5m | Added +64.1k |
| MPM BIOIMPACT LLC 2.29% of their portfolio | 1.3m $14.1m | Added +3.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.2m $13.8m | Added +2.1k |
| MORGAN STANLEY 0.00% of their portfolio | 1.0m $11.5m | Added +201.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 604.7k $6.7m | Added +19.7k |
| STATE STREET CORP 0.00% of their portfolio | 553.9k $6.2m | Added +52.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 245.2k $2.7m | Added +1.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 234.1k $2.6m | Reduced -36.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 232.8k $2.6m | Reduced -310.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 209.8k $2.3m | Added +1.6k |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 201.4k $2.2m | Added +4.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 160.0k $1.8m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 157.0k $1.8m | Added +66.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 127.0k $1.4m | Added +46.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 121.5k $1.4m | Added +110.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 106.4k $1.2m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 105.9k $1.2m | Unchanged |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 99.0k $1.1m | Reduced -24.5k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 91.0k $1.0m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 83.8k $934.3k | Reduced -11.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 79.8k $889.4k | Reduced -6.5k |
| Aberdeen Group plc 0.00% of their portfolio | 66.2k $738.3k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 65.5k $729.8k | Reduced -466 |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 60.2k $671.1k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 60.1k $670.3k | Added +12.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 59.2k $660.0k | Added +15.6k |
| HRT FINANCIAL LP 0.00% of their portfolio | 59.2k $659.0k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 54.4k $606.2k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 50.3k $561.3k | Reduced -83.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 49.9k $555.9k | Added +1.7k |
| TD Asset Management Inc 0.00% of their portfolio | 49.0k $546.4k | Reduced -21.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 47.2k $525.8k | Reduced -17.6k |
| Swiss National Bank 0.00% of their portfolio | 44.2k $492.8k | New |
| CITIGROUP INC 0.00% of their portfolio | 43.5k $485.1k | Added +38.8k |
| Nan Fung Group Holdings Ltd 0.43% of their portfolio | 42.0k $467.7k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 41.0k $468.0k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 38.8k $432.5k | Reduced -1.5k |
| Walleye Capital LLC 0.00% of their portfolio | 38.2k $426.4k | Reduced -39.6k |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 36.2k $403.6k | Reduced -5.9k |
| Inspire Investing, LLC 0.04% of their portfolio | 33.2k $369.7k | New |
| Financial Advisory Group 0.06% of their portfolio | 31.4k $350.3k | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 29.7k $330.7k | Added +8.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 29.1k $324.3k | Added +15.8k |
| UBS Group AG 0.00% of their portfolio | 29.1k $324.2k | Reduced -1.9k |
| BARCLAYS PLC 0.00% of their portfolio | 28.6k $319.3k | Reduced -16.0k |
| AlphaQuest LLC 0.05% of their portfolio | 25.0k $279.1k | New |
| Jump Financial, LLC 0.01% of their portfolio | 24.8k $276.6k | Reduced -140 |
| SG Americas Securities, LLC 0.00% of their portfolio | 23.9k $267.0k | Reduced -6.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 23.7k $264.3k | Reduced -15.8k |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 23.4k $261.0k | Reduced -7.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 22.8k $254.2k | Added +18.4k |
| Trexquant Investment LP 0.00% of their portfolio | 21.0k $234.0k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 20.2k $225.7k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 20.0k $223.0k | Reduced -13.5k |
| BOURGEON CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 19.6k $218.2k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 17.2k $191.6k | Added +14.9k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 15.8k $175.8k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 14.6k $162.4k | Unchanged |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 13.0k $144.9k | Reduced -398 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 12.6k $141.0k | Added +159 |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 12.0k $133.8k | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 11.5k $128.6k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 11.5k $128.1k | Added +366 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 10.9k $62.6k | Added +235 |
| XTX Topco Ltd 0.02% of their portfolio | 10.9k $121.7k | New |
| CORNERCAP INVESTMENT COUNSEL INC 0.02% of their portfolio | 10.4k $116.4k | New |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 10.3k $115.0k | New |
| Forefront Analytics, LLC 0.06% of their portfolio | 10.3k $114.4k | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 10.0k $112.0k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 10.0k $111.5k | New |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 9.6k $106.9k | Added +3.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 9.3k $104.0k | Added +1.0k |
| VIRTUS ADVISERS, LLC 0.04% of their portfolio | 6.6k $73.2k | Reduced -453 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 4.7k $52.9k | Reduced -2.8k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 3.5k $39.0k | Reduced -4.4k |
| EntryPoint Capital, LLC 0.03% of their portfolio | 2.8k $31.7k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.8k $31.1k | Unchanged |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 2.4k $27.0k | New |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 1.6k $17.6k | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 1.3k $14.7k | Reduced -590 |
| Bradley & Co. Private Wealth Management, LLC 0.01% of their portfolio | 1.0k $11.2k | Unchanged |
| AMALGAMATED BANK 0.00% of their portfolio | 897 $10.0k | Reduced -974 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 600 $7.0k | Reduced -7.8k |
| COMERICA BANK 0.00% of their portfolio | 456 $5.1k | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 402 $4.5k | Added +10 |
| Red Tortoise LLC 0.00% of their portfolio | 340 $3.8k | Unchanged |
| Lindbrook Capital, LLC 0.00% of their portfolio | 282 $3.1k | Unchanged |
| Parallel Advisors, LLC 0.00% of their portfolio | 204 $2.3k | Reduced -125 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 138 $2.0k | Unchanged |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 131 $1.5k | Unchanged |
| Private Wealth Management Group, LLC 0.00% of their portfolio | 98 $1.1k | Unchanged |
| Capital Advisors, Ltd. LLC 0.00% of their portfolio | 79 $1.0k | Unchanged |